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31. 发明授权

US4086196A Parathyroid hormone 失效
标题翻译：甲状旁腺激素
公开(公告)号：US4086196A
公开(公告)日：1978-04-25
申请号：US563173
申请日：1975-03-28
申请人： Geoffrey William Tregear
发明人： Geoffrey William Tregear
IPC分类号： A61K38/00 , C07K14/635 , C07C103/52 , C08L37/00
CPC分类号： C07K14/635 , A61K38/00
摘要： A peptide chosen from the group comprising [Ala.sup.1 ]-HPTH-(1-X) and HPTH-(1-X) wherein X is an integer from 27 to 34.
摘要翻译：选自包含[Ala1] -HPTH-（1-X）和HPTH-（1-X）的基团的肽，其中X为27至34的整数。

32. 发明授权

US4021398A Aqueous latex emulsions containing basic aluminum compounds of wood-stain reducing agents 失效
标题翻译：含有木屑减少剂的碱性铝化合物的水性胶乳乳液
公开(公告)号：US4021398A
公开(公告)日：1977-05-03
申请号：US569246
申请日：1975-04-18
申请人： William S. Gilman , John L. Jones , Andrew M. Rubino
发明人： William S. Gilman , John L. Jones , Andrew M. Rubino
IPC分类号： B05D7/06 , C08L31/04
CPC分类号： B05D7/06
摘要： Staining and discoloration of painted wood surfaces, as a result of bleeding into the top or finish coat of soluble coloring matter and tannins naturally present in the wood, is prevented by coating or impregnating the wood with a basic aluminum compound, particularly with a water soluble basic aluminum halide or derivative thereof. The basic aluminum compound may be applied in aqueous solution or non-pigmented emulsion for prefinishing building lumber, or applied in the form of a pigmented emulsion as a primer coat.The present invention relates to novel methods and compositions for application to the surfaces of woods, particularly to stain-susceptible woods, to prevent their staining or discoloring as a result of tannin and tocopherol or other waste-soluble coloring matter present in the raw wood, bleeding or migrating into a subsequently applied preservative or decorative paint film.
摘要翻译：通过用碱性铝化合物涂覆或浸渍木材，特别是与水溶性的涂层或浸渍木材，可以防止由于渗透到木材中天然存在的可溶性着色物质和单宁酸的顶部或底漆而导致的漆木表面的染色和变色碱式卤化铝或其衍生物。碱性铝化合物可以用于水性溶液或非着色乳液中，用于预修筑建筑木材，或以着色乳液的形式作为底漆涂布。

33. 发明授权

US4000279A Pharmaceutical preparations containing 5'-(8'-hydroxyquinolyl)guanidine compounds and methods of using same 失效
标题翻译：含有5' - （8'-羟基喹啉）胍基化合物的药物制剂及其使用方法
公开(公告)号：US4000279A
公开(公告)日：1976-12-28
申请号：US596493
申请日：1975-07-16
申请人： John Lawrence Hughes , Robert Chung-Huan Liu
发明人： John Lawrence Hughes , Robert Chung-Huan Liu
IPC分类号： C07D215/38 , A61K31/47
CPC分类号： C07D215/38 , Y10S514/93
摘要： A pharmaceutical preparation consisting of a pharmaceutical grade carrier and a therapeutically active amount of an aromatic guanidine compound having the formula: ##STR1## or a non-toxic acid addition salt thereof are found to have biologically useful activity. These guanidine preparations and salts are shown to be active as vasoconstrictor agents and obtain useful biological results when deployed with a pharmaceutically acceptable carrier for administration to a host, e.g., man, requiring vasoconstrictive therapy.

34. 发明授权

US3981986A Zirconium-aluminum-polyol buffered anti-perspirant complexes 失效
标题翻译：锆 - 铝多元醇缓冲的防汗配合物
公开(公告)号：US3981986A
公开(公告)日：1976-09-21
申请号：US431639
申请日：1974-01-08
申请人： Andrew M. Rubino
发明人： Andrew M. Rubino
IPC分类号： A61K8/28 , A61K8/34 , A61Q15/00 , C07F5/06 , A61K7/00 , A61K9/00 , C07F7/00
CPC分类号： A61Q15/00 , A61K8/28 , A61K8/345 , C07F5/069 , A61K2800/58
摘要： Water soluble anti-perspirant complexes are provided which comprise a combination of a basic aluminum-polyol compound, a zirconium compound and an organic buffer which may be urea, an amino acid in which the number of amino groups is equal to the number of carboxyl groups in the molecule, an alkaline or hydroxy salt of such amino acid, or mixtures thereof. The various components are present in the complex in amounts such that the Al/Zr mol ratio is about 10:1 to 1:10 and the pH of an aqueous solution containing 5 to 15 weight percent of the complex (based on the oxides of aluminum and zirconium) is at least about 3. The basic aluminum-polyol compounds may be those described in U.S. Pat. Nos. 3,359,169; 3,420,932; 3,405,153 and 3,555,146, particularly basic aluminum chloride-propylene glycol complex. The zirconium compound may be a zirconium oxy (zirconyl) salt and/or zirconium hydroxy salt. Preferred amino acid buffers include glycine and .beta.-alanine and the corresponding salts including the alkaline and alkaline earth glycinates, aluminum dihydroxy or monohydroxy glycinates, and aluminum-magnesium-hydroxy-glycine compounds. The complexes may be used in conventional anti-perspirant forms, including aqueous and/or hydro-alcoholic solutions, powder-in-oil sprays, creams, lotions and sticks.
摘要翻译：提供了水溶性防汗配合物，其包含碱性铝 - 多元醇化合物，锆化合物和可以是尿素的有机缓冲液的组合，氨基数等于羧基数目的氨基酸在该分子中，这种氨基酸的碱金属或羟基盐，或其混合物。复合物中存在各种组分，其量使得Al / Zr摩尔比为约10:1至1:10，并且含有5至15重量％复合物的水溶液的pH（基于铝的氧化物和锆）为至少约3.碱性铝 - 多元醇化合物可以是美国专利No. 第3,359,169号; 3,420,932; 3,405,153和3,555,146，特别是碱性氯化铝 - 丙二醇络合物。锆化合物可以是氧锆（锆）盐和/或锆羟基盐。优选的氨基酸缓冲液包括甘氨酸和β-丙氨酸，以及相应的盐，包括碱和碱土甘蔗酸盐，二羟基或单羟基甘氨酸铝，以及铝 - 镁 - 羟基 - 甘氨酸化合物。络合物可以以常规的防汗剂形式使用，包括水和/或水 - 醇溶液，油包油喷雾剂，乳膏剂，洗剂和粘合剂。

35. 发明授权

US3979510A Aluminum-zirconium anti-perspirant systems with complex aluminum buffers 失效
标题翻译：具有复合铝缓冲液的铝锆防汗系统
公开(公告)号：US3979510A
公开(公告)日：1976-09-07
申请号：US477544
申请日：1974-06-07
申请人： Andrew M. Rubino
发明人： Andrew M. Rubino
IPC分类号： A61K8/28 , A61K8/34 , A61Q15/00 , A61K7/32
CPC分类号： A61K8/28 , A61K8/345 , A61K8/466 , A61Q15/00 , A61K2800/58
摘要： Anti-perspirant complexes are provided which comprise a combination of a basic aluminum compound, a zirconium compound and a complex aluminum buffering compound containing in addition to aluminum two or more of the following: magnesium, calcium, sodium, carbonate, sulfate, hydroxyl and water. The various components are present in the complex in amounts such that the Al/Zr mole ratio is about 10:1 to 1:10 and the pH of an aqueous solution containing 5 to 15 weight percent of the complex (based on the oxides of aluminum and zirconium) is at least about 3. The basic aluminum compound may be any of the usual basic aluminum anti-perspirant salts, particularly the basic aluminum halides, and the zirconium compound may be a zirconium oxy salt and/or zirconium hydroxy salt. The complex aluminum buffer preferably contains among the additional groups or elements magnesium and/or carbonate. Examples of suitable complex aluminum buffers used include well-known antacid complexes such as hydrated magnesium aluminate, hydrated magnesium aluminum sulfate (HMAS), dihydroxy aluminum sodium carbonate (DASC), tetrahydroxy dialuminum magnesium carbonate (TDMC), and co-precipitates or co-dried mixtures of aluminum hydroxide with magnesium carbonate and/or calcium carbonate. The complexes may be used in conventional anti-perspirant forms, including aqueous solutions, aerosol sprays (including powder-in-oil aerosol sprays), as well as creams, lotions and cream sticks.
摘要翻译：提供了防汗配合物，其包含碱性铝化合物，锆化合物和除了铝之外还含有以下两种或更多种的复合铝缓冲化合物的组合：镁，钙，钠，碳酸盐，硫酸盐，羟基和水。复合物中存在各种组分，其量使得Al / Zr摩尔比为约10:1至1:10，并且含有5至15重量％复合物的水溶液的pH（基于铝的氧化物和锆）为至少约3.碱性铝化合物可以是任何通常的碱性铝防汗剂盐，特别是碱性卤化铝，锆化合物可以是氧锆盐和/或锆羟基盐。复合铝缓冲剂优选含有另外的基团或元素镁和/或碳酸盐。使用的合适的复合铝缓冲剂的实例包括众所周知的抗酸配合物，例如水合铝酸镁，水合硫酸镁铝（HMAS），二羟基碳酸铝钠（DASC），四羟基二碳酸铝镁（TDMC）和共沉淀或共 - 干燥的氢氧化铝与碳酸镁和/或碳酸钙的混合物。络合物可以以常规的防汗剂形式使用，包括水溶液，气溶胶喷雾剂（包括油包油气雾剂喷雾剂）以及霜剂，乳液和奶油棒。

36. 发明授权

US3947557A Zinc complexes of basic aluminum bromides and methods of making same 失效
标题翻译：碱性溴化铝的锌络合物及其制备方法
公开(公告)号：US3947557A
公开(公告)日：1976-03-30
申请号：US583381
申请日：1975-06-03
申请人： John L. Jones , Andrew M. Rubino , Charles B. Lindahl
发明人： John L. Jones , Andrew M. Rubino , Charles B. Lindahl
IPC分类号： A61K8/28 , A61Q15/00 , C01F7/56 , C01F7/64 , C01G25/00 , C01G25/04 , C01F7/00 , C01F7/48 , C01G9/04
CPC分类号： A61Q15/00 , A61K8/28 , C01F7/64 , C01G25/006 , C01P2006/82
摘要： Alcohol soluble complexes of basic aluminum bromides may be prepared by adding zirconyl or zinc bromide or chloride, or zirconyl hydroxychloride or hydroxybromide, or mixtures of the above chlorides and bromides to an aqueous solution of five-sixths basic aluminum bromide, and drying the resulting mixture to a substantially friable solid, such as by vacuum or spray drying. The complexes preferably have an Al/Zn or Al/Zr mol ratio of about 3:1 to 20:1, and the complex solids preferably contain about 15 to 30 weight percent water by Karl Fischer analysis. Such complex solids have a high degree of solubility in anhydrous alcohol and a high compatibility with halogenated hydrocarbons. These properties make the complexes suitable for aerosol formulations and particularly antiperspirant compositions.
摘要翻译：碱性溴化铝的醇溶性复合物可以通过将溴化锆或溴化锌或氯化锆或羟基溴化物或羟基溴化物或上述氯化物和溴化物的混合物加入到五分之六碱性溴化铝的水溶液中并将所得混合物到基本上易碎的固体，例如通过真空或喷雾干燥。配合物优选具有约3:1至20:1的Al / Zn或Al / Zr摩尔比，并且通过卡尔费休分析，络合物固体优选含有约15至30重量％的水。这种复合固体在无水醇中的溶解度高，与卤代烃的高相容性。这些性质使复合物适用于气雾剂，特别是止汗组合物。

37. 发明授权

US4876241A Stabilization of biological and pharmaceutical products during thermal inactivation of viral and bacterial contaminants 失效
标题翻译：在病毒和细菌污染物的热失活期间稳定生物和药物产品
公开(公告)号：US4876241A
公开(公告)日：1989-10-24
申请号：US195318
申请日：1988-05-18
申请人： Fred Feldman , Mark S. Klekamp , Michael E. Hrinda , Arthur B. Shaw , Sudhish Chandra
发明人： Fred Feldman , Mark S. Klekamp , Michael E. Hrinda , Arthur B. Shaw , Sudhish Chandra
IPC分类号： A61L2/00
CPC分类号： A61L2/0023 , A61L2/0005
摘要： A method of inactivating pathogens in proteinaceous biological and pharmaceutical products which comprises: mixing the product in an aqueous solution with one or more primary stabilizers selected from the group consisting of sugars and sugar alcohols and one or more secondary stabilizers selected from the group consisting of sodium acetate, potassium acetate, lithium acetate, magnesium acetate, ammonium acetate, barium acetate, sodium sulfate, ammonium sulfate, lithium sulfate, potassium sulfate and magnesium sulfate; and subjecting said aqueous solution to a pathogen inactivating process.
摘要翻译：一种灭活蛋白质生物和药物产品中的病原体的方法，其包括：将产物在水溶液中与一种或多种主要稳定剂混合，所述主要稳定剂选自糖和糖醇，以及一种或多种二级稳定剂，其选自钠乙酸钾，乙酸钾，乙酸锂，乙酸镁，乙酸铵，乙酸钡，硫酸钠，硫酸铵，硫酸锂，硫酸钾和硫酸镁; 并使所述水溶液进行病原体灭活过程。

38. 发明授权

US4758657A Method of purifying Factor VIII:C 失效
标题翻译：净化因子VIII的方法：C
公开(公告)号：US4758657A
公开(公告)日：1988-07-19
申请号：US753822
申请日：1985-07-11
申请人： David L. Farb , Ricardo H. Landaburu
发明人： David L. Farb , Ricardo H. Landaburu
IPC分类号： A61K35/14 , A61K35/16 , A61K38/00 , A61K38/16 , A61K38/43 , C07K14/755 , C07K3/20 , A61K37/02
CPC分类号： C07K14/755 , A61K38/00
摘要： Disclosed is a process for purifying Factor VIII:C in high yield and potency from source material containing Factor VIII:C, Factor VIII:R and other plasma proteins and factors comprising the steps of: adsorbing Factor VIII:C onto a hydrophobic interaction matrix, separating unwanted proteins from Factor VIII:C and eluting Factor VIII:C by a solution containing a surface active agent.
摘要翻译：公开了一种以含有因子VIII：C，因子VIII：R和其他血浆蛋白质的因素从高产量和效力纯化因子VIII：C的方法，包括以下步骤：将因子VIII：C吸附到疏水相互作用基质上，通过含有表面活性剂的溶液从因子VIII：C分离不需要的蛋白质和洗脱因子VIII：C。

39. 发明授权

US4746728A 8-glycine, des-19-leucine-calcitonin 失效
标题翻译： 8-甘氨酸，des-19-亮氨酸降钙素
公开(公告)号：US4746728A
公开(公告)日：1988-05-24
申请号：US859569
申请日：1986-05-05
申请人： Ronald C. Orlowski , Jay K. Seyler
发明人： Ronald C. Orlowski , Jay K. Seyler
IPC分类号： A61K38/00 , C07K14/585 , C07K7/36
CPC分类号： C07K14/585 , A61K38/00
摘要： New peptides are disclosed which have biological activity of the same type as the known calcitonins and which have a glycine at position 8 instead of the natural valine found in that position. In addition these new peptides do not have a leucine in position 19. The position 19 leucine is omitted. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
摘要翻译：公开了新肽，其具有与已知降钙素相同类型的生物活性，并且其在第8位具有甘氨酸而不是在该位置发现的天然缬氨酸。此外，这些新肽在位置19中不具有亮氨酸。省略了位置19亮氨酸。还公开了可以转化成具有这种生物活性的肽的树脂肽; 以及用于制备所述树脂肽和所述降钙素肽的方法。

40. 发明授权

US4659804A (Bis-1,7-S-acetamidomethyl-L-cysteine)salmon calcitonin 失效
标题翻译：（Bis-1,7-S-乙酰氨基甲基-L-半胱氨酸）鲑降钙素
公开(公告)号：US4659804A
公开(公告)日：1987-04-21
申请号：US667197
申请日：1984-11-01
申请人： Ronald C. Orlowski , Jay K. Seyler , Robert L. Colescott , Glenn L. Stahl , Takashi Enkoji , James E. Geever , Everett Flanigan
发明人： Ronald C. Orlowski , Jay K. Seyler , Robert L. Colescott , Glenn L. Stahl , Takashi Enkoji , James E. Geever , Everett Flanigan
IPC分类号： A61K38/00 , C07K14/585 , C07K7/36
CPC分类号： C07K14/585 , A61K38/00
摘要： New peptides are disclosed which have biological activity of the same type as known calcitonins and which do not have a disulfide bond connecting the cysteines at positions one and seven. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin partially protected peptides.
摘要翻译：公开了新的肽，其具有与已知的降钙素相同类型的生物活性，并且其不具有连接第1位和第7位的半胱氨酸的二硫键。还公开了可以转化成具有这种生物活性的肽的树脂肽; 以及用于制备所述树脂肽和所述降钙素部分保护的肽的方法。

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