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31. 发明申请

US20190242871A1 CAPTURE, IDENTIFICATION AND USE OF A NEW BIOMARKER OF SOLID TUMORS IN BODY FLUIDS 审中-公开
公开(公告)号：US20190242871A1
公开(公告)日：2019-08-08
申请号：US16369730
申请日：2019-03-29
申请人： Creatv MicroTech, Inc.
发明人： Daniel ADAMS , Cha-Mei TANG
IPC分类号： G01N33/49 , G01N33/574 , G01N33/487
CPC分类号： G01N33/491 , G01N33/48735 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57434
摘要： A new sensitive cell biomarker of solid tumors is identified in blood. This biomarker can be used to determine presence of solid tumors, rapid determination of treatment response, early detection of cancer, early detection of cancer recurrence, and may be used to determine therapy.

32. 发明申请

US20190128892A1 METHODS OF USING PD-L1 EXPRESSION IN TREATMENT DECISIONS FOR CANCER THERAPY 审中-公开
公开(公告)号：US20190128892A1
公开(公告)日：2019-05-02
申请号：US16092998
申请日：2017-04-14
申请人： Creatv MicroTech, Inc.
发明人： Daniel ADAMS , Cha-Mei TANG
IPC分类号： G01N33/574 , C07K16/28 , A61K39/395 , A61K45/06
摘要： Methods of using detection of PD-L1 expression by circulating cancer cells in the screening, monitoring, treatment and diagnosis of cancer in subjects are disclosed. The methods are based on assaying one or more of circulating tumor cells (CTCs), epithelial to mesenchymal transition CTCs (EMTCTCs), cancer associated macrophage-like cells (CAMLs), and cancer associated vascular endothelial cells (CAVEs) isolated from a subject having cancer for PD-L1 expression.

33. 发明申请

US20180156801A1 USE OF CIRCULATING TUMOR CELL MITOTIC INDEX IN CANCER STRATIFICATION AND DIAGNOSTICS 审中-公开
公开(公告)号：US20180156801A1
公开(公告)日：2018-06-07
申请号：US15576472
申请日：2016-05-26
申请人： CREATV MICROTECH INC.
发明人： Daniel ADAMS , Cha-Mei TANG
IPC分类号： G01N33/574 , G01N33/50
摘要： Circulating tumor cells (CTCs) are associated with metastasis of malignant solid tumors in a patient. Presented here is evidence that CTCs exhibit cell cycle phase variability and that there is a strong correlation between the number of CTCs in a mitotic cell cycle phase and the prospects for long term survival of the subject from which the cells were obtained. Also presented herein are methods of determining the mitotic cell cycle phase of CTCs from a patient having cancer and using the information in grading malignant solid tumors and predicting the likelihood of survival of the patient.

34. 发明申请

US20160021872A1 URINE PRESERVATIVE REAGENT FOR MICROFILTRATION 审中-公开
标题翻译：尿液防腐试剂
公开(公告)号：US20160021872A1
公开(公告)日：2016-01-28
申请号：US14776194
申请日：2014-03-13
申请人： CREATV MICROTECH, INC.
发明人： Peixuan ZHU , Daniel ADAMS , Cha-Mei TANG
IPC分类号： A01N1/02 , G01N33/493 , G01N33/574
CPC分类号： A01N1/021 , A01N1/0215 , G01N33/493 , G01N33/574
摘要： A preservative reagent for urine is disclosed that increases the stability of cells, such as tumor cells, in urine for a period of several weeks. The preservative reagent comprises polyethylene glycol (PEG), ethanol, paraformaldehyde (PFA), and ethylenediaminetetraacetic acid (EDTA), and optionally pH stabilizing reagents.
摘要翻译：公开了用于尿液的防腐剂，其在尿液中增加细胞（例如肿瘤细胞）的稳定性，持续数周。防腐剂包括聚乙二醇（PEG），乙醇，多聚甲醛（PFA）和乙二胺四乙酸（EDTA），以及任选的pH稳定试剂。

35. 发明申请

US20130330721A1 POLYMER MICROFILTRATION DEVICES, METHODS OF MANUFACTURING THE SAME AND THE USES OF THE MICROFILTRATION DEVICES 审中-公开
标题翻译：聚合物微滤装置，其制造方法和微滤装置的用途
公开(公告)号：US20130330721A1
公开(公告)日：2013-12-12
申请号：US13854003
申请日：2013-03-29
申请人： Creatv Micro Tech, Inc.
发明人： Cha-Mei Tang , Yunqi Zhang
IPC分类号： G01N1/40 , B01D29/00
CPC分类号： G01N33/5005 , B01D29/00 , B01D39/16 , B01D39/1692 , B01L3/50 , B01L3/502 , B01L3/5635 , B01L9/00 , B01L2300/0681 , G01N1/4005 , G01N1/4077 , G01N2001/4088 , Y10T29/49826 , Y10T29/49963
摘要： A microfilter comprising a polymer layer formed from photo-definable dry film, and a plurality of apertures each extending through the polymer layer. A microfilter comprising two or more polymer layers formed from photo-definable dry film, and a plurality of apertures or open areas each extending through the polymer layer. Methods of forming apertures in one or more layers of photo-definable dry film are also disclosed. Filter holder designs and methods appropriate to hold microfilters to collect the rare cells and to perform of assays in the filter holder are provided. Microfiltration chip designs and methods appropriate to collect the rare cells and to perform assays in the microfluidic chips are provided. The invention also describes the use of the microfilter, filter holder and microfilter chips to collect rare cells from body fluids and perform assays, and these rare cells can be used for medical and biological research applications.
摘要翻译：一种包含由光可定义干膜形成的聚合物层的微过滤器和各自延伸穿过聚合物层的多个孔。包括由可光限定的干膜形成的两个或更多个聚合物层的微滤器以及各自延伸穿过聚合物层的多个孔或开口区域。还公开了在一个或多个光可定义干膜层中形成孔的方法。提供了适用于容纳微型过滤器以收集稀有细胞并在过滤器保持器中执行测定的过滤器支架设计和方法。提供了适用于收集稀有细胞并在微流控芯片中进行测定的微滤芯片设计和方法。本发明还描述了微型过滤器，过滤器保持器和微过滤器芯片用于从体液中收集稀有细胞并进行测定的用途，并且这些稀有细胞可用于医学和生物研究应用。

36. 发明授权

US08351741B2 Sensitive emission light gathering and flow through detection system 有权
标题翻译：敏感发射光采集和流过检测系统
公开(公告)号：US08351741B2
公开(公告)日：2013-01-08
申请号：US12494152
申请日：2009-06-29
申请人： Cha-Mei Tang , Platte T. Amstutz, III
发明人： Cha-Mei Tang , Platte T. Amstutz, III
IPC分类号： G02B6/32 , G02B6/42 , G02B6/00
CPC分类号： G01N21/0303 , G01N21/255 , G01N21/645 , G01N2021/6473
摘要： A method of detecting fluorescence/absorbance/luminescence from 24-well, 48-well, 96-well, 384-well and 1536-well microplates and other sample containers. The sample is pumped into a waveguide. The waveguide efficiently gathers and guides the emission light to the end of the waveguide. The emission light exits the ends of the waveguide and is focused into a detector. To minimize background caused by the excitation light used for fluorescence, the excitation illuminates the waveguides at 90 degrees. To facilitate reuse, the waveguide assembly can be configured to be washed by an appropriate wash solution.
摘要翻译：从24孔，48孔，96孔，384孔和1536孔微孔板和其他样品容器中检测荧光/吸光度/发光的方法。将样品泵送到波导中。波导有效地将发射光聚集并引导到波导的末端。发射光离开波导的端部并聚焦到检测器中。为了最小化用于荧光的激发光引起的背景，激发以90度照射波导。为了便于重新使用，波导组件可以被配置为被适当的洗涤溶液洗涤。

37. 发明授权

US07565042B2 Sensitive emission light gathering and flow through detection system 有权
标题翻译：敏感发射光采集和流过检测系统
公开(公告)号：US07565042B2
公开(公告)日：2009-07-21
申请号：US11705606
申请日：2007-02-13
申请人： Cha-Mei Tang , Platte T Amstulz, III
发明人： Cha-Mei Tang , Platte T Amstulz, III
IPC分类号： G02B6/32 , G02B6/42 , G02B6/00
CPC分类号： G01N21/0303 , G01N21/255 , G01N21/645
摘要： A luminometer is provided comprising a flow through waveguide and one or more detectors. The flow through waveguide has at least two openings and the sample is free to enter from one opening and exit from the other. The flow through waveguide can be made of material that guides emission light to a bottom end of the flow through waveguide. One or more detectors may be provided which detect the emission light coming out of the bottom of the flow through waveguide. A fluorometer/photometer is also provided that comprises a flow through waveguide, one or more excitation light sources, and one or more optical detectors. The flow through waveguide has a hollow region to hold the sample. The excitation light is introduced at an angle or perpendicular to one surface of the flow through waveguide. The flow through waveguide is made of material that can guide absorption and/or emission light to the bottom end of the flow through waveguide. There are one or more detectors that detect the emission light coming out of the bottom of the flow through waveguide.
摘要翻译：提供了一种发光计，其包括流过波导管和一个或多个检测器。通过波导的流动具有至少两个开口，并且样品自由地从一个开口进入并从另一个开口排出。通过波导的流动可以由将发射光引导到通过波导的流动的底端的材料制成。可以提供一个或多个检测器，其检测从通过波导的流的底部出射的发射光。还提供了一种荧光计/光度计，其包括流过波导管，一个或多个激发光源和一个或多个光学检测器。通过波导的流动具有保持样品的中空区域。激发光以与通过波导的流动的一个表面成一角度或垂直的方式引入。通过波导的流动由能够将吸收和/或发射光引导到通过波导的流动的底端的材料制成。存在一个或多个检测器，其检测从通过波导的流动的底部出来的发射光。

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