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21. 发明申请

US20040019299A1 Methods and devices for automated biopsy and collection of soft tissue 失效
标题翻译：用于自动活检和收集软组织的方法和装置
公开(公告)号：US20040019299A1
公开(公告)日：2004-01-29
申请号：US10364062
申请日：2003-02-11
发明人： Mark A. Ritchart , J. Michael Stuart , Fred H. Burbank , Kenneth M. Galt
IPC分类号： A61B010/00
CPC分类号： A61B10/0266 , A61B6/12 , A61B8/0841 , A61B10/0275 , A61B10/0283 , A61B17/221 , A61B2010/0208 , A61B2010/0225 , A61B2017/303
摘要： Instruments for performing percutaneous biopsy procedures are disclosed, which have advantageous features for improving functionality and performance over prior art devices. These instruments comprise two types, single-use devices, and multiple-use devices having active tissue capture capability. Improved features include the ability to retrieve and evaluate multiple tissue samples during a single insertion procedure, without physical handling of the samples, as well as constructional features, such as a molded tissue cassette housing, variant vacuum port embodiments suited for different tissue environments, and a method for backflushing the instrument to remove biological debris, among others.
摘要翻译：公开了用于执行经皮活检程序的仪器，其具有改善现有技术装置的功能和性能的有利特征。这些仪器包括两种类型的一次性装置，以及具有活性组织捕获能力的多用途装置。改进的特征包括在单次插入过程中检索和评估多个组织样本的能力，而不对样品进行物理处理，以及结构特征，例如模制的组织盒壳体，适合于不同组织环境的变体真空端口实施例，以及一种用于反吹仪器以去除生物碎屑的方法等。

22. 发明申请

US20040019295A1 Specimen collection and application apparatus 有权
标题翻译：标本采集和应用仪器
公开(公告)号：US20040019295A1
公开(公告)日：2004-01-29
申请号：US10205712
申请日：2002-07-25
发明人： David F. Zhou , Nai Shu Wang , Claudia J. R. Shen , Angela J. Q. Shen
IPC分类号： A61B010/00
CPC分类号： A61B10/0096 , A61B10/0038 , Y10T436/25
摘要： A device for quantitively collecting, preserving and mailing a fresh and wet specimen of fecal or other biological matter for later analysis comprises a tubular vessel defining a chamber closed at one axial end by a plug and restricted at the opposite end by a narrow aperture. A stopper for closing the open end of the vessel extends into a stick whose distal portion comprises indentations capable of retaining a portion of the biological matter when the stick is dipped into it. The distal portion of the stick is shaped and dimensioned to intimately and circumferentially contact the edge of the aperture so that the amount of matter introduced into the chamber is limited to the part having penetrated into the indentations. The shank of the stick is dimensioned to seal the aperture once the stopper has been screwed upon the open end of the vessel. The plug mounts a breakable hollow nib and is installed after introduction into the chamber of a metered volume of preserving solution. A cover caps the plug and nib to provide additional sealing of that end of the vessel during transportation.
摘要翻译：一种用于定量收集，保存和邮寄新鲜和潮湿的粪便或其他生物物质样品用于后续分析的装置包括管状容器，其限定在一个轴向端部处由塞子封闭的腔室，并且通过窄孔限制在相对端。用于封闭容器的开口端的塞子延伸成棒，其远端部分包括当棒浸入其中时能够保留生物物质的一部分的凹痕。棒的远端部分的形状和尺寸被设计成紧密地和圆周地接触孔的边缘，使得引入腔室的物质的数量被限制在已经穿入凹口的部分上。一旦塞子已经拧紧在容器的开口端，则该杆的柄的尺寸被设计成密封孔。插头安装了可破碎的空心笔尖，并在导入计量体积的保存溶液的腔室后安装。盖子盖住塞子和笔尖，以便在运输过程中提供该容器端部的额外密封。

23. 发明申请

US20040006284A1 Biopsy device 失效
标题翻译：活检装置
公开(公告)号：US20040006284A1
公开(公告)日：2004-01-08
申请号：US10187564
申请日：2002-07-02
发明人： Peter H. Sayet , Lloyd A. Sutherland , Michael Wolfe
IPC分类号： A61B010/00
CPC分类号： A61B10/0266 , A61B10/0275 , A61B10/04 , A61B10/06 , A61B2010/0225
摘要： A biopsy device includes a housing and at least one biopsy mechanism moveably connected to the housing. The biopsy can be provided on a biopsy arm. An actuator moves the biopsy arm and operates the biopsy mechanism. The biopsy arms with the biopsy mechanisms are preferably removable from the housing, such that the housing can be used again for subsequent biopsy procedures.
摘要翻译：活检装置包括壳体和可移动地连接到壳体的至少一个活检机构。可以在活检组上提供活组织检查。致动器移动活检臂并操作活检机构。具有活检机构的活检臂优选地可从壳体移除，使得壳体可以再次用于随后的活检程序。

24. 发明申请

US20030229293A1 Biopsy method 失效
公开(公告)号：US20030229293A1
公开(公告)日：2003-12-11
申请号：US10164198
申请日：2002-06-06
发明人： John A. Hibner , Elizabeth L. Sebern , Michael Piller
IPC分类号： A61B010/00
CPC分类号： A61B10/0275 , A61B10/0283 , A61B17/3417 , A61B2010/0208 , A61B2010/0225 , A61B2090/395
摘要： A biopsy device having an insert and related method are disclosed. The insert permits a user to obtain a tissue sample surrounding a center core(s) of removed tissue. The additional tissue provides an effective evaluation of whether all the desired tissue has been excised and a determination of whether an acceptable margin of healthy tissue has been removed.

25. 发明申请

US20030225345A1 System and method for improving skin texture monitored with a proof device 审中-公开
标题翻译：用防爆装置监测皮肤纹理改善的系统和方法
公开(公告)号：US20030225345A1
公开(公告)日：2003-12-04
申请号：US10370855
申请日：2003-02-20
申请人： Unilever Home & Personal Care USA, Division of Conopco, Inc.
发明人： Craig Stephen Slavtcheff , Christine Elizabeth Kennedy , Paul James Baker
IPC分类号： A61B010/00
CPC分类号： A61B5/442
摘要： A cosmetic product system is provided which includes a cosmetic composition for improving skin texture, and a test device packaged with the composition. The device includes a mechanism for visualizing progressive improvement in texture imparted by the composition as the latter is applied over a period of time.
摘要翻译：提供了一种化妆品系统，其包括用于改善皮肤纹理的化妆品组合物和与该组合物一起包装的测试装置。该装置包括用于使组合物施加的纹理的逐渐改进的可视化机构，因为后者在一段时间内施加。

26. 发明申请

US20030212343A1 Biopsy needle and biopsy device containing the same 有权
标题翻译：活检针和活检装置含有相同的
公开(公告)号：US20030212343A1
公开(公告)日：2003-11-13
申请号：US10400611
申请日：2003-03-27
发明人： Michael Plishka
IPC分类号： A61B010/00
CPC分类号： A61B10/0275 , A61B17/3417 , A61B2017/3454
摘要： The invention described herein relates to an improved biopsy needle which enhances the accuracy of the sampling procedure and minimizes the trauma caused by the procedure. The biopsy needle comprises a tip that reduces or minimizes undesirable bias of the needle during sampling penetration of the tissue, the tip comprising a plurality of facets arranged and oriented in a manner which improves the interaction between the needle and tissue during its advancement and penetration therein thereby improving the performance of the biopsy needle. The invention also includes a biopsy device comprising the biopsy needle of the invention.
摘要翻译：本文描述的本发明涉及一种改进的活检针，其增强了采样过程的准确性并使由该过程引起的创伤最小化。活检针包括尖端，其在采样穿透组织期间减少或最小化针的不希望的偏压，该尖端包括多个小平面，其以改进针和组织在其前进和穿透期间的相互作用的方式布置和取向从而提高活检针的性能。本发明还包括包括本发明的活检针的活检装置。

27. 发明申请

US20030208136A1 Flexible tip medical instrument 有权
标题翻译：柔性尖端医疗器械
公开(公告)号：US20030208136A1
公开(公告)日：2003-11-06
申请号：US10446989
申请日：2003-05-28
申请人： Promex, Inc.
发明人： Joseph L. Mark , Michael E. Miller
IPC分类号： A61B010/00
CPC分类号： A61B10/0275 , A61B2010/0208 , A61B2010/045
摘要： A biopsy device includes a flexible distal portion for obtaining a biopsy sample from a biopsy site. The device includes a coring cannula with a wall defined between a proximal end and a distal end and defining a lumen therebetween. The wall of the cannula defines a coring relief notch adjacent the distal end has a length along a longitudinal axis of the cannula longer than a diameter of the coring cannula. A wire is slidably disposable within the lumen of the coring cannula and has a proximal end and a distal end and defines a sampling cavity adjacent the distal end. A wire relief notch is positioned adjacent the sampling cavity. The wire relief notch has a length along a longitudinal axis of the wire longer than a width of the wire relief notch. A firing mechanism is engaged to the proximal ends of the coring cannula and the wire and the firing mechanism is operable to move the coring cannula relative to the wire from a second position to a first position to trap tissue from the biopsy site in the sampling cavity. The wire is slidable relative to the coring cannula between the first position retracted within the lumen so that the coring cannula covers the sampling cavity and a second position wherein the distal end of the wire is extended away from the coring cannula to expose the cavity to tissue in the biopsy site.
摘要翻译：活检装置包括用于从活检部位获得活检样本的柔性远端部分。该装置包括取芯插管，其具有限定在近端和远端之间并在其间限定内腔的壁。套管的壁限定邻近远端的取心凹口具有比套管的直径更长的套管的纵向轴线的长度。电线在取芯插管的内腔内是可滑动地一次性的，并且具有近端和远端，并限定与远端相邻的取样腔。线取出槽位于采样腔附近。线切口具有沿着导线的纵向轴线的长度比导线释放槽口的宽度长。击发机构接合到取心插管和线的近端，并且击发机构可操作以将取芯插管相对于线从第二位置移动到第一位置，以将组织从采样腔中的活检部位捕获。导线相对于取芯套管在第一位置缩回内腔之间可滑动，使得取芯套管覆盖采样腔，而第二位置，其中导线的远端从取心套管延伸以将空腔暴露于组织在活检部位。

28. 发明申请

US20030208134A1 Barrett's esophagus cytology device 有权
标题翻译：巴雷特食管细胞学装置
公开(公告)号：US20030208134A1
公开(公告)日：2003-11-06
申请号：US10275336
申请日：2002-11-06
发明人： Dean J. Secrest , Marlin Younker
IPC分类号： A61B010/00
CPC分类号： A61B10/04 , A61B17/3401 , A61B17/3474 , A61B2010/0216 , A61B2017/22067 , A61B2090/061 , A61B2090/062
摘要： A method and apparatus for obtaining esophageal cells for diagnostic purposes comprises inserting the distal end of a flexible support body in a patient's stomach via the esophagus and mouth so that the proximal support body end projects from the mouth. A balloon at the distal support body end is inflated and the support body is withdrawn until the inflated balloon engages the sphincter at the stomach entrance. A support body location is marked that is a predetermined distance from the patient's dental arch when the inflated balloon engages the sphincter at the stomach entrance. The balloon is deflated and the support body is withdrawn so that the marked locatin is adjacent the patient's dental arch. The support body is withdrawn a second predetermined distance and a second support body location, adjacent the patient's dental arch, is marked. A cell collecting element is deployed from within the distal end of the support body so that the cell collecting element is disposed in the esophagus within the predetermined distance from the sphincter. The support body is reciprocated through the second predetermined distance with the cell collecting element deployed so that cells from the esophagus within the second predetermined distance from the sphincter are deposited on the cell collecting element. The cell collecting element is retracted into the body so that it does not engage the esophagus wall, and the body is withdrawn from the patient.
摘要翻译：用于获得用于诊断目的的食管细胞的方法和装置包括通过食管和口将柔性支撑体的远端插入患者的胃中，使得近端支撑体端部从口突出。在远侧支撑体端部的气囊膨胀，并且支撑体被拉出直到充气气囊与胃入口处的括约肌接合。当充气气囊与胃入口处的括约肌接合时，标记出与患者的牙弓预定距离的支撑体位置。气囊被放气并且支撑体被抽出，使得标记的位置与患者的牙弓相邻。将支撑体撤回第二预定距离，并且标记邻近患者牙弓的第二支撑体位置。细胞收集元件从支撑体的远端部分展开，使得细胞收集元件设置在与括约肌预定距离内的食道中。支撑体与第一预定距离往复运动，细胞收集元件展开，使来自括约肌的第二预定距离内的食道的细胞沉积在细胞收集元件上。细胞收集元件缩回到体内，使得细胞收集元件不与食道壁接合，并且将身体从患者身体中取出。

29. 发明申请

US20030195433A1 Localization element with energized tip 有权
标题翻译：带通电尖端的本地化元件
公开(公告)号：US20030195433A1
公开(公告)日：2003-10-16
申请号：US10271850
申请日：2002-10-15
发明人： Roman Turovskiy , Ted Su , Steven Kim , Mani Prakash
IPC分类号： A61B010/00
CPC分类号： A61B90/39 , A61B18/1477 , A61B18/1815 , A61B2018/1425 , A61B2018/1435 , A61B2018/1475 , A61B2018/183 , A61B2090/3908
摘要： This invention is an improved tissue-localizing device with an electrically energized locator element for fixedly yet removably marking a volume of tissue containing a suspect region for excision. The electrical energizing of the locator element facilitates the penetration of the locator element in to subject's tissue and minimizes resistance due to dense or calcified tissues. At least one locator element is deployed into tissue and assumes a predetermined curvilinear shape to define a tissue border containing a suspect tissue region along a path. Multiple locator elements may be deployed to further define the tissue volume along additional paths defining the tissue volume border that do not penetrate the volume. Delivery of electric current may be achieved through monopolar or bipolar electronic configuration depending on design needs. Various energy sources, e.g. radio frequency, microwave or ultrasound, may be implemented in this energized tissue-localizing device.
摘要翻译：本发明是一种改进的组织定位装置，其具有用于固定地可移除地标记包含可疑区域的组织的体积的用于切除的电激励定位元件。定位器元件的电能激励定位元件穿透到受试者的组织中并使由于致密或钙化组织引起的阻力最小化。至少一个定位元件被部署到组织中并且呈现预定的曲线形状以限定沿着路径包含可疑组织区域的组织边界。可以部署多个定位器元件以进一步沿着限定不穿透该体积的组织体积边界的附加路径限定组织体积。根据设计需要，可以通过单极或双极电子配置实现电流传递。各种能量源射频，微波或超声可以在这种激活的组织定位装置中实现。

30. 发明申请

US20030153843A1 Endoscopic submucosal core biopsy device 有权
标题翻译：内窥镜粘膜下核心活检装置
公开(公告)号：US20030153843A1
公开(公告)日：2003-08-14
申请号：US10361684
申请日：2003-02-11
申请人： Scimed Life Systems, a Minnesota Corporation
发明人： Srinivas Nishtalas , Tim E. Ward , James S. Bates , Stephane Gobron
IPC分类号： A61B010/00
CPC分类号： A61B10/0266 , A61B10/04 , A61B17/32053 , A61B2010/0216 , A61B2017/00269 , A61B2017/32004
摘要： An instrument for collecting body tissue includes a tubular cutting member having an exterior surface, a proximal end, and a distal end capable of penetrating body tissue; and a flexible cutting extension coaxially and slidably disposed around the exterior surface of the cutting member, the flexible cutting extensions having a proximal end and distal end capable of cutting tissue located at the distal end of the cutting member and covering the distal end of the cutting member so that tissue that has entered the cutting member is retained in the cutting member. A first tubular member may be connected to the cutting member, and a second tubular member mayb connected to the cutting extension, the second tubular member being coaxially disposed on the first tubular member. A handle mechanism may be connected to the first and second tubular members, the handle mechanism allowing relative movement between the first and second tubular members such that the flexible cutting extension may be extended beyond the distal end of the cutting member.
摘要翻译：用于收集身体组织的仪器包括具有外表面，近端和能够穿透身体组织的远端的管状切割构件; 以及柔性切割延伸部，其同轴且可滑动地设置在所述切割构件的外表面周围，所述柔性切割延伸部具有近端和远端，所述近端和远端能够切割位于所述切割构件的远端处的组织并覆盖所述切割的远端使得已经进入切割构件的纸巾被保留在切割构件中。第一管状构件可以连接到切割构件，并且第二管状构件可以连接到切割延伸部，第二管状构件同轴地设置在第一管状构件上。手柄机构可以连接到第一和第二管状构件，手柄机构允许第一和第二管状构件之间的相对运动，使得柔性切割延伸部可以延伸超过切割构件的远端。

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