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31. 发明授权

US07038035B1 Vaccine-induced hepatitis B viral strain and uses thereof 失效
标题翻译：疫苗诱导的乙型肝炎病毒株及其用途
公开(公告)号：US07038035B1
公开(公告)日：2006-05-02
申请号：US09719533
申请日：1998-06-19
申请人： Chong Jin Oon , Gek Keow Lim , Ai Lin Leong , Yi Zhao , Wei Ning Chen
发明人： Chong Jin Oon , Gek Keow Lim , Ai Lin Leong , Yi Zhao , Wei Ning Chen
IPC分类号： C07H21/04 , C12N7/00 , C12N7/01 , C12N15/09 , C12N15/51
CPC分类号： G01N33/5764 , A61K39/12 , A61K39/29 , C07K14/005 , C07K14/71 , C07K2319/00 , C07K2319/30 , C12N7/00 , C12N2730/10122 , C12N2730/10134 , C12Q1/706
摘要： This invention provides an isolated strain of Hepatitis B virus designated Human Hepatitis B Virus Surface Antigen-'Ś-145 Singapore Strain (Glycine to Arginine) which constituent viral genome is deposited under Accession Nos. P97121504, P97121505 and P97121506 with the European Collection of Cell Culture on 15th Dec. 1997. This invention also provides an isolated nucleic acid encoding a polypeptide which is a mutant major surface antigen of a strain of hepatitis B virus, such polypeptide having an amino acid sequence which differs from the amino acid sequence of a major surface antigen of a wild type hepatitis B virus in that the amino acid at position number 145 of such polypeptide is an arginine rather than a glycine, and the purified peptide. This invention further provides an isolated nucleic acid which encodes a peptide, wherein the peptide is encoded by a nucleic acid molecule comprising nucleotides 527 through 595 of SEQ. ID. No. 1, and the purified peptide. This invention also provides various methods using the disclosed isolated nucleic acids and polypeptides. This invention also provides various uses of the viral strain and its proteins.
摘要翻译：本发明提供了一种分离的乙型肝炎病毒株，命名为人乙型肝炎病毒表面抗原-145新加坡菌株（Glycine to Arginine），其构成病毒基因组以保藏号P97121504，P97121505和P97121506与欧洲细胞集合本发明还提供了编码多肽的分离核酸，其是乙型肝炎病毒株的突变型主要表面抗原，该多肽具有不同于主要的氨基酸序列的氨基酸序列野生型乙型肝炎病毒的表面抗原是这种多肽的位置编号145的氨基酸是精氨酸而不是甘氨酸，和纯化的肽。本发明还提供了编码肽的分离的核酸，其中所述肽由包含SEQ ID NO：5的核苷酸527至595的核酸分子编码。 ID。 1和纯化肽。本发明还提供了使用公开的分离的核酸和多肽的各种方法。本发明还提供了病毒株及其蛋白质的各种用途。

32. 发明申请

US20060057580A1 Biochip with maximization of the reactor number 审中-公开
标题翻译：生物芯片最大化反应器数量
公开(公告)号：US20060057580A1
公开(公告)日：2006-03-16
申请号：US10517452
申请日：2003-01-22
申请人： Fanglin Zou , Chunsheng Chen , Jianxia Wang , Ning Chen
发明人： Fanglin Zou , Chunsheng Chen , Jianxia Wang , Ning Chen
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： B01L3/5088 , B01J2219/00286 , B01J2219/00353 , B01J2219/00364 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00637 , B01J2219/00659 , B01J2219/00662 , B01J2219/00725 , B01L3/502707 , B01L2300/0822 , B01L2300/089 , B01L2400/0406 , B01L2400/0677
摘要： This invention concerns a biochip, consisting primarily of one or several dieplates and one or several substrates with or without probe immobilized, and comprising a maximized number of reactors, wherein: a. said maximization of said reactor number is performed by minimizing structure-covered area on the substrate and/or maximizing effective area on the substrate, wherein said structure is partition structure of the reactor and/or structure other than the reactor; and b. said partition structure is characteristically based on surface partition, hydrophobic surface partition, or height-difference partition.
摘要翻译：本发明涉及一种生物芯片，其主要由一个或几个二极板和一个或多个具有或不具有探针固定的底物组成，并且包括最大数量的反应器，其中：a。通过最小化衬底上的结构覆盖面积和/或使衬底上的有效面积最大化来实现所述反应器数量的最大化，其中所述结构是除了反应器之外的反应器和/或结构的分隔结构; 和b。所述分隔结构的特征是基于表面分隔，疏水表面分隔或高差分区。

33. 发明申请

US20060030618A1 Vanilloid receptor ligands and their use in treatments 审中-公开
公开(公告)号：US20060030618A1
公开(公告)日：2006-02-09
申请号：US11100272
申请日：2005-04-05
申请人： Yunxin Bo , Partha Chakrabarti , Ning Chen , Elizabeth Doherty , Christopher Fotsch , Nianhe Han , Michael Kelly , Qingyian Liu , Mark Norman , Vassil Ognyanov , Xianghong Wang , Jiawang Zhu
发明人： Yunxin Bo , Partha Chakrabarti , Ning Chen , Elizabeth Doherty , Christopher Fotsch , Nianhe Han , Michael Kelly , Qingyian Liu , Mark Norman , Vassil Ognyanov , Xianghong Wang , Jiawang Zhu
IPC分类号： A61K31/353 , C07D319/08
CPC分类号： C07D471/04 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/40 , C07D231/56 , C07D233/38 , C07D237/20 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

34. 发明申请

US20060018178A1 CIRCUIT OF SDRAM AND METHOD FOR DATA COMMUNICATION 有权
标题翻译： SDRAM电路和数据通信方法
公开(公告)号：US20060018178A1
公开(公告)日：2006-01-26
申请号：US10904267
申请日：2004-11-02
申请人： Ying-Chih Yang , Jen-Yi Liao , Yuan-Ning Chen , Chao-Yung Liu
发明人： Ying-Chih Yang , Jen-Yi Liao , Yuan-Ning Chen , Chao-Yung Liu
IPC分类号： G11C8/00
CPC分类号： G11C7/1006 , G11C7/1045 , G11C7/1051 , G11C7/1057 , G11C7/1078 , G11C7/1084 , G11C2207/105
摘要： A data communication circuit of a SDRAM for data communication comprises a plurality of data lines coupled to a plurality of data pins. The number of the data lines, according to an embodiment of the present invention, is less than the number of the data pins. When the data communication circuit receives/outputs data, one of the LDQM pin and the UDQM pin are enabled to receive/output a first part of the data. The other LDQM pin and the UDQM pin are enabled. Accordingly, the data communication circuit of the SDRAM, according to an embodiment of the present invention, is capable of transmitting more data using a bus with a narrow width.
摘要翻译：用于数据通信的SDRAM的数据通信电路包括耦合到多个数据引脚的多条数据线。根据本发明的实施例的数据线的数量小于数据引脚的数量。当数据通信电路接收/输出数据时，使能LDQM引脚和UDQM引脚之一来接收/输出数据的第一部分。另一个LDQM引脚和UDQM引脚被使能。因此，根据本发明的实施例的SDRAM的数据通信电路能够使用窄宽度的总线发送更多的数据。

35. 发明申请

US20050272931A1 Vanilloid receptor ligands and their use in treatments 审中-公开
公开(公告)号：US20050272931A1
公开(公告)日：2005-12-08
申请号：US11099978
申请日：2005-04-05
申请人： Yunxin Bo , Partha Chakrabarti , Ning Chen , Elizabeth Doherty , Christopher Fotsch , Nianhe Han , Michael Kelly , Qingyian Liu , Mark Norman , Vassil Ognyanov , Xianghong Wang , Jiawang Zhu
发明人： Yunxin Bo , Partha Chakrabarti , Ning Chen , Elizabeth Doherty , Christopher Fotsch , Nianhe Han , Michael Kelly , Qingyian Liu , Mark Norman , Vassil Ognyanov , Xianghong Wang , Jiawang Zhu
IPC分类号： C07D249/18 , A61K31/17 , A61K31/18 , A61K31/343 , A61K31/357 , A61K31/36 , A61K31/37 , A61K31/381 , A61K31/4025 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/443 , A61K31/444 , A61K31/453 , A61K31/47 , A61K31/4704 , A61K31/4709 , A61K31/472 , A61K31/496 , A61K31/4965 , A61K31/498 , A61K31/505 , A61K31/517 , A61K31/5375 , A61K31/538 , A61P1/00 , A61P1/04 , A61P1/12 , A61P3/10 , A61P9/00 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/00 , A61P13/10 , A61P17/00 , A61P17/02 , A61P17/04 , A61P17/06 , A61P17/14 , A61P19/02 , A61P25/00 , A61P25/06 , A61P27/02 , A61P29/00 , A61P31/12 , A61P37/08 , A61P43/00 , C07C233/11 , C07C233/15 , C07C233/33 , C07C233/44 , C07C311/13 , C07C311/16 , C07C317/40 , C07C323/35 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/64 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/22 , C07D215/227 , C07D215/32 , C07D215/38 , C07D215/40 , C07D215/42 , C07D217/04 , C07D231/40 , C07D231/56 , C07D233/38 , C07D235/08 , C07D235/26 , C07D237/20 , C07D239/42 , C07D239/88 , C07D239/90 , C07D241/20 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D311/16 , C07D319/18 , C07D319/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D215/16
CPC分类号： C07D471/04 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/40 , C07D231/56 , C07D233/38 , C07D237/20 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

36. 发明申请

US20050267163A1 Vanilloid receptor ligands and their use in treatments 失效
公开(公告)号：US20050267163A1
公开(公告)日：2005-12-01
申请号：US11195302
申请日：2005-08-01
申请人： Elizabeth M. Doherty , Jiawang Zhu , Markian Stec , Mark H. Norman , Vassil I. Ognyanov , Christopher H. Fotsch , Ning Chen , Partha P. Chakrabarti , Liping H. Pettus , Hui-Ling Wang , Xianghong Wang , Premilla Arasasingham
发明人： Elizabeth M. Doherty , Jiawang Zhu , Markian Stec , Mark H. Norman , Vassil I. Ognyanov , Christopher H. Fotsch , Ning Chen , Partha P. Chakrabarti , Liping H. Pettus , Hui-Ling Wang , Xianghong Wang , Premilla Arasasingham
IPC分类号： A61K31/4709 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/5377 , A61P1/00 , A61P1/04 , A61P9/00 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/00 , A61P15/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/14 , A61P19/02 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/06 , A61P27/02 , A61P29/00 , A61P37/08 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/64 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/22 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/40 , C07D231/56 , C07D233/38 , C07D237/20 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , A61K31/4439 , C07D413/02 , C07D417/02 , C07D43/02
CPC分类号： C07D231/40 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/56 , C07D233/38 , C07D237/20 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

37. 发明申请

US20050167393A1 Cleaning process and apparatus for silicate materials 有权
公开(公告)号：US20050167393A1
公开(公告)日：2005-08-04
申请号：US11061013
申请日：2005-02-17
申请人： Samantha Tan , Ning Chen
发明人： Samantha Tan , Ning Chen
IPC分类号： B44C1/22 , C23C16/44 , C23F1/00 , H01L20060101
CPC分类号： C23C16/4404 , C23C16/4407
摘要： A method for treating a surface of a quartz substrate includes preparing a substrate to provide a working surface having an initial roughness; and then ultrasonically acid-etching the working surface to increase the roughness of the working surface by at least about 10%. In one embodiment, the initial surface roughness is greater than about 10 Ra, and in another embodiment the initial surface roughness is greater than about 200 Ra. In a still further embodiment, the initial surface area, if less than about 200 Ra, is increased to greater than about 200 Ra. In other embodiments of the present invention, the working surface roughness is increased by at least about 25% or at least about 50%. Simultaneous with the increase in surface area (as measured by the roughness), the surface defects are reduced to reduce particulate contamination from the substrate.

38. 发明申请

US20050153984A1 Vanilloid receptor ligands and their use in treatments 失效
公开(公告)号：US20050153984A1
公开(公告)日：2005-07-14
申请号：US10956648
申请日：2004-09-30
申请人： Ning Chen , Thomas Nixey , Mark Norman
发明人： Ning Chen , Thomas Nixey , Mark Norman
IPC分类号： A61K31/4439 , A61K31/4709 , A61K31/497 , C07D213/65 , C07D213/68 , C07D213/70 , C07D213/74 , C07D237/14 , C07D237/18 , C07D237/20 , C07D241/18 , C07D241/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D417/02 , C07D417/12 , C07D417/14
CPC分类号： C07D213/65 , C04B35/632 , C07D213/68 , C07D213/70 , C07D213/74 , C07D237/14 , C07D237/18 , C07D237/20 , C07D241/18 , C07D241/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D417/12 , C07D417/14
摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

39. 发明申请

US20050152212A1 Memory controller capable of estimating memory power consumption 有权
标题翻译：能够估计存储器功耗的存储器控制器
公开(公告)号：US20050152212A1
公开(公告)日：2005-07-14
申请号：US11028543
申请日：2005-01-05
申请人： Ying-Chih Yang , Jen-Yi Liao , Yuan-Ning Chen
发明人： Ying-Chih Yang , Jen-Yi Liao , Yuan-Ning Chen
IPC分类号： G11C5/14 , G11C8/00
CPC分类号： G11C5/14
摘要： A memory controller capable of estimating memory power consumption includes a memory control unit, a command dispatch device, plural bank state machines and a power-state and current-accumulation device. The memory control unit generates control signals based on a memory access command sent by a system for accessing a synchronous dynamic random access memory (SDRAM). The command dispatch device synchronously receives the control signals sent by the controller to the SDRAM. The plural bank state machines are connected to the command dispatch device to receive the control signals dispatched by the command dispatch device and accordingly determine whether to transfer its internal state or not. The power-state and current-accumulation device determines on which state the SDRAM is in accordance with states of the plural band state machines, thereby computing current consumption of the SDRAM.
摘要翻译：能够估计存储器功耗的存储器控制器包括存储器控制单元，命令调度装置，多个银行状态机以及功率状态和电流累积装置。存储器控制单元基于由用于访问同步动态随机存取存储器（SDRAM）的系统发送的存储器访问命令来生成控制信号。命令调度设备同步接收控制器发送给SDRAM的控制信号。多个银行状态机连接到命令分派装置，以接收由命令分派装置分派的控制信号，从而确定是否转移其内部状态。功率状态和电流累积装置确定SDRAM根据多个带状态机的状态的哪个状态，从而计算SDRAM的电流消耗。

40. 发明授权

US06787142B2 Mutant human hepatitis B viral strain and uses thereof 失效
标题翻译：突变型人乙型肝炎病毒株及其用途
公开(公告)号：US06787142B2
公开(公告)日：2004-09-07
申请号：US10209264
申请日：2002-07-31
申请人： Chong Jin Oon , Gek Keow Lim , Yi Zhao , Wei Ning Chen
发明人： Chong Jin Oon , Gek Keow Lim , Yi Zhao , Wei Ning Chen
IPC分类号： A61K3929
CPC分类号： C07K14/005 , A61K38/00 , A61K2039/525 , C07K1/22 , C12N2730/10122
摘要： This invention provides an isolated strain of Hepatitis B virus designated Human Hepatitis B Virus Surface Antigen-‘S’-133 Oon Strain (Methionine to Threonine) which constituent viral genome is deposited under Accession Nos. P97121501, P97121502 and P97121503 with the European Collection of Cell Culture on 15th December 1997. This invention also provides an isolated nucleic acid encoding a polypeptide which is a mutant major surface antigen of a strain of hepatitis B virus, such polypeptide having an amino acid sequence which differs from the amino acid sequence of a major surface antigen of a wild type hepatitis B virus in that the amino acid at position number 133 of such polypeptide is a threonine rather than a methionine. This invention also provides an isolated nucleic acid which encodes a peptide, wherein the peptide is encoded by a nucleic acid molecule comprising nucleotides 527 through 595 of SEQ. I.D. No. 1 and the purified peptide. This invention also provides various methods of using the disclosed isolated nucleic acid and peptides.
摘要翻译：本发明提供了一种分离的乙型肝炎病毒株，其命名为人乙型肝炎病毒表面抗原-'S'-133 Oon菌株（甲硫氨酸至苏氨酸），构成病毒基因组以保藏号P97121501，P97121502和P97121503保藏在欧洲集合细胞培养。本发明还提供编码多肽的分离核酸，其是乙型肝炎病毒株的突变型主要表面抗原，该多肽具有不同于氨基酸序列的氨基酸序列的野生型乙型肝炎病毒的主要表面抗原，因为该多肽的第133位的氨基酸是苏氨酸而不是甲硫氨酸。本发明还提供了编码肽的分离的核酸，其中肽由包含SEQ ID NO：5的核苷酸527至595的核酸分子编码。 ID。 1和纯化肽。本发明还提供使用所公开的分离的核酸和肽的各种方法。

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