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21. 发明授权

US08455442B2 Peptides having binding affinity to an antibody which recognizes an epitope on an α1 loop 2 or β2 loop 1 of an adrenoreceptor 有权
标题翻译：具有与识别肾上腺素受体的α1环2或β2环1上的表位的抗体结合亲和力的肽
公开(公告)号：US08455442B2
公开(公告)日：2013-06-04
申请号：US12735416
申请日：2009-01-15
申请人： Rudolf Kunze , Gerd Wallukat , Peter Rosenthal , Richard Straube
发明人： Rudolf Kunze , Gerd Wallukat , Peter Rosenthal , Richard Straube
IPC分类号： A61K38/03 , A61K38/04 , A61K38/08 , C07K4/12 , C07K7/06 , C07K17/00
CPC分类号： C07K17/08 , A61K38/08 , A61K38/1787 , B01J20/286 , B01J20/3251 , C07K14/723 , C07K16/28 , C07K2317/34
摘要： A peptide having an ED50 of less than 500 nm, in particular 10 nM to an antibody which recognizes an epitope on an extracellular α1 loop 2 or β2 loop 1 of a human adrenoceptor wherein the antibody's binding to the epitope results in an increase of γ-secretase activity, an increased release of β-amyolid molecules and/or cellular dysfunction of cerebral blood vessel cells, glia cells or neurons, wherein the ED50 value is measured by bioassay.
摘要翻译：具有小于500nm的ED 50，特别是10nM的肽，其识别人肾上腺素受体的细胞外α1环2或β2环1上的表位的抗体，其中抗体与表位的结合导致γ- 分泌酶活性，β-固体分子的增加释放和/或脑血管细胞，神经胶质细胞或神经元的细胞功能障碍，其中ED 50值通过生物测定来测量。

22. 发明申请

US20130012455A1 Use of ARC for inhibiting cell death during liver failure 有权
标题翻译：在肝衰竭期间使用ARC抑制细胞死亡
公开(公告)号：US20130012455A1
公开(公告)日：2013-01-10
申请号：US13496200
申请日：2010-09-15
申请人： Stefan Donath , Junfeng An
发明人： Stefan Donath , Junfeng An
IPC分类号： A61K38/17 , C12N15/62 , C07K14/435 , C12N5/071 , A61K31/7088 , A61P1/16 , C12N15/85 , C12N15/12 , C07K19/00
CPC分类号： A61K38/1709 , A61K48/005
摘要： The invention refers to the use of a polynucleotide encoding “apoptosis repressor with caspase recruitment domain” (ARC) or a functional fragment thereof, and/or an ARC polypeptide or a functional fragment thereof for inhibiting cell death of a liver cell, in particular during liver failure.
摘要翻译：本发明涉及编码具有半胱天冬酶募集区（ARC）或其功能片段，和/或ARC多肽或其功能片段的凋亡抑制因子的多核苷酸用于抑制肝细胞的细胞死亡，特别是在肝衰竭期间的用途。

23. 发明申请

US20120282629A1 Enhancers of Protein Degradation 有权
标题翻译：蛋白质降解增强剂
公开(公告)号：US20120282629A1
公开(公告)日：2012-11-08
申请号：US13391316
申请日：2010-08-19
申请人： Erich Wanker , Thomas Wiglenda , Julius Tachu Babila , Annett Boddrich , Michael Schmidt , Sandra Neuendorf , Franziska Schiele
发明人： Erich Wanker , Thomas Wiglenda , Julius Tachu Babila , Annett Boddrich , Michael Schmidt , Sandra Neuendorf , Franziska Schiele
IPC分类号： C07C243/22 , C07C255/66 , C07D211/98 , G01N21/64 , C07D215/38 , C07D295/28 , G01N33/566 , C07C241/02 , C07D277/82
CPC分类号： C07C251/86 , C07C255/24 , C07D213/77 , C07D215/38 , C07D233/88 , C07D277/82 , C07D401/12
摘要： The present invention relates to compounds suitable for modulating huntingtin protein processing and useful for treating or preventing huntingtin-related disorders. The invention provides pharmaceutical compositions comprising said compounds and methods of syntheses thereof.
摘要翻译：本发明涉及适用于调节亨廷顿蛋白加工并可用于治疗或预防亨廷顿汀相关疾病的化合物。本发明提供包含所述化合物的药物组合物及其合成方法。

24. 发明授权

US07462703B2 Agent for gene transfer 失效
标题翻译：基因转移代理
公开(公告)号：US07462703B2
公开(公告)日：2008-12-09
申请号：US10355933
申请日：2003-01-31
申请人： Regina Reszka , Antje Berndt
发明人： Regina Reszka , Antje Berndt
IPC分类号： C07H21/04 , A61K31/70 , A61B5/055
CPC分类号： A61K48/0025 , A61K9/1271 , A61K38/00 , C12N15/87
摘要： An agent for the transfer of genetic material comprising a genetic material, PEG-containing liposomes, one or more additional polymer particles and a contrasting agent. The invention also is directed toward methods of preparing the agent, and methods of using the agent to affect gene transfer.
摘要翻译：用于转移遗传物质的试剂，其包含遗传物质，含PEG脂质体，一种或多种另外的聚合物颗粒和对比剂。本发明还涉及制备该试剂的方法，以及使用该试剂影响基因转移的方法。

25. 发明授权

US09574017B2 Peptides having binding affinity to an antibody which recognizes an epitope on an α1 loop 2 or β2 loop 1 of an adrenoreceptor 有权
标题翻译：与对能够识别肾上腺素受体的α1环2或β2环1上的表位的抗体具有结合亲和力的肽
公开(公告)号：US09574017B2
公开(公告)日：2017-02-21
申请号：US13871239
申请日：2013-04-26
申请人： MDC MAX-DELBRUCK-CENTRUM FUR MOLEKULARE MEDIZIN BERLIN-BUCH , FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
发明人： Rudolf Kunze , Gerd Wallukat , Peter Rosenthal , Richard Straube
IPC分类号： C07K17/08 , A61K38/08 , C07K14/72 , C07K16/28 , B01J20/286 , A61K38/17 , B01J20/32
CPC分类号： C07K17/08 , A61K38/08 , A61K38/1787 , B01J20/286 , B01J20/3251 , C07K14/723 , C07K16/28 , C07K2317/34
摘要： A peptide having an ED50 of less than 500 nm, in particular 10 nM to an antibody which recognizes an epitope on an extracellular α1 loop 2 or β2 loop1 of a human adrenoceptor wherein the antibody's binding to the epitope results in an increase of γ-secretase activity, an increased release of β-amyolid molecules and/or cellular dysfunction of cerebral blood vessel cells, glia cells or neurons, wherein the ED50 value is measured by bioassay.
摘要翻译：具有小于500nm的ED 50，特别是10nM识别人肾上腺素受体的细胞外α1环2或β2环1上的表位的抗体的肽，其中抗体与表位的结合导致γ-分泌酶的增加活性，增加β型固体分子的释放和/或脑血管细胞，神经胶质细胞或神经元的细胞功能障碍，其中通过生物测定来测量ED 50值。

26. 发明授权

US09375435B2 Use of a DNA expression construct 有权
标题翻译：使用DNA表达构建体
公开(公告)号：US09375435B2
公开(公告)日：2016-06-28
申请号：US13820888
申请日：2011-09-08
申请人： Wolfgang Walther , Peter M. Schlag , Dennis Kobelt , Manuel Schmidt
发明人： Wolfgang Walther , Peter M. Schlag , Dennis Kobelt , Manuel Schmidt
IPC分类号： A61K48/00 , A61K31/547 , C12N15/85 , A61K38/19 , A61K38/18 , A61P35/00 , C12P21/02 , C12P21/04 , A61K39/00
CPC分类号： A61K31/547 , A61K38/191 , A61K48/005 , A61K48/0066 , A61K2039/53 , C12N15/85 , C12N2800/24
摘要： The present invention relates to the use of a DNA expression construct comprising a dumbbell-shaped circular strand of deoxyribonucleic acids and provides such a construct with a double-stranded stem and single-stranded loops located at both ends of the stem, wherein the stem comprises complementary deoxyribonucleic acids of the circular strand with a promotor sequence, a coding sequence and a termination signal to be administered by jet injection for the treatment of cancer.
摘要翻译：本发明涉及包含哑铃状环状链的脱氧核糖核酸的DNA表达构建体的用途，并且提供这样的构建体，其具有位于茎的两端的双链茎和单链环，其中茎包含具有启动子序列的环状链的互补脱氧核糖核酸，通过喷射注射用于治疗癌症的编码序列和终止信号。

27. 发明申请

US20160008339A1 PSORALEN DERIVATIVES FOR PREVENTING OR TREATING HEART FAILURE OR CARDIAC HYPERTROPHY 审中-公开
标题翻译：用于预防或治疗心脏衰竭或心律失常的PSORALEN衍生物
公开(公告)号：US20160008339A1
公开(公告)日：2016-01-14
申请号：US14412446
申请日：2013-07-02
申请人： MAX-DELBRUCK-CENTRUM FUR MOLEKULARE MEDIZIN
发明人： Enno KLUSSMANN , Jessica TROGER , Walter ROSENTHAL
IPC分类号： A61K31/4433
CPC分类号： A61K31/4433 , C07D493/04
摘要： The present invention relates to compound characterized by a general formula 1, wherein R1 is a aryl or a heteroaryl, and —R2 and R3 independently of each other are hydrogen or a C1-C5 alkyl, but at least one of R2 and R3 is not hydrogen, or together are a C3 or C4 alkyl forming a 5- or 6 membered ring, for use in a method for treating of heart failure, hypertension, cardiac hypertrophy or cancer.
摘要翻译：本发明涉及以通式1为特征的化合物，其中R 1为芳基或杂芳基，R 2和R 3彼此独立地为氢或C 1 -C 5烷基，但R 2和R 3中的至少一个不为氢或一起是形成5-或6元环的C3或C4烷基，用于治疗心力衰竭，高血压，心脏肥大或癌症的方法中。

28. 发明申请

US20140155466A1 USE OF APTAMERS IN THERAPY AND/OR DIAGNOSIS OF AUTOIMMUNE DISEASES 有权
标题翻译： APTAMERS在治疗和/或诊断自身免疫性疾病中的应用
公开(公告)号：US20140155466A1
公开(公告)日：2014-06-05
申请号：US14003675
申请日：2012-03-02
申请人： Ingolf Schimke , Annekathrin Haberland , Gerd Wallukat
发明人： Ingolf Schimke , Annekathrin Haberland , Gerd Wallukat
IPC分类号： C12N15/115 , G01N33/564
CPC分类号： C12N15/115 , A61M1/3679 , C12N2310/16 , C12N2310/317 , C12N2310/3517 , C12N2320/10 , C12N2320/30 , G01N33/564 , G01N33/6854
摘要： The present invention is directed to an aptamer comprising or consisting of the nucleic acid sequence of SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3 and/or a nucleic acid sequence being at least 80% identical to one of SEQ ID No. 1, 2 and 3 for use in therapy and/or diagnosis of autoimmune diseases, wherein the autoimmune disease is cardiomyopathy, dilated cardiomyopathy (DCM), peripartum cardiomyopathy (PPCM), idiopathic cardiomyopathy, Chagas' cardiomyopathy, Chagas' megacolon, Chagas' megaesophagus, Chagas' neuropathy, benign prostatic hyperplasia, scleroderma, psoriasis, Raynaud syndrome, pre-eclamsia, kidney allograft rejection, myocarditis, glaucoma, hypertension, pulmonary hypertension, malignant hypertension, and/or Alzheimer's disease.
摘要翻译：本发明涉及包含SEQ ID No.1，SEQ ID No.2，SEQ ID No.3和/或与SEQ ID No.1，SEQ ID No.2，SEQ ID No.3的核酸序列至少80％同一性的核酸序列或由SEQ ID NO： SEQ ID No.1,2和3用于治疗和/或诊断自身免疫疾病，其中自身免疫疾病是心肌病，扩张型心肌病（DCM），围产期心肌病（PPCM），特发性心肌病，恰加斯氏病，查加斯巨结肠，查加斯巨大食管，恰加斯神经病，良性前列腺增生症，硬皮病，牛皮癣，雷诺综合征，前风疹，肾同种异体移植排斥，心肌炎，青光眼，高血压，肺动脉高压，恶性高血压和/或阿尔茨海默病。

29. 发明授权

US08710088B2 Pharmaceutical and diagnostic compositions for use in the treatment and diagnosis of neurodegenerative diseases or amyloid diseases 失效
标题翻译：用于治疗和诊断神经变性疾病或淀粉样蛋白病的药物和诊断组合物
公开(公告)号：US08710088B2
公开(公告)日：2014-04-29
申请号：US10589276
申请日：2005-02-11
申请人： Erich Wanker , Sabine Engemann , Susanne Rautenberg , Annett Boeddrich , Phoebe Markovic , Dagmar Ehrnhöfer , Martin Herbst , Jacqueline Walther
发明人： Erich Wanker , Sabine Engemann , Susanne Rautenberg , Annett Boeddrich , Phoebe Markovic , Dagmar Ehrnhöfer , Martin Herbst , Jacqueline Walther
IPC分类号： A61K31/425
CPC分类号： A61K31/517 , A61K31/00 , A61K31/122 , A61K31/136 , A61K31/18 , A61K31/473 , A61K31/4745 , A61K31/496 , A61K31/538 , A61K31/65 , A61K49/0002 , A61K51/04
摘要： The present invention relates to pharmaceutical and diagnostic compositions as well as to the use of the active substances contained therein for preparing a pharmaceutical or a diagnostic composition for the treatment or diagnosis of neurodegenerative disorders or amyloid diseases.
摘要翻译：本发明涉及药物和诊断组合物以及其中所含的活性物质用于制备用于治疗或诊断神经变性疾病或淀粉样蛋白病的药物或诊断组合物的用途。

30. 发明授权

US08420386B2 Transposon-based targeting system 有权
标题翻译：基于转座子的靶向系统
公开(公告)号：US08420386B2
公开(公告)日：2013-04-16
申请号：US10544971
申请日：2004-02-10
申请人： Zoltan Ivics , Zsuzsanna Izsvak
发明人： Zoltan Ivics , Zsuzsanna Izsvak
IPC分类号： C12N15/00 , C12N15/87 , C12N15/64 , A61K48/00
CPC分类号： C12N15/90
摘要： The present invention relates to a targeting system comprising, preferably as distinct components (a) a transposon which is devoid of polynucleotide encoding a functional transposase comprising (aa) a polynucleotide of interest and; (ab) a DNA sequence specifically recognized by a DNA binding domain; and (ba) a fusion protein comprising (i) said DNA binding domain; or (ii) a (poly)peptide binding domain binding to a (poly)peptide comprising said DNA binding domain; and (iii) a DNA targeting domain; or (iv) a (poly)peptide binding domain that binds to a cellular or engineered (poly)peptide that comprises a DNA targeting domain; or (bb) a polynucleotide encoding the fusion protein of (ba); and (ca) a transposase or a fragment or derivative thereof having transposase function; or (cb) a polynucleotide encoding the transposase or fragment or derivative thereof having transposase function of (ca).
摘要翻译：本发明涉及靶向系统，其优选包含不同的组分（a）转座子，其不含编码功能性转座酶的多核苷酸，所述多核苷酸包含（aa）感兴趣的多核苷酸; （ab）由DNA结合结构域特异识别的DNA序列; 和（ba）融合蛋白，其包含（i）所述DNA结合结构域; 或（ii）与包含所述DNA结合结构域的（多）肽结合的（多）肽结合结构域; 和（iii）DNA靶向结构域; 或（iv）与包含DNA靶向结构域的细胞或工程化（多）肽结合的（多）肽结合结构域; 或（bb）编码（ba）的融合蛋白的多核苷酸; 和（ca）具有转座酶功能的转座酶或其片段或衍生物; 或（cb）编码具有（ca）的转座酶功能的转座酶或其片段或衍生物的多核苷酸。

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