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31. 发明申请

US20070080218A1 Sale and warranty confirmation management 审中-公开
标题翻译：销售和保修确认管理
公开(公告)号：US20070080218A1
公开(公告)日：2007-04-12
申请号：US11246912
申请日：2005-10-06
申请人： John Madsen , Edmund Taylor
发明人： John Madsen , Edmund Taylor
IPC分类号： G06K15/00
CPC分类号： G06Q30/02
摘要： Sale and warranty confirmation management is disclosed. Product information is displayed for a buyer, and a selection of a desired product is received. A transaction for the desired product is completed, and a transaction confirmation record is stored, wherein the transaction confirmation record is auditable in order to confirm that the transaction for the desired product was completed with the buyer.
摘要翻译：销售和保修确认管理被披露。为买方显示产品信息，并接收所需产品的选择。完成所需产品的交易，并存储交易确认记录，其中交易确认记录是可审计的，以便确认所需产品的交易是否与买方完成。

32. 发明授权

US06805865B1 Compositions and methods for treating cancer and hyperproliferative disorders 失效
标题翻译：用于治疗癌症和过度增殖性疾病的组合物和方法
公开(公告)号：US06805865B1
公开(公告)日：2004-10-19
申请号：US09266543
申请日：1999-03-11
申请人： John W. Holaday , Antonio Ruiz , John Madsen , Stacy M. Plum
发明人： John W. Holaday , Antonio Ruiz , John Madsen , Stacy M. Plum
IPC分类号： A61K39395
CPC分类号： A61K39/0005 , A61K9/127 , A61K38/00 , A61K39/0011 , A61K2039/5258 , A61K2039/55555 , C07K16/22
摘要： Compositions and methods effective for eliciting an immune response for inhibiting abnormal or undesirable cell proliferation, particularly endothelial cell proliferation and angiogenesis related to neovascularization and tumor growth are provided. The compositions comprise a naturally occurring or synthetic protein, peptide, or protein fragment containing all or an active portion of a growth factor in a pharmaceutically acceptable carrier. The preferred growth factors comprise basic fibroblast growth factor and vascular endothelial growth factor. The methods involve administering to a human or animal the compositions described herein in a dosage sufficient to elicit an- immune response. The methods are useful for treating diseases and processes mediated by undesired and uncontrolled cell proliferation, such as cancer, particularly where uncontrolled cell proliferation is influenced by the presence of growth factors. Administration of the composition to a human or animal having metastasized tumors is useful for preventing the growth or expansion of such tumors.
摘要翻译：提供了有效地引发用于抑制异常或不期望的细胞增殖的免疫应答的组合物和方法，特别是与新生血管形成和肿瘤生长相关的内皮细胞增殖和血管生成。组合物包含在药学上可接受的载体中含有生长因子的全部或活性部分的天然存在或合成的蛋白质，肽或蛋白质片段。优选的生长因子包括碱性成纤维细胞生长因子和血管内皮生长因子。所述方法包括以足以引发免疫应答的剂量向人或动物施用本文所述的组合物。该方法可用于治疗由不期望的和不受控制的细胞增殖如癌症介导的疾病和过程，特别是在不受控制的细胞增殖受生长因子的存在影响的情况下。向具有转移性肿瘤的人或动物施用组合物可用于预防这种肿瘤的生长或扩增。

33. 发明授权

US06673828B1 Analogs of 2-Phthalimidinoglutaric acid 有权
标题翻译： 2-邻苯二甲酰氨基嘌呤酸的类似物
公开(公告)号：US06673828B1
公开(公告)日：2004-01-06
申请号：US09309464
申请日：1999-05-11
申请人： Shawn J. Green , Glenn M. Swartz, Jr. , Jamshed H. Shah , John Madsen , Adonia E. Papathanassiu , William Fogler
发明人： Shawn J. Green , Glenn M. Swartz, Jr. , Jamshed H. Shah , John Madsen , Adonia E. Papathanassiu , William Fogler
IPC分类号： A61K314035
CPC分类号： C07D209/46
摘要： The invention provides new and useful analogs of 2-phthalimidinoglutaric acid. These analogs include DL-2-methyl-2-phthalimidinoglutaric acid and hydroxylated analogs of 2-phthalimidinoglutaric. The invention also provides processes for making these analogs. The invention also provides the two individual enantiomers of DL-2-methyl-2-phthalimidinoglutaric acid, (R)-(+)-2-methyl-2-phthalimidinoglutaric acid and (S)-(−)-2-methyl-2-phthalimidinoglutaric acid, and processes for separating these individual enantiomers from the racemate. Further, the invention provides methods for inhibiting angiogenesis and treating angiogenesis-associated diseases, including cancer and macular degeneration, by administering one or more of these compounds.
摘要翻译：本发明提供了新的和有用的2-邻苯二甲酰亚氨基戊二酸的类似物。这些类似物包括DL-2-甲基-2-邻苯二甲酰亚氨基戊二酸和2-邻苯二甲酰亚氨基嘌呤的羟基化类似物。本发明还提供了制备这些类似物的方法。本发明还提供DL-2-甲基-2-邻苯二甲酰亚氨基戊二酸的两种单独的对映异构体，（R） - （+） - 2-甲基-2-邻苯二甲酰亚氨基戊二酸和（S） - （ - ） - 2-甲基-2 - 邻苯二甲酰氨基嘌呤酸，以及从外消旋体中分离这些单独的对映异构体的方法。此外，本发明提供了通过施用这些化合物中的一种或多种来抑制血管发生和治疗血管生成相关疾病（包括癌症和黄斑变性）的方法。

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