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21. 发明申请

US20140012393A1 COMPLEX SUPPORT BODY FOR REGENERATING BONE-CARTILAGE, METHOD FOR MANUFACTURING THEREOF, AND COMPOSITION FOR TREATING BONE AND CARTILAGE RELATED DISEASES COMPRISING SAME AS ACTIVE INGREDIENT 有权
标题翻译：用于再生骨髓的复合支持体，其制造方法，以及用于治疗骨骼和组织相关疾病的组合物，包括作为活性成分的相关疾病
公开(公告)号：US20140012393A1
公开(公告)日：2014-01-09
申请号：US14006401
申请日：2012-02-20
申请人： Jung Woog Shin , Ji Won Shin , So Hee Park
发明人： Jung Woog Shin , Ji Won Shin , So Hee Park
IPC分类号： A61F2/28
CPC分类号： A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2002/30766 , A61L27/12 , A61L27/3817 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2430/02 , A61L2430/06
摘要： The present invention relates to a complex support body for regenerating bone-cartilage, a method for manufacturing thereof, and a composition for treating bone and cartilage related diseases comprising the same as an active ingredient, and more particularly, to a complex support body for regenerating bone-cartilage, which comprises a bone regeneration layer consisting of a biodegradable polymer and a biocompatible ceramic, and a cartilage regeneration layer, which is coupled to the bone regeneration layer and in which cells that can be differentiated into cartilages cells are fixed; a method for manufacturing thereof; and a composition for treating bone and cartilage related diseases comprising the same as an active ingredient. The complex support body of the present invention for regenerating bone-cartilage is manufactured as a three-dimensional support body, which is similar to a living tissue, according to a bioplotting method, and exerts the effect of regeneration into a bone tissue and a cartilage tissue, respectively, depending on materials encountered in the environment where the complex support body for regenerating bone-cartilage is used.
摘要翻译：本发明涉及一种用于再生骨软骨的复合体支撑体，其制造方法和用于治疗骨和软骨相关疾病的组合物，其包含其作为活性成分，更具体地涉及一种用于再生的复合体骨软骨，其包含由生物可降解聚合物和生物相容性陶瓷组成的骨再生层，和软骨再生层，其与骨再生层连接，其中可分化成软骨细胞的细胞被固定; 其制造方法; 以及用于治疗骨和软骨相关疾病的组合物，其包含其作为活性成分。根据生物绘图方法，本发明的用于再生骨软骨的复合支撑体被制造为与生物体组织相似的三维支撑体，并且将再生的效果发挥到骨组织和软骨中组织，这取决于在使用用于再生骨软骨的复合体支撑体的环境中遇到的材料。

22. 发明授权

US08608801B2 Osteochondral implants, arthroplasty methods, devices, and systems 有权
标题翻译：骨软骨植入物，关节成形术方法，装置和系统
公开(公告)号：US08608801B2
公开(公告)日：2013-12-17
申请号：US12498358
申请日：2009-07-06
申请人： Clark T. Hung , Gerard A. Ateshian , Eric G. Lima , James L. Cook , Li Ming Bian
发明人： Clark T. Hung , Gerard A. Ateshian , Eric G. Lima , James L. Cook , Li Ming Bian
IPC分类号： A61F2/30
CPC分类号： B29C39/003 , A61F2/28 , A61F2/30756 , A61F2002/30762 , A61F2002/30766 , A61F2002/30878 , A61F2002/30948 , A61F2002/30952 , A61F2002/30962 , A61F2310/00131 , A61L27/3817 , A61L27/3852 , A61L27/3895 , A61L27/52 , A61L27/56 , A61L2430/06 , B29C39/10 , C12N5/0655 , C12N2501/15 , C12N2533/76
摘要： Implants for resurfacing or repairing one or more articular cartilage bearing surfaces of a biological organism include an engineered tissue and a biocompatible porous substrate secured to the engineered tissue for attaching the implant to a native bone of the biological organism. The engineered tissue includes a scaffold containing a biocompatible material, and a plurality of living chondrocytes supported by the scaffold. Methods for culturing chondrocytes for incorporation into a biocompatible implant are provided. A bioreactor for producing functional cartilaginous tissue from a cell-seeded scaffold and a system for producing functional cartilaginous tissue are also provided.
摘要翻译：用于重建或修复生物生物体的一个或多个关节软骨表面的植入物包括固定到工程组织的工程组织和生物相容性多孔基底，用于将植入物附接到生物体的天然骨。工程组织包括含有生物相容性材料的支架和由支架支撑的多个活的软骨细胞。提供了用于培养软骨细胞并入生物相容性植入物的方法。还提供了用于从细胞种植支架产生功能性软骨组织的生物反应器和用于产生功能性软骨组织的系统。

23. 发明申请

US20130184820A1 PARTIAL JOINT RESURFACING IMPLANT, INSTRUMENTATION, AND METHOD 有权
标题翻译：部分接合植入物，仪器和方法
公开(公告)号：US20130184820A1
公开(公告)日：2013-07-18
申请号：US13724292
申请日：2012-12-21
申请人： BIOPOLY, LLC
发明人： Herbert E. SCHWARTZ , Francis S. PROCH , Nathanael K. CONNER
IPC分类号： A61F2/30
CPC分类号： A61F2/30756 , A61B17/1615 , A61B17/1635 , A61B17/1675 , A61B17/17 , A61B17/1764 , A61B2090/062 , A61F2/30771 , A61F2/4618 , A61F2/4657 , A61F2/4684 , A61F2002/30014 , A61F2002/30065 , A61F2002/30112 , A61F2002/30125 , A61F2002/30224 , A61F2002/30299 , A61F2002/30326 , A61F2002/30327 , A61F2002/30331 , A61F2002/30387 , A61F2002/30759 , A61F2002/30766 , A61F2002/3085 , A61F2002/30878 , A61F2002/30884 , A61F2002/3096 , A61F2002/4662 , A61F2002/4685 , A61F2310/00407 , A61F2310/00796 , A61F2310/00976
摘要： A method of repairing an articular cartilage defect with the partial joint resurfacing implant includes surgically creating an opening in the articular cartilage defect site. The method also includes obtaining a partial resurfacing implant which is implanted into the opening. The partial resurfacing implant includes a top articulating portion, an implant fixation portion, and a locking mechanism. The implant fixation portion including an upper segment coupled to the top articulating portion and a bone interfacing segment configured to facilitate insertion into the articular cartilage defect site. The method further includes the bone interfacing segment being inserted into the opening with the top articulating portion and adjacent articular cartilage being positioned to each other to facilitate motion and load transfer over the defect site. Another method of repairing an articular cartilage defect with a partial joint resurfacing implant and a partial joint resurfacing implant are also disclosed.
摘要翻译：用部分关节表面置换植入物修复关节软骨缺损的方法包括在关节软骨缺损部位手术地产生开口。该方法还包括获得植入开口部分的部分表面置换植入物。部分表面置换植入物包括顶部铰接部分，植入物固定部分和锁定机构。所述植入物固定部分包括联接到所述顶部关节部分的上部段和被构造成便于插入所述关节软骨缺损部位的骨接合部分。所述方法还包括将所述骨接合部分插入到所述开口中，所述骨接合部分具有顶部关节部分，并且相邻的关节软骨彼此定位，以便于在所述缺损部位上的运动和负荷传递。还公开了用部分关节表面置换植入物和部分关节表面置换植入物修复关节软骨缺损的另一种方法。

24. 发明授权

US08293225B2 Method and device for synovial cell-charged collagen membrane or gel 有权
标题翻译：滑膜细胞电荷胶原膜或凝胶的方法和装置
公开(公告)号：US08293225B2
公开(公告)日：2012-10-23
申请号：US12091147
申请日：2006-10-23
申请人： Birgit Schaefer , Lothar Schloesser
发明人： Birgit Schaefer , Lothar Schloesser
IPC分类号： C12N5/00
CPC分类号： A61L27/3852 , A61F2/30756 , A61F2/3094 , A61F2002/30062 , A61F2002/30761 , A61F2002/30766 , A61F2002/30971 , A61F2210/0004 , A61F2310/00365 , A61L27/24 , A61L27/36 , A61L27/3817 , A61L2430/06 , Y10S623/901
摘要： An implant for repair of a cartilaginous defect in a subject includes a collagen matrix charged with synovial cells. A method preparing an implant for repair of a cartilaginous defect in a subject includes obtaining a fluid containing synovial cells and charging the synovial cells to the matrix. A device for preparing a cell-charged implant includes a first chamber and a second chamber, the first and second chambers being separated by a membrane and a perforated filter. The membrane is adapted to collect cells from a cell-containing fluid introduced into the first chamber and the perforated filter is adapted to permit passage or diffusion of the fluid through the second chamber. A method for preparing a cell-charged implant utilizes the device.
摘要翻译：用于修复受试者的软骨缺损的植入物包括装有滑膜细胞的胶原基质。制备用于修复受试者的软骨缺损的植入物的方法包括获得含有滑膜细胞的流体并将滑膜细胞装入基质。用于制备电池充电的植入物的装置包括第一室和第二室，第一和第二室由隔膜和穿孔过滤器隔开。膜适于从引入第一室的含细胞的流体中收集细胞，并且穿孔过滤器适于允许流体通过或扩散通过第二室。用于制备细胞充电植入物的方法利用该装置。

25. 发明申请

US20120239146A1 CARTILAGE IMPLANT 有权
标题翻译：手提植入
公开(公告)号：US20120239146A1
公开(公告)日：2012-09-20
申请号：US13327238
申请日：2011-12-15
申请人： Neil Kizer , Robert Spiro , Jian Yao , Cheryl Renee Blanchard
发明人： Neil Kizer , Robert Spiro , Jian Yao , Cheryl Renee Blanchard
IPC分类号： A61F2/02
CPC分类号： A61L27/3683 , A61F2/28 , A61F2/30756 , A61F2002/30764 , A61F2002/30766 , A61F2310/00293 , A61F2310/00365 , A61F2310/00377 , A61K35/32 , A61L27/3612 , A61L27/3654 , A61L27/3817 , A61L27/3852 , A61L2430/06 , C12N5/0655 , C12N2533/56 , C12N2533/80
摘要： The present invention is directed to compositions having at least one neocartilage particle, juvenile cartilage particle or a combination thereof and a matrix, and methods and devices that include the compositions.
摘要翻译：本发明涉及具有至少一种新软骨颗粒，幼体软骨颗粒或其组合和基质的组合物，以及包含该组合物的方法和装置。

26. 发明授权

US08246692B2 Method for treating a cartilage defect, surgical instrumentation and surgical navigation system 有权
标题翻译：软骨缺损治疗方法，手术器械和手术导航系统
公开(公告)号：US08246692B2
公开(公告)日：2012-08-21
申请号：US12315085
申请日：2008-11-25
申请人： Nicola Giordano
发明人： Nicola Giordano
IPC分类号： A61F2/02 , A61B17/29
CPC分类号： A61B17/29 , A61B17/3421 , A61B2017/00362 , A61B2034/2055 , A61B2034/2068 , A61B2090/067 , A61F2/4618 , A61F2/4657 , A61F2002/30766 , A61F2002/4622 , A61F2002/4658 , A61F2002/4668
摘要： The invention relates to a method for treating a cartilage defect by implanting a cartilage replacement implant through an arthroscopic access, comprising: determining at least one parameter for describing the arthroscopic access, providing a surgical instrumentation comprising at least two different applicator instruments for grasping the cartilage replacement implant, choosing one of the at least two applicator instruments of the instrumentation in dependence upon the at least one parameter determined for describing the arthroscopic access, and grasping and inserting the cartilage replacement implant into the patient's body with the chosen instrument through the arthroscopic access.
摘要翻译：本发明涉及一种通过关节镜检查植入软骨替代植入物来治疗软骨缺损的方法，包括：确定用于描述关节镜检查的至少一个参数，提供包括至少两个不同的施用器械用于抓取软骨的手术器械替代植入物，根据确定用于描述关节镜进入的至少一个参数选择仪器的至少两个施用器械中的一个，以及通过关节镜检查将所述软骨置换植入物夹持并插入患者体内。

27. 发明申请

US20120207736A1 COMPOSITION FOR CARTILAGINOUS TISSUE REPAIR AND A PRODUCTION METHOD THEREFOR 审中-公开
标题翻译：用于组织织物修复的组合物及其生产方法
公开(公告)号：US20120207736A1
公开(公告)日：2012-08-16
申请号：US13503228
申请日：2009-12-03
申请人： Cheong-Ho Jang , Ji-Chul Yu , Sae-Bom Lee , Hyun-Shin Park , Hyun-Jo Kim , Jae-Deog Jang , Se-Ken Yeo , Ju-Hee Park , Seok-Jung Kim
发明人： Cheong-Ho Jang , Ji-Chul Yu , Sae-Bom Lee , Hyun-Shin Park , Hyun-Jo Kim , Jae-Deog Jang , Se-Ken Yeo , Ju-Hee Park , Seok-Jung Kim
IPC分类号： A61K38/48 , A61P19/00
CPC分类号： A61L27/26 , A61F2002/30766 , A61L2400/06 , A61L2430/06 , C08L89/06
摘要： The present invention relates to a composition for cartilaginous tissue repair and to a production method therefor. The present invention comprises the steps of: (a) dissolving freeze-dried fibrinogen in an aprotinin solution; (b) dissolving freeze-dried thrombin in a stabilizing solution; (c) mixing an enriched collagen solution with thrombin and the stabilizing solution; and installing the fibrinogen solution (a) to one side of a dual kit and the solution (c) containing the collagen to the other side, and then mixing and injecting into damaged cartilaginous tissue. In the present invention, which is constituted as described above, biomaterials such as collagen and fibrin are mixed so as to allow damaged cartilaginous tissue to be repaired to a state allowing transplantation onto the tissue, and efficient regeneration is induced, thereby making it possible to reduce surgery-related stress on people and animals while inducing relatively rapid and efficient cartilage repair and regeneration.
摘要翻译：本发明涉及一种用于软骨组织修复的组合物及其制备方法。本发明包括以下步骤：（a）将冷冻干燥的纤维蛋白原溶解在抑肽酶溶液中; （b）将冻干凝血酶溶解在稳定溶液中; （c）将富集的胶原溶液与凝血酶和稳定溶液混合; 并将纤维蛋白原溶液（a）安装在双重试剂盒的一侧和将胶原蛋白溶液（c）另一侧，然后混合并注入损伤的软骨组织中。在如上所述构成的本发明中，混合了诸如胶原和纤维蛋白等生物材料，以便将损伤的软骨组织修复到允许移植到组织上的状态，从而可以有效地再生，减少对人和动物的手术相关压力，同时诱导相对快速和有效的软骨修复和再生。

28. 发明授权

US08221780B2 Nonwoven tissue scaffold 有权
标题翻译：无纺布组织支架
公开(公告)号：US08221780B2
公开(公告)日：2012-07-17
申请号：US11427477
申请日：2006-06-29
申请人： Sridevi Dhanaraj , Stephanie M. Kladakis , Joseph J. Hammer , Dhanuraj Shetty , Mark Timmer
发明人： Sridevi Dhanaraj , Stephanie M. Kladakis , Joseph J. Hammer , Dhanuraj Shetty , Mark Timmer
IPC分类号： A61F2/00
CPC分类号： A61L27/56 , A61F2/30756 , A61F2/3872 , A61F2002/30766 , A61L27/18 , A61L27/54 , A61L27/58 , A61L2300/252 , A61L2300/414 , A61L2430/06 , C08L67/04
摘要： A biocompatible meniscal repair device is disclosed. The tissue repair device includes a scaffold adapted to be placed in contact with a defect in a meniscus, the scaffold comprising a high-density, dry laid nonwoven polymeric material and a biocompatible foam. The scaffold provides increased suture pull-out strength.
摘要翻译：公开了一种生物相容性半月板修复装置。所述组织修复装置包括适于与弯液面中的缺陷接触的支架，所述支架包括高密度干法铺设的非织造聚合物材料和生物相容性泡沫。支架提供增加的缝线拉拔强度。

29. 发明申请

US20120087948A1 PARTICULATE CARTILAGE SYSTEM 有权
标题翻译：颗粒体系
公开(公告)号：US20120087948A1
公开(公告)日：2012-04-12
申请号：US12976704
申请日：2010-12-22
申请人： Neil Kizer , Robert Spiro , Jian Yao , Cheryl Renee Blanchard
发明人： Neil Kizer , Robert Spiro , Jian Yao , Cheryl Renee Blanchard
IPC分类号： A61K35/32 , A61P19/04 , B65D1/34 , A61K9/14
CPC分类号： A61L27/3683 , A61F2/28 , A61F2/30756 , A61F2002/30764 , A61F2002/30766 , A61F2310/00293 , A61F2310/00365 , A61F2310/00377 , A61K35/32 , A61L27/3612 , A61L27/3654 , A61L27/3817 , A61L27/3852 , A61L2430/06 , C12N5/0655 , C12N2533/56 , C12N2533/80
摘要： The present invention is directed to compositions having at least one neocartilage particle, juvenile cartilage particle or a combination thereof and a matrix, and methods and devices that include the compositions.
摘要翻译：本发明涉及具有至少一种新软骨颗粒，幼体软骨颗粒或其组合和基质的组合物，以及包含该组合物的方法和装置。

30. 发明申请

US20120009270A1 TREATMENT METHODS USING A PARTICULATE CARTILAGE SYSTEM 有权
标题翻译：使用粒状体系的处理方法
公开(公告)号：US20120009270A1
公开(公告)日：2012-01-12
申请号：US12976689
申请日：2010-12-22
申请人： Neil Kizer , Robert Spiro , Jian Yao , Cheryl Renee Blanchard
发明人： Neil Kizer , Robert Spiro , Jian Yao , Cheryl Renee Blanchard
IPC分类号： A61K35/32 , A61P19/04 , A61P19/02
CPC分类号： A61L27/3683 , A61F2/28 , A61F2/30756 , A61F2002/30764 , A61F2002/30766 , A61F2310/00293 , A61F2310/00365 , A61F2310/00377 , A61K35/32 , A61L27/3612 , A61L27/3654 , A61L27/3817 , A61L27/3852 , A61L2430/06 , C12N5/0655 , C12N2533/56 , C12N2533/80
摘要： The present invention is directed to compositions having at least one neocartilage particle, juvenile cartilage particle or a combination thereof and a matrix, and methods and devices that include the compositions.
摘要翻译：本发明涉及具有至少一种新软骨颗粒，幼体软骨颗粒或其组合和基质的组合物，以及包含该组合物的方法和装置。

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