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21. 发明申请

US20100099319A1 Systems and Methods for Synthesis of Extended Length Nanostructures 审中-公开
标题翻译：用于合成延长长度纳米结构的系统和方法
公开(公告)号：US20100099319A1
公开(公告)日：2010-04-22
申请号：US12566229
申请日：2009-09-24
申请人： David Lashmore , Joseph J. Brown , Robert C. Dean , Peter L. Antoinette
发明人： David Lashmore , Joseph J. Brown , Robert C. Dean , Peter L. Antoinette
IPC分类号： D01F9/12 , B01J19/00 , B01J19/08 , B05D5/06 , D04H13/00 , B32B9/00 , D04H1/00 , D02G3/00 , F28F7/00 , H02K3/02 , H01F5/00 , H01F27/28 , H01B1/04 , F41H5/02
CPC分类号： B82Y40/00 , B82Y10/00 , B82Y30/00 , C01B32/162 , C01B2202/34 , Y10S438/909 , Y10S977/70 , Y10S977/701 , Y10S977/702 , Y10S977/844 , Y10S977/89 , Y10S977/963 , Y10T428/249978 , Y10T428/2916 , Y10T428/2918 , Y10T428/298 , Y10T442/60 , Y10T442/605
摘要： A system for synthesizing nanostructures using chemical vapor deposition (CVD) is provided. The system includes a housing, a porous substrate within the housing, and on a downstream surface of the substrate, a plurality of catalyst particles from which nanostructures can be synthesized upon interaction with a reaction gas moving through the porous substrate. Electrodes may be provided to generate an electric field to support the nanostructures during growth. A method for synthesizing extended length nanostructures is also provided. The nanostructures are useful as heat conductors, heat sinks, windings for electric motors, solenoid, transformers, for making fabric, protective armor, as well as other applications
摘要翻译：提供了一种使用化学气相沉积（CVD）合成纳米结构的系统。该系统包括壳体，壳体内的多孔基底，以及在基底的下游表面上，多个催化剂颗粒，当与通过多孔基底移动的反应气体相互作用时，可从该催化剂颗粒合成纳米结构。可以提供电极以在生长期间产生电场以支持纳米结构。还提供了一种合成延伸长度纳米结构的方法。纳米结构可用作热导体，散热器，用于电动机的绕组，螺线管，变压器，用于制造织物，保护性装甲以及其它应用

22. 发明授权

US07655269B2 Integrated nanomechanical sensor array chips 失效
标题翻译：集成纳米机械传感器阵列芯片
公开(公告)号：US07655269B2
公开(公告)日：2010-02-02
申请号：US10423832
申请日：2003-04-25
申请人： Theresa S. Mayer , Christine D. Keating
发明人： Theresa S. Mayer , Christine D. Keating
IPC分类号： G01N1/33
CPC分类号： G01N33/54373 , Y10S977/702 , Y10S977/877
摘要： The invention provides sensor, preferably biosensor devices and method of fabrication. The devices have significant advantages over the prior art methods having compatibility with future trends in clinical diagnostics and chemical detection. The underlying principle involves the integration of nanometer diameter, micron long metal or semiconductor rods onto a substrate to form a suspended nanomechanical cantilevers. The cantilever rods are rigidly attached to the substrate on one or both ends, and resonate at a characteristic frequency depending on the diameter, length, and stiffness of the rod. The metal or semiconductor rods are integrated onto the substrate using electrofluidic or fluidic assembly techniques. A receptor coating is placed on the metal or semiconductor rods prior to or following rod alignment using self-assembly chemistries. Sensing is accomplished when the target agent binds to the receptor substance, causing a change in the mass of the cantilever rod, and a corresponding change in the resonant frequency. This change in resonant frequency can be detected using an electrical readout. The sensing circuitry is integrated with CMOS or TFT technologies to form compact multi-analyte senor arrays on single crystal silicon, glass, or polymeric substrates. Circuits can also be included on the substrate to transmit the array data via wireless methods to a remote workstation for analysis. Devices may be integrated on chips with other analysis devices.
摘要翻译：本发明提供了传感器，优选地是生物传感器装置和制造方法。与现有技术方法相比，这些装置具有与临床诊断和化学检测中的未来趋势相容的显着优点。其基本原理涉及将纳米直径，微米长金属或半导体棒整合到基底上以形成悬浮的纳米机械悬臂。悬臂杆在一端或两端刚性连接到基板上，并以取决于杆的直径，长度和刚度的特征频率共振。使用电流或流体组装技术将金属或半导体棒集成到衬底上。在使用自组装化学物质的杆对准之前或之后，将受体涂层放置在金属或半导体棒上。当靶剂与受体物质结合时，可以实现感应，引起悬臂杆质量的变化以及谐振频率的相应变化。可以使用电读出来检测谐振频率的这种变化。感测电路与CMOS或TFT技术集成，以在单晶硅，玻璃或聚合物基板上形成紧凑的多分析物传感器阵列。电路也可以包括在基板上，以通过无线方式将阵列数据传输到远程工作站进行分析。设备可以与其他分析设备集成在芯片上。

23. 发明申请

US20080207553A1 Biodegradable Cationic Polymers 失效
标题翻译：可生物降解阳离子聚合物
公开(公告)号：US20080207553A1
公开(公告)日：2008-08-28
申请号：US12014446
申请日：2008-01-15
申请人： Gang Zhao , Xiaoli Fu , Lei Yu
发明人： Gang Zhao , Xiaoli Fu , Lei Yu
IPC分类号： A61K31/7115 , C08F26/00
CPC分类号： C08G73/02 , A61K31/12 , A61K41/0038 , A61K47/59 , A61K47/593 , A61K48/0041 , A61K49/0002 , C08G63/6856 , C08G73/0206 , C08L67/02 , C08L79/02 , C12N15/88 , Y10S977/702 , Y10S977/704 , Y10S977/705 , C08L2666/26
摘要： Polymers comprising a polyethylenimine, a biodegradable group, and a relatively hydrophobic group are useful for the delivery of bioactive agents to cells.
摘要翻译：包含聚乙烯亚胺，可生物降解基团和相对疏水的基团的聚合物可用于将生物活性剂递送至细胞。

24. 发明申请

US20080160090A1 Laser-Activated Nanothermolysis of Cells 失效
标题翻译：激光激活的细胞纳米热解
公开(公告)号：US20080160090A1
公开(公告)日：2008-07-03
申请号：US11795857
申请日：2006-01-23
申请人： Alexander Oraevsky , Dmitri Lapotko
发明人： Alexander Oraevsky , Dmitri Lapotko
IPC分类号： A61K9/14 , A61P35/02 , A61K33/38
CPC分类号： B82Y5/00 , A61K41/0052 , A61K47/6873 , A61K47/6891 , A61K47/6923 , A61K47/6929 , Y10S977/70 , Y10S977/702
摘要： Provided herein are methods and system to increase selective thermomechanical damage to a biological body, such as a cancer cell or cell associated with a pathophysiological condition. The biological body or cancer cell is specifically targeted with nanoparticulates comprising one or more targeting moieties which form nanoparticulate clusters thereon or therewithin. Pulsed electromagnetic radiation, e.g., optical radiation, having a wavelength spectrum selected for a peak wavelength near to or matching a peak absorption wavelength of the nanoparticulates selectively heats the nanoparticulates thereby generating vapor microbubbles around the clusters causing damage to the targets without affecting any surrounding medium or normal cells or tissues. Also provided is a method of treating leukemia using the methods and system described herein.
摘要翻译：本文提供了增加对生物体（例如癌细胞或与病理生理条件相关的细胞）的选择性热机械损伤的方法和系统。生物体或癌细胞特异性靶向包含一个或多个在其上形成纳米颗粒簇的靶向部分的纳米颗粒。对于接近或匹配纳米颗粒的峰值吸收波长的峰值波长的脉冲电磁辐射，例如光学辐射，选择性地加热纳米颗粒，从而在簇附近产生蒸汽微泡，从而对靶进行破坏而不影响任何周围介质或正常细胞或组织。还提供了使用本文所述的方法和系统治疗白血病的方法。

25. 发明申请

US20080153082A1 Nanoparticle polyanion conjugates and methods of use thereof in detecting analytes 审中-公开
标题翻译：纳米粒子聚阴离子共轭物及其在检测分析物中的应用方法
公开(公告)号：US20080153082A1
公开(公告)日：2008-06-26
申请号：US11890545
申请日：2007-08-06
申请人： James J. Storhoff , Robert L. Letsinger , Susan R. Hagenow
发明人： James J. Storhoff , Robert L. Letsinger , Susan R. Hagenow
IPC分类号： G01N33/53 , C12N11/08 , C07K2/00 , C12N7/00 , C07K17/08 , C07K16/00 , B32B5/16 , C07H21/00 , C12Q1/70 , G01N33/534 , G01N33/554
CPC分类号： G01N33/588 , B82Y15/00 , G01N33/54346 , G01N33/54353 , G01N33/545 , G01N2333/726 , Y10S977/702 , Y10T428/2982
摘要： This invention provides polyanionic polymer conjugates containing non-nucleotide polyanionic polymers that are useful in detecting target analytes such as proteins or small molecules. The invention also provides nanoparticles bound to polyanionic polymer conjugates and methods of preparation and use thereof. The polyanionic polymer conjugates have the formula: L-O—[PO2—O-Z-O]n—PO2—O—X wherein n ranges from 1 to 200; L represents a moiety comprising a functional group for attaching the polyanion polymer to the nanoparticle surface; Z represents a bridging group, and X represents Q, X′ or -Q-X′, wherein Q represents a functional group for attaching a recognition probe to the polyanion polymer, and X′ represents a recognition probe.
摘要翻译：本发明提供含有非核苷酸聚阴离子聚合物的聚阴离子聚合物缀合物，其可用于检测目标分析物如蛋白质或小分子。本发明还提供结合聚阴离子聚合物共轭物的纳米颗粒及其制备和使用方法。聚阴离子聚合物共轭物具有下式：<？in-line-formula description =“In-line Formulas”end =“lead”？> LO- [PO 2 -OZO] n < 其中n的范围为1至200;或其中n的范围为1至200; L表示包含用于将聚阴离子聚合物附着到纳米颗粒表面的官能团的部分; Z表示桥连基，X表示Q，X'或-Q-X'，其中Q表示用于将识别探针附着到聚阴离子聚合物上的官能团，X'表示识别探针。

26. 发明申请

US20080113448A1 Fluorescent Carbon Nanoparticles 有权
标题翻译：荧光碳纳米粒子
公开(公告)号：US20080113448A1
公开(公告)日：2008-05-15
申请号：US11814410
申请日：2006-10-27
申请人： Ya-Ping Sun
发明人： Ya-Ping Sun
IPC分类号： G01N33/533 , B32B9/04 , B05D5/06
CPC分类号： C09K11/025 , C01B32/05 , C09K11/65 , G01N33/587 , Y10S977/70 , Y10S977/702 , Y10S977/703 , Y10S977/704 , Y10S977/705 , Y10S977/773 , Y10T428/2982 , Y10T428/2991 , Y10T428/2998
摘要： Disclosed are photoluminescent particles. The particles include a core nano-sized particle of carbon and a passivation agent bound to the surface of the nanoparticle. The passivation agent can be, for instance, a polymeric material. The passivation agent can also be derivatized for particular applications. For example, the photoluminescent carbon nanoparticles can be derivatized to recognize and bind to a target material, for instance a biologically active material, a pollutant, or a surface receptor on a tissue or cell surface, such as in a tagging or staining protocol.
摘要翻译：披露的是光致发光颗粒。颗粒包括核心纳米尺寸的碳颗粒和与纳米颗粒表面结合的钝化剂。钝化剂可以是例如聚合物材料。钝化剂也可以为特定应用衍生化。例如，可以将光致发光碳纳米颗粒衍生化以识别和结合目标材料，例如组织或细胞表面上的生物活性材料，污染物或表面受体，例如标记或染色方案。

27. 发明申请

US20070117744A1 Compositions comprising poorly water soluble pharmaceutical agents and antimicrobial agents 有权
标题翻译：包含水溶性差的药剂和抗微生物剂的组合物
公开(公告)号：US20070117744A1
公开(公告)日：2007-05-24
申请号：US11514030
申请日：2006-08-30
申请人： Neil Desai , Raj Selvaraj , Andrew Yang , Patrick Soon-Shiong
发明人： Neil Desai , Raj Selvaraj , Andrew Yang , Patrick Soon-Shiong
IPC分类号： A61K38/38 , A61K38/13 , A61K31/4745 , A61K31/427 , A61K31/337 , A61K31/385
CPC分类号： A61K31/337 , A61K9/0019 , A61K9/19 , A61K9/5169 , A61K38/13 , A61K45/06 , A61K47/02 , A61K47/12 , A61K47/183 , A61K47/26 , A61K47/42 , Y02A50/473 , Y10S977/702 , Y10S977/705 , Y10S977/773 , Y10S977/788 , Y10T428/2982 , A61K2300/00
摘要： The present invention provides compositions comprising a poorly water soluble pharmaceutical agent, a carrier protein, and an antimicrobial agent, wherein significant microbial growth is inhibited in the composition. The amount of the antimicrobial agent in the composition may be below the level that induces a toxicological effect or at a level where a potential side effect can be controlled or tolerated. Also provided are compositions comprising a poorly water soluble pharmaceutical agent, a carrier protein, a sugar, and optionally an antimicrobial agent. Methods of using the compositions are also provided.
摘要翻译：本发明提供了包含水溶性差的药剂，载体蛋白和抗微生物剂的组合物，其中组合物中显着的微生物生长被抑制。组合物中抗微生物剂的量可以低于诱导毒性作用的水平或者可以控制或耐受潜在副作用的水平。还提供了包含难溶于水的药剂，载体蛋白，糖和任选的抗微生物剂的组合物。还提供了使用组合物的方法。

28. 发明申请

US20070116765A1 Aqueous dispersion of hydrogel nanoparticles with inverse thermoreversible gelation 失效
标题翻译：具有逆热反应凝胶化的水凝胶纳米颗粒的水分散体
公开(公告)号：US20070116765A1
公开(公告)日：2007-05-24
申请号：US10581678
申请日：2004-12-09
申请人： Zhibing Hu , Xiaohu Xia
发明人： Zhibing Hu , Xiaohu Xia
IPC分类号： C12N15/09 , A61K9/14
CPC分类号： A61K9/0024 , A61K9/06 , A61K9/10 , A61K9/1635 , A61K9/5138 , A61K9/5161 , A61K9/5192 , Y10S977/702 , Y10S977/897 , Y10S977/906
摘要： An aqueous dispersion of hydrogel nanoparticles and methods of making the aqueous dispersion of hydrogel nanoparticless having an interpenetrating polymer network (“IPN”) are described. The uniformed sized mono-disperse IPN nanoparticles have inverse thermo gelation properties that allow therapeutic medications to be uniformly distributed in a liquid form of the aqueous dispersion of hydrogel nanoparticles. Such medications can then be released from a solid form of the aqueous dispersion of hydrogel nanoparticles in time dependant manor.
摘要翻译：描述了水凝胶纳米颗粒的水分散体和制备具有互穿聚合物网络（“IPN”）的纳米级水凝胶的水性分散体的方法。均匀尺寸的单分散IPN纳米颗粒具有逆热凝胶化性质，其允许治疗性药物均匀分布在液体形式的水凝胶纳米颗粒的水分散体中。然后可以从固体形式的时间依赖性的水凝胶纳米颗粒的水分散体中释放这些药物。

29. 发明申请

US20060258751A1 Biodegradable cationic polymers 失效
标题翻译：可生物降解的阳离子聚合物
公开(公告)号：US20060258751A1
公开(公告)日：2006-11-16
申请号：US11216986
申请日：2005-08-31
申请人： Gang Zhao , Xiaoli Fu , Lei Yu
发明人： Gang Zhao , Xiaoli Fu , Lei Yu
IPC分类号： A61K31/12
CPC分类号： C08G73/02 , A61K31/12 , A61K41/0038 , A61K47/59 , A61K47/593 , A61K48/0041 , A61K49/0002 , C08G63/6856 , C08G73/0206 , C08L67/02 , C08L79/02 , C12N15/88 , Y10S977/702 , Y10S977/704 , Y10S977/705 , C08L2666/26
摘要： Polymers comprising a polyethylenimine, a biodegradable group, and a relatively hydrophobic group are useful for the delivery of bioactive agents to cells.
摘要翻译：包含聚乙烯亚胺，可生物降解基团和相对疏水的基团的聚合物可用于将生物活性剂递送至细胞。

30. 发明授权

US07112315B2 Molecular nanowires from single walled carbon nanotubes 有权
标题翻译：单壁碳纳米管的分子纳米线
公开(公告)号：US07112315B2
公开(公告)日：2006-09-26
申请号：US09354531
申请日：1999-07-15
申请人： Ching-Hwa Kiang
发明人： Ching-Hwa Kiang
IPC分类号： D01F9/12 , C01N11/04
CPC分类号： C12N11/04 , B82Y15/00 , D01F9/12 , Y10S977/702 , Y10S977/705 , Y10S977/75 , Y10S977/762
摘要： Unique single walled nanotube compositions and methods for making the composition wherein the nanotubes encloses foreign material capable of forming thread-like material having a solid form at ambient temperatures and pressures.
摘要翻译：独特的单壁纳米管组合物和制备组合物的方法，其中纳米管包围能够在环境温度和压力下形成具有固体形式的线状材料的异物。

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