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21. 发明授权

US5786142A Electrophoresis and fluorescence detection method 失效
标题翻译：电泳和荧光检测方法
公开(公告)号：US5786142A
公开(公告)日：1998-07-28
申请号：US452719
申请日：1995-05-30
申请人： John A. Renfrew , James W. Cassidy
发明人： John A. Renfrew , James W. Cassidy
IPC分类号： G01N27/447 , G01N30/86 , C12Q1/68 , B01D61/42 , C25B1/00 , G01N15/06
CPC分类号： G01N27/44721 , G01N30/8603
摘要： An improved electrophoresis and fluorescence detection method for nucleotide sequences comprises a fluorescence sensing region along the path of nucleotide detection, coupled with amplification and integration in an integrator of output signals in the form of activity peaks. The output signal, which is converted to a voltage signal, is summed with a programmable offset generated by an inexpensive eight-bit D/A converter. The offset signal is selected to establish a lower starting point for the dynamic range of analog-digital conversion, and is selected to null some or all of the background fluorescence level. The integrator is switchable under program control. The integrator is switched on for long and short integration intervals. The short intervals permit sensing over a dynamic range accommodating very high levels of fluorescence; very high peaks may be measured and features of the peaks distinguished. The long intervals permit sensing over a dynamic range that is optimized for the peaks associated with the smaller peaks of individual nucleotides. In this way, the dynamic range of the analog-digital conversion permits the highest possible resolution over the range of interest during the time in which the sequencing of the nucleotides takes place. The method of nucleotide sequencing and analysis is fast, economical, and yields data with high resolution.
摘要翻译：用于核苷酸序列的改进的电泳和荧光检测方法包括沿着核苷酸检测途径的荧光感测区域，以及在活性峰形式的输出信号的积分器中的放大和积分。转换为电压信号的输出信号与由廉价的八位D / A转换器产生的可编程偏移相加。选择偏移信号以建立模拟数字转换的动态范围的较低起始点，并选择为零部分或全部背景荧光水平。集成商可在程序控制下切换。积分器接通长和短的积分间隔。短时间间隔允许在适应非常高水平荧光的动态范围内进行感测; 可以测量非常高的峰，并区分峰的特征。长间隔允许感测针对与各个核苷酸的较小峰相关联的峰优化的动态范围。以这种方式，模拟数字转换的动态范围允许在发生核苷酸测序的时间内在感兴趣的范围内达到最高可能的分辨率。核苷酸测序和分析的方法快速，经济，并且产生高分辨率的数据。

22. 发明授权

US5304494A Method of analyzing hydrocarbon oil mixtures using gel-permeation chromatography 失效
标题翻译：使用凝胶渗透色谱分析烃油混合物的方法
公开(公告)号：US5304494A
公开(公告)日：1994-04-19
申请号：US865438
申请日：1992-04-09
申请人： Pierre Eisenmann
发明人： Pierre Eisenmann
IPC分类号： G01N30/86 , G01N33/28 , G01N33/26 , G01N30/02
CPC分类号： G01N33/2829 , G01N30/8603
摘要： A method of analyzing a mixture of hydrocarbon oils by using gel-permeation chromatography together with infrared detection. According to the method the signals from the infrared detector are combined to form fingerprints (M) which are characteristic of the samples being analyzed and which represent the molecular size distribution of the various hydrocarbon fractions in the samples. Then, the fingerprints are combined either to determine the concentration and the fingerprints of an unknown oil present in a mixture of two oils, or else the concentrations of n known oils in a mixture of the n oils.
摘要翻译：通过使用凝胶渗透色谱与红外检测分析烃油的混合物的方法。根据该方法，来自红外检测器的信号被组合以形成指纹（M），其是正在分析的样品的特征，并且代表样品中各种烃馏分的分子尺寸分布。然后，将指纹组合以确定存在于两种油的混合物中的未知油的浓度和指纹，或者在n种油的混合物中的n种已知油的浓度。

23. 发明授权

US3593010A Analogue integration apparatus with compensation for drift 失效
标题翻译：具有补偿补偿的模拟整合装置
公开(公告)号：US3593010A
公开(公告)日：1971-07-13
申请号：US3593010D
申请日：1969-10-06
申请人： UNIVERSAL OIL PROD CO
发明人： SAMPSON ROBERT W
IPC分类号： G01R19/00 , G01N30/86 , G06G7/186 , G06G7/18
CPC分类号： G01N30/8603 , G01N30/8606 , G06G7/1865
摘要： A primary signal network which compensates for drift error developed in a voltage-integrating network operating on the primary signal voltage. A compensating voltage is developed in the primary signal network independent of the normal primary voltage signal. This compensating voltage offsets the drift voltage and improves the accuracy of the integration of the primary signal voltage over the period of measurement and integration.

24. 发明授权

US3404260A Analyzing varying signals 失效
标题翻译：分析变化的信号
公开(公告)号：US3404260A
公开(公告)日：1968-10-01
申请号：US49076465
申请日：1965-09-08
申请人： SHELL OIL CO
发明人： JOHNSON JR HENRY WILSON
IPC分类号： G01N30/86 , G06F17/00 , H03M1/00
CPC分类号： G06K9/0053 , G01N30/8603 , H03M1/30

25. 发明授权

US3375701A Methods and apparatus for interpreting overlapping signals 失效
标题翻译：用于解释重叠信号的方法和装置
公开(公告)号：US3375701A
公开(公告)日：1968-04-02
申请号：US42104664
申请日：1964-12-24
申请人： CHEMCELL 1963 LTD
发明人： WELLS ARKSEY GRAYDON
IPC分类号： G01N30/86 , G06G7/75 , H04J3/10
CPC分类号： H04J3/10 , G01N30/8603 , G01N30/8631 , G06G7/75

26. 发明授权

US3185820A Integrator and recorder apparatus 失效
标题翻译：集成器和记录仪
公开(公告)号：US3185820A
公开(公告)日：1965-05-25
申请号：US17242562
申请日：1962-02-12
申请人： INFOTRONICS CORP
发明人： WILLIAMS ALVIE P , JONES HAL J , FRISBY CLINTON D , NIVEN JR FRANCIS J
IPC分类号： G01N30/86 , H03M1/00
CPC分类号： G01N30/8603 , H03M1/00 , H03M1/34

27. 发明授权

US3038662A Integrator readout device 失效
标题翻译：集成器读出装置
公开(公告)号：US3038662A
公开(公告)日：1962-06-12
申请号：US76369858
申请日：1958-09-26
申请人： UNION CARBIDE CORP
发明人： FERTIG RAYMOND B
IPC分类号： G01N30/86
CPC分类号： G01N30/8603

28. 发明授权

US3009060A Gas chromatography 失效
标题翻译：气相色谱法
公开(公告)号：US3009060A
公开(公告)日：1961-11-14
申请号：US60903356
申请日：1956-09-10
申请人： NAT RES CORP
发明人： ROEHRIG JONATHAN R
IPC分类号： G01N27/66 , G01N30/86 , G06G7/186
CPC分类号： G01N27/66 , G01N30/8603 , G06G7/1865

29. 发明申请

US20100161238A1 Method and System for Detecting Peptide Peaks in HPLC-MS Signals 审中-公开
标题翻译： HPLC-MS信号中检测肽峰的方法和系统
公开(公告)号：US20100161238A1
公开(公告)日：2010-06-24
申请号：US12602319
申请日：2008-05-30
申请人： Salvatore Cappadona , Linda Pattini , Sergio Cerutti , Peter James , Fredrik Levander
发明人： Salvatore Cappadona , Linda Pattini , Sergio Cerutti , Peter James , Fredrik Levander
IPC分类号： G01N30/86 , H01J49/26 , G06F19/00
CPC分类号： G01N30/8675 , G01N30/8603 , G01N30/8617 , G01N30/8641
摘要： The present invention relates to a method, a computer tool and a system for detecting peptide peaks in measurement signals (11) generated by HPLC-MS instruments. The method comprises the steps of: providing an intensity column vector (SIC) representative of the elution values at a specific mass value (m/z) of the measurement signal (11); cam. performing a wavelet decomposition (15) of such values of said intensity column vector (SIC) to generate a first processed vector (16) representative of the smoothed intensity values of the intensity column vector (SIC); providing a threshold value (S) and performing a wavelet decomposition (17) as a function of the value of said threshold (S) to generate the second processed vector (18) representative of said intensity column vector (SIC) cleaned of any oscillations generated by stochastic noise (e(t)); processing said first processed vector (16) and said second processed vector (18) to generate a third processed vector (19) identifying the baseline values of said intensity column vector (SIC); processing said intensity column vector (SIC) and said second (18) and third (19) vectors to generate e filtered vector (20) identifying any peak value (ZJ) below the background noise (12).
摘要翻译：本发明涉及一种用于检测由HPLC-MS仪器产生的测量信号（11）中的肽峰的方法，计算机工具和系统。该方法包括以下步骤：提供代表测量信号（11）的特定质量值（m / z）的洗脱值的强度列向量（SIC）; 凸轮执行所述强度列向量（SIC）的这些值的小波分解（15）以产生表示强度列向量（SIC）的平滑强度值的第一处理向量（16）; 提供阈值（S）并且作为所述阈值（S）的值的函数执行小波分解（17），以生成代表产生的任何振荡的所述强度列向量（SIC）的第二处理向量（18）通过随机噪声（e（t））; 处理所述第一处理向量（16）和所述第二处理向量（18）以产生识别所述强度列向量（SIC）的基线值的第三处理向量（19）; 处理所述强度列向量（SIC）和所述第二（18）和第三（19）向量，以产生识别低于背景噪声（12）的任何峰值（ZJ）的滤波向量（20）。

30. 发明授权

US6112161A Method, apparatus, and article of manufacture for enhanced intergration of signals 失效
标题翻译：用于增强信号整合的方法，装置和制造
公开(公告)号：US6112161A
公开(公告)日：2000-08-29
申请号：US932150
申请日：1997-09-17
申请人： Paul C. Dryden , Bruce D. Quimby
发明人： Paul C. Dryden , Bruce D. Quimby
IPC分类号： G01N30/86
CPC分类号： G01N30/8603 , G01N30/8624 , G01N2030/8854 , G01N30/8606 , G01N30/8641
摘要： A method, apparatus, and article of manufacture for enhanced integration of signals, such as those generated by chromatographs. In one embodiment an approximate baseline used for integration of a signal is improved to reduce error. Alternate embodiments filter drift, noise, or both from a signal prior to integration or simulated distillation. The signals are processed according to a computer program stored in a memory. The methods include steps for subtracting an approximate baseline from the signal, defining a noise band in the resulting difference, and forming a composite baseline by substituting signal data for baseline data wherever the difference does not exceed the threshold, thus leaving the parts of the approximate baseline that correspond to signal peaks unchanged.
摘要翻译：用于增强信号集成的方法，装置和制品，例如由色谱仪产生的信号。在一个实施例中，用于信号积分的近似基线被改进以减少误差。替代实施例在集成或模拟蒸馏之前从信号滤波漂移，噪声或二者。信号根据存储在存储器中的计算机程序进行处理。这些方法包括从信号中减去近似基线的步骤，在所得到的差值中定义噪声带，并通过将信号数据代入基线数据形成复合基线，无论差值不超过阈值，因此留下近似的部分对应于信号峰的基线不变。

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