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31. 发明申请

US20050009085A1 44 Human secreted proteins 审中-公开
标题翻译：人类分泌的蛋白质
公开(公告)号：US20050009085A1
公开(公告)日：2005-01-13
申请号：US10918446
申请日：2004-08-16
申请人： David LaFleur , Steven Ruben , Craig Rosen , Paul Moore , Yanggu Shi , Hla Kyaw , Ying-Fei Wei
发明人： David LaFleur , Steven Ruben , Craig Rosen , Paul Moore , Yanggu Shi , Hla Kyaw , Ying-Fei Wei
IPC分类号： G01N33/50 , A61K31/711 , A61K38/00 , A61K48/00 , A61P7/02 , A61P9/00 , A61P9/10 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , G01N33/15 , C07H21/04
CPC分类号： C12Q1/6883 , A61K35/13 , A61K38/00 , C07K14/47 , G01N33/6893 , Y02A50/465
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

32. 发明授权

US5815268A Lithographic lens wavefront and distortion tester 失效
标题翻译：平版镜透镜波前和失真测试仪
公开(公告)号：US5815268A
公开(公告)日：1998-09-29
申请号：US672291
申请日：1996-06-28
申请人： L. David LaFleur
发明人： L. David LaFleur
IPC分类号： G01J9/00 , G01B9/02
CPC分类号： G01J9/00
摘要： A measurement device (2) for measuring a collimated wave front through a lithographic lens includes a radiant energy source (4), a lens group (6) for collimating light emitted from said radiant energy source and directing said collimated light (7) toward a reference surface (10). A first binary optic (12) disposed in line with said collimated light and located adjacent to an input conjugate of a lens under test. A second binary optic (18) is arranged in a spaced relationship and in line with said first binary optic for retroreflecting light passing through a lithographic lens disposed between said first and second binary optics. A recording system (8,9) is provided for recording an interference with the light retroreflected-reflected back through said lens and through said reference surface.
摘要翻译：用于通过光刻透镜测量准直波前的测量装置（2）包括辐射能源（4），用于准直从所述辐射能源发射的光的透镜组（6），并将所述准直光（7）朝向参考表面（10）。第一二进制光学器件（12），与所述准直光线对齐设置，并且与被测镜片的输入共轭相邻。第二二进制光学器件（18）以间隔的关系布置并与所述第一二元光学器件一致，用于回射通过设置在所述第一和第二二元光学器件之间的光刻透镜的光。提供一种记录系统（8,9），用于记录通过所述透镜并通过所述参考表面的后向反射回光的干涉。

33. 发明申请

US20160046678A1 MULTIVALENT AND MONOVALENT MULTISPECIFIC COMPLEXES AND THEIR USES 审中-公开
标题翻译：多功能和单一多元复合物及其用途
公开(公告)号：US20160046678A1
公开(公告)日：2016-02-18
申请号：US14776816
申请日：2014-03-14
申请人： Viktor ROSCHKE , David LAFLEUR , David M. HILBERT , Peter KIENER
发明人： Viktor ROSCHKE , David LAFLEUR , David M. HILBERT , Peter KIENER
IPC分类号： C07K14/435 , C07K7/08 , C12N9/00 , C07K16/40 , C07K16/28 , A61K45/06 , C07K16/18
CPC分类号： C07K14/435 , A61K38/00 , A61K45/06 , A61K2039/505 , C07K7/08 , C07K16/18 , C07K16/24 , C07K16/28 , C07K16/2848 , C07K16/2863 , C07K16/32 , C07K16/40 , C07K2317/31 , C07K2317/35 , C07K2317/76 , C07K2319/00 , C12N9/0002 , Y02A50/412
摘要： Compositions containing multivalent and monovalent multispecific complexes having scaffolds such as antibodies that support such binding functionalities are described. The use of and methods of compositions containing multivalent and monovalent multispecific complexes having scaffolds, such as antibodies, that support such binding functionalities are also described.
摘要翻译：描述了含有多价和单价多特异性复合物的组合物，其具有支架，例如支持这种结合功能的抗体。还描述了含有支持这种结合功能的支架例如抗体的含有多价和一价多特异性复合物的组合物的使用和方法。

34. 发明申请

US20120100166A1 Ang-2 Binding Complexes and Uses Thereof 审中-公开
标题翻译： Ang-2结合复合物及其用途
公开(公告)号：US20120100166A1
公开(公告)日：2012-04-26
申请号：US13184485
申请日：2011-07-15
申请人： Viktor Roschke , David Lafleur , David M. Hilbert , Peter Kiener
发明人： Viktor Roschke , David Lafleur , David M. Hilbert , Peter Kiener
IPC分类号： A61K38/17 , C07K7/08 , C07K19/00 , C12N15/62 , A61P37/06 , C12P21/02 , C12N1/19 , A61P19/02 , A61P29/00 , A61P1/00 , C07K14/00 , C12N5/10
CPC分类号： C07K14/47 , A61K38/00 , A61K47/6811 , A61K47/6813 , A61K47/6843 , A61K47/6845 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6879 , C07K16/22 , C07K16/24 , C07K16/241 , C07K16/2863 , C07K16/2866 , C07K16/3046 , C07K16/32 , C07K2317/73 , C07K2317/77 , C07K2319/01 , C07K2319/30 , C12N9/0002
摘要： Complexes containing one or more modular recognition domains (MRDs) and MRDs attached to scaffolds including antibodies are described. The manufacture of these complexes are the use of these complexes to treat and diagnose diseases and disorders are also described.
摘要翻译：描述了包含一个或多个模块识别结构域（MRD）和连接到包括抗体的支架的MRD的复合物。这些复合物的制备是也描述了这些复合物用于治疗和诊断疾病和病症的用途。

35. 发明申请

US20100130450A1 Methods of Treating Fungal Infections 审中-公开
标题翻译：治疗真菌感染的方法
公开(公告)号：US20100130450A1
公开(公告)日：2010-05-27
申请号：US12598679
申请日：2008-05-05
申请人： Kim Lewis , Michael David Lafleur
发明人： Kim Lewis , Michael David Lafleur
IPC分类号： A61K31/655 , C12Q1/06 , A61K31/438 , A61K31/44 , A61K31/16 , A61P31/10 , A61P31/04
CPC分类号： A61K31/05 , A61K31/10 , A61K31/166 , A61K31/4412 , A61K31/472 , A61K31/473 , A61K31/655 , C12Q1/18 , A61K2300/00
摘要： Methods of identifying compounds that potentiate the activity of antifungal agents, potentiators identified by these methods, and methods of using potentiators are disclosed.
摘要翻译：公开了鉴定增强抗真菌剂活性的化合物的方法，通过这些方法鉴定的增强剂以及使用增效剂的方法。

36. 发明申请

US20070154918A1 44 Human Secreted Proteins 审中-公开
标题翻译： 44人类分泌蛋白
公开(公告)号：US20070154918A1
公开(公告)日：2007-07-05
申请号：US11608978
申请日：2006-12-11
申请人： David LaFleur , Steven Ruben , Craig Rosen , Paul Moore , Yanggu Shi , Hla Kyaw , Ying-Fei Wei
发明人： David LaFleur , Steven Ruben , Craig Rosen , Paul Moore , Yanggu Shi , Hla Kyaw , Ying-Fei Wei
IPC分类号： C12Q1/68 , G01N33/53 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C12Q1/6883 , A61K35/13 , A61K38/00 , C07K14/47 , G01N33/6893 , Y02A50/465
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

37. 发明申请

US20070048282A1 Albumin fusion proteins 审中-公开
公开(公告)号：US20070048282A1
公开(公告)日：2007-03-01
申请号：US11500314
申请日：2006-08-08
申请人： Craig Rosen , William Haseltine , Paul Moore , Jason Bock , Adam Bell , Yanggu Shi , David LaFleur
发明人： Craig Rosen , William Haseltine , Paul Moore , Jason Bock , Adam Bell , Yanggu Shi , David LaFleur
IPC分类号： A61K38/21 , A61K38/38 , C12P21/04 , C12N15/00
CPC分类号： C07K14/765 , A61K38/00 , C07K2319/31 , C07K2319/35 , C12N15/62
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

38. 发明申请

US20060084082A1 186 human secreted proteins 审中-公开
公开(公告)号：US20060084082A1
公开(公告)日：2006-04-20
申请号：US11144947
申请日：2005-06-06
申请人： Steven Ruben , Craig Rosen , Daniel Soppet , Kenneth Carter , Daniel Bednarik , Gregory Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul Young , John Greene , Ann Ferrie , D. Duan , Jing-Shan Hu , Kimberly Florence , Henrik Olsen , Carrie Fischer , Reinhard Ebner , Laurie Brewer , Paul Moore , Yanggu Shi , David LaFleur , Yi Li , ZhiZhen Zeng , Hla Kyaw
发明人： Steven Ruben , Craig Rosen , Daniel Soppet , Kenneth Carter , Daniel Bednarik , Gregory Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul Young , John Greene , Ann Ferrie , D. Duan , Jing-Shan Hu , Kimberly Florence , Henrik Olsen , Carrie Fischer , Reinhard Ebner , Laurie Brewer , Paul Moore , Yanggu Shi , David LaFleur , Yi Li , ZhiZhen Zeng , Hla Kyaw
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C12N9/00
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/47 , G01N33/566 , G01N2800/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

39. 发明申请

US20050239099A1 27 human secreted proteins 审中-公开
标题翻译： 27种人体分泌的蛋白质
公开(公告)号：US20050239099A1
公开(公告)日：2005-10-27
申请号：US10963903
申请日：2004-10-14
申请人： Steven Ruben , Jian Ni , Reinhard Ebner , Craig Rosen , Yanggu Shi , Charles Birse , Kimberly Florence , George Komatsoulis , David LaFleur , Paul Moore , Henrik Olsen , Paul Young
发明人： Steven Ruben , Jian Ni , Reinhard Ebner , Craig Rosen , Yanggu Shi , Charles Birse , Kimberly Florence , George Komatsoulis , David LaFleur , Paul Moore , Henrik Olsen , Paul Young
IPC分类号： G01N33/50 , A61K31/711 , A61K38/00 , A61K48/00 , A61P9/00 , A61P17/00 , A61P19/02 , A61P25/02 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/12 , A61P35/00 , A61P37/00 , A61P43/00 , C07H21/04 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N15/09 , C12P21/02 , C12Q1/00 , C12Q1/02 , C12Q1/68 , C12Q1/6883 , G01N33/15 , G01N33/53 , G01N33/566
CPC分类号： C07K14/47 , C12Q1/00 , C12Q1/6883
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

40. 发明申请

US20050208619A1 29 human secreted proteins 审中-公开
标题翻译： 29人分泌蛋白
公开(公告)号：US20050208619A1
公开(公告)日：2005-09-22
申请号：US10878523
申请日：2004-06-29
申请人： Craig Rosen , Steven Ruben , Reinhard Ebner , Roxanne Duan , Jian Ni , Daniel Soppet , Paul Moore , Yanggu Shi , David LaFleur , Henrik Olsen , Charles Birse , George Komatsoulis
发明人： Craig Rosen , Steven Ruben , Reinhard Ebner , Roxanne Duan , Jian Ni , Daniel Soppet , Paul Moore , Yanggu Shi , David LaFleur , Henrik Olsen , Charles Birse , George Komatsoulis
IPC分类号： G01N33/50 , A61K38/00 , A61K45/00 , A61P9/10 , A61P17/02 , A61P17/06 , A61P25/00 , A61P25/02 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/28 , A61P29/00 , A61P31/00 , A61P31/04 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/06 , C07H21/04 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N15/09 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566
CPC分类号： C07H21/04 , C07K14/47 , C07K16/18 , C07K2317/622 , C07K2319/30
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

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