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31. 发明授权

US08409126B2 Selective cytopheresis devices and related methods thereof 有权
公开(公告)号：US08409126B2
公开(公告)日：2013-04-02
申请号：US12827606
申请日：2010-06-30
申请人： H. David Humes , Deborah Buffington
发明人： H. David Humes , Deborah Buffington
IPC分类号： A61M37/00 , C02F1/44
CPC分类号： A61M1/3687 , A61K31/34 , A61M1/34 , A61M1/341 , A61M1/3621 , A61M1/3633 , A61M1/3666 , A61M1/3667 , A61M1/3672 , A61M1/3679 , A61M2205/3331 , G01N33/56972
摘要： The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.

32. 发明申请

US20120277720A1 SELECTIVE CYTOPHERESIS DEVICES AND RELATED METHODS THEREOF 有权
公开(公告)号：US20120277720A1
公开(公告)日：2012-11-01
申请号：US13531870
申请日：2012-06-25
申请人： H. David Humes , Deborah Buffington
发明人： H. David Humes , Deborah Buffington
IPC分类号： A61M1/36 , A61M1/34
CPC分类号： A61M1/3687 , A61K31/34 , A61M1/34 , A61M1/341 , A61M1/3621 , A61M1/3633 , A61M1/3666 , A61M1/3667 , A61M1/3672 , A61M1/3679 , A61M2205/3331 , G01N33/56972
摘要： The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.

33. 发明授权

US08048419B2 Extracorporeal cell-based therapeutic device and delivery system 有权
标题翻译：体外细胞治疗装置和输送系统
公开(公告)号：US08048419B2
公开(公告)日：2011-11-01
申请号：US11670123
申请日：2007-02-01
申请人： H. David Humes
发明人： H. David Humes
IPC分类号： A61K39/00 , A01N63/00 , G01N33/554
CPC分类号： A61M5/14 , A61M1/3655 , A61M1/3687 , A61M1/3689 , A61M2202/09
摘要： Extracorporeal cell-based therapeutic devices and delivery systems are disclosed which provide a method for therapeutic delivery of biologically active molecules produced by living cells in response to a dynamic physiologic environment. Exemplary designs are disclosed. In a first exemplary embodiment the device includes long hollow fibers in which a layer of cells are grown within the intraluminal volume or within a double hollow-filled chamber. In another exemplary embodiment the device includes a wafer or a series of wafers forms a substrate onto which cells are grown. The wafer(s) are then inserted into a device. The devices are intended to be extracorporeal. Disclosed is a device for delivering a pre-selected molecule, for example, a hormone, into a mammal's systemic circulation. The device may also deliver a member of different cell products. The device comprises an anchoring element that can be anchored to an inner wall of an extracorporeal tube for blood. The device also comprises a capsule that is held in place within the extracorporeal tube for blood or fluid by an anchor. The device is adapted to secure viable cells which produce and secrete the pre-selected molecule into blood or fluid passing the capsule. The invention also provides a minimally invasive method for percutaneously introducing into a preselected blood vessel or body cavity the device of the invention.
摘要翻译：公开了基于体外细胞的治疗装置和递送系统，其提供了响应于动态生理环境而由活细胞产生的生物活性分子的治疗递送的方法。公开了示例性设计。在第一示例性实施例中，该装置包括长的中空纤维，其中细胞层在管腔内体积内生长或在双重中空填充的腔室内生长。在另一个示例性实施例中，该装置包括晶片或一系列晶片形成其上生长细胞的基底。然后将晶片插入设备中。这些设备旨在体外。公开了用于将预先选择的分子例如激素递送到哺乳动物的全身循环中的装置。该装置还可以递送不同细胞产品的成员。该装置包括锚定元件，该锚定元件可以锚定到用于血液的体外管的内壁。该装置还包括一个胶囊，其通过锚固件保持在用于血液或流体的体外管内的适当位置。该装置适于将产生和分泌预先选择的分子的活细胞固定到通过胶囊的血液或液体中。本发明还提供了一种用于经皮引入本发明的装置的预选血管或体腔的微创方法。

34. 发明申请

US20110196280A1 SELECTIVE CYTOPHERESIS DEVICES AND RELATED METHODS THEREOF 有权
标题翻译：选择性细胞培养装置及其相关方法
公开(公告)号：US20110196280A1
公开(公告)日：2011-08-11
申请号：US13087995
申请日：2011-04-15
申请人： H. David Humes , Deborah Buffington
发明人： H. David Humes , Deborah Buffington
IPC分类号： A61M1/34
CPC分类号： A61M1/3687 , A61K31/34 , A61M1/34 , A61M1/341 , A61M1/3621 , A61M1/3633 , A61M1/3666 , A61M1/3667 , A61M1/3672 , A61M1/3679 , A61M2205/3331 , G01N33/56972
摘要： The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.
摘要翻译：本发明涉及用于治疗和/或预防受试者内的炎性病症的系统和装置及相关方法。更具体地，本发明涉及隔离白细胞和/或血小板然后抑制其炎症作用的系统，装置和相关方法。

35. 发明授权

US6150164A Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo 失效
标题翻译：适用于体内或离体的生物人造肾的方法和组合物
公开(公告)号：US6150164A
公开(公告)日：2000-11-21
申请号：US941228
申请日：1997-09-30
申请人： H. David Humes
发明人： H. David Humes
IPC分类号： A61K45/00 , A61M1/16 , A61M1/34 , A61M1/36 , B01D67/00 , B01D69/00 , B01D69/14 , C12N5/02 , C12N5/071 , C12N5/077 , C12N5/00 , C12N5/06 , C12N5/08
CPC分类号： C12N5/0686 , A61M1/3489 , A61M1/3687 , B01D67/0088 , B01D69/00 , B01D69/141 , C12M21/08 , C12M25/10 , C12N5/0697 , A61M1/16 , A61M1/1678 , C12N2502/1347 , C12N2502/256 , C12N2502/28 , C12N2510/00 , C12N2510/02
摘要： A novel cell seeded hollow fiber bioreactor is described as a potential bioartificial kidney. Endothelial cells along with pericyte, vascular smooth muscle, and/or mesangial cells or any mesenchymally derived support cells are seeded along a hollow fiber in a perfused bioreactor to reproduce the ultrafiltration function and transport function of the kidney. Maintenance of tissue specific function and ultrastructure suggest that this bioreactor provides an economical device for treating renal failure.
摘要翻译：一种新型细胞接种的中空纤维生物反应器被描述为潜在的生物人造肾。将内皮细胞与周细胞，血管平滑肌和/或肾小球膜细胞或任何间充质衍生的支持细胞一起沿着灌注的生物反应器中的中空纤维接种以再现肾脏的超滤功能和转运功能。组织特异性功能和超微结构的维持表明，该生物反应器是治疗肾功能衰竭的经济手段。

36. 发明授权

US6060270A Methods and compositions for isolation and growth of kidney tubule stem cells, in vitro kidney tubulogenesis and ex vivo construction of renal tubules 失效
标题翻译：用于分离和生长肾小管干细胞的方法和组合物，体外肾细胞生成和肾小管的体外构建
公开(公告)号：US6060270A
公开(公告)日：2000-05-09
申请号：US449912
申请日：1995-05-25
申请人： H. David Humes
发明人： H. David Humes
IPC分类号： C12N15/09 , A61F2/02 , A61K31/20 , A61K31/557 , A61K31/57 , A61K33/12 , A61K33/24 , A61K35/12 , A61K38/22 , A61K48/00 , A61P13/02 , A61P15/00 , C12M3/06 , C12N5/00 , C12N5/02 , C12N5/071 , C12N5/074 , C12N5/10 , C12N15/63 , C12N15/85 , C12N15/00 , A61K38/18
CPC分类号： C12N5/0686 , C12N5/0687 , A61K35/12 , A61K48/00 , C12N2501/11 , C12N2501/148 , C12N2501/15 , C12N2501/385 , C12N2502/28 , C12N2510/00 , C12N2533/54
摘要： Methods, including culture media conditions, which provide for isolation and purification of renal tubule stem cells and for in vitro kidney tubulogenesis are disclosed. The methods rely on culturing adult kidney cells in a culture media treated with combinations of transforming growth factor-.beta..sub.1, epidermal growth factor, and all-trans retinoic acid.
摘要翻译：公开了包括提供肾小管干细胞分离和纯化以及体外肾细胞发生的方法，包括培养基条件。该方法依赖于在转化生长因子-β1，表皮生长因子和全反式视黄酸组合处理的培养基中培养成年肾细胞。

37. 发明授权

US5686289A Method and compositions of a bioartificial kidney suitable for use in vivo or ex vivo 失效
标题翻译：适用于体内或离体的生物人造肾的方法和组合物
公开(公告)号：US5686289A
公开(公告)日：1997-11-11
申请号：US487327
申请日：1995-06-07
申请人： H. David Humes , Deborah A. Cieslinski
发明人： H. David Humes , Deborah A. Cieslinski
IPC分类号： C12N15/09 , A61F2/02 , A61K31/20 , A61K31/557 , A61K31/57 , A61K33/12 , A61K33/24 , A61K35/12 , A61K38/22 , A61K48/00 , A61L27/00 , A61M1/14 , A61M1/18 , A61P13/02 , A61P15/00 , C12M3/06 , C12N5/00 , C12N5/02 , C12N5/071 , C12N5/074 , C12N5/10 , C12N15/63 , C12N15/85 , A61K38/18
CPC分类号： C12N5/0687 , A61F2/022 , C12M21/08 , C12M23/06 , C12M25/02 , C12M29/04 , C12M29/16 , C12N5/069 , C12N5/0697 , A61K35/12 , A61K48/00 , C12N2501/11 , C12N2501/15 , C12N2501/385 , C12N2502/256 , C12N2502/28 , C12N2510/00 , C12N2533/54
摘要： A novel cell seeded hollow fiber bioreactor is described as a potential bioartificial kidney. Renal cells are seeded along a hollow fiber in a perfused bioreactor to reproduce the ultrafiltration function and transport function of the kidney. Maintenance of tissue specific function and ultrastructure suggest that this bioreactor provides an economical device for treating renal failure as well as studying renal tubululogenesis in vitro.
摘要翻译：一种新型细胞接种的中空纤维生物反应器被描述为潜在的生物人造肾。将肾细胞沿着中空纤维接种在灌注的生物反应器中以再现肾脏的超滤功能和转运功能。维持组织特异性功能和超微结构表明，该生物反应器为治疗肾衰竭以及在体外研究肾脏肾小管生成提供了经济手段。

38. 发明申请

US20130288370A1 CYTOPHERESIS CARTRIDGES AND USE THEREOF 审中-公开
标题翻译： CYTOPHERESIS CARTRIDGES及其用途
公开(公告)号：US20130288370A1
公开(公告)日：2013-10-31
申请号：US13878954
申请日：2011-10-14
申请人： H. David Humes , Deborah Buffington , Christopher J. Pino
发明人： H. David Humes , Deborah Buffington , Christopher J. Pino
IPC分类号： C12N5/078
CPC分类号： C12N5/0634 , A61M1/1698 , A61M1/3672 , A61M1/3675 , A61M1/3679 , A61M2202/0427 , A61M2202/0439 , B01D63/02 , B01D2313/44
摘要： The present invention relates to a cytopheretic cartridge for use in treating and/or preventing inflammatory conditions within a subject and to related methods. More particularly, the invention relates to a cytopheretic cartridge that includes a housing and, disposed within the housing, a solid support capable of sequestering activated leukocytes and/or platelets.
摘要翻译：本发明涉及用于治疗和/或预防受试者内的炎性病症的细胞底物盒和相关方法。更具体地说，本发明涉及一种包括壳体和在外壳内设置能够隔离活化的白细胞和/或血小板的固体支持物的细胞底物盒。

39. 发明申请

US20120258011A1 SELECTIVE CYTOPHERESIS DEVICES AND RELATED METHODS THEREOF 有权
公开(公告)号：US20120258011A1
公开(公告)日：2012-10-11
申请号：US13531872
申请日：2012-06-25
申请人： H. David Humes , Deborah Buffington
发明人： H. David Humes , Deborah Buffington
IPC分类号： A61M1/34
CPC分类号： A61M1/3687 , A61K31/34 , A61M1/34 , A61M1/341 , A61M1/3621 , A61M1/3633 , A61M1/3666 , A61M1/3667 , A61M1/3672 , A61M1/3679 , A61M2205/3331 , G01N33/56972
摘要： The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.

40. 发明申请

US20100268147A1 SELECTIVE CYTOPHERESIS DEVICES AND RELATED METHODS THEREOF 有权
公开(公告)号：US20100268147A1
公开(公告)日：2010-10-21
申请号：US12827609
申请日：2010-06-30
申请人： H. David Humes , Deborah Buffington
发明人： H. David Humes , Deborah Buffington
IPC分类号： A61M1/36
CPC分类号： A61M1/3687 , A61K31/34 , A61M1/34 , A61M1/341 , A61M1/3621 , A61M1/3633 , A61M1/3666 , A61M1/3667 , A61M1/3672 , A61M1/3679 , A61M2205/3331 , G01N33/56972
摘要： The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.

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