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21. 发明授权

US10302661B2 Method for treating a cancer patient based on atomic therapeutic indexes and non-radiation therapy 有权
公开(公告)号：US10302661B2
公开(公告)日：2019-05-28
申请号：US15717246
申请日：2017-09-27
申请人： Atomic Oncology Pty Ltd
发明人： George L. Gabor Miklos
IPC分类号： G01N21/31 , G01N21/71 , G01N22/00 , G01N33/84 , H01J49/16 , G01N23/085 , G01N23/223 , G01N33/574 , G01N33/48
摘要： The present invention relates to the generation of an Atomic Therapeutic Indicator (ATI) for a test sample by the quantification of manganese; in voxels of a 3D region of the sample, wherein the 3D region is topographically defined by co-ordinates X′×Y′×Z. The ATI is used to assess the radio-responsiveness i.e. sensitivity or resistance to radiation treatment, of a cancer i.e. a tumor/neoplasm. In a preferred embodiment, the present invention relates to a method of generating the ATI, assessing the radio-responsiveness of a tumor/neoplasm based on the ATI and, based on the assessment, either treating or not treating the tumor with radiation.The present invention also relates to a method of determining if a cancer is likely to reoccur post radiation treatment comprising quantifying the level of manganese in voxels of a 3D region of a test sample from the cancer and determining the frequency of high metallomic regions (HMRs) in the cancer, wherein a high frequency of HMRs is indicative that the cancer is likely to reoccur and a low frequency of HMRs is indicative that the cancer is unlikely to reoccur; and associated methods of treatment.The invention further relates to a method of determining the radio-responsiveness of a melanoma, the method comprising determining the level of melanin in a test sample from the melanoma, wherein the lower the level of melanin the more sensitive the melanoma is to radiation and the higher the level of melanin the more resistant the melanoma is to radiation; and associated methods of treatment.

22. 发明申请

US20190145915A1 CELL FOR X-RAY ANALYSIS AND X-RAY ANALYSIS APPARATUS 审中-公开
公开(公告)号：US20190145915A1
公开(公告)日：2019-05-16
申请号：US16189004
申请日：2018-11-13
申请人： Inter-University Research Institute Corporation High Energy Accelerator Research Organization
发明人： Ken'ichi Kimijima , Masao Kimura , Daiji Asahara , Yasuhiro Onishi
IPC分类号： G01N23/20033 , G01N23/085 , G01N23/2055
CPC分类号： G01N23/20033 , G01N23/085 , G01N23/2055
摘要： Provided are a cell for X-ray analysis and an X-ray analysis apparatus that enable simultaneous X-ray diffraction and X-ray absorption fine structure measurements of a material (sample) in the same field of view on the sample (same position on the sample). The cell for X-ray analysis of the present invention enables simultaneous X-ray diffraction and X-ray absorption fine structure measurements of a sample in the same field of view on the sample and includes a furnace including a space where the sample is held and a focused heater heating the sample, a first window provided to the furnace and through which X-rays directed at the sample is incident, a second window provided to the furnace and from which X-rays emerging from the sample exit, a third window provided to the furnace, and a holder that positions the sample in the space. The cell for X-ray analysis makes it possible to simultaneously measure X-ray diffraction of the sample at outside of the second window and X-ray absorption fine structure of the sample through the third window.

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