专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明授权

US07078395B1 Methods for treating or preventing cancer by preventing, inhibiting or arresting cell cycling 失效
标题翻译：通过预防，抑制或阻止细胞循环来治疗或预防癌症的方法
公开(公告)号：US07078395B1
公开(公告)日：2006-07-18
申请号：US09561453
申请日：2000-04-28
申请人： Michael John Reed , Barry Victor Lloyd Potter
发明人： Michael John Reed , Barry Victor Lloyd Potter
IPC分类号： A61K31/56
CPC分类号： A61K31/56
摘要： There is provided use of a cyclic compound or a pharmaceutically active salt thereof in the manufacture of a medicament to prevent and/or inhibit and/or arrest cell cycling, wherein the cyclic compound comprises at least one ring, wherein Group I and Group II, independently of each other, are attached to a ring of the cyclic compound; wherein Group I is a hydrocarbyl or an oxyhydrocarbyl group; and wherein Group II is a group of the formula X is P or S; when X is P, Y is ═O or S, Z is —OH and R is hydrocarbyl or H; when X is S, Y is ═O, Z is ═O, and R is hydrocarbyl or N(R1)(R2), wherein each of R1 and R2 is independently selected from H or a hydrocarbyl group.
摘要翻译：提供环状化合物或其药物活性盐在制备用于预防和/或抑制和/或阻止细胞循环的药物中的用途，其中所述环状化合物包含至少一个环，其中第I组和第II组，彼此独立地连接到环状化合物的环上; 其中组I是烃基或氧代烃基; 并且其中II族是式X的基团是P或S; 当X为P时，Y为-O或S，Z为-OH，R为烃基或H; 当X为S时，Y为-O，Z为-O，R为烃基或N（R 1 H 2）（R 2），其中R > 1 和R 2 <2个独立地选自H或烃基。

32. 发明授权

US06653298B2 Composition 失效
标题翻译：组成
公开(公告)号：US06653298B2
公开(公告)日：2003-11-25
申请号：US09755429
申请日：2001-01-05
申请人： Barry Victor Lloyd Potter , Michael John Reed , Walter Elger , Gudrun Roddersen , Heinrich-Thomas Proske
发明人： Barry Victor Lloyd Potter , Michael John Reed , Walter Elger , Gudrun Roddersen , Heinrich-Thomas Proske
IPC分类号： A61K3156
CPC分类号： A61K31/565 , A61K31/566 , A61K31/567
摘要： Disclosed and claimed are methods for oral contraception, or a hormone replacement therapy, or for treating breast cancer, in a patient in need thereof involving administering to the patient, at a dosage of no greater than 200 &mgr;g/day per 70 kg subject, a compound having Formula (I): wherein X in combination with K form a steroidal ring and R5 is a sulphamate group that has of the formula: wherein each of R1 and R2 is H.
摘要翻译：公开并要求保护的是在有需要的患者中口服避孕或激素替代疗法或治疗乳腺癌的方法，包括以每70kg受试者不超过200杯/天的剂量向患者施用具有式（I）的化合物：其中X与K结合形成甾族环，R 5是具有下式的氨基磺酸酯基团：其中R 1和R 2各自为H.

33. 发明授权

US06017904A Steroid sulphatase inhibitors 失效
标题翻译：类固醇硫酸酶抑制剂
公开(公告)号：US06017904A
公开(公告)日：2000-01-25
申请号：US44984
申请日：1998-03-20
申请人： Michael John Reed , Barry Victor Lloyd Potter
发明人： Michael John Reed , Barry Victor Lloyd Potter
IPC分类号： A61K31/565 , A61K31/56 , A61K31/566 , A61K31/661 , A61K31/663 , A61P35/00 , A61P43/00 , C07F9/145 , C07J31/00 , C07J51/00 , C07J53/00 , C12N9/16 , A61K31/66
CPC分类号： C07J51/00 , C07J31/006
摘要： Phosphate esters of formula: ##STR1## for use in the inhibition of steroid sulfatase enzyme, wherein R is as defined in the specification and the -O-polycycle represents a residue of a sterol.
摘要翻译：磷酸酯，其用于抑制类固醇硫酸酯酶，其中R如说明书中所定义，-O-多环代表固醇的残基。

34. 发明授权

US6011024A Steroid sulphatase inhibitors 失效
公开(公告)号：US6011024A
公开(公告)日：2000-01-04
申请号：US111927
申请日：1998-07-08
申请人： Michael John Reed , Barry Victor Lloyd Potter
发明人： Michael John Reed , Barry Victor Lloyd Potter
IPC分类号： A61K31/37 , C07D311/16 , C07D311/30 , C07D311/32 , C07D311/36 , C07J41/00 , A61K31/165
CPC分类号： A61K31/37 , C07D311/16 , C07D311/30 , C07D311/32 , C07D311/36 , C07J41/0072
摘要： A method of inhibiting steroid sulphatase activity in a subject in need of same is described. The method comprises administering to said subject a steroid sulphatase inhibiting amount of a ring system compound; which ring system compound comprises a ring to which is attached a sulphamate group of the formula ##STR1## wherein each of R.sub.1 and R.sub.2 is independently selected from H, alkyl, alkenyl, cycloalkyl and aryl, or together represent alkylene optionally containing one or more hetero atoms or groups in the alkylene chain; and wherein said compound is an inhibitor of an enzyme having steroid sulphatase activity (E.C.3.1.6.2); and if the sulphamate group of said compound is replaced with a sulphate group to form a sulphate compound and incubated with a steroid sulphatase enzyme (E.C.3.1.6.2) at a pH 7.4 and 37.degree. C. it would provide a K.sub.m value of less than 50 .mu.M.

35. 发明申请

US20190102850A1 SMART CITY COMMODITY EXCHANGE WITH SMART CONTRACTS 审中-公开
公开(公告)号：US20190102850A1
公开(公告)日：2019-04-04
申请号：US15720305
申请日：2017-09-29
申请人： David McMakin Wheeler , Ned M. Smith , Thimas Barnes Abels , Michael John Reed , Clair Michael Bowman , Thomas John Barnes
发明人： David McMakin Wheeler , Ned M. Smith , Thimas Barnes Abels , Michael John Reed , Clair Michael Bowman , Thomas John Barnes
IPC分类号： G06Q50/18 , G06Q30/06 , G06Q20/12
摘要： Embodiments involve using smart contracts in a decentralized network as a framework for a smart city commodity exchange. In at least one embodiment, consumers and service providers negotiate terms and conditions of a smart contract for providing goods or services to the consumer. The service provider may provide all requested goods and services or bundle goods and services provided from multiple vendors. Verification of smart contract fulfillment may be assisted by information from sensors or other independent data collection. The service provider may provide discounted services in exchange for information to provide to a third party. Resources of both the consumer and service provide are committed during smart contract negotiations until completion of the smart contract, or rejection of the offered terms. Resource commitments, smart contract generation, performance of the smart contract and intermediate transactions are recorded in public ledgers according to Blockchain protocols. Other embodiments are described and claimed.

36. 发明授权

US08093279B2 Compound 有权
标题翻译：复合
公开(公告)号：US08093279B2
公开(公告)日：2012-01-10
申请号：US12555342
申请日：2009-09-08
申请人： Lok Wai Lawrence Woo , Toby Jackson , Atul Purohit , Michael John Reed , Gillian Reed, legal representative , Barry Victor Lloyd Potter
发明人： Lok Wai Lawrence Woo , Toby Jackson , Atul Purohit , Michael John Reed , Barry Victor Lloyd Potter
IPC分类号： A61K31/44 , C07D249/00
CPC分类号： C07D249/08 , C07D405/10
摘要： There is provided a compound of Formula I wherein R3, R4, R5, R6 and R7 are independently selected from H and —Y—R8; wherein each R8 is independently selected from —OH, hydrocarbyl groups, oxyhydrocarbyl groups, cyano (—CN), nitro (—NO2), H-bond acceptors, and halogens; wherein at least one of R3, R4, R5, R6 and R7 is —Y—R8 wherein R8 is selected from substituted and unsubstituted heterocyclic rings and amino substituted phenyl groups, wherein X is a bond or a linker group; wherein Y is an optional linker group; and wherein ring A is optionally further substituted; wherein R9 is selected from H, —OH and —OSO2NR1R2; wherein R1 and R2 are independently selected from H and hydrocarbyl; wherein (a) X is a bond and at least one of R3, R4, R5, R6 and R7 is —Y—R8; OR (b) R9 is —OSO2NR1R2 or —OH and four of R3, R4, R5, R6 and R7 are H and one of R3, R4, R5, R6 and R7 is —Y—R8.
摘要翻译：提供式I的化合物，其中R 3，R 4，R 5，R 6和R 7独立地选自H和-Y-R 8; 其中每个R 8独立地选自-OH，烃基，羟基烃基，氰基（-CN），硝基（-NO 2），H-键受体和卤素; 其中R 3，R 4，R 5，R 6和R 7中的至少一个是-Y-R 8，其中R 8选自取代和未取代的杂环和氨基取代的苯基，其中X是键或连接基团; 其中Y是任选的连接基团; 并且其中环A任选进一步被取代; 其中R9选自H，-OH和-OSO2NR1R2; 其中R1和R2独立地选自H和烃基; 其中（a）X是键，并且R 3，R 4，R 5，R 6和R 7中的至少一个是-Y-R 8; 或（b）R9为-OSO2NR1R2或-OH，R3，R4，R5，R6和R7中的4个为H，R3，R4，R5，R6和R7之一为-Y-R8。

37. 发明授权

US07968561B2 Steroidal compounds as steroid sulphatase inhibitors 失效
标题翻译：甾类化合物作为类固醇硫酸酯酶抑制剂
公开(公告)号：US07968561B2
公开(公告)日：2011-06-28
申请号：US12200252
申请日：2008-08-28
申请人： Barry Victor Lloyd Potter , Michael John Reed , Lok Wai Lawrence Woo , Atul Purohit , Paul Foster
发明人： Barry Victor Lloyd Potter , Michael John Reed , Lok Wai Lawrence Woo , Atul Purohit , Paul Foster
IPC分类号： A01N43/42 , A61K31/44 , C07D221/18 , C07D221/22
CPC分类号： C07J63/00
摘要： There is provided a compound having Formula I wherein G is a fluorocarbyl group, and wherein R1 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group.
摘要翻译：提供具有式I的化合物，其中G是氟代羰基，其中R 1是氨基磺酸酯基，膦酸酯基，硫代膦酸酯基，磺酸酯基或磺酰胺基中的任何一个。

38. 发明授权

US07893284B2 Oestrogen derivatives as inhibitors of steroid sulphatase 失效
标题翻译：雌激素衍生物作为类固醇硫酸酯酶的抑制剂
公开(公告)号：US07893284B2
公开(公告)日：2011-02-22
申请号：US11233945
申请日：2005-09-23
申请人： Matthew Leese , Atul Purohit , Michael John Reed , Simon Paul Newman , Surinder Kuman Chander , Fabrice Jourdan , Barry Victor Lloyd Potter
发明人： Matthew Leese , Atul Purohit , Michael John Reed , Simon Paul Newman , Surinder Kuman Chander , Fabrice Jourdan , Barry Victor Lloyd Potter
IPC分类号： C07J3/00 , C07J1/00
CPC分类号： C07J43/00 , C07J41/00
摘要： The present invention provides a compound comprising a steroidal ring system and an optional group R1 selected from any one of —OH, a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; wherein the D ring of the steroidal ring system is substituted by a group R2 of the formula -L-R3, wherein L is an optional linker group and R3 is selected from groups which are or which comprise one of a nitrite group, an alcohol, an ester, an ether, an amine and an alkene, provided that when R3 is or comprises an alcohol, L is present; and wherein the A ring of the steroidal ring system is substituted at position 2 or 4 with a group R4, wherein R4 is a hydrocarbyl group.
摘要翻译：本发明提供了包含甾族环系统和选自-OH，氨基磺酸盐基团，膦酸盐基团，硫代膦酸盐基团，磺酸盐基团或磺酰胺基团中的任何一个的任选基团R1的化合物; 其中甾族环体系的D环被式-L-R3的基团R 2取代，其中L是任选的连接基团，并且R 3选自亚硝酸根基团，醇，酯，醚，胺和烯烃，条件是当R3是或包含醇时，存在L; 并且其中所述甾族环系统的A环在位置2或4与基团R 4取代，其中R 4是烃基。

39. 发明授权

US07745472B2 Compound 有权
标题翻译：复合
公开(公告)号：US07745472B2
公开(公告)日：2010-06-29
申请号：US12056920
申请日：2008-03-27
申请人： Barry Victor Lloyd Potter , Lok Wai Lawrence Woo , Atul Purohit , Michael John Reed , Oliver Brook Sutcliffe , Christian Bubert
发明人： Barry Victor Lloyd Potter , Lok Wai Lawrence Woo , Atul Purohit , Michael John Reed , Oliver Brook Sutcliffe , Christian Bubert
IPC分类号： A61K31/4196 , C07D249/08
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D413/12 , C07D417/12
摘要： There is provided a compound of Formula I wherein each T is independently selected from H, hydrocarbyl, —F—R, and a bond with one of D, E, P or Q, or together with one of P and Q forms a ring; Z is a suitable atom the valency of which is m; D, E and F are each independently of each other an optional linker group, wherein when Z is nitrogen E is other than CH2 and C═O; P, Q and R are independently of each other a ring system; and at least Q comprises a sulphamate group.
摘要翻译：提供式I的化合物，其中每个T独立地选自H，烃基，-F-R和与D，E，P或Q之一的键，或与P和Q中的一个形成环; Z是一个合适的原子，其化合价是m; D，E和F各自独立地为任选的连接基团，其中当Z为氮时，E不是CH 2且C = O; P，Q和R彼此独立地是环系; 并且至少Q包含氨基磺酸酯基团。

40. 发明申请

US20080312266A1 Steroidal Compounds For Inhibiting Steroid Sulphatase 失效
标题翻译：用于抑制类固醇硫酸酶的甾体化合物
公开(公告)号：US20080312266A1
公开(公告)日：2008-12-18
申请号：US11855603
申请日：2007-09-14
申请人： Barry Victor Lloyd Potter , Michael John Reed , Lok Wai Lawrence Woo
发明人： Barry Victor Lloyd Potter , Michael John Reed , Lok Wai Lawrence Woo
IPC分类号： A61K31/435 , C07D221/18 , C12Q1/34 , A61P35/00
CPC分类号： C07J1/0051 , C07J63/00 , C07J63/008
摘要： There is provided a compound having Formula (I) wherein G is H or a substituent, and wherein R1 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group, capable of inhibiting steroid sulphatase.
摘要翻译：提供了具有式（I）的化合物，其中G是H或取代基，并且其中R 1是能够抑制类固醇硫酸酯酶的氨基磺酸酯基，膦酸酯基，硫代膦酸酯基，磺酸酯基或磺酰胺基中的任何一种。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式