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21. 发明申请

US20030226565A1 Proportional pressure assist ventilation controlled by a diaphragm electromyographic signal 有权
标题翻译：比例压力辅助通气由隔膜肌电信号控制
公开(公告)号：US20030226565A1
公开(公告)日：2003-12-11
申请号：US10405300
申请日：2003-04-02
发明人： Christer Sinderby , Jennifer Beck
IPC分类号： A61M016/00
CPC分类号： A61B5/0492 , A61M16/0051 , A61M16/026 , A61M2210/1014 , A61M2230/08 , A61M2230/60 , Y10S128/925
摘要： A closed loop system uses (a) the intensity of the diaphragm electromyogram (EMG) for a given inspiratory volume; (b) the inspiratory volume for a given EMG intensity; or (c) a combination of (a) and (b); in view of controlling the level of gas flow, gas volume or gas pressure delivered by a mechanical (lung) ventilator. The closed loop ventilator system enables for automatic or manual adjustment of the level of inspiratory support in proportion to changes in the neuro-ventilatory efficiency such that the neural drive remains stable at a desired target level. An alarm can also be used to detect changes in neuroventilatory efficiency in view of performing manual adjustments.
摘要翻译：闭环系统使用（a）给定吸气体积的隔膜肌电图（EMG）的强度; （b）给定EMG强度的吸气量; 或（c）（a）和（b）的组合; 考虑到控制由机械（肺）通气机输送的气体流量，气体体积或气体压力的水平。闭环呼吸机系统能够与神经通气效率的变化成比例地自动或手动地调整吸气支持水平，使得神经驱动器保持稳定在期望的目标水平。鉴于执行手动调整，报警器也可用于检测神经病效率的变化。

22. 发明授权

US12070601B2 Stimulation system for exercising diaphragm and method of operation thereof 有权
公开(公告)号：US12070601B2
公开(公告)日：2024-08-27
申请号：US15202463
申请日：2016-07-05
申请人： Pinnacle Bionics, Inc.
发明人： Antonio Garcia Martins , Don Headley
IPC分类号： A61N1/36 , A61M16/00 , A61N1/04 , A61N1/05
CPC分类号： A61N1/3601 , A61M16/0051 , A61N1/0456 , A61N1/0551 , A61N1/36017 , A61N1/36031 , A61N1/36034 , A61M2016/0027 , A61M2016/0039 , A61M2016/0042 , A61M2205/332 , A61M2205/3375 , A61M2205/3569 , A61M2205/3584 , A61M2205/3592 , A61M2205/50 , A61M2205/502 , A61M2205/581 , A61M2205/583 , A61M2205/8206 , A61M2210/1014 , A61M2230/202 , A61M2230/205 , A61M2230/50 , A61M2230/63 , A61M2230/65
摘要： An apparatus for reducing ventilation induced diaphragm disuse in a patient receiving ventilation support from a mechanical ventilator (MV), including: an electrode array of first and second types and comprising a plurality of electrodes configured to stimulate a phrenic nerve of the patient; and at least one controller configured to: identify a type of electrode array from at least two different types, generate a stimulus signal for stimulating a phrenic nerve of the patient based upon the identity of the electrode type.

23. 发明公开

US20240207552A1 DEVICE, PROCESS AND COMPUTER PROGRAM FOR DETERMINING SITUATIONS OF A PATIENT 审中-公开
公开(公告)号：US20240207552A1
公开(公告)日：2024-06-27
申请号：US17919064
申请日：2022-02-28
申请人： Drägerwerk AG & Co. KGaA
发明人： Marcus EGER , Frank FRANZ
IPC分类号： A61M16/00
CPC分类号： A61M16/026 , A61M16/0003 , A61M2205/3303 , A61M2205/3327 , A61M2205/502 , A61M2210/1014 , A61M2210/1025 , A61M2230/08 , A61M2230/40
摘要： A device, a process and a computer program, pertaining to a determination of situations during breathing or during a ventilation are described. Concepts for obtaining, detecting or determining information are described. The information, for example, is information concerning the respiratory muscles of the patient, concerning a load-bearing capacity of a patient, concerning a need for breathing assistance and also concerning the possibilities of adequately assisting the breathing by stimulation are very valuable in the treatment and therapy of living beings or patients.

24. 发明申请

US20160310730A1 STIMULATION SYSTEM FOR EXERCISING DIAPHRAGM AND METHOD OF OPERATION THEREOF 审中-公开
标题翻译：用于锻炼透镜的刺激系统及其操作方法
公开(公告)号：US20160310730A1
公开(公告)日：2016-10-27
申请号：US15202463
申请日：2016-07-05
申请人： Pinnacle Bionics, Inc.
发明人： Antonio Garcia Martins , Don Headley
IPC分类号： A61N1/36 , A61N1/04 , A61N1/05 , A61M16/00
CPC分类号： A61N1/3601 , A61M16/0051 , A61M16/024 , A61M2016/0027 , A61M2016/0039 , A61M2016/0042 , A61M2205/332 , A61M2205/3375 , A61M2205/3569 , A61M2205/3584 , A61M2205/3592 , A61M2205/50 , A61M2205/502 , A61M2205/581 , A61M2205/583 , A61M2205/8206 , A61M2210/1014 , A61M2230/202 , A61M2230/205 , A61M2230/50 , A61M2230/63 , A61M2230/65 , A61N1/0456 , A61N1/0551 , A61N1/36014 , A61N1/36017
摘要： An apparatus for reducing ventilation induced diaphragm disuse in a patient receiving ventilation support from a mechanical ventilator (MV), including: an electrode array of first and second types and comprising a plurality of electrodes configured to stimulate a phrenic nerve of the patient; and at least one controller configured to: identify a type of electrode array from at least two different types, generate a stimulus signal for stimulating a phrenic nerve of the patient based upon the identity of the electrode type.
摘要翻译：一种用于在通过机械通气机（MV）接收通气支架的患者中减少通气引起的隔膜不利的装置，包括：第一和第二类型的电极阵列，并且包括多个电极，所述电极构造成刺激患者的膈神经; 以及至少一个控制器，其被配置为：从至少两种不同类型识别电极阵列的类型，基于所述电极类型的身份产生用于刺激所述患者的膈神经的刺激信号。

25. 发明申请

US20160279361A1 DETECTION OF ASYNCHRONY 审中-公开
标题翻译：检测异常
公开(公告)号：US20160279361A1
公开(公告)日：2016-09-29
申请号：US15172543
申请日：2016-06-03
申请人： ResMed Limited
发明人： Qestra Camille Mulqueeny , Stephen James Redmond , Nigel Hamilton Lovell
IPC分类号： A61M16/00 , A61M16/06 , A61M16/04 , A61M16/08
CPC分类号： A61M16/0066 , A61B5/085 , A61B5/087 , A61B5/091 , A61B5/7264 , A61M16/0003 , A61M16/026 , A61M16/04 , A61M16/06 , A61M16/0875 , A61M2016/0027 , A61M2016/003 , A61M2016/0036 , A61M2205/502 , A61M2205/52 , A61M2210/1014 , A61M2230/005 , A61M2230/42 , A61M2230/46 , A61M2230/65
摘要： A controller or processor(s) implements detection of respiratory related conditions, such as asynchrony, associated with use of a respiratory treatment apparatus or ventilator. Based on data derived from sensor signals associated with the respiratory treatment, the detector may evaluate a feature set of detection values to determine whether or not an asynchrony occurs in a breath of the patient's respiratory cycle such as by comparing the values against a set of thresholds. Different events may also be identified based on the particular feature set and threshold(s) involved in the detection processing. Automated determination of feature sets may also be implemented to design different asynchrony event classifiers. The methodologies may be implemented by computers or by respiratory treatment apparatus. The detection of such asynchrony events can then also serve as part of control logic for automated adjustments to the control parameters of the respiratory treatment generated by the respiratory treatment apparatus.
摘要翻译：控制器或处理器实施与呼吸治疗设备或呼吸机的使用相关联的呼吸相关状况的检测，例如不同步。基于从与呼吸治疗相关联的传感器信号导出的数据，检测器可以评估检测值的特征集合，以确定在患者的呼吸周期的呼吸中是否发生不同步，例如通过将值与一组阈值进行比较。也可以基于检测处理中涉及的特定特征集和阈值来识别不同的事件。还可以实现特征集的自动确定以设计不同的异步事件分类器。方法可以由计算机或呼吸治疗设备来实现。因此，这种不同步事件的检测也可以作为用于自动调整由呼吸治疗装置产生的呼吸治疗的控制参数的控制逻辑的一部分。

26. 发明申请

US20140305434A1 Method And System For Patient-Synchronized Ventilatory Assist With Endotracheal Through-Flow 有权
标题翻译：方法和系统为患者同步通气辅助与气管内通流
公开(公告)号：US20140305434A1
公开(公告)日：2014-10-16
申请号：US13806816
申请日：2011-06-29
申请人： Jennifer Beck , Christer Sinderby
发明人： Jennifer Beck , Christer Sinderby
IPC分类号： A61M16/00 , A61M16/10 , A61M16/12 , A61M16/16 , A61M16/20 , A61M16/04
CPC分类号： A61M16/0003 , A61B5/0488 , A61B5/087 , A61B5/4836 , A61M16/00 , A61M16/0012 , A61M16/0051 , A61M16/0069 , A61M16/024 , A61M16/04 , A61M16/042 , A61M16/0486 , A61M16/1005 , A61M16/12 , A61M16/125 , A61M16/16 , A61M16/161 , A61M16/202 , A61M16/205 , A61M2016/0018 , A61M2016/0021 , A61M2016/0027 , A61M2016/0033 , A61M2202/0208 , A61M2210/1014 , A61M2230/08 , A61M2230/60
摘要： A ventilatory assist system and method are disclosed. The system comprises a tube for connection to a patient's airway, inspiratory and expiratory tube lumens connected to the tube, an inspiratory air source connected to the inspiration tube lumen, and a controller of air pressure in the expiratory tube lumen. The pressure controller is responsive to a physiological breathing signal representative of patient's inspiratory effort to allow air flow through the expiratory tube lumen during a patient's expiration phase, partially restricting the air flow through the expiratory tube lumen to a so minimum air flow during a patient's inspiration phase. During both respiratory phases, a unidirectional air flow is produced through the inspiratory and expiratory tube lumens to prevent air expired by the patient from being breathed again. The physiological breathing signal allows synchronization of the ventilatory assist with breathing efforts of the patient.
摘要翻译：公开了一种通气辅助系统和方法。该系统包括用于连接到患者气道的管，连接到管的吸气和呼气管腔，连接到吸气管腔的吸气空气源和呼气管内腔中的气压控制器。压力控制器响应于代表患者吸气作用的生理呼吸信号，以允许空气在患者呼气期间流过呼气管腔，在患者的吸气期间部分限制通过呼气管内腔的气流至如此最小的气流相。在两个呼吸阶段期间，通过吸气和呼气管腔产生单向空气流，以防止患者再次呼吸的患者呼出空气。生理呼吸信号允许通气辅助与患者的呼吸努力同步。

27. 发明申请

US20130345571A1 Electrode Positioning 有权
标题翻译：电极定位
公开(公告)号：US20130345571A1
公开(公告)日：2013-12-26
申请号：US13920698
申请日：2013-06-18
申请人： Maquet Critical Care AB
发明人： Christer SINDERBY , Jennifer Beck , Frederik Jalde , Joachim Sallvin
IPC分类号： A61B5/08
CPC分类号： A61B5/08 , A61B5/0421 , A61B5/0488 , A61M16/00 , A61M16/024 , A61M2016/0021 , A61M2202/0208 , A61M2210/1014 , A61M2210/105 , A61M2230/04 , A61M2230/08 , A61M2230/60 , A61M2230/005
摘要： In a method for positioning linear array of electrodes (LAE) mounted on distal end section of elongated flexible member in patient's respiratory airways (PRA) at level of diaphragm, a length of the member pre-determined to position LEA at the level of the diaphragm is inserted through PRA. Signals representative of an electrical activity of the diaphragm (EAdi) are detected through LAE, presence/absence of ECG signal components is detected in EAdi signals, and position of LAE in PRA is detected in response to presence/absence of ECG signal components in EAdi signals. Lower esophageal sphincter activity may be detected in EAdi signals, and position of LAE in PRA determined in response to the detected lower esophageal sphincter. End-expiratory occlusion of PRA may be performed to verify that the electrical activity of the diaphragm coincides with a negative deflection of PRA pressure again in view of determining adequate positioning of LAE.
摘要翻译：在用于将患者呼吸气道（PRA）中的细长柔性构件的远端部分上安装的电极线性阵列（LAE）定位在隔膜水平面上的方法中，预先确定将该位置LEA定位在隔膜水平处的部件的长度通过PRA插入。通过LAE检测代表隔膜电活动的信号（EAdi），在EAdi信号中检测到ECG信号成分的存在/不存在，并且响应EADi中ECG信号成分的存在/不存在来检测LAE在PRA中的位置信号。食管下端括约肌活动可能在EAdi信号中检测到，LAE在PRA中的位置是根据检测到的食道下括约肌而确定的。考虑到确定LAE的适当定位，可以执行PRA的呼气末阻塞以验证隔膜的电活动再次与PRA压力的负偏转重合。

28. 发明授权

US08281792B2 Electromagnetic diaphragm assist device and method for assisting a diaphragm function 有权
标题翻译：电磁隔膜辅助装置及辅助隔膜功能的方法
公开(公告)号：US08281792B2
公开(公告)日：2012-10-09
申请号：US11648908
申请日：2007-01-03
申请人： John W Royalty
发明人： John W Royalty
IPC分类号： A61B19/00
CPC分类号： A61B5/0809 , A61F2002/043 , A61F2250/0001 , A61H31/02 , A61M2210/1014
摘要： A diaphragm assist device includes a magnetic mat adapted for mounting inside a human body adjacent the diaphragm. The mat is made from a material responsive to application of an electromagnetic field so as to be movable into compressive relation with the diaphragm in response to application of the electromagnetic field thereto and movable out of the compressive relation to permit the diaphragm to relax when application of the electromagnetic field is discontinued. The device also includes an electromagnetic assembly adapted for surrounding the torso of the human body in functionally cooperative relation with respect to the mat, and for alternately generating and discontinuing the electromagnetic field so that the mat alternately moves into and out of the compressive relation with the diaphragm. The device also includes a controller constructed and arranged to control an intensity level of the electromagnetic field generated by the electromagnetic assembly.
摘要翻译：隔膜辅助装置包括适于安装在邻近隔膜的人体内的磁性垫。该垫由响应于施加电磁场的材料制成，以响应于向其施加电磁场而移动成与隔膜的压缩关系，并且可移出压缩关系，以允许隔膜在施加电磁场停止。该装置还包括电磁组件，其适于围绕人体的功能性协调关系围绕人体躯干，并且用于交替地产生和中断电磁场，使得垫交替地移动到和/ 隔膜该装置还包括构造和布置成控制由电磁组件产生的电磁场的强度水平的控制器。

29. 发明申请

US20120137250A1 Ventilator-Initiated Prompt Regarding Detection Of Fluctuations In Resistance 有权
标题翻译：呼吸机启动关于检测电阻波动的提示
公开(公告)号：US20120137250A1
公开(公告)日：2012-05-31
申请号：US12955523
申请日：2010-11-29
申请人： Gary Milne , Kirk Hensley , Peter R. Doyle , Gardner Kimm
发明人： Gary Milne , Kirk Hensley , Peter R. Doyle , Gardner Kimm
IPC分类号： G08B23/00 , G06F3/048
CPC分类号： A61M16/0051 , A61M16/0057 , A61M16/0063 , A61M16/026 , A61M16/0833 , A61M16/1065 , A61M2016/0021 , A61M2016/0027 , A61M2016/0036 , A61M2205/502 , A61M2205/505 , A61M2205/584 , A61M2210/1014 , A61M2230/20 , A61M2230/43 , A61M2230/46 , G06F19/00 , G06F19/3481
摘要： This disclosure describes systems and methods for monitoring ventilatory parameters, analyzing ventilatory data associated with those parameters, and providing useful notifications and/or recommendations to clinicians. For example, many clinicians may not easily identify or recognize data patterns and correlations indicative of a fluctuation in resistance during mechanical ventilation of a patient. Furthermore, clinicians may not easily determine potential causes for the fluctuation in resistance and/or steps for mitigating the fluctuation in resistance. According to embodiments, a ventilator may be configured to monitor and evaluate diverse ventilatory parameters to detect fluctuations in resistance and may issue suitable notifications and recommendations to the clinician based on potential causes of the fluctuation, ventilatory and/or patient data, etc. The suitable notifications and recommendations may further be provided in a hierarchical format such that the clinician may selectively access information regarding the fluctuation in resistance.
摘要翻译：本公开描述了用于监测通气参数的系统和方法，分析与这些参数相关的通气数据，以及向临床医师提供有用的通知和/或建议。例如，许多临床医生可能不容易识别或识别指示患者的机械通气期间电阻波动的数据模式和相关性。此外，临床医生可能不容易确定阻力波动的潜在原因和/或减轻阻力波动的步骤。根据实施例，呼吸机可以被配置为监测和评估各种通气参数以检测电阻的波动，并且可以基于波动，通气和/或患者数据等的潜在原因向临床医生发布合适的通知和建议。适当的可以以分层格式进一步提供通知和建议，使得临床医生可以选择性地访问关于阻力波动的信息。

30. 发明申请

US20120000470A1 Ventilator-Initiated Prompt Regarding Auto-PEEP Detection During Pressure Ventilation 有权
标题翻译：呼吸机启动关于压力通气期间自动PEEP检测的提示
公开(公告)号：US20120000470A1
公开(公告)日：2012-01-05
申请号：US12827130
申请日：2010-06-30
申请人： Gary Milne , Kirk Hensley , Peter R. Doyle , Gardner Kimm
发明人： Gary Milne , Kirk Hensley , Peter R. Doyle , Gardner Kimm
IPC分类号： A61M16/00 , G06F3/048
CPC分类号： A61M16/0063 , A61B5/08 , A61M16/0051 , A61M16/026 , A61M16/0833 , A61M2016/0021 , A61M2016/0027 , A61M2016/0036 , A61M2205/502 , A61M2205/505 , A61M2205/584 , A61M2210/1014 , A61M2230/20 , A61M2230/43 , A61M2230/46 , G06F19/00 , G16H40/63 , G16H50/20
摘要： This disclosure describes systems and methods for monitoring and evaluating ventilatory parameters, analyzing ventilatory data associated with those parameters, and providing useful notifications and/or recommendations to clinicians. Modern ventilators monitor, evaluate, and graphically represent a myriad of ventilatory parameters. However, many clinicians may not easily identify or recognize data patterns and correlations indicative of certain patient conditions, changes in patient condition, and/or effectiveness of ventilatory treatment. Further, clinicians may not readily determine appropriate ventilatory adjustments that may address certain patient conditions and/or the effectiveness of ventilatory treatment. Specifically, clinicians may not readily detect or recognize the presence of Auto-PEEP during various types of pressure ventilation. According to embodiments, a ventilator may be configured to monitor and evaluate diverse ventilatory parameters to detect Auto-PEEP and may issue suitable notifications and recommendations to the clinician when Auto-PEEP is implicated. The suitable notifications and recommendations may further be provided in a hierarchical format.
摘要翻译：本公开描述了用于监测和评估通气参数的系统和方法，分析与这些参数相关联的通气数据，并向临床医生提供有用的通知和/或建议。现代呼吸机监测，评估和图形化表示无数通气参数。然而，许多临床医生可能不容易识别或识别指示某些患者状况，患者状况变化和/或通气治疗有效性的数据模式和相关性。此外，临床医生可能不能容易地确定可以解决某些患者状况和/或通气治疗的有效性的适当的通气调节。具体来说，临床医生在各种类型的压力通气期间可能不能容易地检测或识别Auto-PEEP的存在。根据实施例，呼吸机可以被配置为监测和评估各种通气参数以检测自动PEEP，并且当涉及Auto-PEEP时可以向临床医生发布合适的通知和建议。可以以分层格式进一步提供合适的通知和建议。

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