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21. 发明授权

US08093166B2 Bioactive glass compositions 有权
标题翻译：生物活性玻璃组合物
公开(公告)号：US08093166B2
公开(公告)日：2012-01-10
申请号：US11743769
申请日：2007-05-03
申请人： Loredana Moimas , Eija Pirhonen
发明人： Loredana Moimas , Eija Pirhonen
IPC分类号： C03C3/097 , C03C3/089 , C03C3/078
CPC分类号： C03C4/0007 , A61L27/10 , A61L27/306 , A61L27/446 , C03C3/089 , C03C3/097 , C03C4/0014
摘要： A bioactive glass composition, a method and an implant. The glass composition comprising SiO2, Na2O, K2O, CaO, and P2O5, having the following composition: SiO2 48-52 wt-%, Na2O 9-15 wt-%, K2O 12-18 wt-%, CaO 10-16 wt-%, P2O5 1-7 wt-%, TiO2 0.2-2 wt-%, B2O3 0-4 wt-%, and MgO 0-6 wt-%, wherein Na2O+K2O>25 wt-%, MgO+CaO>14 wt-%, and B2O3/P2O5>0.3.
摘要翻译：生物活性玻璃组合物，方法和植入物。包含SiO 2，Na 2 O，K 2 O，CaO和P 2 O 5的玻璃组合物具有以下组成：SiO 2 48-52重量％，Na 2 O 9-15重量％，K 2 O 12-18重量％，CaO 10-16重量％％，P 2 O 5 1-7重量％，TiO 2 0.2-2重量％，B 2 O 3 0-4重量％和MgO 0-6重量％，其中Na 2 O + K 2 O> 25重量％，MgO + CaO> 14 wt％，B2O3 / P2O5> 0.3。

22. 发明申请

US20110295190A1 Wound Dressing and Methods of Making and Using the Same 审中-公开
标题翻译：伤口敷料及其使用方法
公开(公告)号：US20110295190A1
公开(公告)日：2011-12-01
申请号：US13206720
申请日：2011-08-10
申请人： Nicole David , David Fink , Alain Tranchemontagne
发明人： Nicole David , David Fink , Alain Tranchemontagne
IPC分类号： A61M37/00 , A61L15/22 , A61P17/02 , A61L15/28 , A61K9/70 , A61K31/785
CPC分类号： A61K45/06 , A61K33/00 , A61K33/08 , A61K33/24 , A61K33/30 , A61K33/38 , A61K33/42 , A61L15/46 , A61L26/0061 , A61L26/0066 , A61L2300/102 , A61L2300/104 , A61L2300/206 , A61L2300/404 , A61L2300/45 , A61L2300/602 , A61L2300/62 , C03C3/16 , C03C4/0014 , C03C4/0035 , C03C2204/02 , A61K2300/00
摘要： Anti-microbial wound dressings, methods of making anti-microbial wound dressings and methods of treating wounds with an anti-microbial wound dressing are provided. The anti-microbial wound dressings can include a water-soluble film-forming polymeric carrier material and a water-soluble glass-encapsulated anti-microbial agent, which is embedded within the carrier and/or coated on a surface thereof. Additional active agents useful in wound care can also be embedded in and/or coated on a surface of the carrier and/or water-soluble glass.
摘要翻译：提供抗微生物伤口敷料，制造抗微生物伤口敷料的方法以及用抗微生物伤口敷料治疗伤口的方法。抗微生物伤口敷料可以包括水溶性成膜聚合物载体材料和水溶性玻璃包封的抗微生物剂，其被嵌入载体内和/或涂覆在其表面上。可用于伤口护理的其它活性剂也可嵌入载体和/或水溶性玻璃的表面和/或涂覆在载体和/或水溶性玻璃的表面上。

23. 发明申请

US20080118579A1 Medical Device and Its use 审中-公开
标题翻译：医疗器械及其用途
公开(公告)号：US20080118579A1
公开(公告)日：2008-05-22
申请号：US11666297
申请日：2005-11-02
申请人： Hannu Jarvelainen , Matti Laato , Jukka Salonen , Erik Vedel
发明人： Hannu Jarvelainen , Matti Laato , Jukka Salonen , Erik Vedel
IPC分类号： A61K33/06 , A61P17/02 , A61K33/00 , A61K33/32 , A61K31/69 , A61K31/665
CPC分类号： A61L15/18 , A61K9/0024 , A61K9/1611 , A61L27/10 , C03C3/078 , C03C4/0007 , C03C4/0014
摘要： The invention relates to a medical device comprising non-sintered bioactive glass particles or fibres having a diameter in the range 5-100 μm, bioactive glass comprising SiO2, Na2O, CaO, K2O, MgO, B2O3 and P2O5, wherein the amount of SiO2 is 50-65 wt-% of the final total weight, Na2O is 5-26 wt-% of the final total weight, CaO is 10-25 wt-% of the final total weight, K2O is 0-15 wt-% of the final total weight, MgO is 0-6 wt-% of the final total weight, B2O3 is 0-4 wt-% of the final total weight, and P2O5 is 0-4 wt-% of the final total weight, provided that the total amount of Na2O and K2O is 10-30 wt-% of the final total weight The device is essentially drug free. The invention also relates to the use of said composition for treating lesions associated with compromised or poor vascularisation and for preventing avascular fibrosis.
摘要翻译：本发明涉及包含非烧结生物活性玻璃颗粒或直径在5-100μm范围内的纤维的医疗装置，包含SiO 2，Na 2 O 2的生物活性玻璃，CaO，K 2 O，MgO，B 2 O 3和P 2 O 5， / SUB>，其中SiO 2的量为最终总重量的50-65重量％，Na 2 O 2为最终总重量的5-26重量％总重量，CaO为最终总重量的10-25重量％，K 2 O 2为最终总重量的0-15重量％，MgO为0-6重量％最终总重量，B 2 O 3 O 3是最终总重量的0-4重量％，P 2 O 5 如果Na 2 O 2和K 2 O 2的总量为10-30重量％，则其最终总重量为0-4重量％最终总重量的百分比该装置基本上是无毒的。本发明还涉及所述组合物用于治疗与受损或差的血管形成相关的损伤并用于预防无血管纤维化的用途。

24. 发明申请

US20070162151A1 Resorbable macroporous bioactive glass scaffold and method of manufacture 有权
标题翻译：可再生大孔生物活性玻璃支架及其制造方法
公开(公告)号：US20070162151A1
公开(公告)日：2007-07-12
申请号：US11329469
申请日：2006-01-11
申请人： Jiang Chang , Weiming Gu , Jipin Zhong
发明人： Jiang Chang , Weiming Gu , Jipin Zhong
IPC分类号： A61F2/28
CPC分类号： A61F2/28 , A61F2/4644 , A61F2002/2817 , A61F2002/2835 , A61F2002/30011 , A61F2002/30032 , A61F2002/30062 , A61F2002/30224 , A61F2002/30957 , A61F2002/30968 , A61F2210/0004 , A61F2230/0069 , A61F2250/0023 , A61F2250/003 , A61F2310/00329 , A61L27/10 , A61L27/56 , A61L27/58 , C03B19/06 , C03B19/08 , C03C3/062 , C03C3/097 , C03C3/112 , C03C4/0007 , C03C4/0014 , C03C11/00 , C03C12/00 , C03C14/00 , C03C14/008
摘要： A resorbable, macroporous bioactive glass scaffold comprising approximately 24-45% CaO, 34-50% SiO2, 0-25% Na2O, 5-17% P2O5, 0-5% MgO and 0-1% CaF2 by mass percent, produced by mixing with pore forming agents and specified heat treatments.
摘要翻译：包含大约24-45％的CaO，34-50％的SiO 2，0-25％的Na 2 O，5-17％的P < 通过与成孔剂和规定的热量混合制备的二氧化钛，0-5％MgO和0-1％CaF 2质量％治疗。

25. 发明申请

US20180072604A1 Bioactive Glass Scaffolds, and Method of Making 审中-公开
公开(公告)号：US20180072604A1
公开(公告)日：2018-03-15
申请号：US15819855
申请日：2017-11-21
申请人： MO SCI, CORP.
发明人： Steven Jung
IPC分类号： C03B19/06 , C03C4/00 , A61F2/28 , A61L24/00 , A61L15/08 , A61L31/14 , A61L31/02 , A61L27/56 , A61L27/10 , C03B19/10 , C03C3/04 , A61L27/54 , A61L27/58 , C03B32/02 , C03C11/00 , A61L24/02
CPC分类号： C03B19/06 , A61F2/28 , A61L15/08 , A61L24/0036 , A61L24/02 , A61L27/10 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/026 , A61L31/146 , A61L2300/102 , A61L2430/02 , A61L2430/34 , C03B19/108 , C03B19/109 , C03B32/02 , C03C3/04 , C03C4/0007 , C03C4/0014 , C03C11/00 , C03C2204/00 , Y10T428/315
摘要： A glass, glass-ceramic, or ceramic bead is described, with an internal porous scaffold microstructure that is surrounded by an amorphous shield. The shield serves to protect the internal porous microstructure of the shield while increasing the overall strength of the porous microstructure and improve the flowability of the beads either by themselves or in devices such as biologically degradable putty that would be used in bone or soft tissue augmentation or regeneration. The open porosity present inside the bead will allow for enhanced degradability in-vivo as compared to solid particles or spheres and also promote the growth of tissues including but not limited to all types of bone, soft tissue, blood vessels, and nerves.

26. 发明授权

US09850157B2 Bioactive glass scaffolds, and method of making 有权
公开(公告)号：US09850157B2
公开(公告)日：2017-12-26
申请号：US14692378
申请日：2015-04-21
申请人： MO SCI, CORP.
发明人： Steven Jung
IPC分类号： A61F2/28 , C03B19/06 , C03C4/00 , C03C11/00 , A61L27/10 , A61L27/56 , A61L31/02 , A61L31/14 , A61L15/08 , A61L24/00 , A61L24/02 , C03B19/10 , A61L27/54 , A61L27/58 , C03B32/02 , C03C3/04
CPC分类号： C03B19/06 , A61F2/28 , A61L15/08 , A61L24/0036 , A61L24/02 , A61L27/10 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/026 , A61L31/146 , A61L2300/102 , A61L2430/02 , A61L2430/34 , C03B19/108 , C03B19/109 , C03B32/02 , C03C3/04 , C03C4/0007 , C03C4/0014 , C03C11/00 , C03C2204/00 , Y10T428/315
摘要： A glass, glass-ceramic, or ceramic bead is described, with an internal porous scaffold microstructure that is surrounded by an amorphous shield. The shield serves to protect the internal porous microstructure of the shield while increasing the overall strength of the porous microstructure and improve the flowability of the beads either by themselves or in devices such as biologically degradable putty that would be used in bone or soft tissue augmentation or regeneration. The open porosity present inside the bead will allow for enhanced degradability in-vivo as compared to solid particles or spheres and also promote the growth of tissues including but not limited to all types of bone, soft tissue, blood vessels, and nerves.

27. 发明授权

US09731994B2 Vitreous composition, bioactive vitreous fibers and fabrics, and articles 有权
公开(公告)号：US09731994B2
公开(公告)日：2017-08-15
申请号：US14911444
申请日：2014-08-12
申请人： Fundação Universidade Federal De São Carlos
发明人： Edgar Dutra Zanotto , Oscar Peitl Filho , Marina Trevelin Souza
IPC分类号： C03C3/097 , C03C13/00 , C03C25/24 , A61L27/10 , C03B37/02 , C03C25/12 , C03C25/10 , A61L27/56 , A61K33/08 , A61L27/34 , A61L27/54 , C03C4/00 , C03C12/00 , A61L27/12 , A61L27/58 , C03B19/01 , A61K33/22 , A61K33/38 , A61K33/42 , B33Y10/00 , B33Y80/00
CPC分类号： C03C3/097 , A61K33/08 , A61K33/22 , A61K33/38 , A61K33/42 , A61L27/10 , A61L27/12 , A61L27/34 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/404 , A61L2300/412 , A61L2400/18 , A61L2420/02 , A61L2430/02 , B33Y10/00 , B33Y80/00 , C03B19/01 , C03B37/02 , C03C4/0007 , C03C4/0014 , C03C4/0021 , C03C12/00 , C03C13/00 , C03C25/10 , C03C25/12 , C03C25/24 , C03C2204/02 , C03C2213/02 , C08L89/06
摘要： A vitreous composition according to Table (I) is described. Continuous vitreous fibers are obtained by downdrawing said molten composition, with a length ranging from millimeters to kilometers and diameters ranging from 2 μm to 3 mm. The fibers are covered with collagen and form vitreous fabrics. The fabrics form articles with a variety of medical uses.

28. 发明申请

US20140272418A1 BIOACTIVE GLASS SCAFFOLDS, AND METHOD OF MAKING 有权
标题翻译：生物玻璃制品及其制造方法
公开(公告)号：US20140272418A1
公开(公告)日：2014-09-18
申请号：US13836207
申请日：2013-03-15
申请人： MOSCI CORP.
发明人： Steven Jung
IPC分类号： C03C4/00
CPC分类号： C03B19/06 , A61F2/28 , A61L15/08 , A61L24/0036 , A61L24/02 , A61L27/10 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/026 , A61L31/146 , A61L2300/102 , A61L2430/02 , A61L2430/34 , C03B19/108 , C03B19/109 , C03B32/02 , C03C3/04 , C03C4/0007 , C03C4/0014 , C03C11/00 , C03C2204/00 , Y10T428/315
摘要： A glass, glass-ceramic, or ceramic bead is described, with an internal porous scaffold microstructure that is surrounded by an amorphous shield. The shield serves to protect the internal porous microstructure of the shield while increasing the overall strength of the porous microstructure and improve the flowability of the beads either by themselves or in devices such as biologically degradable putty that would be used in bone or soft tissue augmentation or regeneration. The open porosity present inside the bead will allow for enhanced degradability in-vivo as compared to solid particles or spheres and also promote the growth of tissues including but not limited to all types of bone, soft tissue, blood vessels, and nerves.
摘要翻译：描述了玻璃，玻璃陶瓷或陶瓷珠，其具有被无定形屏蔽包围的内部多孔支架微结构。屏蔽件用于保护屏蔽件的内部多孔微结构，同时增加多孔微结构的总体强度并且通过其本身或在用于骨骼或软组织增大中的生物可降解腻子的装置中提高珠粒的流动性，或再生。存在于珠粒内的开放孔隙将允许与固体颗粒或球体相比在体内增强的降解性，并且还促进组织的生长，包括但不限于所有类型的骨，软组织，血管和神经。

29. 发明授权

US08673016B2 Devices and methods for tissue engineering 有权
标题翻译：组织工程的设备和方法
公开(公告)号：US08673016B2
公开(公告)日：2014-03-18
申请号：US13448965
申请日：2012-04-17
申请人： James Jenq Liu
发明人： James Jenq Liu
IPC分类号： A61F2/28 , A61F2/02
CPC分类号： A61F2/4465 , A61F2/02 , A61F2/28 , A61F2/30734 , A61F2/3094 , A61F2/44 , A61F2002/30062 , A61F2002/3092 , A61F2002/30968 , A61F2002/4495 , A61F2210/0004 , A61F2310/00329 , A61L27/10 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2400/18 , A61L2430/02 , A61L2430/38 , C03C4/0014 , C03C10/0009 , C03C11/00 , C03C13/006 , C03C2204/00 , C03C2213/02 , Y10T428/249928
摘要： A resorbable tissue scaffold fabricated from bioactive glass fiber forms a rigid three-dimensional porous matrix having a bioactive composition. Porosity in the form of interconnected pore space is provided by the space between the bioactive glass fiber in the porous matrix. Strength of the bioresorbable matrix is provided by bioactive glass that fuses and bonds the bioactive glass fiber into the rigid three-dimensional matrix. The resorbable tissue scaffold supports tissue in-growth to provide osteoconductivity as a resorbable tissue scaffold, used for the repair of damaged and/or diseased bone tissue.
摘要翻译：由生物活性玻璃纤维制成的可再吸收的组织支架形成具有生物活性成分的刚性三维多孔基质。互连孔隙形式的孔隙度由多孔基质中的生物活性玻璃纤维之间的空间提供。生物可吸收基质的强度由生物活性玻璃提供，其将生物活性玻璃纤维熔合并结合到刚性三维基质中。可再吸收的组织支架支持组织生长以提供作为可再吸收的组织支架的骨传导性，用于修复受损和/或患病的骨组织。

30. 发明申请

US20130173001A1 Devices and Methods for Tissue Engineering 有权
公开(公告)号：US20130173001A1
公开(公告)日：2013-07-04
申请号：US13678644
申请日：2012-11-16
申请人： James Jenq Liu , Adam Wallen , Juha-Pekka Nuutinen
发明人： James Jenq Liu , Adam Wallen , Juha-Pekka Nuutinen
IPC分类号： A61F2/30 , A61F2/44 , A61F2/02
CPC分类号： A61F2/4465 , A61F2/02 , A61F2/28 , A61F2/30734 , A61F2/3094 , A61F2/44 , A61F2002/30062 , A61F2002/3092 , A61F2002/30968 , A61F2002/4495 , A61F2210/0004 , A61F2310/00329 , A61L27/10 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2400/18 , A61L2430/02 , A61L2430/38 , C03C4/0014 , C03C10/0009 , C03C11/00 , C03C13/006 , C03C2204/00 , C03C2213/02 , Y10T428/249928
摘要： A resorbable tissue scaffold fabricated from bioactive glass fiber forms a rigid three-dimensional porous matrix having a bioactive composition. Porosity in the form of interconnected pore space is provided by the space between the bioactive glass fiber in the porous matrix. Strength of the bioresorbable matrix is provided by bioactive glass that fuses and bonds the bioactive glass fiber into the rigid three-dimensional matrix. The resorbable tissue scaffold supports tissue in-growth to provide osteoconductivity as a resorbable tissue scaffold, used for the repair of damaged and/or diseased bone tissue.

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