专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明授权

US3360436A Radioopaque compounds and methods of preparing the same 失效
标题翻译：不透射线的化合物及其制备方法
公开(公告)号：US3360436A
公开(公告)日：1967-12-26
申请号：US32308563
申请日：1963-11-12
申请人： EPROVA LTD
发明人： ERNST FELDER , DAVIDE PITRE
IPC分类号： A61K49/04 , C07C233/00
CPC分类号： A61K49/04 , A61K49/0447 , A61K49/0452 , A61K49/0461 , C07C233/00

22. 发明申请

US20150297756A1 Protein-Based Nanobubble X-Ray Imaging Method and Agent 审中-公开
标题翻译：基于蛋白质的纳米烟雾X射线成像方法和试剂
公开(公告)号：US20150297756A1
公开(公告)日：2015-10-22
申请号：US14692075
申请日：2015-04-21
申请人： Brown University
发明人： Christoph Rose-Petruck , Trevor Douglas , Danielle Rand , Masaki Uchida
IPC分类号： A61K49/04 , A61M5/00 , G01R33/56 , A61B6/00
CPC分类号： A61M5/007 , A61B6/06 , A61B6/481 , A61K49/0461
摘要： Systems, compositions, methods and kits employ protein shells, such as ferritin or viral capsid shells, herein called nanobubbles, to enhance X-ray images of cells or body tissue under certain x-ray imaging methods. The nanobubbles have sub-micron size such as about 10 nm, about 40, 60, or 100 nm and may be functionalized for effective delivery to or uptake by a target tissue, in vivo or a cell culture. The nanobubbles are hollow, having a central core which may be empty or contain a fluid, such that the shells effectively form long-lived bubbles in the imaged environment, and are of low electron density and have different scattering properties than the surrounding tissue. X-ray imaging by spatial frequency heterodyne imaging enhances visualization or detection of tissue regions bearing the shells. The protein shells may be further treated to assure biocompatibility and/or to resist undesired interactions with non-targeted tissue, such as scavenging by the liver, or attack by the immune system. For example the nanobubbles may be filled with a hydrophobic gas such as perfluoropropane (octafluoropropane) to maintain their shape and resist hydrophilic interactions and delay the degradation of the protein shells. The nanobubbles may also be coated or treated by a surface-functionalization processes to effectively target specific tissues or tumor types, allow parenteral delivery, and/or deliver drugs or other agents to the imaged sites—so that when visualized by X-ray scatter imaging the presence of the nanobubbles indicates the existence and extent of the tumor or diseased tissue.
摘要翻译：系统，组合物，方法和试剂盒使用蛋白质壳，例如铁蛋白或病毒衣壳，在本文中称为纳米气泡，以在某些x射线成像方法下增强细胞或身体组织的X射线图像。纳米气泡具有亚微米尺寸，例如约10nm，约40,60或100nm，并且可以在体内或细胞培养物中进行官能化以有效递送至靶组织或由靶组织摄取。纳米气泡是中空的，具有可以是空的或含有流体的中心芯，使得壳在成像环境中有效地形成长寿命的气泡，并且具有低于周围组织的不同的散射特性。通过空间频率外差成像的X射线成像增强了带有壳的组织区域的可视化或检测。可以进一步处理蛋白质壳体以确保生物相容性和/或抵抗与非靶向组织的不期望的相互作用，例如肝脏清除或免疫系统的攻击。例如，纳米气泡可以用诸如全氟丙烷（八氟丙烷）的疏水性气体填充，以保持其形状并抵抗亲水相互作用并延缓蛋白质壳的降解。纳米气泡也可以通过表面官能化方法进行涂覆或治疗，以有效地靶向特定组织或肿瘤类型，允许胃肠外递送，和/或将药物或其它试剂递送到成像部位，使得当通过X射线散射成像纳米气泡的存在表明肿瘤或病变组织的存在和程度。

23. 发明申请

US20140276021A1 ENTERIC CT CONTRAST MATERIAL BASED ON LOW-Z ATOMS 审中-公开
标题翻译：基于LOW-Z ATOMS的ENTERIC CT对比材料
公开(公告)号：US20140276021A1
公开(公告)日：2014-09-18
申请号：US14215827
申请日：2014-03-17
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： Benjamin M. YEH , Yanjun FU , Tejal DESAI
IPC分类号： A61B6/00 , A61B6/03 , A61K49/04
CPC分类号： A61B6/481 , A61B6/032 , A61K49/0419 , A61K49/0461
摘要： The present invention provides particulate contrast media for use in CT imaging. The contrast media are based on particles of low-Z elements. In an exemplary embodiment, the invention provides an enteric contrast medium formulation. An exemplary formulation comprises, (a) an enteric contrast medium comprising essentially water-insoluble particles of a material selected from microparticles and nanoparticles. Exemplary particles comprise a material comprising a plurality of atoms of an element with an atomic number from 6 to 52. In various embodiments, the particles are coated with a material compatible with enteric administration of the formulation to a subject in need of such administration. In an exemplary embodiment, the contrast medium is incorporated into a pharmaceutically acceptable vehicle in which the particles are suspended. The invention also provides methods for imaging of body parts simultaneously enhanced with contrast media of the invention and with other contrast media of a different type using CT imaging, including dual energy or spectral CT imaging. The invention also provides methods for the digital separation of CT signal produced by the contrast media of the invention from the CT signal produced by other contrast media or bodily tissues, to generate multiple resultant CT images with individual contrast materials subtracted or highlighted.
摘要翻译：本发明提供用于CT成像的微粒造影剂。造影剂基于低Z元素的颗粒。在一个示例性实施方案中，本发明提供了一种肠造影剂制剂。示例性制剂包括（a）肠溶造影剂，其基本上包含选自微粒和纳米颗粒的材料的水不溶性颗粒。示例性颗粒包括具有原子序数为6至52的元素的多个原子的材料。在各种实施方案中，颗粒被涂覆有与需要这种给药的受试者肠溶性配制相容的材料。在一个示例性实施方案中，将造影剂并入其中悬浮颗粒的药学上可接受的载体中。本发明还提供了使用CT成像（包括双能量或光谱CT成像）同时增强本发明的造影剂和不同类型的其它造影剂的身体部位成像的方法。本发明还提供了将由本发明的造影剂产生的CT信号与由其他造影剂或身体组织产生的CT信号进行数字分离的方法，以生成多个产生的CT图像，其中减去或突出显示各个造影剂。

24. 发明授权

US07014839B2 Light imaging contrast agents 失效
公开(公告)号：US07014839B2
公开(公告)日：2006-03-21
申请号：US10286988
申请日：2002-11-01
申请人： Jo Klaveness , Bjorn Fuglaas , Pål Rongved , Edvin Johannesen , Paul Mark Henrichs , Wolfgang Hans Heinrich Gunther , Edward Richard Bacon , John Luke Toner , Gregory Lynn McIntire , Vinay C. Desai
发明人： Jo Klaveness , Bjorn Fuglaas , Pål Rongved , Edvin Johannesen , Paul Mark Henrichs , Wolfgang Hans Heinrich Gunther , Edward Richard Bacon , John Luke Toner , Gregory Lynn McIntire , Vinay C. Desai
IPC分类号： A61K49/00
CPC分类号： B82Y5/00 , A61K49/001 , A61K49/0015 , A61K49/0032 , A61K49/0034 , A61K49/0043 , A61K49/0052 , A61K49/0078 , A61K49/0082 , A61K49/0084 , A61K49/0433 , A61K49/0461 , A61K49/0466 , A61K49/0485 , A61K49/223 , A61K49/227
摘要： The present invention relates to the use of particulate materials as contrast agents in in vivo light imaging.

25. 发明申请

US20040258744A1 Blood-pool carrier for lipophilic imaging agents 失效
标题翻译：用于亲脂显像剂的血液池载体
公开(公告)号：US20040258744A1
公开(公告)日：2004-12-23
申请号：US10692311
申请日：2003-10-23
发明人： Raymond E. Counsell , Marc A. Longino , Jamey P. Weichert
IPC分类号： A61K009/127
CPC分类号： A61K49/0461 , A61K9/1075 , A61K9/1275 , A61K49/0433 , A61K49/1806 , A61K51/0406 , A61K51/0478 , A61K51/1217 , B82Y5/00 , Y10S514/938 , Y10S977/829 , Y10S977/905 , Y10S977/927 , Y10S977/93
摘要： A surface-modified lipoprotein-like oil-in-water emulsion useful as a blood-pool selective delivery vehicle for lipophilic imaging agents or lipophilic derivatives of water-soluble imaging agents. The blood-pool selective delivery vehicle remains in the blood for several hours, shows very little early hepatic sequestration, and is cleared from the blood within 24 hours. The mean diameter of the oil phase is less than 150 nm which minimizes sequestration by the reticuloendothelial system. The surface of the oil phase is modified with a polyethyl glycol-modified phospholipid to prevent normal interactions with the receptor sites of the hepatocytes. In radiographic imaging, radioactive or stable, synthetic or semi-synthetic polyhalogenated triglycerides, such as 2-oleoylglycerol-1,3-bisnull7-(3-amino-2,4,6-triiodophenyl)heptanoatenull, or lipid soluble derivatives of traditional water-soluble contrast agents, such as aliphatic esters of iopanoic, diatrizoic, and acetrizoic acid, may be incorporated into the lipophilic core of a lipoprotein-like emulsion particle.
摘要翻译：用作脂溶性成像剂或水溶性成像剂的亲脂性衍生物的血液池选择性递送载体的表面改性脂蛋白样水包油乳液。血液池选择性输送载体在血液中保持数小时，显示出非常少的早期肝脏螯合，并在24小时内从血液中清除。油相的平均直径小于150nm，其最小化网状内皮系统的螯合。用聚乙二醇修饰的磷脂修饰油相的表面以防止与肝细胞的受体位点的正常相互作用。放射摄影成像中，放射性或稳定的合成或半合成多卤甘油三酸酯如2-油酰甘油-1,3-双[7-（3-氨基-2,4,6-三碘苯基）庚酸酯]或脂溶性衍生物的传统的水溶性造影剂，如碘，脂肪族和代谢酸的脂肪族酯可以并入脂蛋白样乳液颗粒的亲脂性核心中。

26. 发明授权

US06645463B1 Blood-pool selective carrier for lipophilic imaging agents 失效
标题翻译：用于亲脂显像剂的血液池选择性载体
公开(公告)号：US06645463B1
公开(公告)日：2003-11-11
申请号：US09058715
申请日：1998-04-10
申请人： Raymond E. Counsell , Marc A. Longino , Jamey P. Weichert
发明人： Raymond E. Counsell , Marc A. Longino , Jamey P. Weichert
IPC分类号： A61K5100
CPC分类号： A61K49/0461 , A61K9/1075 , A61K9/1275 , A61K49/0433 , A61K49/1806 , A61K51/0406 , A61K51/0478 , A61K51/1217 , B82Y5/00 , Y10S514/938 , Y10S977/829 , Y10S977/905 , Y10S977/927 , Y10S977/93
摘要： A surface-modified lipoprotein-like oil-in-water emulsion useful as a blood-pool selective delivery vehicle for lipophilic imaging agents or lipophilic derivatives of water-soluble imaging agents. The blood-pool selective delivery vehicle remains in the blood for several hours, shows very little early hepatic sequestration, and is cleared from the blood within 24 hours. The mean diameter of the oil phase is less than 150 nm which minimizes sequestration by the reticuloendothelial system. The surface of the oil phase is modified with a polyethyl glycol-modified phospholipid to prevent normal interactions with the receptor sites of the hepatocytes. In radiographic imaging, radioactive or stable, synthetic or semi-synthetic polyhalogenated triglycerides, such as 2-oleoylglycerol-1,3-bis[7-(3-amino-2,4,6-triiodophenyl)heptanoate], or lipid soluble derivatives of traditional water-soluble contrast agents, such as aliphatic esters of iopanoic, diatrizoic, and acetrizoic acid, may be incorporated into the lipophilic core of a lipoprotein-like emulsion particle.
摘要翻译：用作脂溶性成像剂或水溶性成像剂的亲脂性衍生物的血液池选择性递送载体的表面改性脂蛋白样水包油乳液。血液池选择性输送载体在血液中保持数小时，显示出非常少的早期肝脏螯合，并在24小时内从血液中清除。油相的平均直径小于150nm，其最小化网状内皮系统的螯合。用聚乙二醇修饰的磷脂修饰油相的表面以防止与肝细胞的受体位点的正常相互作用。放射摄影成像中，放射性或稳定的合成或半合成多卤甘油三酸酯如2-油酰甘油-1,3-双[7-（3-氨基-2,4,6-三碘苯基）庚酸酯]或脂溶性衍生物的传统的水溶性造影剂，如碘，脂肪族和代谢酸的脂肪族酯可以并入脂蛋白样乳液颗粒的亲脂性核心中。

27. 发明授权

US06540981B2 Light imaging contrast agents 失效
标题翻译：光成像造影剂
公开(公告)号：US06540981B2
公开(公告)日：2003-04-01
申请号：US09732917
申请日：2000-12-11
申请人： Jo Klaveness , Bjorn Fuglass , Pål Rongved , Edvin Johannesen , Paul Mark Hendrichs , Wolfgang Hans Heinrich Gunther , Edward Richard Bacon , John Luke Toner , Gregory Lynn McIntire , Vinay C. Desai
发明人： Jo Klaveness , Bjorn Fuglass , Pål Rongved , Edvin Johannesen , Paul Mark Hendrichs , Wolfgang Hans Heinrich Gunther , Edward Richard Bacon , John Luke Toner , Gregory Lynn McIntire , Vinay C. Desai
IPC分类号： A61K4900
CPC分类号： B82Y5/00 , A61K49/001 , A61K49/0015 , A61K49/0032 , A61K49/0034 , A61K49/0043 , A61K49/0052 , A61K49/0078 , A61K49/0082 , A61K49/0084 , A61K49/0433 , A61K49/0461 , A61K49/0466 , A61K49/0485 , A61K49/223 , A61K49/227
摘要： The present invention relates to the use of particulate materials as contrast agents in in vivo light imaging.
摘要翻译：本发明涉及在体内光成像中使用颗粒材料作为造影剂。

28. 发明授权

US06426367B1 Methods for selectively occluding blood supplies to neoplasias 有权
标题翻译：有选择地阻塞血液供应到肿瘤的方法
公开(公告)号：US06426367B1
公开(公告)日：2002-07-30
申请号：US09946129
申请日：2001-09-04
申请人： Undurti N. Das
发明人： Undurti N. Das
IPC分类号： A61K320
CPC分类号： A61K49/0476 , A61K31/201 , A61K31/202 , A61K31/28 , A61K31/557 , A61K33/00 , A61K45/06 , A61K49/0461 , A61K2300/00
摘要： Disclosed are methods of selectively reducing the blood supply to a neoplastic region, such as a tumor region, thereby selectively causing necrosis of the neoplastic tissue without substantial necrosis of adjoining tissues. In particular, methods are disclosed of selectively reducing the blood supply to a neoplastic region, such as a tumor region, by causing selectively occlusion of blood vessels feeding the neoplastic region. The invention also provides methods of selectively causing anti-angiogenic action in a neoplastic region, such as a tumor region, with the result that new blood vessels are not formed to sustain the neoplasia. The methods employ intra-arterial injection of polyunsaturated fatty acids, preferably in the form of salts, preferably with a lymphographic agent, and optionally with an anti-cancer drug, and/or a cytokine. The invention also provides solutions of PUFAs, or salts of PUFAs, in combination with a lymphographic agent.
摘要翻译：公开了选择性地减少肿瘤区域如肿瘤区域的血液供应的方法，从而选择性地引起肿瘤组织的坏死而没有相邻组织的实质坏死。特别地，公开了通过引起供应赘生物区域的血管的选择性闭塞来选择性地减少对肿瘤区域（例如肿瘤区域）的血液供应的方法。本发明还提供了在诸如肿瘤区域的肿瘤性区域中选择性地引起抗血管生成作用的方法，结果是不形成新的血管以维持瘤形成。该方法采用多不饱和脂肪酸的动脉内注射，优选以盐的形式，优选用淋巴细胞剂，任选地与抗癌药物和/或细胞因子一起注射。本发明还提供PUFAs或PUFA的盐与淋巴药剂组合的溶液。

29. 发明申请

US20010027172A1 Omega-hydrofluoroalkyl ethers, precursor carboxylic acids and derivatives thereof, and their preparation and application 失效
标题翻译： ω-氢氟烷基醚，前体羧酸及其衍生物及其制备和应用
公开(公告)号：US20010027172A1
公开(公告)日：2001-10-04
申请号：US09789788
申请日：2001-02-20
申请人： 3M Innovative Properties Company
发明人： George G.I. Moore , Richard M. Flynn , Miguel A. Guerra , John G. Owens
IPC分类号： C11D001/00
CPC分类号： A61K9/0026 , A61K49/0461 , A61K49/1806 , A61K49/226 , A62D1/00 , A62D1/0028 , A62D1/0035 , A62D1/0085 , B01D12/00 , B23K35/386 , C07C41/16 , C07C41/18 , C07C41/22 , C07C41/24 , C07C43/123 , C07C43/126 , C07C43/192 , C07C43/313 , C07C59/135 , C07C69/708 , C07C2601/14 , C07C2602/28 , C07D319/06 , C08J9/143 , C08J2203/146 , C11D1/004 , C11D7/28 , C07C43/13 , C07C43/12
摘要： Normally liquid, omega-hydrofluoroalkyl ether compounds (and selected mixtures thereof) have a saturated perfluoroaliphatic chain of carbon atoms interrupted by one or more ether oxygen atoms. The compounds can be prepared, e.g., by decarboxylation of the corresponding fluoroalkyl ether carboxylic acids and are useful, e.g., in cleaning and drying applications.
摘要翻译：通常液体的ω-氢氟烷基醚化合物（及其选择的混合物）具有被一个或多个醚氧原子间隔的碳原子的饱和全氟脂肪族链。化合物可以例如通过相应的氟烷基醚羧酸的脱羧来制备，并且可用于例如清洁和干燥应用。

30. 发明授权

US5424056A X-ray contrast compositions containing iodoaniline derivatives and pharmaceutically acceptable clays 失效
标题翻译：含有碘苯胺衍生物和药学上可接受的粘土的X射线对比组合物
公开(公告)号：US5424056A
公开(公告)日：1995-06-13
申请号：US236287
申请日：1994-04-29
申请人： Stephen B. Ruddy , Gregory L. McIntire , Mary E. Roberts , Thomas J. Caulifield , Eugene R. Cooper
发明人： Stephen B. Ruddy , Gregory L. McIntire , Mary E. Roberts , Thomas J. Caulifield , Eugene R. Cooper
IPC分类号： A61K49/04 , G01N21/00
CPC分类号： A61K49/0404 , A61K49/0409 , A61K49/0461
摘要： Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising an iodoaniline derivative as the x-ray producing agent in combination with a pharmaceutically acceptable clay in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.
摘要翻译：公开了用于口服或逆行检查胃肠道的X射线造影剂组合物，其包含与药学上可接受的载体中的药学上可接受的粘土组合的作为x射线产生剂的碘苯胺衍生物; 以及它们用于胃肠道诊断放射学的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式