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21. 发明授权

US11826332B2 Antimicrobial compositions and uses thereof 有权
公开(公告)号：US11826332B2
公开(公告)日：2023-11-28
申请号：US17360966
申请日：2021-06-28
申请人： Board of Regents, The University of Texas System
发明人： Joel Rosenblatt , Issam Raad
IPC分类号： A61K31/20 , A61K45/06 , A61K31/21 , A61K31/715 , A61K31/732 , C08L5/00 , C08L5/06 , C08L5/08 , C08L89/00 , A61L29/04 , A61L29/16 , A61K33/40 , A61P31/02 , A61D7/00 , A61M3/02 , A61M25/00 , A61M25/10 , A61M39/22
CPC分类号： A61K31/20 , A61D7/00 , A61K31/21 , A61K31/715 , A61K31/732 , A61K33/40 , A61K45/06 , A61L29/043 , A61L29/16 , A61M3/0262 , A61M3/0283 , A61M25/0017 , A61M25/1011 , A61M39/22 , A61P31/02 , C08L5/00 , C08L5/06 , C08L5/08 , C08L89/00 , A61L2300/404 , A61L2300/406 , A61M2210/0693 , A61M2210/1082 , A61M2210/1089 , A61M2210/12 , A61M2250/00 , C08L89/00 , C08L5/00 , C08L89/00 , C08L5/08 , C08L89/00 , C08L5/06 , A61K31/715 , A61K2300/00 , A61K31/732 , A61K2300/00 , A61K31/20 , A61K2300/00 , A61K31/21 , A61K2300/00 , A61K33/40 , A61K2300/00 , A61L29/043 , C08L5/08 , A61L29/043 , C08L5/06
摘要： In some aspects, provided herein are antimicrobial compositions comprising partially esterified polygalacturonic acid and certain fatty acids (e.g., caprylic acid). In some embodiments, the antimicrobial composition may be administered (e.g., topically or orally) to a subject, such as a human patient to treat an infection (e.g., an infection comprising a biofilm). In some aspects, improved catheters are provided.

22. 发明申请

US20180201694A1 CHITIN DERIVATIVES, METHOD FOR PRODUCTION AND USES THEREOF 审中-公开
公开(公告)号：US20180201694A1
公开(公告)日：2018-07-19
申请号：US15105153
申请日：2014-12-16
申请人： JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH (JNCASR)
发明人： Jayanta Haldar , Jiaul Hoque , Goutham Belagula Manjunath , Padma Akkapeddi
IPC分类号： C08B37/08 , A01N43/16 , C09D5/14 , C09D105/08 , A61K31/722 , A61P31/04 , A61P31/10 , A61P31/12 , A01N59/16 , A61L15/28 , A61L15/44 , A61L26/00 , A61L27/20 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16 , A61L31/04 , A61L29/16 , A61L29/08 , A61L29/04
CPC分类号： C08B37/003 , A01N33/12 , A01N43/16 , A01N59/16 , A61K31/722 , A61L15/28 , A61L15/44 , A61L17/005 , A61L17/145 , A61L26/0023 , A61L26/0066 , A61L27/20 , A61L27/34 , A61L27/54 , A61L29/043 , A61L29/085 , A61L29/16 , A61L31/042 , A61L31/10 , A61L31/16 , A61L2300/404 , A61L2300/606 , A61P31/04 , A61P31/10 , A61P31/12 , C08L5/08 , C09D5/14 , C09D105/08 , Y02A50/473 , A01N43/40 , A01N43/42 , A01N43/90 , A01N45/00
摘要： The present disclosure relates to chitin derivatives of Formula (I), its isomers, prodrugs and pharmaceutically acceptable salts thereof. The present disclosure further relates to a process of preparing the chitin derivatives, its isomers, prodrugs and pharmaceutically acceptable salts thereof. The compounds of the present disclosure are useful in antimicrobial coatings. The present disclosure further relates to an antibacterial polymeric nanocomposite and a process for preparing the antibacterial polymeric nanocomposites.

23. 发明申请

US20160038636A1 CHITOSAN HYDROGEL DERIVATIVES AS A COATING AGENT WITH BROAD SPECTRUM OF ANTIMICROBIAL ACTIVITIES 有权
标题翻译： CHOSOSAN氢化衍生物作为具有广谱抗体活性的涂层剂
公开(公告)号：US20160038636A1
公开(公告)日：2016-02-11
申请号：US14922369
申请日：2015-10-26
申请人： Nanyang Technological University
发明人： Chan Bee Eng Mary , Poon Yin Fun , Mouad Lamrani , Shinichi Hamaguchi
IPC分类号： A61L27/34 , A61L27/52 , A61L31/04 , A61K8/04 , A61L31/14 , A61K8/73 , A61Q19/00 , A61L27/54 , A61L31/16
CPC分类号： A61L27/34 , A61K8/042 , A61K8/736 , A61L27/20 , A61L27/52 , A61L27/54 , A61L29/043 , A61L29/085 , A61L29/145 , A61L31/042 , A61L31/10 , A61L31/145 , A61L31/16 , A61L2300/232 , A61L2300/404 , A61Q19/00 , C08B37/003 , C08F290/10 , C08G81/00 , C08J3/075 , C08J3/24 , C08J3/28 , C08J2305/08 , G02B1/043 , C08L1/00 , C08F220/28 , C08L5/08
摘要： The present invention relates to water soluble quaternized chitosan derivatives which form hydrogel matrix with broad antimicrobial properties for the protection and coating of medical device. Hydrogel is attractive as an antimicrobial coating since its hydrophilicity intrinsically prevents the reversible nonspecific attachment of microbes. In order to achieve hydrogel formation, quaternized chitosan can be grafted with polymerizable groups, especially photocrosslinkable groups, such as methacrylates, PEG derivatives and be converted into hydrogels through a thermal or UV polymerization process. Hydrogels are hydrated cross-linked polymeric systems that contain water in an equilibrium state forming cushion water shield. The present invention is widely used in many medical devices. This invention describes the formation of novel hydrogels based on quaternized ammonium chitosan derivatives which has been grafted with photocrosslinkable groups, hence providing hydrogels as antimicrobial water shield coating agent.
摘要翻译：本发明涉及水溶性季铵化壳聚糖衍生物，其形成具有广泛抗微生物性质的水凝胶基质用于保护和涂覆医疗装置。水凝胶作为抗微生物涂层是有吸引力的，因为它的亲水性本质上防止微生物的可逆非特异性附着。为了实现水凝胶形成，季铵化壳聚糖可以用可聚合基团，特别是可光致交联的基团如甲基丙烯酸酯，PEG衍生物接枝，并通过热或UV聚合方法转化成水凝胶。水凝胶是水合交联聚合物体系，其在平衡状态下形成缓冲水屏蔽层。本发明广泛应用于许多医疗装置。本发明描述了基于已经用光可交联基团接枝的季铵化壳聚糖衍生物的新型水凝胶的形成，因此提供水凝胶作为抗微生物水屏蔽涂层剂。

24. 发明申请

US20140186415A1 POLYMER COMPOSITION AND POLYMER MATERIAL 审中-公开
标题翻译：聚合物组合物和聚合物材料
公开(公告)号：US20140186415A1
公开(公告)日：2014-07-03
申请号：US14132796
申请日：2013-12-18
申请人： Industrial Technology Research Institute
发明人： Ting-Yu SHIH , Tse-Min TENG , Chia-Chun WANG , Yu-Hua CHEN , Jui-Hsiang CHEN , Mei-Ju YANG , Shu-Fang CHIANG , Yen-Chun CHEN , Chia-Ni CHANG
IPC分类号： A61L15/28 , A61L15/24 , A61L29/04 , A61L27/20 , A61L27/16 , A61L29/16 , A61L15/44 , A61L27/54
CPC分类号： A61K31/4172 , A61K31/715 , A61K31/717 , A61K31/728 , A61K31/765 , A61K47/58 , A61K47/61 , A61L15/24 , A61L15/28 , A61L15/44 , A61L27/16 , A61L27/20 , A61L27/54 , A61L29/041 , A61L29/043 , A61L29/16 , A61L31/042 , A61L31/048 , A61L31/16 , A61L2300/204 , A61L2300/434 , C08B11/04 , C08B11/08 , C08B11/20 , C08B15/06 , C08B37/0072 , C08L1/08 , C08L1/26 , C08L1/284 , C08L5/08
摘要： A polymer composition including a polymer having a hydroxyl group and a histidine or a histidine derivative grafted to the polymer having a hydroxyl group. A polymer material is also provided, including a polymer composition which includes a polymer having a hydroxyl group, and a histidine or a histidine derivative grafted to the polymer having a hydroxyl group.
摘要翻译：包括具有羟基的聚合物和接枝到具有羟基的聚合物上的组氨酸或组氨酸衍生物的聚合物组合物。还提供了聚合物材料，包括包含具有羟基的聚合物的聚合物组合物和接枝到具有羟基的聚合物上的组氨酸或组氨酸衍生物。

25. 发明申请

US20130276669A1 PROCESSING OF ACYLCHITOSAN HYDROGELS 有权
标题翻译：醋酸羟胺的加工
公开(公告)号：US20130276669A1
公开(公告)日：2013-10-24
申请号：US13850568
申请日：2013-03-26
申请人： Thomas Freier
发明人： Thomas Freier
IPC分类号： A61L31/04
CPC分类号： A61L31/042 , A61K9/0024 , A61K9/0092 , A61K9/1652 , A61K47/36 , A61L27/20 , A61L27/34 , A61L27/50 , A61L27/52 , A61L29/043 , A61L29/085 , A61L29/14 , A61L29/145 , A61L31/10 , A61L31/14 , A61L31/145 , C08B37/003 , C08J3/075 , C08J2305/08 , C08L5/08 , D01D5/06 , D01F9/00
摘要： An article containing N-acylchitosan is manufactured by a process comprising the steps of providing a mixture containing chitosan and/or N-acylchitosan, and extruding the mixture to form an N-acylchitosan hydrogel. Alternatively, the process comprising the steps of providing a chitosan and/or N-acylchitosan hydrogel, and extruding the hydrogel. An article with a memorized shape is formed by fixing the N-acylchitosan hydrogel in a desired shape, and at least partially drying the fixed hydrogel. A patient is treated by injecting the N-acylchitosan hydrogel.
摘要翻译：包含N-酰基壳聚糖的制品通过包括以下步骤的方法制备，所述方法包括提供含有壳聚糖和/或N-酰基壳聚糖的混合物，并挤出混合物以形成N-酰基壳聚糖水凝胶。或者，该方法包括以下步骤：提供壳聚糖和/或N-酰基壳聚糖水凝胶，并挤出水凝胶。具有记忆形状的制品通过将N-酰基壳聚糖水凝胶固定成所需形状并至少部分干燥固定的水凝胶而形成。通过注射N-酰基壳聚糖水凝胶来治疗患者。

26. 发明申请

US20120164208A1 CHITOSAN HYDROGEL DERIVATIVES AS A COATING AGENT WITH BROAD SPECTRUM OF ANTIMICROBIAL ACTIVITIES 有权
标题翻译： CHOSOSAN氢化衍生物作为具有广谱抗体活性的涂层剂
公开(公告)号：US20120164208A1
公开(公告)日：2012-06-28
申请号：US13383684
申请日：2009-07-13
申请人： Chan Bee Eng Mary , Poon Yin Fun , Mouad Lamrani , Shinichi Hamaguchi
发明人： Chan Bee Eng Mary , Poon Yin Fun , Mouad Lamrani , Shinichi Hamaguchi
IPC分类号： A61K9/00 , A61K31/722 , A61K8/60 , C08B37/08
CPC分类号： A61L27/34 , A61K8/042 , A61K8/736 , A61L27/20 , A61L27/52 , A61L27/54 , A61L29/043 , A61L29/085 , A61L29/145 , A61L31/042 , A61L31/10 , A61L31/145 , A61L31/16 , A61L2300/232 , A61L2300/404 , A61Q19/00 , C08B37/003 , C08F290/10 , C08G81/00 , C08J3/075 , C08J3/24 , C08J3/28 , C08J2305/08 , G02B1/043 , C08L1/00 , C08F220/28 , C08L5/08
摘要： The present invention relates to water soluble quaternized chitosan derivatives which form hydrogel matrix with broad antimicrobial properties for the protection and coating of medical device. Hydrogel is attractive as an antimicrobial coating since its hydrophilicity intrinsically prevents the reversible nonspecific attachment of microbes.In order to achieve hydrogel formation, quaternized chitosan can be grafted with polymerizable groups, especially photocrosslinkable groups, such as methacrylates, PEG derivatives and be converted into hydrogels through a thermal or UV polymerization process. Hydrogels are hydrated cross-linked polymeric systems that contain water in an equilibrium state forming cushion water shield. The present invention is widely used in many medical devices for example biomedical devices such as contact lenses, bio-implants such as urinary catheters, pacemaker, heart valves, artificial heart, mammary prosthesis, intraocular lenses, wound dressings, artificial organs and delivery carriers for the bioactive reagents, total joint replacement due to their high degree of biocompatibility, antimicrobial property and good wetting characteristics. This invention describes the formation of novel hydrogels based on quaternized ammonium chitosan derivatives which has been grafted with photocrosslinkable groups, hence providing hydrogels as antimicrobial water shield coating agent.
摘要翻译：本发明涉及水溶性季铵化壳聚糖衍生物，其形成具有广泛抗微生物性质的水凝胶基质用于保护和涂覆医疗装置。水凝胶作为抗微生物涂层是有吸引力的，因为它的亲水性本质上防止微生物的可逆非特异性附着。为了实现水凝胶形成，季铵化壳聚糖可以用可聚合基团，特别是可光致交联的基团如甲基丙烯酸酯，PEG衍生物接枝，并通过热或UV聚合方法转化成水凝胶。水凝胶是水合交联聚合物体系，其在平衡状态下形成缓冲水屏蔽层。本发明广泛用于诸如隐形眼镜，诸如导尿管，心脏起搏器，心脏瓣膜，人造心脏，乳房假体，人工晶状体，伤口敷料，人造器官和输送载体等生物医学装置的生物医学装置生物活性试剂，由于其高生物相容性，抗菌性和良好的润湿特性而导致的总关节置换。本发明描述了基于已经用光可交联基团接枝的季铵化壳聚糖衍生物的新型水凝胶的形成，因此提供水凝胶作为抗微生物水屏蔽涂层剂。

27. 发明授权

US07947378B2 Medical assembly suitable for long-term implantation and method for fabricating the same 有权
标题翻译：适合长期植入的医疗装置及其制造方法
公开(公告)号：US07947378B2
公开(公告)日：2011-05-24
申请号：US12906262
申请日：2010-10-18
申请人： Michael F. Mattes , Alvin S. Rhorer
发明人： Michael F. Mattes , Alvin S. Rhorer
IPC分类号： B32B27/30
CPC分类号： A61L29/085 , A61L27/30 , A61L27/34 , A61L29/043 , A61L29/10 , A61L31/082 , A61L31/10 , Y10T428/31663 , Y10T428/31667 , Y10T428/31855 , C08L5/04
摘要： A process for fabricating a medical assembly having a medical device at least a portion of which is formed of inorganic material is provided. The medical assembly is suitable for substantially long-term implantation in a host animal. The process includes modifying a surface of the medical device to form a hydrophilic adhesion-promoting surface. The hydrophilic adhesion-promoting surface is coated with an alginate solution comprising alginate and the alginate is reacted with alkaline earth metal cations.
摘要翻译：提供一种制造具有至少一部分由无机材料形成的医疗装置的医疗组件的方法。医疗组件适合于在宿主动物中基本上长期植入。该方法包括改变医疗装置的表面以形成亲水的增粘表面。亲水性粘附促进表面用包含藻酸盐的藻酸盐溶液涂覆，藻酸盐与碱土金属阳离子反应。

28. 发明申请

US20110034825A1 Medical Assembly Suitable for Long-Term Implantation and Method for Fabricating the Same 有权
标题翻译：适用于长期植入的医疗装置及其制造方法
公开(公告)号：US20110034825A1
公开(公告)日：2011-02-10
申请号：US12906262
申请日：2010-10-18
申请人： Michael F. Mattes , Alvin S. Rhorer
发明人： Michael F. Mattes , Alvin S. Rhorer
IPC分类号： A61B5/01 , A61B5/00 , A61M39/22 , B32B9/04 , B32B27/06
CPC分类号： A61L29/085 , A61L27/30 , A61L27/34 , A61L29/043 , A61L29/10 , A61L31/082 , A61L31/10 , Y10T428/31663 , Y10T428/31667 , Y10T428/31855 , C08L5/04
摘要： A process for fabricating a medical assembly having a medical device at least a portion of which is formed of inorganic material is provided. The medical assembly is suitable for substantially long-term implantation in a host animal. The process includes modifying a surface of the medical device to form a hydrophilic adhesion-promoting surface. The hydrophilic adhesion-promoting surface is coated with an alginate solution comprising alginate and the alginate is reacted with alkaline earth metal cations.
摘要翻译：提供一种制造具有至少一部分由无机材料形成的医疗装置的医疗组件的方法。医疗组件适合于在宿主动物中基本上长期植入。该方法包括改变医疗装置的表面以形成亲水的增粘表面。亲水性粘附促进表面用包含藻酸盐的藻酸盐溶液涂覆，藻酸盐与碱土金属阳离子反应。

29. 发明申请

US20080254125A1 Processing of Chitosan and Chitosan Derivatives 有权
标题翻译：壳聚糖和壳聚糖衍生物的加工
公开(公告)号：US20080254125A1
公开(公告)日：2008-10-16
申请号：US12067727
申请日：2006-10-11
申请人： Thomas Freier
发明人： Thomas Freier
IPC分类号： A61K9/00
CPC分类号： A61L31/042 , A61K9/0024 , A61K9/0092 , A61K9/1652 , A61K47/36 , A61L27/20 , A61L27/34 , A61L27/50 , A61L27/52 , A61L29/043 , A61L29/085 , A61L29/14 , A61L29/145 , A61L31/10 , A61L31/14 , A61L31/145 , C08B37/003 , C08J3/075 , C08J2305/08 , C08L5/08 , D01D5/06 , D01F9/00
摘要： An article containing N-acylchitosan is manufactured by a process comprising the steps of providing a mixture containing chitosan and/or N-acylchitosan, and extruding the mixture to form an N-acylchitosan hydrogel. Alternatively, the process comprising the steps of providing a chitosan and/or N-acylchitosan hydrogel, and extruding the hydrogel. An article with a memorized shape is formed by fixing the N-acylchitosan hydrogel in a desired shape, and at least partially drying the fixed hydrogel. A patient is treated by injecting the N-acylchitosan hydrogel.
摘要翻译：包含N-酰基壳聚糖的制品通过包括以下步骤的方法制备，所述方法包括提供含有壳聚糖和/或N-酰基壳聚糖的混合物，并挤出混合物以形成N-酰基壳聚糖水凝胶。或者，该方法包括以下步骤：提供壳聚糖和/或N-酰基壳聚糖水凝胶，并挤出水凝胶。具有记忆形状的制品通过将N-酰基壳聚糖水凝胶固定成所需形状并至少部分干燥固定的水凝胶而形成。通过注射N-酰基壳聚糖水凝胶来治疗患者。

30. 发明申请

US20050119219A1 Ester derivatives of hyaluronic acid for the preparation of hydrogel materials by photocuring 有权
标题翻译：透明质酸的酯衍生物用于通过光固化制备水凝胶材料
公开(公告)号：US20050119219A1
公开(公告)日：2005-06-02
申请号：US10507472
申请日：2003-03-12
申请人： Davide Bellini , Anna Zanellato
发明人： Davide Bellini , Anna Zanellato
IPC分类号： C12N5/06 , A61F2/16 , A61F2/24 , A61F2/84 , A61J1/10 , A61K9/00 , A61K9/06 , A61K31/728 , A61K47/36 , A61L27/00 , A61L27/20 , A61L29/04 , A61L31/04 , A61P17/02 , A61P27/02 , A61P41/00 , A61P43/00 , C08B37/08 , A61K31/715 , A01N43/04
CPC分类号： A61K9/0014 , A61K9/0019 , A61K47/36 , A61L27/20 , A61L29/043 , A61L31/042 , C08B37/0072 , C08L5/08
摘要： The present invention relates to hyaluronic acid ester derivatives, whose carboxylic groups are partially esterified with hydroxy groups of propiophenone derivatives, to the hydrogel materials consisting of the said hyaluronic acid ester derivatives, to their preparation process by photocuring of the hyaluronic acid ester derivatives, and their use in the biomedical, sanitary and surgical fields, and in the medical field as controlled release systems for drugs.
摘要翻译：本发明涉及其羧基被苯丙酮衍生物的羟基部分酯化的透明质酸酯衍生物与由所述透明质酸酯衍生物组成的水凝胶材料，其透明质酸酯衍生物的光固化制备方法和它们在生物医学，卫生和外科领域以及在医疗领域中作为药物的控制释放系统的应用。

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