专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明授权

US09111739B2 Ionization method and apparatus using electrospray, and analyzing method and apparatus 有权
标题翻译：使用电喷雾的电离方法和装置，以及分析方法和装置
公开(公告)号：US09111739B2
公开(公告)日：2015-08-18
申请号：US13491331
申请日：2012-06-07
申请人： Kenzo Hiraoka
发明人： Kenzo Hiraoka
IPC分类号： H01J49/26 , H01J49/16 , G01N30/72 , G01N1/38
CPC分类号： H01J49/165 , G01N1/38 , G01N30/7266 , H01J49/0404 , H01J49/0445 , H01J49/167
摘要： It is arranged so that living tissue that has not been pretreated can be adopted as a sample of interest. A sample is introduced into at least a tip portion of a hollow insulated sample holder 11 having a small hole 11a in the tip portion. A slender metal wire 12, which has been inserted into the sample holder 11 from the rear, is projected outwardly from the sample holder 11 through the hole 11a while being brought into contact with the sample. A high voltage is applied to the slender metal wire 12 at least in a portion of a time period in which the tip of the slender metal wire 12 is being projected outwardly from the hole 11a, thereby ionizing, by electrospray, the sample adhering to the tip of the slender metal wire 12. The ions are introduced into an analyzing apparatus and are analyzed.
摘要翻译：可以采用未经预处理的活体组织作为感兴趣的样本。至少在尖端部分具有小孔11a的中空绝缘样品保持器11的尖端部分中引入样品。已经从后方插入到样品保持器11中的细长金属线12在与样品接触的同时通过孔11a从样品保持器11向外突出。至少在细长金属线12的前端从孔11a向外突出的时间段的至少一部分时间内对细长的金属线12施加高电压，从而通过电喷雾使附着在细长金属线12的尖端。将离子引入分析装置并进行分析。

22. 发明授权

US08847154B2 Ion transfer tube for a mass spectrometer system 有权
标题翻译：用于质谱仪系统的离子转移管
公开(公告)号：US08847154B2
公开(公告)日：2014-09-30
申请号：US13333948
申请日：2011-12-21
申请人： Eloy R. Wouters , Alexander A. Makarov , R. Paul Atherton , Jean Jacques Dunyach
发明人： Eloy R. Wouters , Alexander A. Makarov , R. Paul Atherton , Jean Jacques Dunyach
IPC分类号： H01J49/26 , H01J49/42 , H01J49/04
CPC分类号： H01J49/0404 , B23H7/02 , B23H9/14
摘要： An ion transfer tube for a mass spectrometer comprises a core member and a first jacket tube member at least partially enclosing the core member and providing one or more channels therethrough. A method of forming an ion transfer tube, comprises: providing a first jacket tube member having a length and an internal bore, the internal bore passing along the length and defining an interior surface of circular cross section; removing at least one portion of the first jacket tube member adjacent to the interior surface so as to form at least one groove, channel, slot, recess or embayment of or in the interior surface; and providing a core member within the bore of the jacket tube member such that remnant portions of the interior surface of circular cross section mate against portions of an exterior surface of the core member.
摘要翻译：用于质谱仪的离子传递管包括芯构件和至少部分地包围芯构件并且提供穿过其中的一个或多个通道的第一护套管构件。一种形成离子转移管的方法，包括：提供具有长度和内孔的第一套管构件，所述内孔沿着所述长度通过并限定圆形横截面的内表面; 移除与所述内表面相邻的所述第一套管构件的至少一部分，以便形成所述内表面中或所述内表面中的至少一个凹槽，通道，槽，凹槽或沉积物; 并且在所述护套管构件的所述孔内提供芯构件，使得所述圆形横截面的内表面的残留部分与所述芯构件的外表面的部分配合。

23. 发明授权

US08829431B2 Nanomanipulation coupled nanospray mass spectrometry (NMS) 有权
公开(公告)号：US08829431B2
公开(公告)日：2014-09-09
申请号：US13795994
申请日：2013-03-12
申请人： University of North Texas
发明人： Guido Fridolin Verbeck, IV
IPC分类号： G01N1/04 , H01J49/04 , G01N21/65 , H01J49/00
CPC分类号： H01J49/0027 , G01N21/65 , H01J49/0404 , H01J49/0459 , H01J49/167
摘要： A coupled nanomanipulation and nanospray mass spectrometry (NMS) system for single cell, single organelle, and ultra-trace molecular analysis is disclosed herein. The system primarily comprises a bio-workstation coupled to a NMS. The bio-workstation primarily comprises of a nanomanipulator stage with a plurality of nano-positioners attached to a cabinet with a piezo voltage source and a pressure injector. The present invention further describes a fingerprint lift method that when coupled with the system disclosed herein can be used for retrieval and analysis of trace amounts of drug and explosive residues. The system described herein has been used in the areas of trace and document analysis within the forensic field, trace fiber analysis, and electrostatic lifts for illicit drugs, as well as document and painting analysis.

24. 发明授权

US08766177B2 Nanomanipulation coupled nanospray mass spectrometry (NMS) 有权
标题翻译：纳米操纵耦合纳喷射质谱（NMS）
公开(公告)号：US08766177B2
公开(公告)日：2014-07-01
申请号：US13270962
申请日：2011-10-11
申请人： Guido Fridolin Verbeck, IV
发明人： Guido Fridolin Verbeck, IV
IPC分类号： H01J49/04 , H01J49/10 , H01J49/16
CPC分类号： H01J49/0027 , G01N21/65 , H01J49/0404 , H01J49/0459 , H01J49/167
摘要： A coupled nanomanipulation and nanospray mass spectrometry (NMS) system for single cell, single organelle, and ultra-trace molecular analysis is disclosed herein. The system primarily comprises a bio-workstation coupled to a NMS. The bio-workstation primarily comprises of a nanomanipulator stage with a plurality of nano-positioners attached to a cabinet with a piezo voltage source and a pressure injector. The present invention further describes a fingerprint lift method that when coupled with the system disclosed herein can be used for retrieval and analysis of trace amounts of drug and explosive residues. The system described herein has been used in the areas of trace and document analysis within the forensic field, trace fiber analysis, and electrostatic lifts for illicit drugs, as well as document and painting analysis.
摘要翻译：本文公开了用于单细胞，单细胞器和超微量分子分析的偶联纳米操纵和纳喷射质谱（NMS）系统。该系统主要包括耦合到NMS的生物工作站。生物工作站主要包括具有多个纳米定位器的纳米操纵器台，该纳米定位器用压电电压源和压力注射器连接到机柜。本发明进一步描述了当与本文公开的系统耦合时可用于追踪和分析痕量的药物和爆炸性残留物的指纹提升方法。本文描述的系统已被用于法医领域的追踪和文件分析，微量纤维分析和非法药物静电升降以及文件和绘画分析领域。

25. 发明授权

US08698075B2 Orthogonal ion injection apparatus and process 有权
标题翻译：正交离子注入装置及工艺
公开(公告)号：US08698075B2
公开(公告)日：2014-04-15
申请号：US13114869
申请日：2011-05-24
申请人： Ruwan T. Kurulugama , Mikhail E. Belov
发明人： Ruwan T. Kurulugama , Mikhail E. Belov
IPC分类号： H01J49/06
CPC分类号： H01J49/065 , H01J49/0404 , H01J49/044
摘要： An orthogonal ion injection apparatus and process are described in which ions are directly injected into an ion guide orthogonal to the ion guide axis through an inlet opening located on a side of the ion guide. The end of the heated capillary is placed inside the ion guide such that the ions are directly injected into DC and RF fields inside the ion guide, which efficiently confines ions inside the ion guide. Liquid droplets created by the ionization source that are carried through the capillary into the ion guide are removed from the ion guide by a strong directional gas flow through an inlet opening on the opposite side of the ion guide. Strong DC and RF fields divert ions into the ion guide. In-guide orthogonal injection yields a noise level that is a factor of 1.5 to 2 lower than conventional inline injection known in the art. Signal intensities for low m/z ions are greater compared to convention inline injection under the same processing conditions.
摘要翻译：描述了一种正交离子注入装置和方法，其中离子通过位于离子导向器一侧的入口直接注入垂直于离子引导轴的离子导向器中。加热的毛细管的末端放置在离子导向器内，使得离子直接注入到离子导向器内的DC和RF场中，这有效地将离子限制在离子导向器内。由电离源产生的通过毛细管进入离子导向器的液滴通过强力的定向气流从离子导向器的相反侧的入口开口从离子导向器移除。强直流和射频场将离子转移到离子导向器中。导向正交注入产生比现有技术中已知的常规在线注入低1.5至2倍的噪声电平。在相同的处理条件下，与常规的直线注入相比，低m / z离子的信号强度更大。

26. 发明授权

US08686351B2 Systems and methods for transfer of ions for analysis 有权
标题翻译：用于离子转移的系统和方法进行分析
公开(公告)号：US08686351B2
公开(公告)日：2014-04-01
申请号：US13937913
申请日：2013-07-09
申请人： Purdue Research Foundation
发明人： Zheng Ouyang , Robert Graham Cooks , Sandilya Venkata Garimella , Jason David Harper , Nicholas Alan Charipar
IPC分类号： H01J37/301 , H01J49/04 , H01J3/18
CPC分类号： H01J49/0404 , G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/04 , H01J49/0409 , H01J49/0422 , H01J49/0459 , H01J49/10 , H01J49/26 , H01J49/40 , H01J49/4215
摘要： The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device.
摘要翻译：本发明一般涉及用于转移离子进行分析的系统和方法。在某些实施方案中，本发明提供了一种用于分析样品的系统，该样品包括用于将样品分子转化成大气压的区域中的气相离子的电离源，离子分析装置和可操作地耦合到气体的离子传递构件气体发生装置，其中气体流动产生装置产生将气相离子通过离子传递构件转移到离子分析装置的入口的层流气流。

27. 发明申请

US20130320207A1 MASS SPECTROMETER 有权
公开(公告)号：US20130320207A1
公开(公告)日：2013-12-05
申请号：US13909299
申请日：2013-06-04
申请人： HITACHI HIGH-TECHNOLOGIES CORPORATION
发明人： Hidetoshi MOROKUMA , Koji ISHIGURO , Shun KUMANO
IPC分类号： H01J49/04
CPC分类号： H01J49/0404 , H01J49/00 , H01J49/005 , H01J49/04 , H01J49/0409 , H01J49/0422 , H01J49/0431 , H01J49/0495 , H01J49/10 , H01J49/24
摘要： Provided is a mass spectrometer capable of easy exchange of a measurement sample and suppressing a carryover. The mass spectrometer includes a mass spectrometry section, an ion source the internal pressure of which is reduced by a differential pumping from the mass spectrometry section and the ion source ionizes the sample gas, a sample container in which the sample gas is generated by vaporizing the measurement sample, a thin pipe that introduces the sample gas generated in the sample container into the ion source, an elastic tube of openable and closable that connects the sample container and the thin pipe, a pair of weirs that closes or opens the elastic tube so as to sandwich the elastic tube, and a cartridge that integrates the sample container, the thin pipe, and the elastic tube, and is detachable in a lump from a main body of the mass spectrometer.

28. 发明申请

US20130284915A1 MASS SPECTROMETRY METHOD, MASS SPECTROMETER, AND MASS SPECTROMETRY SYSTEM 审中-公开
标题翻译：质谱法，质谱仪和质谱仪系统
公开(公告)号：US20130284915A1
公开(公告)日：2013-10-31
申请号：US13997714
申请日：2011-12-26
申请人： Haruo Shimada , Yoshimasa Nakatani , Yuka Noritake , Kazumasa Kinoshita , Yasuo Shida
发明人： Haruo Shimada , Yoshimasa Nakatani , Yuka Noritake , Kazumasa Kinoshita , Yasuo Shida
IPC分类号： H01J49/04
CPC分类号： H01J49/04 , H01J49/0404 , H01J49/0468
摘要： A mass spectrometry method of the present invention is a method for conducting mass spectrometry in such a manner that an ion that is produced from a sample is introduced into a mass spectrometer by using DART or DESI, wherein the mass spectrometer has an ion introduction part for introducing the ion thereinto and the ion introduction part is heated at a predetermined timing.
摘要翻译：本发明的质谱法是以通过使用DART或DESI将由样品产生的离子引入质谱仪的方式进行质谱分析的方法，其中，所述质谱仪具有用于在其中引入离子和离子引入部分在预定的时间被加热。

29. 发明授权

US08557023B2 Device for preparing a gas flow for introduction thereof into a mass spectrometer 有权
标题翻译：用于制备用于将其引入质谱仪的气流的装置
公开(公告)号：US08557023B2
公开(公告)日：2013-10-15
申请号：US12935260
申请日：2009-03-18
申请人： Reinhold Pesch
发明人： Reinhold Pesch
IPC分类号： B01D53/22
CPC分类号： H01J49/0422 , G01N1/4005 , G01N2001/4016 , H01J49/0404
摘要： The invention relates to a device for preparing a gas flow for introduction thereof into a mass spectrometer, wherein the gas flow contains one or more analytes and has helium as carrier gas. According to the invention, a selective separating device is provided for separating off a part of the carrier gas from the gas flow (10), to form a residual gas flow (11) and a separated carrier gas flow (12). A higher fraction of the analyte is present therein than in the gas flow and in the separated carrier gas flow there is a lower fraction of the analyte.
摘要翻译：本发明涉及一种用于制备用于将其引入质谱仪的气流的装置，其中气流含有一种或多种分析物并具有氦气作为载气。根据本发明，提供一种选择性分离装置，用于将一部分载气与气流（10）分离，形成残留气流（11）和分离的载气流（12）。分析物的比例高于气体流中，分离的载气流中分析物的分数较低。

30. 发明授权

US08549893B2 System and method for a gas chromatograph to mass spectrometer interface 有权
标题翻译：用于气相色谱仪到质谱仪界面的系统和方法
公开(公告)号：US08549893B2
公开(公告)日：2013-10-08
申请号：US12399574
申请日：2009-03-06
申请人： Edward B. McCauley
发明人： Edward B. McCauley
IPC分类号： G01N30/02
CPC分类号： G01N30/7206 , G01N30/30 , G01N2030/3084 , H01J49/0404 , H01J49/0422
摘要： A system for interfacing a gas chromatograph (GC) to a mass spectrometer the GC comprising a GC column partially contained within a GC oven, the mass spectrometer comprising a housing enclosing an interior having an ion source, the system comprising: a conduit extending from the GC oven to the mass spectrometer and comprising an interior volume that is contiguous with an interior volume of the GC oven; and a duct extending from a region of relatively high or relatively low pressure within the GC oven to the conduit interior volume and operable so as to transmit a flow of air or gas between the region of relatively high or relatively low pressure and the conduit interior volume, wherein a portion of the GC column extends through the conduit interior volume to the ion source.
摘要翻译：一种用于将气相色谱仪（GC）与质谱仪接口的系统，GC包括部分包含在GC烘箱内的GC柱，质谱仪包括封闭具有离子源的内部的壳体，该系统包括：从 GC烘箱到质谱仪并且包括与GC烘箱的内部体积邻接的内部容积; 以及从GC烘箱内的相对较高或相对较低压力的区域延伸到导管内部容积并且可操作以在相对较高或相对较低压力的区域和导管内部体积之间传递空气或气体流的管道，其中GC柱的一部分延伸穿过导管内部体积到离子源。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式