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31. 发明授权

US09271654B2 Thermoacoustic imaging with quantitative extraction of absorption map 有权
标题翻译：热声成像与定量提取吸收图
公开(公告)号：US09271654B2
公开(公告)日：2016-03-01
申请号：US13381207
申请日：2009-06-29
申请人： Daniel Razansky , Vasilis Ntziachristos , Amir Rosenthal
发明人： Daniel Razansky , Vasilis Ntziachristos , Amir Rosenthal
IPC分类号： A61B5/00 , G01N21/17
CPC分类号： A61B5/0095 , A61B5/0059 , A61B5/0093 , G01N21/17 , G01N21/1702
摘要： A method of thermoacoustic imaging of an object includes providing thermoacoustic signals representing a mechanical wave response to a delivery of electromagnetic energy into the imaged object, reconstructing an energy deposition image representing a local energy absorption within the object based on the thermoacoustic signals, and decomposing the energy deposition image into a quantitative absorption image representing a distribution of a local absorption coefficient in the object and at least one further image component.
摘要翻译：一种物体的热声成像方法包括提供表示机械波响应的热声信号，以将电磁能量传送到成像对象中，基于热声信号重建表示对象内局部能量吸收的能量沉积图像，并分解能量沉积图像转换为表示物体中局部吸收系数分布的定量吸收图像和至少一个其它图像分量。

32. 发明申请

US20150272445A1 HYBRID CATHETER SYSTEM 审中-公开
标题翻译：混合导管系统
公开(公告)号：US20150272445A1
公开(公告)日：2015-10-01
申请号：US14437765
申请日：2013-10-18
申请人： Amir ROZENTAL , Farouc JAFFER , Vasilis NTZIACHRISTOS , R. Nika NUDELMAN
发明人： Amir Rozental , Farouc Jaffer , Vasilis Ntziachristos , Nika R. Nudelman
IPC分类号： A61B5/00
CPC分类号： A61B5/0095 , A61B1/00071 , A61B1/0011 , A61B1/00165 , A61B1/043 , A61B1/07 , A61B5/0071 , A61B5/0084 , A61B5/6852 , A61B8/12 , A61B8/4416 , A61B8/445 , A61B2562/0204 , A61B2562/0238
摘要： System and method for obtaining information about a target structure. The system includes an optoelectrical element with an optical fiber having a core, a coating surrounding the core, an optical axis, a proximal end, and a distal end. The optoelectrical element also includes an electrical connector embedded within the coating along the optical axis between the proximal end and the distal end. A. transducer is disposed at the distal end and electrically connected to the electrical connector. The transducer is operable to detect a first energy, generated in response to light that has been transmitted from the proximal end to the distal end and outcoupled from the distal end toward the target structure, and to convert the received first energy to an electrical signal to be transmitted along the electrical connector.
摘要翻译：用于获取关于目标结构的信息的系统和方法。该系统包括具有光纤的光电元件，其具有芯，围绕芯的涂层，光轴，近端和远端。光电元件还包括沿着近端和远端之间的光轴嵌入涂层内的电连接器。 A.换能器设置在远端并电连接到电连接器。换能器可操作以检测响应于已经从近端传递到远端并且从远端朝向目标结构输出的光而产生的第一能量，并且将接收到的第一能量转换为电信号沿电连接器传输。

33. 发明申请

US20140363066A1 SYSTEM FOR CREATING A TOMOGRAPHIC OBJECT IMAGE BASED ON MULTIPLE IMAGING MODALITIES 有权
标题翻译：基于多种成像模式创建图像对象图像的系统
公开(公告)号：US20140363066A1
公开(公告)日：2014-12-11
申请号：US14358037
申请日：2011-11-18
申请人： Vasilis Ntziachristos , Angelica Ale
发明人： Vasilis Ntziachristos , Angelica Ale
IPC分类号： G06T11/00
CPC分类号： G06T11/006 , G06T2210/41 , G06T2211/40
摘要： A system for creating an object image of an object under investigation, comprises a computing device being configured for creating the object image by using first tomography data of the object provided by a first tomography system and second tomography data of the object provided by a second tomography system, wherein the computing device is configured for calculating a first forward model describing the first tomography data using the second tomography data, performing a first inversion of the first forward model, calculating a parameter set using the first inversion, and performing a second inversion using the parameter set to obtain the object image to be created. Furthermore, a method of imaging an object under investigation is described, wherein the system for creating an object image is used.
摘要翻译：一种用于创建被调查对象的对象图像的系统，包括：计算设备，被配置为通过使用由第一层析摄影系统提供的对象的第一层析成像数据和由第二层析成像仪提供的对象的第二层析成像数据来创建对象图像系统，其中所述计算设备被配置为使用所述第二断层摄影数据来计算描述所述第一断层摄影数据的第一前向模型，执行所述第一正向模型的第一倒置，使用所述第一倒置来计算参数集合，以及使用该参数设置为获取要创建的对象图像。此外，描述了一种对待调查对象进行成像的方法，其中使用用于创建对象图像的系统。

34. 发明授权

US08812088B2 Imaging volumes with arbitrary geometries in contact and non-contact tomography 有权
标题翻译：在接触和非接触层析成像中具有任意几何形状的成像体积
公开(公告)号：US08812088B2
公开(公告)日：2014-08-19
申请号：US13460005
申请日：2012-04-30
申请人： Jorge Ripoll Lorenzo , Vasilis Ntziachristos , Karen Madden
发明人： Jorge Ripoll Lorenzo , Vasilis Ntziachristos , Karen Madden
IPC分类号： A61B6/00
CPC分类号： A61B5/0073 , A61B5/0059 , A61B5/0071 , A61B5/415 , A61B5/418 , A61B5/4504 , A61B5/4528 , A61B5/4887 , G01N21/4795 , G01N33/49
摘要： A method for tomographic imaging of diffuse medium includes directing waves into a diffusive medium, solving a surface-bounded inversion problem by forward field calculations through decomposition of contributions from the multiple reflections from an arbitrary surface within the diffusive medium or outside the diffusive medium into a sum of different orders of reflection up to an arbitrary order, and using contact or non-contact measurements of waves outside said diffusive medium to generate a tomographic image.
摘要翻译：扩散介质的层析成像方法包括将波浪引导到扩散介质中，通过将来自多个反射的贡献从扩散介质内或扩散介质外部的任意表面的贡献分解为正向场计算来解决表面有界反转问题，将不同反射次数的总和直到任意次序，以及使用所述漫射介质外的波的接触或非接触测量来产生断层图像。

35. 发明申请

US20120302879A1 FLUORESCENCE-MEDIATED MOLECULAR TOMOGRAPHY 审中-公开
标题翻译：荧光介导的分子造影
公开(公告)号：US20120302879A1
公开(公告)日：2012-11-29
申请号：US13481568
申请日：2012-05-25
申请人： Vasilis Ntziachristos , Ralph Weissleder
发明人： Vasilis Ntziachristos , Ralph Weissleder
IPC分类号： A61B6/02
CPC分类号： A61B5/0073 , G01N21/4795 , G01N21/6428 , G01N2021/6484
摘要： This invention relates to a fluorescence-mediated molecular tomographic imaging system, designed to detect near-infrared fluorescence activation in deep tissues. The system can use targeted fluorescent molecular probes or highly sensitive activatable fluorescence molecular probes. Such probes add molecular specificity and yield high fluorescence contrast, to allow early detection and molecular target assessment of diseased tissue, such as cancers, in vivo. The new tomographic imaging system enables three-dimensional localization in deep tissues and quantitation of molecular probes.
摘要翻译：本发明涉及一种荧光介导的分子断层成像系统，设计用于检测深部组织中的近红外荧光激活。该系统可以使用靶向荧光分子探针或高灵敏度可激活的荧光分子探针。这样的探针增加分子特异性并产生高荧光对比度，以允许在体内对病变组织（例如癌症）进行早期检测和分子靶标评估。新的断层成像系统能够在深层组织中进行三维定位，并对分子探针进行定量。

36. 发明申请

US20120220851A1 IMAGING DEVICE AND METHOD FOR OPTOACOUSTIC IMAGING OF SMALL ANIMALS 审中-公开
标题翻译：小动物光学成像的成像装置和方法
公开(公告)号：US20120220851A1
公开(公告)日：2012-08-30
申请号：US13386491
申请日：2010-07-23
申请人： Daniel Razansky , Vasilis Ntziachristos
发明人： Daniel Razansky , Vasilis Ntziachristos
IPC分类号： A61B6/00
CPC分类号： A61B5/0073 , A61B5/0095 , A61B6/508 , A61B8/13 , A61B2503/40 , G01N21/1702 , G01N21/39 , G01N2021/1787 , G01N2201/0826
摘要： An imaging device configured for optoacoustic imaging of an object, including an illumination device including optical components arranged to illuminate the object, a detector device comprising an array of detector elements arranged in a tank and arranged to detect acoustic signals created in the object, and a container device including a tank arranged to accommodate the detector device, the object and a matching transmission medium, a holding device adapted to position and move the object relative to the illumination device and the detector device, wherein the optical components are arranged in the tank to illuminate the object from different directions.
摘要翻译：一种被配置用于物体的光声成像的成像装置，包括包括布置成照射物体的光学部件的照明装置，包括布置在罐中并被布置成检测在物体中产生的声信号的检测器元件阵列的检测器装置，以及容器装置，包括布置成容纳检测器装置的容器，物体和匹配的传输介质，适于相对于照明装置和检测器装置定位和移动物体的保持装置，其中光学部件布置在罐中从不同的方向照亮物体。

37. 发明授权

US08190241B2 Fluorescence-mediated molecular tomography 有权
标题翻译：荧光介导的分子断层扫描
公开(公告)号：US08190241B2
公开(公告)日：2012-05-29
申请号：US12126745
申请日：2008-05-23
申请人： Vasilis Ntziachristos , Ralph Weissleder
发明人： Vasilis Ntziachristos , Ralph Weissleder
IPC分类号： A61B6/00
CPC分类号： A61B5/0073 , G01N21/4795 , G01N21/6428 , G01N2021/6484
摘要： This invention relates to a fluorescence-mediated molecular tomographic imaging system, designed to detect near-infrared fluorescence activation in deep tissues. The system can use targeted fluorescent molecular probes or highly sensitive activatable fluorescence molecular probes. Such probes add molecular specificity and yield high fluorescence contrast, to allow early detection and molecular target assessment of diseased tissue, such as cancers, in vivo. The new tomographic imaging system enables three-dimensional localization in deep tissues and quantitation of molecular probes.
摘要翻译：本发明涉及一种荧光介导的分子断层成像系统，设计用于检测深部组织中的近红外荧光激活。该系统可以使用靶向荧光分子探针或高灵敏度可激活的荧光分子探针。这样的探针增加分子特异性并产生高荧光对比度，以允许在体内对病变组织（例如癌症）进行早期检测和分子靶标评估。新的断层成像系统能够在深层组织中进行三维定位，并对分子探针进行定量。

38. 发明申请

US20120123256A1 THERMOACOUSTIC IMAGING WITH QUANTITATIVE EXTRACTION OF ABSORPTION MAP 有权
标题翻译：热量摄影与定量抽取吸收图
公开(公告)号：US20120123256A1
公开(公告)日：2012-05-17
申请号：US13381207
申请日：2009-06-29
申请人： Daniel Razansky , Vasilis Ntziachristos , Amir Rosenthal
发明人： Daniel Razansky , Vasilis Ntziachristos , Amir Rosenthal
IPC分类号： A61B6/00 , G06K9/00
CPC分类号： A61B5/0095 , A61B5/0059 , A61B5/0093 , G01N21/17 , G01N21/1702
摘要： A method of thermoacoustic imaging of an object includes providing thermoacoustic signals representing a mechanical wave response to a delivery of electromagnetic energy into the imaged object, reconstructing an energy deposition image representing a local energy absorption within the object based on the thermoacoustic signals, and decomposing the energy deposition image into a quantitative absorption image representing a distribution of a local absorption coefficient in the object and at least one further image component.
摘要翻译：一种物体的热声成像方法包括提供表示机械波响应的热声信号，以将电磁能量传送到成像对象中，基于热声信号重建表示对象内局部能量吸收的能量沉积图像，并分解能量沉积图像转换为表示物体中局部吸收系数分布的定量吸收图像和至少一个其它图像分量。

39. 发明申请

US20110301453A1 Method and System for Free Space Optical Tomography of Diffuse Media 有权
标题翻译：漫射介质的自由空间光学层析成像方法与系统
公开(公告)号：US20110301453A1
公开(公告)日：2011-12-08
申请号：US13099929
申请日：2011-05-03
申请人： Vasilis Ntziachristos , Jorge Ripoll
发明人： Vasilis Ntziachristos , Jorge Ripoll
IPC分类号： A61B6/00
CPC分类号： A61B5/0066 , A61B5/0071 , A61B5/0073 , A61B5/1076 , A61B5/1077
摘要： A method and a system for free space optical tomography provides one or more light source and one or more light sensors spaced, which in one embodiment are spaced apart from and object to be imaged. A surface capture system coupled to a variety of optical models provides the method and system with the ability to render accurate tomographic images though the light has propagated both through a diffuse medium and, in on embodiment, also through free space to the one or more light sensors.
摘要翻译：用于自由空间光学断层摄影的方法和系统提供了一个或多个光源和一个或多个间隔开的光传感器，在一个实施例中，光传感器与要成像的物体间隔开。耦合到各种光学模型的表面捕获系统为方法和系统提供了能够呈现精确的断层图像的能力，尽管光已经通过漫射介质传播，并且在实施例中也通过自由空间传播到一个或多个光传感器。

40. 发明授权

US07647091B2 Method and system for free space optical tomography of diffuse media 有权
标题翻译：漫射介质的自由空间光学层析成像方法与系统
公开(公告)号：US07647091B2
公开(公告)日：2010-01-12
申请号：US10543728
申请日：2004-02-05
申请人： Vasilis Ntziachristos , Jorge Ripoll
发明人： Vasilis Ntziachristos , Jorge Ripoll
IPC分类号： A61B6/00
CPC分类号： A61B5/0066 , A61B5/0071 , A61B5/0073 , A61B5/1076 , A61B5/1077
摘要： A method and a system for free space optical tomography provides one or more light source and one or more light sensors spaced, which in one embodiment are spaced apart from and object to be imaged. A surface capture system coupled to a variety of optical models provides the method and system with the ability to render accurate tomographic images though the light has propagated both through a diffuse medium and, in on embodiment, also through free space to the one or more light sensors.
摘要翻译：用于自由空间光学断层摄影的方法和系统提供了一个或多个光源和一个或多个间隔开的光传感器，在一个实施例中，光传感器与要成像的物体间隔开。耦合到各种光学模型的表面捕获系统为方法和系统提供了能够呈现精确的断层图像的能力，尽管光已经通过漫射介质传播，并且在实施例中也通过自由空间传播到一个或多个光传感器。

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