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21. 发明授权

US08697411B2 Streptomyces griseoplanus comprising an α-galactosidase for removing immunodominant α-galactose monosaccharides from blood group B or AB reactive cells 有权
标题翻译：包含α-半乳糖苷酶的灰色链霉菌，用于从血型B或AB反应性细胞中除去免疫优势的α-半乳糖单糖
公开(公告)号：US08697411B2
公开(公告)日：2014-04-15
申请号：US13205588
申请日：2011-08-08
申请人： Henrik Clausen , Humberto de la Vega , Cheryl Hill , Qiyong Peter Liu
发明人： Henrik Clausen , Humberto de la Vega , Cheryl Hill , Qiyong Peter Liu
IPC分类号： C12N9/24
CPC分类号： C12N5/0641 , C12N9/2402 , C12N9/2465 , C12Q1/34 , C12R1/465 , C12Y302/01022 , C12Y302/01049
摘要： This invention relates to enzymatic removal of type A and B antigens from blood group A, B, and AB reactive cells in blood products, and thereby converting these to non-A and non-B reactive cells. The invention further relates to using unique α-N-acetylgalactosaminidases and α-galactosidases with superior kinetic properties for removing the immunodominant monosaccharides of the blood group A and B antigens and improved performance in enzymatic conversion of red blood cells. The preferred unique α-N-acetylgalactosaminidases and α-galactosidases exhibit the following characteristics: (i) exclusive, preferred or no less than 10% substrate specificity for the type A and B branched polysaccharide structures relative to measurable activity with simple mono- and disaccharide structures and aglycon derivatives hereof; (ii) optimal performance at neutral pH with blood group oligosaccharides and in enzymatic conversion of cells; and (iii) a favorable kinetic constant Km with mono- and oligosaccharide substrates. The conversion methods of the invention use significantly lower amounts of recombinant glycosidase enzymes than previous and result in complete sero-conversion of all blood group A and B red cells.
摘要翻译：本发明涉及从血型A，B，AB型反应性细胞中分离A型和B型抗原，从而将其转化为非A型和非B型细胞。本发明还涉及使用独特的α-N-乙酰半乳糖胺酶和具有优异动力学性质的α-半乳糖苷酶，用于去除血型A和B抗原的免疫优势单糖，并提高了红细胞酶促转化的表现。优选的独特的α-N-乙酰半乳糖胺酶和α-半乳糖苷酶具有以下特征：（i）相对于简单的单糖和二糖的可测量的活性，对于A型和B型支链多糖结构，独特的，优选的或不低于10％的底物特异性结构和糖苷配基衍生物; （ii）在中性pH下用血型寡糖和细胞酶促转化的最佳性能; 和（iii）具有单糖和寡糖底物的有利的动力学常数Km。本发明的转化方法比以前使用显着更低量的重组糖苷酶，并导致所有血型A和B红细胞的完全血清转化。

22. 发明授权

US08668907B2 Highly functional enzyme having α-galactosidase activity 有权
标题翻译：具有α-半乳糖苷酶活性的高功能酶
公开(公告)号：US08668907B2
公开(公告)日：2014-03-11
申请号：US13667294
申请日：2012-11-02
申请人： Tokyo Metropolitan Organization for Medical Science , Altif Laboratories
发明人： Hitoshi Sakuraba , Youichi Tajima , Mai Ito , Seiichi Aikawa , Fumiko Aikawa
IPC分类号： A61K38/43 , A61K38/47 , C12N9/40 , C12P21/06 , C07H21/04 , C07K1/00
CPC分类号： C12N9/2465 , A61K38/00 , C12N9/2402 , C12Y302/01022 , C12Y302/01049
摘要： The present invention provides, as an enzyme which can be used for enzyme replacement therapy for Fabry disease, a protein having α-galactosidase activity, which shows no allergic adverse side effect, shows a high stability in blood, and can be easily incorporated into a cell of an affected organ. The protein of the present invention is a protein which has acquired α-galactosidase activity by changing the structure of the active site of wild-type human α-N-acetylgalactosaminidase.
摘要翻译：本发明提供作为可用于法布里病的酶替代疗法的酶，不具有过敏性副作用的具有α-半乳糖苷酶活性的蛋白质在血液中显示高稳定性，并且可以容易地并入受影响器官的细胞。本发明的蛋白质是通过改变野生型人α-N-乙酰半乳糖胺酶的活性位点的结构而获得α-半乳糖苷酶活性的蛋白质。

23. 发明授权

US08633221B2 Method of enhancing lysosomal α-galactosidase A 有权
标题翻译：增强溶酶体α-半乳糖苷酶A的方法
公开(公告)号：US08633221B2
公开(公告)日：2014-01-21
申请号：US12624026
申请日：2009-11-23
申请人： Jian-Qiang Fan , Satoshi Ishii
发明人： Jian-Qiang Fan , Satoshi Ishii
IPC分类号： A61K31/445 , A61K31/435 , C07D211/40 , C12N9/40
CPC分类号： A61K31/445 , A61K31/70 , A61K31/7008 , C07D451/06 , C12N9/2465
摘要： A method of enhancing the activity of lysosomal α-Galactosidase A (α-Gal A) in mammalian cells and for treatment of Fabry disease by administration of 1-deoxy-galactonojirimycin and related compounds.
摘要翻译：一种增强哺乳动物细胞中溶酶体α-半乳糖苷酶A（α-GalA）的活性并通过给予1-脱氧 - 半乳糖吉非霉素及相关化合物治疗法布里病的方法。

24. 发明申请

US20130295065A1 NUCLEIC ACID CONSTRUCT FOR EXPRESSION OF ALPHA-GALACTOSIDASE IN PLANTS AND PLANT CELLS 有权
标题翻译：用于在植物和植物细胞中表达ALPHA-糖蛋白酶的核酸构建体
公开(公告)号：US20130295065A1
公开(公告)日：2013-11-07
申请号：US13980910
申请日：2011-09-07
申请人： Avidor Shulman , Uri Hanania , Tali Kizhner , Yoseph Shaaltiel
发明人： Avidor Shulman , Uri Hanania , Tali Kizhner , Yoseph Shaaltiel
IPC分类号： C12N9/24
CPC分类号： C12N9/2465 , A61K38/47 , C12N15/8257
摘要： Nucleic acid expression constructs are provided and, more particularly, nucleic acid constructs for expression of human alpha-galactosidase in plant cells, cells expressing the nucleic acid construct, producing the human alpha-galactosidase and uses thereof.
摘要翻译：提供核酸表达构建体，更具体地，涉及在植物细胞中表达人α-半乳糖苷酶的核酸构建体，表达核酸构建体的细胞，产生人α-半乳糖苷酶及其用途。

25. 发明授权

US08568712B2 Enzyme and prebiotic combinations for enhancing probiotic efficacy 有权
标题翻译：用于提高益生菌功效的酶和益生元组合
公开(公告)号：US08568712B2
公开(公告)日：2013-10-29
申请号：US13749512
申请日：2013-01-24
申请人： Randolph S. Porubcan , Sonja Lea Yonak
发明人： Randolph S. Porubcan , Sonja Lea Yonak
IPC分类号： A61K38/43 , A61K38/54
CPC分类号： A61K38/47 , A61K9/148 , A61K31/201 , A61K31/685 , A61K31/702 , A61K35/20 , A61K38/54 , C12N9/2465 , C12Y302/01001 , C12Y302/01003 , C12Y302/01015 , C12Y302/01022 , C12Y304/22002 , C12Y304/22033 , A61K2300/00
摘要： This disclosure relates to enhancing growth and/or activity of lactobacilli using a prebiotic formulation which includes iso-malto oligosaccharides and α-galactosidase; and to enhancing growth and/or activity of bifidobacteria using a prebiotic formulation which includes iso-malto oligosaccharides and β-glucanase. Other combinations of fibers and enzymes are described below which also stimulate growth and activity of lactobacilli or bifidobacteria. These combinations of enzymes and prebiotics can be taken separately or added to foods, including desserts.
摘要翻译：本公开涉及使用包括异麦芽低聚糖和α-半乳糖苷酶的益生元制剂来增强乳酸杆菌的生长和/或活性; 并且使用包括异麦芽低聚糖和β-葡聚糖酶的益生元制剂来增强双歧杆菌的生长和/或活性。下面描述纤维和酶的其它组合，其也刺激乳酸杆菌或双歧杆菌的生长和活性。这些酶和益生元的组合可以单独服用或加入到食品中，包括甜点。

26. 发明授权

US08436018B2 Method for increasing the activity of lysosomal enzymes 有权
标题翻译：增加溶酶体酶活性的方法
公开(公告)号：US08436018B2
公开(公告)日：2013-05-07
申请号：US12890014
申请日：2010-09-24
申请人： Jian-Qiang Fan , Satoshi Ishii , Naoki Asano
发明人： Jian-Qiang Fan , Satoshi Ishii , Naoki Asano
IPC分类号： A61K31/445
CPC分类号： A61K31/445 , A61K31/70 , A61K31/7008 , C07D451/06 , C12N9/2465
摘要： Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method are imino sugars and related compounds. In particular, C8-12-alkyl derivatives of N-alkyl-deoxynojirimycin, isofagomine compounds, and calystegine compounds are effective to enhance glucocerebrosidase activity.
摘要翻译：通过以有效增加酶的活性的量施用葡糖脑苷脂酶的竞争性抑制剂，在哺乳动物细胞中增强与戈谢病相关的酶的活性的方法。用于该方法的优选化合物是亚氨基糖和相关化合物。特别地，N-烷基脱氧野尻霉素的C8-12-烷基衍生物，异佛胺化合物和钙半胱氨酸化合物对增强葡糖脑苷脂酶活性是有效的。

27. 发明申请

US20130102039A1 Methods of Producing Triacylglyceride Compositions Comprising Tailored Oils 有权
标题翻译：生产含有定型油的三酰基甘油酯组合物的方法
公开(公告)号：US20130102039A1
公开(公告)日：2013-04-25
申请号：US13630757
申请日：2012-09-28
申请人： Scott Franklin , Aravind Somanchi , Janice Wee , George Rudenko , Jeffrey L. Moseley , Walt Rakitsky
发明人： Scott Franklin , Aravind Somanchi , Janice Wee , George Rudenko , Jeffrey L. Moseley , Walt Rakitsky
IPC分类号： C12P7/64
CPC分类号： C12N15/79 , A23D7/00 , A23D9/00 , A23K20/158 , C11B1/00 , C11C3/00 , C12N9/0071 , C12N9/16 , C12N9/2431 , C12N9/2465 , C12N15/67 , C12N15/8216 , C12P7/64 , C12P7/6445 , C12P7/6463 , C12Y114/19001 , C12Y301/02 , C12Y301/02014 , C12Y302/01022 , C12Y302/01026 , Y02E50/13 , Y02P30/20 , Y02T50/678
摘要： Methods and compositions for the production of food compositions, oils, fuels, oleochemicals, and other compounds in recombinant microorganisms are provided, including oil-bearing microorganisms and methods of low cost cultivation of such microorganisms. Microalgal cells containing exogenous genes encoding, for example, a lipase, a sucrose transporter, a sucrose invertase, a fructokinase, a polysaccharide-degrading enzyme, a keto acyl-ACP synthase enzyme, a fatty acyl-ACP thioesterase, a fatty acyl-CoA/aldehyde reductase, a fatty acyl-CoA reductase, a fatty aldehyde reductase, a fatty aldehyde decarbonylase, and/or an acyl carrier protein are useful in manufacturing food compositions, and transportation fuels such as renewable diesel, biodiesel, and renewable jet fuel, as well as oleochemicals such as functional fluids, surfactants, soaps and lubricants.
摘要翻译：提供了用于在重组微生物中生产食品组合物，油，燃料，油脂化合物和其它化合物的方法和组合物，包括含油微生物和这种微生物的低成本培养的方法。包含编码例如脂肪酶，蔗糖转运蛋白，蔗糖转化酶，果糖激酶，多糖降解酶，酮酰基-ACP合成酶，脂肪酰基-ACP硫酯酶，脂肪酰辅酶A的外源基因的微藻细胞 /醛还原酶，脂肪酰辅酶A还原酶，脂肪醛还原酶，脂肪醛脱羰酶和/或酰基载体蛋白质可用于制造食品组合物，以及运输燃料如可再生柴油，生物柴油和可再生喷气燃料，以及诸如功能流体，表面活性剂，肥皂和润滑剂的油脂化学品。

28. 发明申请

US20120328592A1 STABILIZED ALPHA-GALACTOSIDASE AND USES THEREOF 有权
标题翻译：稳定的阿尔法胶质糖苷酶及其用途
公开(公告)号：US20120328592A1
公开(公告)日：2012-12-27
申请号：US13582482
申请日：2011-03-02
申请人： Avidor Shulman , Llya Ruderfer , Tehila Ben-Moshe , Talia Sheckhter , Yaniv Azulay , Yoseph Shaaltiel , Tali Kizhner
发明人： Avidor Shulman , Llya Ruderfer , Tehila Ben-Moshe , Talia Sheckhter , Yaniv Azulay , Yoseph Shaaltiel , Tali Kizhner
IPC分类号： A61K38/47 , A61P3/00 , C12N9/96
CPC分类号： C12N9/2465 , A61K38/00 , C12Y302/01022
摘要： Multimeric protein structures comprising at least two alpha-galactosidase monomers being covalently linked to one another via a linking moiety are disclosed herein, as well a process for preparing same, and methods of treating Fabry disease via administration of a multimeric protein structure. The disclosed multimeric protein structures exhibit an improved performance, in terms of enhanced activity and/or a longer lasting activity under both lysosomal conditions and in a serum environment.
摘要翻译：本文公开了包含通过连接部分彼此共价连接的至少两个α-半乳糖苷酶单体的多聚体蛋白质结构，以及其制备方法，以及通过施用多聚体蛋白质结构治疗法布里病的方法。根据在溶酶体条件和血清环境中增强的活性和/或更持久的活性方面，所公开的多聚体蛋白质结构表现出改进的性能。

29. 发明申请

US20120308595A1 Novel Immunogenic Compositions For The Prevention And Treatment of Meningococcal Disease 审中-公开
标题翻译：用于预防和治疗脑膜炎球菌疾病的新型免疫原性组合物
公开(公告)号：US20120308595A1
公开(公告)日：2012-12-06
申请号：US13455518
申请日：2012-04-25
申请人： Gary W. Zlotnick , Leah Diane Fletcher , John Erwin Farley , Liesel A. Bernfield , Robert J. Zagursky , Benjamin J. Metcalf
发明人： Gary W. Zlotnick , Leah Diane Fletcher , John Erwin Farley , Liesel A. Bernfield , Robert J. Zagursky , Benjamin J. Metcalf
IPC分类号： A61K39/095 , A61P31/04 , A61P37/04 , C07K14/22 , C07H21/04
CPC分类号： A61K39/095 , A61K39/00 , A61K39/39 , A61K47/543 , A61K47/646 , A61K2039/505 , A61K2039/53 , A61K2039/54 , A61K2039/55505 , A61K2039/55572 , A61K2039/55577 , A61K2039/58 , A61K2039/6087 , C07K14/22 , C07K16/1217 , C12N9/2417 , C12N9/2465 , C12N9/2471 , G01N33/56911 , G01N2333/22 , Y10S530/825
摘要： The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that immunospecifically bind to the foregoing and nucleic acid sequences encoding each of the foregoing, as well as the use of same in immunogenic compositions that are effective against infection by Neisseria meningitidis serogroup B.
摘要翻译：本发明涉及奈瑟氏菌ORF2086蛋白质，其可以从胎儿菌株分离或重组制备的交联反应性免疫原性蛋白质，包括其免疫原性部分，其生物等同物，免疫特异性结合前述的抗体和编码上述每一种的核酸序列，作为以及在针对脑膜炎奈瑟氏球菌血清群B感染有效的免疫原性组合物中的用途。

30. 发明申请

US20120141507A1 TARGETING OF GLYCOPROTEIN THERAPEUTICS 有权
标题翻译： GLYCOPROTEIN治疗方案的目标
公开(公告)号：US20120141507A1
公开(公告)日：2012-06-07
申请号：US13354855
申请日：2012-01-20
申请人： James Stefano
发明人： James Stefano
IPC分类号： A61K39/395 , A61P43/00 , C07K17/06 , A61K38/47 , C12N9/96
CPC分类号： A61K38/47 , A61K47/60 , A61K47/61 , A61K47/64 , C12N9/2465 , C12N9/96 , C12Y302/01022
摘要： Methods of making ligand-decorated polymer conjugates of therapeutic glycoproteins are described. Improved targeting of glycoproteins to specific tissues is achieved by masking the natural carbohydrate and other surface determinants with high molecular weight polymers, such as, e.g., PEG, polysialic acid, etc., which in turn are decorated with target-specific ligands. In some embodiments, acid-labile linkages in such conjugates or rapidly degradable masking groups allow for the intracellular release of the polymer from the glycoprotein, for example, under conditions found in lysosomes.
摘要翻译：描述了制备治疗性糖蛋白的配体缀合的聚合物缀合物的方法。通过用高分子量聚合物（例如PEG，聚唾液酸等）掩蔽天然碳水化合物和其它表面决定簇来实现糖蛋白靶向特定组织的改进，其又用靶特异性配体装饰。在一些实施方案中，这种缀合物或快速可降解的掩蔽基团中的酸不稳定键可以允许聚合物从糖蛋白的细胞内释放，例如在溶酶体中发现的条件下。

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