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31. 发明申请

US20110269671A1 NISIN DERIVATIVES AND THE USE THEREOF 有权
标题翻译： NISIN衍生物及其用途
公开(公告)号：US20110269671A1
公开(公告)日：2011-11-03
申请号：US12991880
申请日：2009-05-08
申请人： Paul Cotter , Colin Hill , Desmond Field
发明人： Paul Cotter , Colin Hill , Desmond Field
IPC分类号： A61K38/16 , C07H21/00 , A61P31/04 , A23L1/035 , C12N1/21 , A23C19/11 , A23L3/3526 , A23L2/52 , C07K14/195 , C12N15/63
CPC分类号： C07K14/315 , A23C19/11 , A23L3/34635 , A61K38/164
摘要： The present invention relates to a nisin derivative comprising amino acid substitutions in the peptide sequence encoding the hinge region of the protein, wherein the derivative exhibits an increased anti-microbial activity.
摘要翻译：本发明涉及在编码蛋白质铰链区的肽序列中包含氨基酸取代的乳链菌肽衍生物，其中该衍生物表现出增加的抗微生物活性。

32. 发明申请

US20110150504A1 COHERENT OPTICAL RECEIVER SYSTEM AND METHOD FOR DETECTING PHASE MODULATED SIGNALS 审中-公开
标题翻译：相关光接收机系统和检测相位调制信号的方法
公开(公告)号：US20110150504A1
公开(公告)日：2011-06-23
申请号：US12959169
申请日：2010-12-02
申请人： Andrew Ellis , Selwan K. Ibrahim , Stylianos Sygletos
发明人： Andrew Ellis , Selwan K. Ibrahim , Stylianos Sygletos
IPC分类号： H04B10/06
CPC分类号： H04B10/63 , H04B10/60 , H04B10/613
摘要： One aspect of the invention is a homodyne coherent receiver, suitable for high speed phase shift keying (PSK), the receiver comprising a receiver for receiving an incoming signal having a carrier-less modulation format, a signal conditioning sub-system that generates a carrier component from the incoming signal, and an optical injection phase locked loop (OIPLL) that phase locks the generated carrier component of the incoming signal. Embodiments of the invention may enable DSP free detection of optical PSK signals, which may be required in next generation fiber transmission systems and in optical constellation analyzer systems. In addition, embodiments of the invention may provide improved receiver sensitivity performance comparing to prior art systems using direct detection schemes. Also, embodiments of the invention may be advantageous in terms of cost and energy efficiency.
摘要翻译：本发明的一个方面是适用于高速相移键控（PSK）的零差相干接收机，该接收机包括用于接收具有无载波调制格式的输入信号的接收机，产生载波的信号调节子系统来自输入信号的分量，以及相位锁定输入信号的所生成的载波分量的光注入锁相环（OIPLL）。本发明的实施例可以实现对光PSK信号的DSP免费检测，这在下一代光纤传输系统和光学星座分析仪系统中可能是需要的。此外，与使用直接检测方案的现有技术系统相比，本发明的实施例可以提供改进的接收机灵敏度性能。此外，本发明的实施例在成本和能量效率方面可能是有利的。

33. 发明申请

US20110019823A1 OPTICAL COMMUNICATION SYSTEM AND METHOD FOR SECURE DATA COMMUNICATION USING QUANTUM KEY DISTRIBUTION 有权
标题翻译：光通信系统和使用量子密钥分发来保护数据通信的方法
公开(公告)号：US20110019823A1
公开(公告)日：2011-01-27
申请号：US12922196
申请日：2009-03-13
申请人： Paul Townsend
发明人： Paul Townsend
IPC分类号： H04K1/00
CPC分类号： H04L9/0852
摘要： The invention provides time-synchronised transmission of data on the (polarisation or phase-modulated) QKD channel and the (on-off modulated) conventional channel such that a QKD bit is only transmitted when a zero, or sequence of zeros, is transmitted on the conventional channel. Also, there is co-directional propagation of the QKD and conventional channel. Further, there is dispersion management through wavelength selection or control of fibre properties or other means such that the “walk-off in time of the QKD pulses and the Raman pulses generated by the ones on the conventional channel is less than or of the order of one bit period. The latter can be achieved, for example, by placing the conventional and QKD channel wavelengths close to the point where the group velocity-induced time delay for optical pulses propagating in the fibre reaches a minimum. This dispersion minimum occurs at a wavelength of 1.3 microns in standard fibre. The invention discloses a receiver embodiment to implement the invention.
摘要翻译：本发明提供对（偏振或相位调制）QKD信道和（开关调制的）常规信道上的数据的时间同步传输，使得仅当零或零序列被发送时才发送QKD比特传统渠道。此外，还存在QKD和常规信道的共向传播。此外，通过波长选择或光纤特性控制或其他方式进行色散管理，使得“QKD脉冲在时间上的移动和由常规信道上的信号产生的拉曼脉冲”小于或等于一段时间后者可以通过例如将常规和QKD信道波长放置在靠近在光纤中传播的光脉冲的组速度引起的时间延迟达到最小的点来实现。该分散体的最小值在标准纤维中发生在1.3微米的波长处。本发明公开了一种实现本发明的接收机实施例。

34. 发明申请

US20100284979A1 Modulation of Tissue Fatty Acid Composition of a Host by Human Gut Bacteria 审中-公开
标题翻译：通过人肠细菌调节宿主的组织脂肪酸组成
公开(公告)号：US20100284979A1
公开(公告)日：2010-11-11
申请号：US12681045
申请日：2008-09-30
申请人： Liam O'Mahony , Fergus Shanahan , Eamonn Quigley , Paul Ross , Catherine Stanton
发明人： Liam O'Mahony , Fergus Shanahan , Eamonn Quigley , Paul Ross , Catherine Stanton
IPC分类号： A61K35/74 , A61P25/28 , A61P19/02 , A61P25/24 , A61P17/00 , A61P11/06 , C12N1/20
CPC分类号： C12N1/20 , A23L33/135 , A61K31/201 , A61K35/74 , A61K35/744 , A61K35/745 , A61K35/747 , C12P7/6427 , C12P7/6472 , C12R1/01
摘要： The current invention provides use of a CLA-producing bacterium for the in vivo conversion in the gut of polyunsaturated fatty acids to CLA. The CLA-producing bacterium is selected from one or more of the group consisting of propionibacteria, lactobacilli, lactococci and streptococci, and bifidobacteria.
摘要翻译：本发明提供了使CLA产生细菌用于多不饱和脂肪酸肠内体内转化成CLA的用途。产生CLA的细菌选自丙酸杆菌属，乳杆菌属，乳球菌属和链球菌属中的一种或多种，以及双歧杆菌。

35. 发明申请

US20100111543A1 OPTICAL COMMUNICATION SYSTEM 审中-公开
标题翻译：光通信系统
公开(公告)号：US20100111543A1
公开(公告)日：2010-05-06
申请号：US12531048
申请日：2008-03-13
申请人： Chi Wai Chow , Giuseppe Talli , Andrew Ellis , Paul Townsend
发明人： Chi Wai Chow , Giuseppe Talli , Andrew Ellis , Paul Townsend
IPC分类号： H04B10/04
CPC分类号： H04B10/2587
摘要： An optical transmitter is of the reflective modulation type and has a means of generating reflection, a mixer for mixing a data stream and a sub-carrier, and an optical modulator for modulating an optical carrier with the output from the mixer in order to avoid optical beat-interference noise arising from, for example, Rayleigh backscattering. The modulator is in one embodiment of the interferometric type such as a Mach-Zehnder Modulator (MZM) operated to suppress the optical carrier at the transmitter output in order to reduce optical beat interference noise. The modulator preferably implements CSS-AMPSK modulation, which suppresses optical beat noise and achieves strong dispersion tolerance, enabling, for example, 10 Gb/s data transmission over 100 km distance without dispersion compensation. The transmitter may have a duobinary encoder, which encodes the data prior to mixing with the sub-carrier.
摘要翻译：光发射机具有反射调制型，具有产生反射的装置，用于混合数据流和副载波的混频器以及用于利用混频器的输出调制光载波的光调制器，以避免光例如由瑞利后向散射引起的干扰噪声。在诸如Mach-Zehnder调制器（MZM）的干涉式的一个实施例中，调制器被操作以抑制发射机输出处的光载波，以便减少光拍干扰噪声。调制器优选地实现CSS-AMPSK调制，其抑制光学差拍噪声并且实现强的色散容限，使得能够例如在100km距离上进行10Gb / s的数据传输而没有色散补偿。发射机可以具有双二进制编码器，其在与子载波混合之前对数据进行编码。

36. 发明授权

US5986595A Reduction of mismatch errors for multibit oversampled data converters 失效
标题翻译：减少多位过采样数据转换器的失配误差
公开(公告)号：US5986595A
公开(公告)日：1999-11-16
申请号：US810950
申请日：1997-02-27
申请人： Colin Lyden , Aidan Keady
发明人： Colin Lyden , Aidan Keady
IPC分类号： H03M1/06 , H03M1/76
CPC分类号： H03M1/0668 , H03M1/765 , H03M3/464 , H03M3/502
摘要： Mismatch errors within oversampled analog to digital (ADC) and digital to analog (DAC) data converters limit the overall conversion accuracy. A circuit is provided which interchanges the analog segments within a multibit oversampled converter in a fashion to move the mismatch errors away from the overall converter's passband frequencies and towards other frequencies where they do not interfere with the signal to be converted. The circuit works by minimizing the differences in the signals which control the individual segments. Circuits may be provided for achieving first, second and higher order "shaping" of the mismatch errors. The invention also provides a circuit in which exchange of the analog elements with the DACs of multibit oversampled converters is effected using a circular queue, so moving the mismatch errors to high frequency where they do not interfere with the signal to be converted.
摘要翻译：过采样模数（ADC）和数模（DAC）数据转换器中的不匹配误差限制了整体转换精度。提供了一种电路，其以多位过采样转换器中的模拟段交换方式，以将失配误差移动离开整个转换器的通带频率，并朝着不干扰要转换的信号的其他频率移动。该电路通过最小化控制各个段的信号的差异而起作用。可以提供电路以实现失配误差的第一，第二和更高阶“成形”。本发明还提供了一种电路，其中使用循环队列来实现模拟元件与多位过采样转换器的DAC的交换，从而将失配误差移动到高频，其中它们不干扰要转换的信号。

37. 发明授权

US5019506A Plasmid and uses thereof 失效
标题翻译：质粒及其用途
公开(公告)号：US5019506A
公开(公告)日：1991-05-28
申请号：US242259
申请日：1988-09-08
申请人： Charles Daly , Gerald F. Fitzgerald , Aidan Coffey , Veronica A. Costello , Maeve C. Murphy , Andreas Baumgartner
发明人： Charles Daly , Gerald F. Fitzgerald , Aidan Coffey , Veronica A. Costello , Maeve C. Murphy , Andreas Baumgartner
IPC分类号： C07K14/315 , C12N1/21
CPC分类号： C07K14/315
摘要： Plasmids carrying one or more genes which confer phage insensitivity upon Streptococcus lactis or Streptococcus lactis subsp. diacetylactis as well as Streptococcus cremoris bacteria in which the insensitivity is not destroyed at temperatures of up to 40.degree. C. are described. DNA fragments are also described which encode phage insensitivity. Such plasmids and DNA fragments are suitable for conferring phage insensitivity upon bacteria or food starter cultures containing bacteria.
摘要翻译：携带一种或多种赋予乳链球菌或乳链球菌亚种的噬菌体不敏感的基因的质粒。描述了在高达40℃的温度下不破坏不敏感性的二乙酰乳杆菌以及乳链球菌（Streptococcus cremoris）。还描述了编码噬菌体不敏感性的DNA片段。这样的质粒和DNA片段适合于赋予细菌或包含细菌的食物发酵剂培养物不敏感的噬菌体。

38. 发明公开

US20240197827A1 PSG1 FOR USE IN THE TREATMENT OF OSTEOARTHRITIS 审中-公开
公开(公告)号：US20240197827A1
公开(公告)日：2024-06-20
申请号：US18555431
申请日：2022-04-14
申请人： UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
发明人： Tom Moore , Anthony James Peterson Clover
IPC分类号： A61K38/17 , A61K9/00 , A61P19/02 , C07K16/30
CPC分类号： A61K38/1774 , A61K9/0019 , A61P19/02 , C07K16/3092
摘要： The use of Fc-tagged Pregnancy-specific glycoprotein 1 (PSG1-Fc) in a method of treatment of osteoarthritis or damaged cartilage in a human, in which the PSG1 is administered by intra-articular injection, is described. Also described is the use of CC49 in a method of treatment of osteoarthritis or damaged cartilage in an equine mammal, in which the CC49 is administered by intra-articular injection. (FIG. 3A-C) Also described is the use of PSG1 in a method of treatment of wounds, scarring, burns and diabetic ulcers in a mammal.

39. 发明授权

US11813618B2 Monolithic integrated mesh device for fluid dispensers and method of making same 有权
公开(公告)号：US11813618B2
公开(公告)日：2023-11-14
申请号：US16082027
申请日：2017-03-06
申请人： University College Cork—National University of Ireland, Cork
发明人： Nathan Jackson , Alan Mathewson , Zbigniew Olszewski
IPC分类号： B05B17/06 , B05B17/00
CPC分类号： B05B17/0653 , B05B17/0646 , B06B2201/77
摘要： The invention provides a monolithic integrated mesh device for atomization or pumping of a fluid or liquid comprising a plurality of apertures and a piezoelectric material. The piezoelectric material is bonded to the mesh device at an atomic scale. In one embodiment the monolithic micro-fabricated device of the invention includes piezoelectric material that eliminates the need for expensive assembly process and improves reliability. This also has advantage of requiring lower operating voltage and less complicated circuitry.

40. 发明授权

US11772978B2 Method for synthesising microparticles 有权
公开(公告)号：US11772978B2
公开(公告)日：2023-10-03
申请号：US16860970
申请日：2020-04-28
申请人： UNIVERSITY COLLEGE CORK-NATIONAL UNIVERSITY OF IRELAND, CORK
发明人： Justin Holmes , Michael Morris , John Hanrahan , Donal Keane , Mark Copley
IPC分类号： C01B37/02 , C01B33/12
CPC分类号： C01B37/02 , C01B33/12 , Y10T428/2982
摘要： A method for synthesizing mesoporous silica microparticles comprising the steps of: preparing a sol from an ammonium catalyzed hydrolysis and condensation reaction of a pre-sol solution comprising a silica precursor and a structure directing agent dissolved in a mixed solvent system comprising an alcohol and water to produce mesoporous particles of silica with an average diameter of up to about 50 μm; hydrothermally treating the particles to increase the pore size; treating the particles to remove residual structure directing agent; and further increasing the pore size using controlled dissolution.

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