专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明申请

US20030191178A1 Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents 有权
标题翻译：环戊烷庚（烯）酸，2-杂芳基烯基衍生物作为治疗剂
公开(公告)号：US20030191178A1
公开(公告)日：2003-10-09
申请号：US10383896
申请日：2003-03-07
发明人： Robert M. Burk
IPC分类号： C07D333/24 , A61K031/558
CPC分类号： A61K31/559 , A61K31/5585
摘要： The present invention provides cyclopentane heptanoic acid, 2 heteroaryl alkyl or alkenyl derivatives which may be substituted in the 1-position with hydroxyl, alkyloxy, amino and amido groups, e.g. 1-OH cyclopentane heptanoic acid, 2 heteroarylalkenyl derivatives. In particular, these derivatives are 7-null5-hydroxy-2-(heteroatom-substituted hydroxyhydrocarbyl)-3-hydroxycyclopentylnull heptanoic or heptenoic acids and amine, amide, ether, ester and alchohol derivatives of said acids wherein one or more of said hydroxy groups are replaced with an ether group. These compounds are potent ocular hypotensive and are particularly suited for the management of glaucoma. Moreover, the compounds of this invention are smooth muscle relaxants with broad application in systemic hypertensive and pulmonary diseases; with additional application in gastrointestinal disease, reproduction, fertility, incontinence, shock, inflammation, immune regulation, disorder of bone metabolism, renal dysfunction, cancer and other hypoproliferative diseases.
摘要翻译：本发明提供环戊烷庚酸，2个可被羟基，烷氧基，氨基和酰氨基取代的杂芳基烷基或烯基衍生物，例如。 1-OH环戊烷庚酸，2个杂芳基烯基衍生物。特别地，这些衍生物是所述酸的7- [5-羟基-2-（杂原子取代的羟基烃基）-3-羟基环戊基]庚酸或庚烯酸和胺，酰胺，醚，酯和醇醇衍生物，其中一个或多个所述羟基被醚基取代。这些化合物是有效的眼低血压并且特别适用于治疗青光眼。此外，本发明的化合物是广泛应用于全身高血压和肺部疾病的平滑肌松弛剂; 在胃肠道疾病，繁殖，生育能力，失禁，休克，炎症，免疫调节，骨代谢紊乱，肾功能障碍，癌症和其他低增殖性疾病中的应用。

22. 发明申请

US20030171287A1 Medicinal compositions for angiogenic therapy 审中-公开
标题翻译：用于血管生成治疗的药物组合物
公开(公告)号：US20030171287A1
公开(公告)日：2003-09-11
申请号：US10312435
申请日：2003-04-28
发明人： Ryuichi Morishita , Hiromi Koike , Tadashi Tanabe , Motokuni Aoki
IPC分类号： A61K048/00 , A61K038/18
CPC分类号： A61K38/52 , A61K31/5585 , A61K31/711 , A61K38/1709 , A61K38/1833 , A61K38/1858 , A61K48/00 , A61K2300/00
摘要： The present invention provides: (1) pharmaceutical compositions for angiogenic therapy which contain, as the active ingredients, at least one substance selected from substances having vasodilating effect and/or platelet aggregation inhibitory effect, and substances producing them; and a gene encoding an angiogenesis factor; (2) agents for potentiating the angiogenic effect of a gene encoding an angiogenesis factor that contain, as the active ingredient, at least one substance selected from substances having vasodilating effect and/or platelet aggregation inhibitory effect and substances producing them; (3) an angiogenic agent which contains a prostacyclin synthase gene as the active ingredient; (4) pharmaceutical compositions for angiogenic therapy which contain ets-1 gene and another gene encoding an angiogenesis factor as the active ingredients; (4) an agent which contain ets 1 gene as the active ingredient for potentiating the angiogenic effect of another gene encoding an angiogenesis factor; and (5) an angiogenic agent which contains ets-1 gene as the active ingredient.
摘要翻译：本发明提供：（1）血管生成治疗用药物组合物，其含有选自具有血管扩张作用和/或血小板聚集抑制作用的物质中的至少一种物质作为活性成分，以及生成它们的物质; 和编码血管生成因子的基因; （2）增强编码血管生成因子的基因的血管生成作用的药剂，其含有选自具有血管扩张作用和/或血小板聚集抑制作用的物质和/或血小板聚集抑制作用的物质中的至少一种物质作为活性成分; （3）含有前列环素合酶基因作为活性成分的血管生成剂; （4）含有ets-1基因和编码血管生成因子的另一基因作为活性成分的用于血管生成治疗的药物组合物; （4）含有ets1基因作为增强编码血管生成因子的另一基因的血管生成作用的活性成分的药剂; 和（5）含有ets-1基因作为活性成分的血管生成剂。

23. 发明授权

US06593313B2 Co-administration of a prostaglandin and an androgenic agent in the treatment of female sexual dysfunction 有权
标题翻译：共同管理前列腺素和雄激素药物治疗女性性功能障碍
公开(公告)号：US06593313B2
公开(公告)日：2003-07-15
申请号：US09905458
申请日：2001-07-13
申请人： Virgil A. Place , Leland F. Wilson , Paul C. Doherty, Jr. , Mark S. Hanamoto , Alfred P. Spivack , Neil Gesundheit , Sean R. Bennett
发明人： Virgil A. Place , Leland F. Wilson , Paul C. Doherty, Jr. , Mark S. Hanamoto , Alfred P. Spivack , Neil Gesundheit , Sean R. Bennett
IPC分类号： A61K3119
CPC分类号： B82Y5/00 , A61K9/0034 , A61K9/02 , A61K31/00 , A61K31/15 , A61K31/21 , A61K31/295 , A61K31/48 , A61K31/5377 , A61K31/557 , A61K31/5575 , A61K31/5585 , A61K31/56 , A61K45/06 , A61K2300/00
摘要： Methods and formulations for treating female sexual dysfunction are provided. A pharmaceutical composition formulated so as to contain a selected vasoactive agent is administered to the vagina, vulvar area or urethra of the individual undergoing treatment. Suitable vasoactive agents are vasodilators, including naturally occurring prostaglandins, synthetic prostaglandin derivatives, endothelial-derived relaxation factors, vasoactive intestinal polypeptide agonists, smooth muscle relaxants, leukotriene inhibitors, and others. The formulations are also useful for preventing the occurrence of yeast infections, improving vaginal muscle tone and tissue health, enhancing vaginal lubrication, and minimizing excess collagen deposition. A clitoral drug delivery device is also provided.
摘要翻译：提供了治疗女性性功能障碍的方法和制剂。将配制成含有选择的血管活性剂的药物组合物施用于经历治疗的个体的阴道，外阴区域或尿道。合适的血管活性剂是血管扩张剂，包括天然存在的前列腺素，合成的前列腺素衍生物，内皮衍生的松弛因子，血管活性肠多肽激动剂，平滑肌松弛剂，白细胞三烯抑制剂等。该制剂也可用于预防酵母菌感染的发生，改善阴道肌张力和组织健康，增强阴道润滑，并使过量的胶原蛋白沉积最小化。还提供阴蒂药物递送装置。

24. 发明授权

US06573390B2 Cyclopentane heptan (ENE)OIC acid, 2-heteroarylalkenyl derivatives as therapeutic agents 有权
标题翻译：环戊烷庚烷（ENE）OIC酸，2-杂芳基烯基衍生物作为治疗剂
公开(公告)号：US06573390B2
公开(公告)日：2003-06-03
申请号：US09755393
申请日：2001-01-05
申请人： Robert M. Burk
发明人： Robert M. Burk
IPC分类号： C07D33302
CPC分类号： A61K31/559 , A61K31/5585
摘要： The present invention provides cyclopentane heptanoic acid, 2 heteroaryl alkyl or alkenyl derivatives which may be substituted in the 1-position with hydroxyl, alkyloxy, amino and amido groups, e.g. 1-OH cyclopentane heptanoic acid, 2 heteroarylalkenyl derivatives. In particular, these derivatives are 7-[5-hydroxy-2-(heteroatom-substituted hydroxyhydrocarbyl)-3-hydroxycyclopentyl]heptanoic or heptenoic acids and amine, amide, ether, ester and alchohol derivatives of said acids wherein one or more of said hydroxy groups are replaced with an ether group. These compounds are potent ocular hypotensive and are particularly suited for the management of glaucoma. Moreover, the compounds of this invention are smooth muscle relaxants with broad application in systemic hypertensive and pulmonary diseases; with additional application in gastrointestinal disease, reproduction, fertility, incontinence, shock, inflammation, immune regulation, disorder of bone metabolism, renal dysfunction, cancer and other hypoproliferative diseases.
摘要翻译：本发明提供环戊烷庚酸，2个可被羟基，烷氧基，氨基和酰氨基取代的杂芳基烷基或烯基衍生物，例如。 1-OH环戊烷庚酸，2个杂芳基烯基衍生物。特别地，这些衍生物是所述酸的7- [5-羟基-2-（杂原子取代的羟基烃基）-3-羟基环戊基]庚酸或庚烯酸和胺，酰胺，醚，酯和醇醇衍生物，其中一个或多个所述羟基被醚基取代。这些化合物是有效的眼低血压并且特别适用于治疗青光眼。此外，本发明的化合物是广泛应用于全身高血压和肺部疾病的平滑肌松弛剂; 在胃肠道疾病，繁殖，生育能力，失禁，休克，炎症，免疫调节，骨代谢紊乱，肾功能障碍，癌症和其他低增殖性疾病中的应用。

25. 发明授权

US06469016B1 Treatment of female sexual dysfunction using phosphodiesterase inhibitors 有权
标题翻译：使用磷酸二酯酶抑制剂治疗女性性功能障碍
公开(公告)号：US06469016B1
公开(公告)日：2002-10-22
申请号：US09499959
申请日：2000-02-08
申请人： Virgil A. Place , Leland F. Wilson , Paul C. Doherty, Jr. , Mark S. Hanamoto , Alfred P. Spivack , Neil Gesundheit , Sean R. Bennett
发明人： Virgil A. Place , Leland F. Wilson , Paul C. Doherty, Jr. , Mark S. Hanamoto , Alfred P. Spivack , Neil Gesundheit , Sean R. Bennett
IPC分类号： A61K3151
CPC分类号： B82Y5/00 , A61K9/0034 , A61K9/02 , A61K31/00 , A61K31/15 , A61K31/21 , A61K31/295 , A61K31/48 , A61K31/5377 , A61K31/557 , A61K31/5575 , A61K31/5585 , A61K31/56 , A61K45/06 , A61K2300/00
摘要： Methods and formulations for treating female sexual dysfunction are provided. A pharmaceutical composition formulated so as to contain a selected vasoactive agent is administered to the vagina, vulvar area or urethra of the individual undergoing treatment. Suitable vasoactive agents are vasodilators, including naturally occurring prostaglandins, synthetic prostaglandin derivatives, endothelial-derived relaxation factors, vasoactive intestinal polypeptide agonists, smooth muscle relaxants, leukotriene inhibitors, and others. The formulations are also useful for preventing the occurrence of yeast infections, improving vaginal muscle tone and tissue health, enhancing vaginal lubrication, and minimizing excess collagen deposition. A clitoral drug delivery device is also provided.
摘要翻译：提供了治疗女性性功能障碍的方法和制剂。将配制成含有选择的血管活性剂的药物组合物施用于经历治疗的个体的阴道，外阴区域或尿道。合适的血管活性剂是血管扩张剂，包括天然存在的前列腺素，合成的前列腺素衍生物，内皮衍生的松弛因子，血管活性肠多肽激动剂，平滑肌松弛剂，白细胞三烯抑制剂等。该制剂也可用于预防酵母菌感染的发生，改善阴道肌张力和组织健康，增强阴道润滑，并使过量的胶原蛋白沉积最小化。还提供阴蒂药物递送装置。

26. 发明申请

US20020147223A1 Agent for enhancing accumulation of drugs in tumor tissues 审中-公开
标题翻译：用于增强肿瘤组织中药物积聚的药剂
公开(公告)号：US20020147223A1
公开(公告)日：2002-10-10
申请号：US10095614
申请日：2002-03-12
发明人： Hiroshi Maeda , Michio Hara
IPC分类号： A61K031/559 , A61K031/5585
CPC分类号： A61K49/0021 , A61K9/0019 , A61K31/5585 , A61K47/22 , C07D307/93
摘要： An agent for enhancing accumulation of drugs in tumor tissues, which can enhance accumulation of the drugs in tumor tissues, which drugs are used for diagnosis or therapy of tumors, is disclosed. The agent for enhancing accumulation of drugs in tumor tissues according to the invention comprises as an effective ingredient a prostaglandin I derivative such as beraprost or a salt thereof.
摘要翻译：公开了一种用于增强肿瘤组织中积累药物的药剂，其可以增强药物在肿瘤组织中的积累，所述药物用于肿瘤的诊断或治疗。根据本发明的用于增强药物在肿瘤组织中积累的药剂包括前列腺素I衍生物如贝前列素或其盐作为有效成分。

27. 发明申请

US20020099003A1 Treatment of female sexual dysfunction with vasoactive agents, particularly vasoactive intestinal polypeptide and agonists thereof 审中-公开
标题翻译：用血管活性剂治疗女性性功能障碍，特别是血管活性肠多肽及其激动剂
公开(公告)号：US20020099003A1
公开(公告)日：2002-07-25
申请号：US09929818
申请日：2001-08-13
发明人： Leland F. Wilson , Virgil A. Place
IPC分类号： A61K038/17 , A61K031/56
CPC分类号： B82Y5/00 , A61K9/0034 , A61K31/00 , A61K31/15 , A61K31/21 , A61K31/295 , A61K31/48 , A61K31/5377 , A61K31/557 , A61K31/5575 , A61K31/5585 , A61K31/56 , A61K38/2278 , A61K45/06 , Y10S930/17 , A61K2300/00
摘要： Methods for treating female sexual dysfunction are provided. A pharmaceutical composition containing a vasoactive agent selected from vasoactive intestinal polypeptide (VIP) and VIP agonists is administered to the vagina and/or vulvar region of the individual undergoing treatment. The formulations are also useful for improving vaginal muscle tone and tissue health, enhancing vaginal lubrication, and minimizing excess collagen deposition. Pharmaceutical formulations and kits are also provided.
摘要翻译：提供了治疗女性性功能障碍的方法。将含有选自血管活性肠肽（VIP）和VIP激动剂的血管活性剂的药物组合物施用于经历治疗的个体的阴道和/或外阴区域。该制剂还可用于改善阴道肌张力和组织健康，增强阴道润滑和最小化多余的胶原沉积。还提供药物制剂和试剂盒。

28. 发明申请

US20020004524A1 Bile secretion promoting composition 有权
标题翻译：胆汁分泌促进成分
公开(公告)号：US20020004524A1
公开(公告)日：2002-01-10
申请号：US09827375
申请日：2001-04-06
发明人： Ryuji Ueno , Makoto Suematsu
IPC分类号： A61K031/5585 , A61K031/5575
CPC分类号： A61K31/558 , A61K31/5575 , A61K31/5585
摘要： Disclosed is a method for promoting bile secretion, which comprises administering an effective amount of a certain 15-keto-prostaglandin compound to a subject having a disease or condition associated with bile secretion deficient. Also disclosed is a method for treatment of a liver to be transplanted in a liver transplantation process, which comprises contacting the liver with a liquid composition comprising the 15-keto-prostaglandin compound as above.
摘要翻译：公开了一种促进胆汁分泌的方法，其包括向具有与胆汁分泌不足相关的疾病或病症的受试者施用有效量的某些15-酮 - 前列腺素化合物。还公开了一种用于治疗在肝移植过程中移植的肝脏的方法，其包括使肝脏与包含如上所述的15-酮前列腺素化合物的液体组合物接触。

29. 发明申请

US20020002150A1 Cyclopentane(ENE)heptenoic or heptanoic acids and derivatives thereof useful as therapeutic agents 有权
标题翻译：环戊烷（ENE）庚烯或庚酸及其衍生物可用作治疗剂
公开(公告)号：US20020002150A1
公开(公告)日：2002-01-03
申请号：US09919318
申请日：2001-07-31
申请人： ALLERGAN SALES, INC.
发明人： Robert M. Burk
IPC分类号： A61K031/66 , A61K031/5575 , A61K031/5578
CPC分类号： A61K31/5585 , A61K31/557 , A61K31/5575 , A61K31/559 , C07C405/00 , C07C405/0016 , C07C405/0041 , C07C405/0058 , Y10S514/912
摘要： The invention relates to 7-null5-hydroxy-2-(hydroxyhydrocarbyl or heteroatom-substituted hydroxy hydrocarbyl)-3-hydroxycyclopentyl(enyl)null heptanoic or heptenoic acids and derivatives of said acids, wherein one or more of said hydroxy groups are replaced by an ether group. The compounds of the present invention are potent ocular hypotensives, and are particularly suitable for the management of glaucoma.
摘要翻译：本发明涉及7- [5-羟基-2-（羟基烃基或杂原子取代的羟基烃基）-3-羟基环戊基（烯基）]庚酸或庚烯酸和所述酸的衍生物，其中一个或多个所述羟基被替换由一个醚组。本发明的化合物是有效的眼睛低血压剂，特别适用于治疗青光眼。

30. 发明授权

US06328979B1 Sustained release medicinal compositions 失效
标题翻译：缓释药物组合物
公开(公告)号：US06328979B1
公开(公告)日：2001-12-11
申请号：US09582384
申请日：2000-06-23
申请人： Noboru Yamashita , Akira Takagi , Masataka Katsuma , Katsumi Saito , Yuuki Takaishi , Tatsuo Yasuda , Yutaka Takahashi , Mitsuo Mitomi
发明人： Noboru Yamashita , Akira Takagi , Masataka Katsuma , Katsumi Saito , Yuuki Takaishi , Tatsuo Yasuda , Yutaka Takahashi , Mitsuo Mitomi
IPC分类号： A61K900
CPC分类号： A61K9/0024 , A61K9/0019 , A61K9/06 , A61K31/557 , A61K31/5575 , A61K31/5585 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/186 , A61K47/20 , A61K47/36 , A61K47/42 , A61K47/44
摘要： The present invention relates to sustained-release pharmaceutical compositions for ionic pharmaceutically active substances (excluding ionic prostanoic acid derivatives) containing ionic compounds having opposite charges to those of the active substances and increasing hydrophobicity of the active substances. More specifically, the invention relates to sustained-release pharmaceutical compositions comprising the ionic pharmaceutically active substances and the ionic compounds having opposite charges to those of the active substances and increasing hydrophobicity of the active substances that contain hydrophobic groups in the molecule thereof. The pharmaceutical composition of the invention can exhibit excellent sustained release effect of the active substance, irrespective of water solubility possessed by the ionic pharmaceutically active substances.
摘要翻译：本发明涉及含有与活性物质具有相反电荷的离子化合物的离子药物活性物质（不含离子前列腺酸衍生物）的持续释放药物组合物，并且活性物质的疏水性增加。更具体地，本发明涉及包含离子药物活性物质和具有与活性物质相反的电荷的离子化合物的缓释药物组合物，并且其分子中含有疏水基团的活性物质的疏水性增加。本发明的药物组合物可以表现出优异的活性物质的缓释作用，而与离子药物活性物质所具有的水溶性无关。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式