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21. 发明申请

US20110071073A1 Detection of mutations in a gene associated with resistance to viral infection, OAS1 有权
标题翻译：检测与病毒感染相关的基因中的突变，OAS1
公开(公告)号：US20110071073A1
公开(公告)日：2011-03-24
申请号：US11592711
申请日：2006-11-02
申请人： Shawn P. Iadonato , Charles L. Magness , Gary Rosenberg , Christina A. Scherer
发明人： Shawn P. Iadonato , Charles L. Magness , Gary Rosenberg , Christina A. Scherer
IPC分类号： A61K38/00 , C07K14/00 , A61P43/00 , C12Q1/70 , C07H21/04 , A61K48/00
CPC分类号： C12Q1/707 , A61K38/45 , C07K16/40 , C12N9/1241 , C12N15/1137 , C12Q1/6876 , C12Q1/6883 , C12Q1/6888 , C12Q1/70 , C12Q2600/156 , C12Q2600/172 , Y02A50/385 , Y02A50/387 , Y02A50/393 , Y02A50/463 , Y02A50/465 , Y02A50/53 , Y02A50/54
摘要： A method for detecting a mutation related to the gene encoding OAS1. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the mutated gene, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human OAS1, including antisense oligonucleotides, methods, and compositions specific for human OAS1, are also provided.
摘要翻译：用于检测与编码OAS1的基因有关的突变的方法。这个和其他公开的突变与人类对包括丙型肝炎的病毒感染的抗性相关。还提供了由突变基因编码的蛋白质或多肽或编码该蛋白质或多肽的多核苷酸组成的治疗剂。还提供人OAS1的抑制剂，包括反义寡核苷酸，方法和人类OAS1特异性的组合物。

22. 发明申请

US20100267583A1 METHOD AND KIT FOR DETECTION OF HEPATITIS A VIRUS NEUTRALIZING ANTIBODIES 审中-公开
标题翻译：用于检测乙型肝炎病毒中毒抗体的方法和试剂盒
公开(公告)号：US20100267583A1
公开(公告)日：2010-10-21
申请号：US12760858
申请日：2010-04-15
申请人： Ali AZIZI
发明人： Ali AZIZI
IPC分类号： C40B30/06 , C40B40/00
CPC分类号： G01N33/5768 , G01N2469/20 , Y02A50/54
摘要： A rapid immunoassay method for the detection of anti-Hepatitis A Virus (HAV) neutralizing antibodies is described herein. This microplate-based enzymatic assay may be applicable in virological diagnostics, in evaluating the immunogenicity of candidate immunogenic compositions, such as HAV vaccines, or in quantifying functional neutralizing antibodies during the course of HAV infection.
摘要翻译：本文描述了用于检测抗甲型肝炎病毒（HAV）中和抗体的快速免疫测定方法。这种基于微孔板的酶测定法可用于病毒学诊断，评估候选免疫原性组合物（例如HAV疫苗）的免疫原性，或在HAV感染过程中定量功能性中和抗体。

23. 发明申请

US20100184159A1 Compositions, Methods, and Kits for Selective Amplification of Nucleic Acids 审中-公开
标题翻译：用于核酸选择性扩增的组合物，方法和试剂盒
公开(公告)号：US20100184159A1
公开(公告)日：2010-07-22
申请号：US12692557
申请日：2010-01-22
申请人： Vissarion AIVAZACHVILI , Konard Faulstich , Tony Tran
发明人： Vissarion AIVAZACHVILI , Konard Faulstich , Tony Tran
IPC分类号： C12P19/34
CPC分类号： C12Q1/6827 , C12Q1/6844 , C12Q1/6853 , Y02A50/54 , C12Q2525/307 , C12Q2531/125 , C12Q2525/117 , C12Q2561/125 , C12Q2537/143
摘要： The current teachings are directed to compositions, methods, and kits for selectively amplifying and for detecting target sequences. In some embodiments, a circularizable probe and/or a probe pair are disclosed for selectively amplifying target sequences. Methods for selectively amplifying target sequences are also disclosed, as are methods for detecting selectively amplified target sequences. Certain embodiments of the disclosed methods comprise a circularizable probe, a probe pair, comprising a first probe and a second probe, or both. In certain embodiments, a multiplicity of different circularizable probes, a multiplicity of different probe sets, or a multiplicity of different circularizable probes and a multiplicity of different probe sets are provided to selectively amplify or to detect a multiplicity of different target sequences, typically in a multiplex reaction. According to certain disclosed methods, surrogates of the target sequences are selectively amplified, including without limitation ligated probes, first amplification products, second amplification products, or combinations thereof. In some embodiments, selectively amplified target sequences or their surrogates are detected, directly or indirectly, indicating the presence of the corresponding target sequence. Kits to facilitate the performance of the disclosed methods are also provided.
摘要翻译：目前的教导涉及用于选择性扩增和检测靶序列的组合物，方法和试剂盒。在一些实施方案中，公开了可圆化探针和/或探针对，用于选择性扩增靶序列。还公开了选择性扩增靶序列的方法，以及用于检测选择性扩增的靶序列的方法。所公开方法的某些实施方案包括可圆化的探针，包括第一探针和第二探针的探针对，或两者。在某些实施方案中，提供多个不同的可圆化探针，多个不同的探针组或多个不同的可环化探针和多个不同的探针组，以选择性地扩增或检测多种不同靶序列，通常在多重反应。根据某些公开的方法，选择性扩增靶序列的替代物，包括但不限于连接的探针，第一扩增产物，第二扩增产物或其组合。在一些实施方案中，直接或间接检测选择性扩增的靶序列或其替代物，表明存在相应的靶序列。还提供了用于促进所公开方法的性能的套件。

24. 发明申请

US20100151445A1 Multiplex Method for Detecting an Infection 审中-公开
标题翻译：检测感染的多重检测方法
公开(公告)号：US20100151445A1
公开(公告)日：2010-06-17
申请号：US12600297
申请日：2008-06-06
申请人： Christine Charpentier , Stephane Gadelle , Nadine Lambert , Amparo Sanjuan
发明人： Christine Charpentier , Stephane Gadelle , Nadine Lambert , Amparo Sanjuan
IPC分类号： C12Q1/70 , G01N33/53
CPC分类号： G01N33/56983 , G01N33/54333 , G01N33/569 , G01N33/56911 , G01N33/576 , G01N2333/02 , G01N2333/10 , Y02A50/54
摘要： The invention relates to a method for the in vitro diagnostic detection of an infection with a microorganism, comprising placing a biological sample, in a single assay receptacle, in the presence of particles, each carrying at least one specific detectable physical parameter, and belonging to at least two different groups, one of the groups carrying an anti-IgM capture antibody and the other group carrying a capture antigen derived from said microorganism.
摘要翻译：本发明涉及用于体外诊断检测微生物感染的方法，包括将生物样品置于单个测定容器中，在存在颗粒的情况下，每个载体具有至少一个特定的可检测的物理参数，属于至少两个不同的组，携带抗IgM捕获抗体的一个组，另一个携带来自所述微生物的捕获抗原的组。

25. 发明申请

US20090202575A1 IMMUNOSTIMULATORY NUCLEIC ACID MOLECULES 审中-公开
标题翻译：免疫细胞核酸分子
公开(公告)号：US20090202575A1
公开(公告)日：2009-08-13
申请号：US12248493
申请日：2008-10-09
申请人： Arthur M. Krieg , Joel N. Kline , Dennis Klinman
发明人： Arthur M. Krieg , Joel N. Kline , Dennis Klinman
IPC分类号： A61K39/00
CPC分类号： A61K39/00 , A61K31/00 , A61K31/4706 , A61K31/7048 , A61K31/711 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68 , Y02A50/412 , Y02A50/464 , Y02A50/466 , Y02A50/54
摘要： Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
摘要翻译：公开了含有未甲基化CpG二核苷酸的核酸和基于其刺激免疫应答的能力并将Th2应答重定向到受试者中Th1应答的治疗效用。公开了治疗特应性疾病，包括特应性皮炎的方法。

26. 发明申请

US20090123472A1 DETECTION OF MUTATIONS IN A GENE ASSOCIATED WITH RESISTANCE TO VIRAL INFECTION, OAS1 有权
标题翻译：检测与抗病毒感染相关的基因中的突变
公开(公告)号：US20090123472A1
公开(公告)日：2009-05-14
申请号：US12061548
申请日：2008-04-02
申请人： Shawn P. Iadonato , Charles L. Magness , Gary Rosenberg , Christina A. Scherer
发明人： Shawn P. Iadonato , Charles L. Magness , Gary Rosenberg , Christina A. Scherer
IPC分类号： A61K39/395 , C12Q1/68 , C12N9/00 , A61K38/43 , A61K9/127 , C12N15/11 , C07H21/00 , C12N15/00 , C12N5/06 , A61K31/7088 , C07K16/18
CPC分类号： C12Q1/707 , A61K38/45 , C07K16/40 , C12N9/1241 , C12N15/1137 , C12Q1/6876 , C12Q1/6883 , C12Q1/6888 , C12Q1/70 , C12Q2600/156 , C12Q2600/172 , Y02A50/385 , Y02A50/387 , Y02A50/393 , Y02A50/463 , Y02A50/465 , Y02A50/53 , Y02A50/54
摘要： A method for detecting a mutation related to the gene encoding OAS1. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the mutated gene, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human OAS1, including antisense oligonucleotides, methods, and compositions specific for human OAS1, are also provided.
摘要翻译：用于检测与编码OAS1的基因有关的突变的方法。这个和其他公开的突变与人类对包括丙型肝炎的病毒感染的抗性相关。还提供了由突变基因编码的蛋白质或多肽或编码该蛋白质或多肽的多核苷酸组成的治疗剂。还提供人OAS1的抑制剂，包括反义寡核苷酸，方法和人类OAS1特异性的组合物。

27. 发明申请

US20080102445A1 Nucleic Acid Amplification Controls 有权
标题翻译：核酸扩增控制
公开(公告)号：US20080102445A1
公开(公告)日：2008-05-01
申请号：US11929089
申请日：2007-10-30
申请人： Gregory Chiklis , James Hengst
发明人： Gregory Chiklis , James Hengst
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： C12Q1/70 , C07K14/005 , C12N7/00 , C12N2730/10122 , C12N2730/10163 , C12N2740/15022 , C12N2740/16022 , C12N2740/16063 , C12N2740/16222 , C12N2770/24322 , C12N2770/24363 , C12Q1/6888 , C12Q1/689 , C12Q2600/166 , Y02A50/54 , Y02A50/59
摘要： The present invention discloses positive control material for nucleic acid amplification based detection of microorganisms in biological samples. The control material comprises purified microorganism that is rendered non-infectious but is amenable to nucleic acid amplification. Also disclosed is a process for making and using the control material.
摘要翻译：本发明公开了用于基于核酸扩增的检测生物样品中微生物的阳性对照物质。对照物质包含纯化的微生物，其被赋予非感染性，但适于进行核酸扩增。还公开了制造和使用控制材料的方法。

28. 发明申请

US20080008997A1 Proximity ligation assays with peptide conjugate 'burrs' and aptamers for the sensitive detection of spores and cancer cells 审中-公开
标题翻译：具有肽缀合物“毛刺”和适配体的接近连接测定法用于敏感检测孢子和癌细胞
公开(公告)号：US20080008997A1
公开(公告)日：2008-01-10
申请号：US11512439
申请日：2006-08-30
申请人： Matthew Levy , Andrew Ellington , Supriya Pai
发明人： Matthew Levy , Andrew Ellington , Supriya Pai
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： G01N33/56983 , G01N33/56911 , G01N33/56966 , G01N2458/10 , Y02A50/54
摘要： The present invention includes compositions and methods for the detection of specific targets on a surface that includes one or more peptides and one or more oligonucleotides connected by a joint to a detectable marker, wherein the joint between the peptides, the oligonucleotides or both the peptides and oligonucleotides are immobilized.
摘要翻译：本发明包括用于检测表面上特异性靶标的组合物和方法，其包括一个或多个肽和一个或多个通过接头与可检测标记连接的寡核苷酸，其中肽，寡核苷酸或肽两者之间的接合寡核苷酸被固定化。

29. 发明申请

US20060040259A1 Method for inhibition of viral infection 审中-公开
公开(公告)号：US20060040259A1
公开(公告)日：2006-02-23
申请号：US11000691
申请日：2004-11-30
申请人： Jeffrey Glenn
发明人： Jeffrey Glenn
IPC分类号： C12Q1/70 , A61K38/06
CPC分类号： G01N33/502 , A61K31/365 , A61K38/005 , A61K38/06 , C07K14/005 , C12N7/00 , C12N2760/10122 , C12N2760/10163 , C12Q1/18 , C12Q1/6897 , G01N33/5008 , G01N33/5067 , G01N33/56983 , G01N33/5765 , G01N2333/91165 , Y02A50/463 , Y02A50/54
摘要： The invention is directed to inhibiting viral morphogenesis and viral infection. In particular, it concerns effecting such inhibition by inhibiting the prenylation or post prenylation reactions of a viral or host protein.

30. 发明申请

US20060003955A1 Immunostimulatory nucleic acid molecules 有权
公开(公告)号：US20060003955A1
公开(公告)日：2006-01-05
申请号：US11067587
申请日：2005-02-25
申请人： Arthur Krieg , Joel Kline , Dennis Klinman , Alfred Steinberg
发明人： Arthur Krieg , Joel Kline , Dennis Klinman , Alfred Steinberg
IPC分类号： A61K48/00
CPC分类号： A61K39/00 , A61K31/00 , A61K31/4706 , A61K31/7048 , A61K31/711 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68 , Y02A50/412 , Y02A50/464 , Y02A50/466 , Y02A50/54
摘要： Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.

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