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21. 发明授权

US06623421B1 External magnetic actuation valve for intraurethral artificial urinary sphincter 失效
标题翻译：用于尿道人造尿道括约肌的外部磁致动阀
公开(公告)号：US06623421B1
公开(公告)日：2003-09-23
申请号：US09673162
申请日：2001-01-11
申请人： Guillermo Rivero Rodriguez , Marta Multigner Dominguez , Jose Maria Garcia Paez , Joaquin Carballido Rodriguez , Eduardo Jorge Herrero , Francisco Javier Tendillo Cortijo
发明人： Guillermo Rivero Rodriguez , Marta Multigner Dominguez , Jose Maria Garcia Paez , Joaquin Carballido Rodriguez , Eduardo Jorge Herrero , Francisco Javier Tendillo Cortijo
IPC分类号： A61F200
CPC分类号： A61F2/0018
摘要： External magnetically actuated valve for an artificial intraurethral urinary sphincter. External magnetically actuated valve for an artificial intraurethral urinary sphincter, allowing urine control for people suffering from urinary incontinence or retention, by the application of an external magnetic field. After valve (1), object of the present invention, is placed in the patient's urethra (9), said patient may control urination. Urine is evacuated when a permanent magnet (3) is approached to the body of the patient. Closing is automatic. The system is provided with a safety system to prevent over pressures in bladder (8).
摘要翻译：用于人造尿道尿道括约肌的外部磁力驱动阀。用于人造尿道尿道括约肌的外部磁力驱动阀，允许通过施加外部磁场对患有尿失禁或潴留的人进行尿液控制。在本发明的阀（1）之后，将患者的尿道（9）放置在患者的尿道（9）中，所述患者可以控制排尿。当永久磁铁（3）靠近患者身体时，排尿。关闭是自动的。该系统配有安全系统，以防止膀胱过度压力（8）。

22. 发明授权

US06610317B2 Porous paclitaxel matrices and methods of manufacture thereof 有权
公开(公告)号：US06610317B2
公开(公告)日：2003-08-26
申请号：US09798824
申请日：2001-03-02
申请人： Julie Straub , Howard Bernstein , Donald E. Chickering, III , Sarwat Khattak , Greg Randall
发明人： Julie Straub , Howard Bernstein , Donald E. Chickering, III , Sarwat Khattak , Greg Randall
IPC分类号： A61F200
CPC分类号： A61K9/1623 , A61K9/1611 , A61K9/1635 , A61K9/1694 , Y10S977/906
摘要： Paclitaxel is provided in a porous matrix form, which allows the drug to be formulated without Cremophor and administered as a bolus. The paclitaxel matrices preferably are made using a process that includes (i) dissolving paclitaxel in a volatile solvent to form a paclitaxel solution, (ii) combining at least one pore forming agent with the paclitaxel solution to form an emulsion, suspension, or second solution, and (iii) removing the volatile solvent and pore forming agent from the emulsion, suspension, or second solution to yield the porous matrix of paclitaxel. The pore forming agent can be either a volatile liquid that is immiscible with the paclitaxel solvent or a volatile solid compound, preferably a volatile salt. In a preferred embodiment, spray drying is used to remove the solvents and the pore forming agent. In a preferred embodiment, microparticles of the porous paclitaxel matrix are reconstituted with an aqueous medium and administered parenterally, or processed using standard techniques into tablets or capsules for oral administration.

23. 发明授权

US06605295B1 Storage-stable ophthalmic compositions comprising diclofenac and ofloxacin 失效
标题翻译：包含双氯芬酸和氧氟沙星的储存稳定的眼用组合物
公开(公告)号：US06605295B1
公开(公告)日：2003-08-12
申请号：US09462731
申请日：2000-03-20
申请人： Gunther Bellmann , Gudrun Claus-Herz , Christoph Kessler
发明人： Gunther Bellmann , Gudrun Claus-Herz , Christoph Kessler
IPC分类号： A61F200
CPC分类号： A61K31/535 , Y10S514/914 , A61K31/195 , A61K2300/00
摘要： The invention relates to stable ophthalmic preparations including the penetrant antiphlogistic diclofenac or salts thereof and the penetrant antibiotic ofloxacin present in the form of the racemate, an enantiomer, particularly levofloxacin, or the corresponding hydrochloride thereof. The preparations may be used for treating eye infections and/or inflammations and for preventing infections before and after eye surgery.
摘要翻译：本发明涉及稳定的眼科制剂，包括渗透性消炎双氯芬酸或其盐，以外消旋物形式存在的渗透性抗生素氧氟沙星，对映异构体，特别是左氧氟沙星或其相应的盐酸盐。该制剂可用于治疗眼睛感染和/或炎症并且用于预防眼睛手术前后的感染。

24. 发明授权

US06599520B2 Method of inducing new bone growth in porous bone sites 有权
公开(公告)号：US06599520B2
公开(公告)日：2003-07-29
申请号：US10100475
申请日：2002-03-14
申请人： Nelson L. Scarborough , James Russell
发明人： Nelson L. Scarborough , James Russell
IPC分类号： A61F200
CPC分类号： A61L27/3608 , A61B17/7061 , A61F2/28 , A61L24/0005 , A61L27/365 , A61L27/3654
摘要： A method of treating a condition in a vertebrate animal characterized by bone having increased porosity and/or decreased bone mineral density. The porous bone is injected with an effective amount of a flowable bone composition. Also provided is a kit for the treatment of porous bone wherein a flowable bone composition is contained within an injectable delivery system.

25. 发明授权

US06599516B1 Malleable implant containing solid element that resorbs or fractures to provide access channels 有权
$Malleable implant containing solid element that resorbs or fractures to provide access channels$
标题翻译：含有固体元素的可塑性植入物可以吸收或断裂以提供通道
公开(公告)号：US06599516B1
公开(公告)日：2003-07-29
申请号：US09661828
申请日：2000-09-14
申请人： David Knaack
发明人： David Knaack
IPC分类号： A61F200
CPC分类号： A61L31/148 , A61L27/12 , A61L27/16 , A61L27/18 , A61L27/225 , A61L27/24 , A61L27/56 , A61L27/58 , A61L31/02 , A61L31/044 , A61L31/046 , A61L31/048 , A61L31/06 , A61L31/146 , C08L33/12 , C08L67/04
摘要： A malleable implant for implantation into living tissue is prepared having access means for cells into the interior of the implant. The implant is capable of being deformed under pressure required to insert the implant into an implant site. The access means can be hollow or solid. The solid comprises a material that more rapidly resorbs in vivo than the malleable implant to provide channels, or comprises a mechanically weak material that fractures under force at an implant site to produce channels or cracks. The access means may be inserted in the malleable implant at an implant site. A multilaminar structure may be formed having layers of malleable implant and layers of access means, or the access means may be heterogeneously distributed throughout the malleable implant. A kit can contain a powder such as calcium phosphate for making a paste implant material, and an access means insertable into the paste.
摘要翻译：制备用于植入生物组织的可延展植入物，其具有用于将细胞进入植入物内部的进入装置。植入物能够在将植入物插入植入部位所需的压力下变形。进入装置可以是中空的或固体的。固体包括在体内比可延展的植入物更快地吸收以提供通道的材料，或包括在植入部位处在力作用下产生通道或裂缝的机械弱材料。进入装置可以在植入部位插入可延展的植入物中。可以形成多层结构，其具有可延展的植入物层和存取装置层，或者访问装置可以非均匀地分布在整个可延展的植入物中。试剂盒可以含有用于制造糊料植入材料的粉末如磷酸钙，以及可插入糊料中的通道装置。

26. 发明授权

US06596274B1 Biological material containing bone marrow stem cells partially or completely differentiated into connective tissue cells and a hyaluronic acid ester matrix 失效
标题翻译：含有骨髓干细胞的生物材料部分或完全分化成结缔组织细胞和透明质酸酯基质
公开(公告)号：US06596274B1
公开(公告)日：2003-07-22
申请号：US09041287
申请日：1998-03-12
申请人： Giovanni Abatangelo , Lanfranco Callegaro
发明人： Giovanni Abatangelo , Lanfranco Callegaro
IPC分类号： A61F200
CPC分类号： A61L27/3804 , A61K35/12 , A61L15/28 , A61L27/20 , A61L27/3633 , A61L27/365 , A61L27/3654 , A61L27/3847 , A61L27/3852 , A61L27/3895 , A61L27/60 , C12N5/0068 , C12N5/0654 , C12N5/0655 , C12N5/0656 , C12N5/0663 , C12N2500/32 , C12N2500/38 , C12N2501/115 , C12N2501/39 , C12N2533/70 , C08L5/08
摘要： A biological material comprising two components is provided containing a first component comprising alternatively (1) a culture of autologous or homologous bone marrow stem cells partially or completely differentiated into specific connective tissue cellular lines or (2) a sole extracellular matrix free from any cellular component secreted by the specific connective tissue cellular lines; and a second component containing a three-dimensional biocompatible and biodegradable matrix consisting of a hyaluronic acid ester having a degree of esterification comprised between 25 and 100%. The specific tissue cell lines are selected from fibroblasts, osteoblasts, myoblasts, adipocytes, chondrocytes and endothelial cells. The biological material is suitable for use as a dermal substitute in cutaneous lesions as well as repairing damaged connective tissue.
摘要翻译：提供包含两种组分的生物材料，其含有第一组分，所述第一组分可选地（1）部分或完全分化成特定结缔组织细胞系的自体或同源骨髓干细胞的培养物或（2）不含任何细胞组分的唯一细胞外基质由特定的结缔组织细胞系分泌; 以及含有三维生物相容性和可生物降解性基质的第二组分，所述基质由具有25-100％酯化度的透明质酸酯组成。特定组织细胞系选自成纤维细胞，成骨细胞，成肌细胞，脂肪细胞，软骨细胞和内皮细胞。生物材料适合用作皮肤损伤中的皮肤替代物，以及修复受损的结缔组织。

27. 发明授权

US06595910B2 Method for treating fecal incontinence 失效
公开(公告)号：US06595910B2
公开(公告)日：2003-07-22
申请号：US09882522
申请日：2001-06-15
申请人： David E. Silverman , Alan Stein
发明人： David E. Silverman , Alan Stein
IPC分类号： A61F200
CPC分类号： A61F2/0009 , A61B17/00491 , A61B17/12022 , A61B17/12036 , A61B17/12099 , A61B17/12186 , A61B17/3478 , A61B2017/00495 , A61F2/0036 , A61M5/31593
摘要： A method for treating fecal incontinence in a body of a mammal having a rectum formed by a rectal wall extending to an anus wherein the rectal wall includes a sphincter muscle surrounding the anus. At least one nonaqueous solution is introduced into the rectal wall in the vicinity of the anus. A nonbiodegradable solid is formed in the rectal wall from the at least one nonaqueous solution.

28. 发明授权

US06589549B2 Bioactive agent delivering system comprised of microparticles within a biodegradable to improve release profiles 有权
公开(公告)号：US06589549B2
公开(公告)日：2003-07-08
申请号：US09906041
申请日：2001-07-13
申请人： Chung Shih , Gaylen Zentner
发明人： Chung Shih , Gaylen Zentner
IPC分类号： A61F200
CPC分类号： A61K9/0024 , A61K9/06 , A61K9/1647 , A61K47/34
摘要： A composition and method for releasing a bio-active agent or a drug within a biological environment in a controlled manner is disclosed. The composition is a dual phase polymeric agent—delivery composition comprising a continuous biocompatible gel phase, a discontinuous particulate phase comprising defined microparticles and an agent to be delivered. A microparticle containing a bio-active agent is releasably entrained within a biocompatible polymeric gel matrix. The bioactive agent release may be contained in the microparticle phase alone or in both the microparticles and the gel matrix. The release of the agent is prolonged over a period of time, and the delivery may be modulated and/or controlled. In addition, a second agent may be loaded in some of the microparticles and/or the gel matrix.

29. 发明授权

US06585993B2 Controlled release neurotoxin system 失效
标题翻译：控制释放神经毒素系统
公开(公告)号：US06585993B2
公开(公告)日：2003-07-01
申请号：US10096501
申请日：2002-03-11
申请人： Stephen Donovan , Daniel G. Brady
发明人： Stephen Donovan , Daniel G. Brady
IPC分类号： A61F200
CPC分类号： A61K9/0024 , A61K38/4893 , Y10S514/964
摘要： A biocompatible implant for continuous in vivo release of a neurotoxin over a treatment period extending from one month to five years. The implant can be made of casting a solution of a polymer, such as an ethyl vinyl acetate copolymer and the neurotoxin. The neurotoxin can be a botulinum toxin.
摘要翻译：在一个月至五年的治疗期内连续体内释放神经毒素的生物相容性植入物。植入物可以通过浇铸聚合物如乙酸乙烯酯共聚物和神经毒素的溶液来制备。神经毒素可以是肉毒杆菌毒素。

30. 发明授权

US06579226B2 Delivery of cardiac constraint jacket 有权
标题翻译：交付心脏约束夹克
公开(公告)号：US06579226B2
公开(公告)日：2003-06-17
申请号：US09921475
申请日：2001-08-03
申请人： John C. Vanden Hoek , Jody L. Rivers
发明人： John C. Vanden Hoek , Jody L. Rivers
IPC分类号： A61F200
CPC分类号： A61F2/2481 , A61B17/00491 , A61B2017/0649 , A61F2002/0072 , A61F2002/2484
摘要： A cardiac constraint jacket is formed of flexible material defining a volume between an open upper end and a lower end. The jacket is dimensioned for an apex of a patient's heart to be inserted into the volume through the open upper end and for the jacket to be slipped over the heart. A delivery device is used to place the jacket on the heart. The delivery device includes a plurality of attachment locations. Each of the attachment locations is releasably secured to separate positions surrounding a periphery of the open upper end of the jacket. The delivery device also includes a control arrangement which is selectively movable between an open position and a closed position. The control arrangement is connected to the attachment locations such that the attachment locations are in a compact array urging the open upper end of the jacket into a collapsed configuration when the control member is in the closed position. When the control arrangement is in the open position, the attachment locations are in an open array. The attachment locations urge the open upper end of the jacket into an open configuration sufficient for the heart to be inserted into the jacket volume through the open upper end and for the jacket to be slipped over said heart.
摘要翻译：心脏约束护套由限定开口上端和下端之间的体积的柔性材料形成。外套的尺寸适合患者心脏的顶点，以通过开放的上端插入体积中，并且夹克被滑过心脏。输送装置用于将夹套放置在心脏上。输送装置包括多个附接位置。每个附接位置可释放地固定到围绕外套的敞开的上端周边的分离位置。输送装置还包括可在打开位置和关闭位置之间选择性地移动的控制装置。控制装置连接到附接位置，使得当控制构件处于关闭位置时，附接位置处于紧凑的阵列中，从而使夹套的敞开的上端成为收缩构型。当控制装置处于打开位置时，附接位置处于开放阵列中。附接位置促使外套的敞开的上端形成为足够的开放构造，以使心脏能够通过敞开的上端插入护套体积中，并且护套能够滑过所述心脏。

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