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21. 发明申请

US20040052801A1 Streptococcal C5a peptidase vaccine 有权
标题翻译：链球菌C5a肽酶疫苗
公开(公告)号：US20040052801A1
公开(公告)日：2004-03-18
申请号：US10412026
申请日：2003-04-11
申请人： Regents of the University of Minnesota
发明人： Paul Patrick Cleary , Deborah K. Stafslien
IPC分类号： A61K039/00 , A61K039/38
CPC分类号： C12N9/52 , A61K39/00 , Y10S530/806 , Y10S530/825
摘要： Novel vaccines for use against null-hemolytic Streptococcus colonization or infection are disclosed. The vaccines contain an immunogenic amount of a variant of streptococcal C5a peptidase (SCP). Also disclosed is a method of protecting a susceptible mammal against null-hemolytic Streptococcus colonization or infection by administering such a vaccine. Enzymatically inactive SCP, and polynucleotides encoding these SCP proteins are further disclosed.
摘要翻译：公开了用于抗β-溶血性链球菌定居或感染的新型疫苗。疫苗含有免疫原性量的链球菌C5a肽酶（SCP）的变体。还公开了通过施用这样的疫苗来保护易感染的哺乳动物免受β-溶血性链球菌定植或感染的方法。进一步公开了酶活性SCP，以及编码这些SCP蛋白的多核苷酸。

22. 发明申请

US20040043032A1 Vaccine 审中-公开
标题翻译：疫苗
公开(公告)号：US20040043032A1
公开(公告)日：2004-03-04
申请号：US10297256
申请日：2003-05-12
发明人： lan Farquhar Campbell McKenzie , Geoffrey Allan Pietersz , Christina Cheers , John Stambas
IPC分类号： A61K039/00 , A61K039/38
CPC分类号： A61K31/715 , A61K39/0208 , A61K39/04 , A61K39/12 , A61K39/15 , A61K39/385 , A61K39/39 , A61K2039/541 , A61K2039/543 , A61K2039/545 , A61K2039/55544 , A61K2039/55566 , A61K2039/55583 , A61K2039/57 , A61K2039/6087 , C12N2710/20034 , C12N2720/12334 , Y02A50/412
摘要： The present invention provides a method of immunising a subject comprising the step of administering a composition comprising an antigen and a carbohydrate polymer comprising mannose to a mucosal site of the subject, methods of use of the composition for vaccination and sterilization and use of the composition in manufacturing a medicament.
摘要翻译：本发明提供免疫受试者的方法，包括以下步骤：将包含抗原和包含甘露糖的碳水化合物聚合物的组合物施用于受试者的粘膜部位，使用该组合物进行疫苗接种和灭菌的方法以及使用该组合物制造药物。

23. 发明申请

US20040028691A1 Fat composition for oral or enternal administraiton and hexacosanoic acid depressant 失效
标题翻译：口服或内服和二十六烷酸抑制剂的脂肪组成
公开(公告)号：US20040028691A1
公开(公告)日：2004-02-12
申请号：US10415412
申请日：2003-04-29
发明人： Yasunobu Antoku , Kosuke Tsukamoto , Fumihiko Koike , Takashi Tokuyama , Hirotoshi Hayasawa , Mitsunori Takase , Kyoichi Oshida
IPC分类号： A61K039/00 , A61K039/38
CPC分类号： A61K31/232
摘要： A fat composition for oral or enteral administration which contains eicosapentaenoic acid and/or a derivative thereof, docosahexaenoic acid and/or a derivative thereof, and a C20 or higher monoenoic acid and/or a derivative thereof and functions to diminish hexacosanoic acid; and a hexacosanoic acid depressant which comprises as active ingredients eicosapentaenoic acid and/or a derivative thereof, docosahexaenoic acid and/or a derivative thereof, and a C20 or higher monoenoic acid and/or a derivative thereof. They can be prepared by extraction from a fish oil or the like, purification, blending, etc. Based on the function of diminishing hexacosanoic acid, the composition and the depressant produce an aging-inhibitory effect on cell membranes, which is effective in the prevention and treatment of lifestyle-related diseases.
摘要翻译：用于口服或肠内给药的脂肪组合物，其包含二十碳五烯酸和/或其衍生物，二十二碳六烯酸和/或其衍生物，以及C20或更高级的单烯酸和/或其衍生物，并且具有减少二十六烷酸的功能; 和二十碳三烯酸抑制剂，其包含二十碳五烯酸和/或其衍生物，二十二碳六烯酸和/或其衍生物，以及C20或更高级的单烯酸和/或其衍生物作为活性成分。它们可以通过从鱼油等中提取，纯化，混合等制备。基于减少二十五烷酸的功能，组合物和抑制剂对细胞膜产生抑制老化的作用，这对预防有效和生活方式相关疾病的治疗。

24. 发明申请

US20040009184A1 Recombinant intracellular pathogen immunogenic compositions and methods for use 有权
标题翻译：重组细胞内病原体免疫原性组合物和使用方法
公开(公告)号：US20040009184A1
公开(公告)日：2004-01-15
申请号：US10439611
申请日：2003-05-15
发明人： Marcus A. Horwitz , Gunter Harth , Michael V. Tullius
IPC分类号： A61K039/00 , A61K039/38
CPC分类号： A61K39/04 , A61K38/00 , A61K2039/522 , A61K2039/523 , C07K14/35
摘要： Immunogenic compositions comprising recombinant attenuated intracellular pathogens that have been transformed to express recombinant immunogenic antigens of the same or other intracellular pathogens are provided. Exemplary immunogenic compositions include, but are not limited to attenuated recombinant Mycobacteria expressing the major extracellular non-fusion proteins of Mycobacteria and/or other intracellular pathogens. Other embodiments are provided wherein the recombinant attenuated intracellular pathogen is auxotrophic.
摘要翻译：提供了包含重组减毒细胞内病原体的免疫原性组合物，其被转化以表达相同或其它细胞内病原体的重组免疫原性抗原。示例性免疫原性组合物包括但不限于表达分枝杆菌和/或其它细胞内病原体的主要细胞外非融合蛋白的减毒重组分枝杆菌。提供了其中重组减毒细胞内病原体是营养缺陷型的其它实施方案。

25. 发明申请

US20040009183A1 Vaccine against Staphylococcus intoxication 失效
标题翻译：针对葡萄球菌中毒的疫苗
公开(公告)号：US20040009183A1
公开(公告)日：2004-01-15
申请号：US10405871
申请日：2003-04-02
发明人： John S. Lee , Peter Pushko , Jonathan F. Smith , Robert G. Ulrich
IPC分类号： A61K039/00 , A61K039/38
CPC分类号： C07K14/32 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , C07K14/31 , C12N2799/021
摘要： Using nucleic acids encoding mutant SEA and SEB exotoxins from Staphylococcus aureus, compositions and methods for use in inducing an immune response which is protective against staphylococcal aureus intoxication in subjects is described.
摘要翻译：描述了使用编码来自金黄色葡萄球菌的突变体SEA和SEB外毒素的核酸，用于诱导在受试者中保护葡萄球菌金黄色葡萄球菌中毒的免疫应答的组合物和方法。

26. 发明申请

US20040009180A1 Transdermal botulinum toxin compositions 审中-公开
标题翻译：经皮肉毒毒素组合物
公开(公告)号：US20040009180A1
公开(公告)日：2004-01-15
申请号：US10194805
申请日：2002-07-11
申请人： Allergan, Inc.
发明人： Stephen Donovan
IPC分类号： A61K039/00 , A61K039/38 , A61K009/70 , A61F013/00
CPC分类号： A61N7/00 , A61K9/127 , A61K9/7084 , A61K31/045 , A61K38/4893 , A61K41/0028 , A61K47/10 , Y02A50/469
摘要： Pharmaceutical compositions for transdermal administration of neurotoxins to a patient include a neurotoxin, such as a botulinum toxin, and an enhancing agent that facilitates absorption of the neurotoxin through the skin of the patient and does not eliminate the bioactivity associated with the neurotoxin. The pharmaceutical compositions are topically applied on a patient, and may be provided in a transdermal patch.
摘要翻译：用于向患者透皮施用神经毒素的药物组合物包括神经毒素，例如肉毒杆菌毒素和促进神经毒素通过患者皮肤吸收的增强剂，并且不消除与神经毒素相关的生物活性。药物组合物局部施用于患者，并且可以提供在透皮贴剂中。

27. 发明申请

US20040005327A1 Immune T-cell stimulation 审中-公开
标题翻译：免疫T细胞刺激
公开(公告)号：US20040005327A1
公开(公告)日：2004-01-08
申请号：US10439162
申请日：2003-05-15
发明人： Subramanian Iyer , Ruye Xing
IPC分类号： A61K039/00 , A61K039/38
CPC分类号： C07K16/12 , A61K35/57 , A61K2039/542 , C07K2317/11 , C07K2317/23
摘要： The present invention is a novel approach for stimulating or enhancing immune T-cells in an animal. In particular, the invention is directed to an egg, and more specifically, a fraction thereof of a size less than 3000 daltons, obtained from an avian that has been hyperimmunized with one or more immunogens. The ingestion by an animal of an effective amount of the hyperimmune egg or fraction thereof causes a significant increase in the overall T-cell population in that animal.
摘要翻译：本发明是一种刺激或增强动物免疫T细胞的新方法。特别地，本发明涉及从已经用一种或多种免疫原超免疫的禽类获得的卵，更具体地，其小于3000道尔顿的级分。动物摄入有效量的超免疫卵或其部分导致该动物的整个T细胞群体的显着增加。

28. 发明申请

US20040005325A1 Helicobacter felis vaccine 失效
标题翻译：幽门螺杆菌疫苗
公开(公告)号：US20040005325A1
公开(公告)日：2004-01-08
申请号：US09904994
申请日：2001-07-13
发明人： Johannes Gerardus Kusters , Giovanni Cattoli
IPC分类号： A61K039/00 , A61K039/38
CPC分类号： C12N9/80 , A61K39/00 , C07K14/205
摘要： The present invention relates to novel Helicobacter felis urease subunit polypeptides and to nucleic acid sequences encoding these subunit polypeptides, to DNA fragments and recombinant DNA molecules comprising the nucleic acid sequences encoding these subunit polypeptides, to live recombinant carriers and to host cells comprising nucleic acid sequences encoding these subunit polypeptides. Also, the invention relates to the subunit polypeptides for use in vaccines and the use in the manufacturing thereof, to vaccines comprising said subunit polypeptides and to methods for the preparation of such vaccines. Furthermore, the invention relates to diagnostic methods for the detection of Helicobacter felis specific nucleic acid sequences, Helicobacter felis antigenic material and to antibodies against Helicobacter felis.
摘要翻译：本发明涉及新颖的幽门螺杆菌脲酶亚基多肽和编码这些亚单位多肽的核酸序列，涉及包含编码这些亚单位多肽的核酸序列的DNA片段和重组DNA分子，以及包含核酸序列的宿主细胞编码这些亚基多肽。此外，本发明还涉及用于疫苗的亚单位多肽及其制备中使用的疫苗，包括所述亚单位多肽的疫苗以及制备这种疫苗的方法。此外，本发明涉及用于检测幽门螺杆菌特异性核酸序列，幽门螺杆菌抗原物质和针对幽门螺杆菌抗体的诊断方法。

29. 发明申请

US20030224009A1 Bacterial expression systems 审中-公开
标题翻译：细菌表达系统
公开(公告)号：US20030224009A1
公开(公告)日：2003-12-04
申请号：US10434837
申请日：2003-05-09
申请人： The University of Queensland
发明人： Tamsin Deborah Terry , Michael Paul Jennings
IPC分类号： A61K039/00 , A61K039/38
CPC分类号： C12N15/68 , A61K2039/52 , C12N9/82 , C12N15/70 , C12N15/74
摘要： An inducible expression system is provided that includes an inducible ansB promoter co-dependently regulatable by cyclic AMP and anaerobiosis. The expression system is particularly suited to chromosomal expression of immunogenic proteins in attenuated bacterial vaccines. Protein expression from an E. coli-derived ansB promoter is particularly effective in a Salmonella host bacterium.
摘要翻译：提供了可诱导的表达系统，其包括通过环AMP和厌氧菌共同可调节的诱导型ansB启动子。表达系统特别适用于减毒细菌疫苗中的免疫原性蛋白的染色体表达。来自大肠杆菌的ansB启动子的蛋白质表达在沙门氏菌宿主细菌中特别有效。

30. 发明申请

US20030224004A1 Chlamydia antigens and corresponding DNA fragments and uses thereof 审中-公开
公开(公告)号：US20030224004A1
公开(公告)日：2003-12-04
申请号：US10359289
申请日：2003-02-06
申请人： Aventis Pasteur Limited
发明人： Andrew D. Murdin , Raymond P. Oomen , Joe Wang , Pamela Dunn
IPC分类号： A61K039/00 , A61K039/38
CPC分类号： C07K14/295 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , A61K2039/53 , C07K2319/00
摘要： The present invention provides nucleic acids, proteins and vectors for a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae. The method employs a vector containing a nucleotide sequence encoding a transmembrane protein of a strain of Chlamydia pneumoniae and a promoter to effect expression of the transmembrane protein gene product in the host. Modifications are possible within the scope of this invention.

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