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31. 发明授权

US06379697B1 Stabilization of photosensitive materials 失效
标题翻译：感光材料的稳定化
公开(公告)号：US06379697B1
公开(公告)日：2002-04-30
申请号：US08750269
申请日：1998-04-09
申请人： Gregory Gregoriadis , Yannis Loukas
发明人： Gregory Gregoriadis , Yannis Loukas
IPC分类号： A61K9127
CPC分类号： A61K9/1271 , A61K9/127
摘要： Liposomes containing a photosensitive material, which undergoes photodegredation on exposure to U.V. light, is retained within the liposome together with a light absorbing material capable of increasing the photostability of the photosensitive. Methods of preparing pharmaceutical compositions containing these liposomes are provided.
摘要翻译：含有感光材料的脂质体，其在暴露于紫外线下经历光降解。光与能够增加感光性的光稳定性的光吸收材料一起保留在脂质体内。提供制备含有这些脂质体的药物组合物的方法。

32. 发明申请

US20120121689A1 SMALL INTERFERING RNA DELIVERY 审中-公开
标题翻译：小干扰RNA交付
公开(公告)号：US20120121689A1
公开(公告)日：2012-05-17
申请号：US13128216
申请日：2009-11-09
申请人： Andrew David Bacon , Peter Laing , Gregory Gregoriadis
发明人： Andrew David Bacon , Peter Laing , Gregory Gregoriadis
IPC分类号： A61K9/127 , A61P9/00 , A61P31/12 , A61P31/18 , A61P3/10 , A61P29/00 , A61P19/02 , A61P35/00 , A61P19/10 , A61P37/00 , A61P1/16 , A61K31/713 , A61P3/04 , B82Y5/00
CPC分类号： A61K9/1278 , A61K9/127 , A61K9/1277 , A61K47/26 , B82Y5/00 , C12N15/111 , C12N15/113 , C12N15/88 , C12N2310/14 , C12N2320/32 , C12N2320/35 , C12N2330/30 , Y10S977/773 , Y10S977/80 , Y10S977/907 , Y10S977/915
摘要： A liposomal siRNA composition is described. The liposomes are formed of neutral liposome forming components, and the composition comprising additionally sugar. The composition provides reduced expression of target gene, without causing systemic toxicity. The composition is produced by a dehydration-rehydration technique to provide high yields and good control of liposome size.
摘要翻译：描述脂质体siRNA组合物。脂质体由中性脂质体形成组分形成，并且该组合物另外包含糖。该组合物提供靶基因的降低的表达，而不引起全身毒性。该组合物通过脱水 - 再水合技术产生，以提供高产率和良好的脂质体大小控制。

33. 发明授权

US08075896B2 Method to enhance an immune response of nucleic acid vaccination 有权
标题翻译：增强核酸疫苗免疫应答的方法
公开(公告)号：US08075896B2
公开(公告)日：2011-12-13
申请号：US12566587
申请日：2009-09-24
申请人： Andrew David Bacon , Peter Laing , Gregory Gregoriadis , Wilson Romero Caparros-Wanderley
发明人： Andrew David Bacon , Peter Laing , Gregory Gregoriadis , Wilson Romero Caparros-Wanderley
IPC分类号： A61K39/00 , A61K9/127 , C12N15/00 , C12N15/63 , C07H21/04
CPC分类号： A61K9/1277 , A61K39/00 , A61K39/12 , A61K39/145 , A61K39/292 , A61K39/39 , A61K2039/5252 , A61K2039/53 , A61K2039/55555 , A61K2039/70 , C07H21/04 , C12N7/00 , C12N2730/10134 , C12N2760/16134
摘要： A composition comprising liposomes associated with a nucleic acid operatively encoding an antigenic protein and with an assistor protein, wherein the assistor protein shares at least one epitope with the antigenic protein, and wherein the nucleic acid and said assistor protein are associated with the same liposomes is described. The composition provides an improved immune response compared to mixtures of liposomes some of which are associated with the nucleic acid and some of which are associated with the assistor protein.
摘要翻译：一种组合物，其包含与可操作地编码抗原性蛋白质和蛋白质蛋白质的核酸相关联的脂质体，其中所述组合物蛋白质与所述抗原蛋白质共享至少一个表位，并且其中所述核酸和所述组合物蛋白质与相同的脂质体相关联描述。与脂质体的混合物相比，组合物提供了改善的免疫应答，其中一些与核酸相关，并且其中一些与核苷酸蛋白质相关。

34. 发明申请

US20100056427A1 N-TERMINAL DERIVATISATION OF PROTEINS WITH POLYSACCHARIDES 有权
标题翻译：蛋白质与多糖的N-末端衍生物
公开(公告)号：US20100056427A1
公开(公告)日：2010-03-04
申请号：US12375012
申请日：2007-07-25
申请人： Sanjay Jain , Peter Laing , Gregory Gregoriadis
发明人： Sanjay Jain , Peter Laing , Gregory Gregoriadis
IPC分类号： A61K38/16 , C07K1/10 , C12N9/96
CPC分类号： A61K47/61 , A61K38/00 , A61K38/1816 , A61K38/193 , A61K38/465 , C07K14/505 , C07K14/52 , C07K14/535 , C07K14/575 , C12N9/22 , C12Y301/21001 , Y02A50/473
摘要： The present invention relates to methods for producing N-terminal derivatives of proteins in which a polysaccharide, preferably having at least terminal sialic units and preferably consisting essentially only of sialic acid units, is reacted at the N-terminus of a protein or peptide under controlled conditions to produce an N-terminal derivative. The controlled conditions include use of acidic pH for the derivatisation step and a higher pH for purification. The derivatives are useful for improving pharmacokinetics and pharmacodynamics of proteins and peptides.
摘要翻译：本发明涉及生产蛋白质的N-末端衍生物的方法，其中优选具有至少末端唾液酸单元并且优选仅基本上由唾液酸单元组成的多糖在受控的蛋白质或肽的N-末端处反应产生N-末端衍生物的条件。受控条件包括使用酸性pH用于衍生化步骤和较高的pH用于纯化。该衍生物可用于改善蛋白质和肽的药代动力学和药效学。

35. 发明授权

US07384923B2 Liposomes 有权
标题翻译：脂质体
公开(公告)号：US07384923B2
公开(公告)日：2008-06-10
申请号：US10617734
申请日：2003-07-14
申请人： Gregory Gregoriadis
发明人： Gregory Gregoriadis
IPC分类号： A61K31/70 , A61K9/127 , C12P21/06 , C12N21/00
CPC分类号： C12N15/88 , A61K9/1272 , A61K2039/53
摘要： Cationic liposomes with entrapped polynucleotide in the intravesicular space are described. The liposomes include cationic components such as cationic lipids such as DOTAP. Preferably the method of forming liposomes uses the dehydration-rehydration method in the presence of the polynucleotide. The polynucleotide preferably operatively encodes an antigen capable of eliciting a desired immune response, that is, is a gene vaccine.
摘要翻译：描述了在囊内空间内具有夹带多核苷酸的阳离子脂质体。脂质体包括阳离子组分如阳离子脂质如DOTAP。优选地，形成脂质体的方法在多核苷酸的存在下使用脱水 - 再水化方法。多核苷酸优选有效地编码能够引发所需免疫应答的抗原，即基因疫苗。

36. 发明授权

US07381421B2 Liposomes 有权
标题翻译：脂质体
公开(公告)号：US07381421B2
公开(公告)日：2008-06-03
申请号：US10149670
申请日：2000-12-12
申请人： Gregory Gregoriadis
发明人： Gregory Gregoriadis
IPC分类号： A61K9/127
CPC分类号： A61K48/00 , A61K9/127 , A61K9/1272 , Y10S424/812
摘要： Polyanionic therapeutic compounds, generally nucleic acids, are complexed with calcium phosphate and entrapped within liposomes. For DNA vaccines, the complexation and entrapment process provides improved immune response for gene vaccines delivered intramuscularly.
摘要翻译：聚阴离子治疗化合物（通常为核酸）与磷酸钙络合并被包埋在脂质体内。对于DNA疫苗，络合和捕获过程为肌内递送的基因疫苗提供了改善的免疫应答。

37. 发明申请

US20050220858A1 Method to enhance an immune response of nucleic acid vaccination 有权
标题翻译：增强核酸疫苗免疫应答的方法
公开(公告)号：US20050220858A1
公开(公告)日：2005-10-06
申请号：US10520169
申请日：2003-07-07
申请人： Andrew Bacon , Peter Laing , Gregory Gregoriadis , Wilson Caparros-Wanderley
发明人： Andrew Bacon , Peter Laing , Gregory Gregoriadis , Wilson Caparros-Wanderley
IPC分类号： A61K9/127 , A61K39/00 , A61K39/145 , A61K47/18 , A61K47/24 , A61K47/28 , A61K48/00 , A61P31/00 , A61P31/12 , A61P31/16 , A61P37/04 , C12N15/88
CPC分类号： A61K9/1277 , A61K39/00 , A61K39/12 , A61K39/145 , A61K39/292 , A61K39/39 , A61K2039/5252 , A61K2039/53 , A61K2039/55555 , A61K2039/70 , C07H21/04 , C12N7/00 , C12N2730/10134 , C12N2760/16134
摘要： A composition for the co-delivery to a cell of a nucleic acid and an assistor protein, comprising vesicles, nucleic acid and protein, wherein the nucleic acid operatively encodes an antigenic protein or portion thereof which shares at least one epitope with the assistor protein, the composition comprising said nucleic acid and said assistor protein associated with the same vesicles as one another. A preferred embodiment is a composition comprising liposomes formed from liposome forming materials and, associated with the liposomes, nucleic acid operatively encoding an antigenic protein and an assistor protein, wherein the assistor protein shares at least one epitope with the antigenic protein. The composition is for use as a vaccine and provides improved immune response compared to non-vesicular compositions, or mixtures of liposomes some of which are associated with nucleic acid and some of which are associated with assistor protein.
摘要翻译：一种用于共同递送至核酸细胞和组合蛋白的组合物，其包含囊泡，核酸和蛋白质，其中所述核酸可操作地编码与所述蛋白质共有至少一个表位的抗原蛋白质或其部分，所述组合物包含与彼此相同的囊泡相关的所述核酸和所述组合物蛋白质。优选的实施方案是包含由脂质体形成材料形成的脂质体并且与脂质体相关联的核酸，其可操作地编码抗原蛋白质和蛋白酶蛋白质的组合物，其中所述助剂蛋白质与抗原蛋白质共享至少一个表位。组合物用作疫苗并且与非囊泡组合物相比提供改善的免疫应答，或脂质体的混合物，其中一些与核酸相关，并且其中一些与核苷酸蛋白质相关。

38. 发明授权

US06322809B1 Liposomes containing particulate materials 失效
标题翻译：含有颗粒物质的脂质体
公开(公告)号：US06322809B1
公开(公告)日：2001-11-27
申请号：US08624556
申请日：1996-09-20
申请人： Gregory Gregoriadis , Sophia George Antimisiaris , Ihsan Gursel
发明人： Gregory Gregoriadis , Sophia George Antimisiaris , Ihsan Gursel
IPC分类号： A61K9127
CPC分类号： A61K9/1277 , A61K9/127 , Y10S977/907 , Y10S977/918
摘要： A method is provided for the formation of liposomes of 0.1 &mgr;m to 50 &mgr;m in diameter having unilamella or multilamella structure and containing water insoluble or undissolved particulate materials comprising (a) forming liposomes and removing substantially all of any organic solvent used in their preparation, (b) freeze drying the liposomes so formed and then (c) rehydrating them in intimate admixture with the particulate material. Preferred encapsulated materials are particulate materials, most preferably microorganisms, plant or animals cells or water insoluble structures having organic solvent labile biochemical or immunological activity, but any water insoluble particulate may be encapsulated using the method. For example, catalysts or drugs that are sparingly soluble may also be so incorporated such that slow release into the patient's body may be provided while release of detergents included in the many lipoome preparation protocols may be avoided.
摘要翻译：提供一种用于形成直径为0.1μm至50μm的脂质体的方法，其具有单丝单胞菌属或多面体结构并且含有水不溶性或未溶解的颗粒材料，其包含（a）形成脂质体并基本上除去其制备中使用的任何有机溶剂（ b）冷冻干燥所形成的脂质体，然后（c）将其与颗粒材料紧密混合后再水合。优选的包封材料是颗粒材料，最优选微生物，植物或动物细胞或具有有机溶剂不稳定的生物化学或免疫活性的水不溶性结构，但是可以使用该方法包封任何水不溶性颗粒。例如，微溶的催化剂或药物也可以这样并入，从而可以提供缓慢释放到患者体内，同时可以避免许多脂质体制剂方案中包含的去污剂的释放。

39. 发明授权

US5846951A Pharmaceutical compositions 失效
标题翻译：药物组合物
公开(公告)号：US5846951A
公开(公告)日：1998-12-08
申请号：US431474
申请日：1995-05-01
申请人： Gregory Gregoriadis
发明人： Gregory Gregoriadis
IPC分类号： A61K9/127 , A61K47/48 , A61K31/715 , A61K9/62
CPC分类号： A61K9/1271 , A61K47/4823 , A61K47/48815 , Y10S977/801 , Y10S977/805 , Y10S977/906 , Y10S977/907 , Y10S977/915 , Y10S977/917 , Y10S977/926
摘要： Polysaccharides comprising at least 5 sialic acid residues per molecule are used to increase the circulation time of an active ingredient, for instance by decreasing the immunogenicity and/or increasing the stability in vivo of pharmaceutically active compounds. The pharmaceutically active compound may be a foreign protein which is covalently bound to the polysaccharide. Alternatively, the active compound may be associated with a drug delivery system (DDS), for instance a macro-molecular DDS or a particulate DDS, such as liposomes. The polysaccharide is usually a bacterial polysaccharide, e.g., a glycolipid or a derivative thereof, for instance polysaccharide B or E. Coli K1, N. meningitidis, Moraxella liquifaciens or Pasteurella aeroginosis, or K92 of E. Coli K92 strain.
摘要翻译：每分子含有至少5个唾液酸残基的多糖用于增加活性成分的循环时间，例如通过降低药物活性化合物的免疫原性和/或增加体内的稳定性。药物活性化合物可以是与多糖共价结合的外来蛋白质。或者，活性化合物可以与药物递送系统（DDS）相关联，例如大分子DDS或颗粒DDS，例如脂质体。多糖通常是细菌多糖，例如糖脂或其衍生物，例如多糖B或大肠杆菌K1，脑膜炎奈瑟菌，流感嗜血杆菌或嗜碱性乳杆菌病，或大肠杆菌K92菌株的K92。

40. 发明授权

US4117113A Immunological preparations 失效
标题翻译：免疫学准备
公开(公告)号：US4117113A
公开(公告)日：1978-09-26
申请号：US826409
申请日：1977-08-22
申请人： Anthony Clifford Allison , Gregory Gregoriadis
发明人： Anthony Clifford Allison , Gregory Gregoriadis
IPC分类号： A61K9/127 , A61K39/12 , A61K39/145 , A61K39/39 , A61K39/18
CPC分类号： A61K39/145 , A61K39/12 , A61K39/39 , A61K9/127 , C12N7/00 , A61K2039/55555 , A61K2039/55572 , C12N2760/16134 , C12N2760/16151 , C12N2760/16251 , C12N2760/16351 , Y10S424/812
摘要： Immunological preparations are described in which liposomes having negative charge are used as adjuvants for the purposes of human and veterinary vaccines containing viral antigens. The formulation of influenza antigen in liposomes formed with egg lecithin is described and the adjuvant effect demonstrated.

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