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    • 22. 发明授权
    • Device for varying and adjusting transmitted illumination for microscopes
    • 用于显微镜变化和调整透射照明的装置
    • US07692857B2
    • 2010-04-06
    • US11539002
    • 2006-10-05
    • Johannes KnoblichTobias KaufholdDetlef Hein
    • Johannes KnoblichTobias KaufholdDetlef Hein
    • G02B21/06B02B21/00
    • G02B21/125G02B21/06
    • The present invention serves to vary and adjust the transmitted light illumination in microscopes, particularly with respect to the numerous, different illumination situations. The device, according to the invention comprises modules for darkfield illumination, brightfield illumination, and/or diffuse illumination and/or for adapting the object field in which an illumination unit can be selectively coupled to different modules and in which actuators are provided for implementing the adjustments within the modules and for producing the desired connections, these actuators being operated by means of operating elements of a control unit. The adjustments within the modules and the implemented connections are detected and are stored in the control unit so as to be reproducible. The proposed solution makes possible a broad application by means of an ergonomic arrangement of the operating elements and adjusting and/or changing the illumination situations in a simple and reproducible manner.
    • 本发明用于在显微镜中改变和调节透射光照明,特别是关于许多不同照明情况。 根据本发明的装置包括用于暗场照明,明场照明和/或漫射照明的模块和/或用于适配对象场,其中照明单元可以选择性地耦合到不同的模块,并且其中提供致动器用于实现 模块内的调整和用于产生所需的连接,这些致动器通过控制单元的操作元件操作。 检测模块内的调整和实现的连接,并将其存储在控制单元中以便可再现。 所提出的解决方案可以通过操作元件的人机工程学布置来广泛应用,并以简单和可再现的方式调整和/或改变照明情况。
    • 23. 发明授权
    • Microscope, particularly a laser scanning microscope with adaptive optical arrangement
    • 显微镜,特别是具有自适应光学布置的激光扫描显微镜
    • US07633053B2
    • 2009-12-15
    • US10461234
    • 2003-06-13
    • Ralf WolleschenskyMichael Kempe
    • Ralf WolleschenskyMichael Kempe
    • H01J3/14G02B7/04G02B17/00
    • G02B21/002G02B26/06
    • A microscope, particularly a laser scanning microscope, with an adaptive optical device in the microscope beam path, comprising two reflective adaptive elements, at least one of which is constructed as an adaptive optical element, both of which are oriented with their reflector surface vertical to the optical axes of the microscope beam path, and a polarizing beam splitter whose splitter layer is located in the vertex of two orthogonal arms of the microscope beam path or two orthogonal portions of a folded microscope beam path, wherein a first adaptive element is associated with one arm and the other adaptive element is associated with the second arm, and a quarter-wave plate is located in each arm between the beam splitter and reflective adaptive element, and a detection device to which the detection light is directed and which is linked to the adaptive elements by evaluating and adjusting devices.
    • 在显微镜光路中具有自适应光学装置的显微镜,特别是激光扫描显微镜,包括两个反射自适应元件,其中至少一个被构造为自适应光学元件,它们的反射器表面垂直于 显微镜光束路径的光轴和分束器层位于显微镜光束路径的两个正交臂的顶点或折叠显微镜光束路径的两个正交部分的顶点的偏振分束器,其中第一自适应元件与 一个臂和另一个自适应元件与第二臂相关联,四分之一波片位于分束器和反射自适应元件之间的每个臂中,以及检测装置,检测光被引导到该检测装置, 通过评估和调整设备的自适应元件。
    • 24. 发明授权
    • Arrangement and method for compensation of the temperature dependency of detectors in spectrometers
    • 用于补偿光谱仪中检测器的温度依赖性的布置和方法
    • US07573023B2
    • 2009-08-11
    • US11335937
    • 2006-01-20
    • Felix KerstanUlrich Zeh
    • Felix KerstanUlrich Zeh
    • H01J7/24
    • G01J3/02G01J3/0286G01J3/2803
    • The present invention is directed to an arrangement and the associated method for the compensation of the temperature dependency of detectors in spectrometers. In the solution according to the invention, the arrangement for compensation of the temperature dependency of detectors in spectrometers comprises an illumination unit, an entrance slit, an imaging grating, a detector and a controlling and evaluating unit. A second temperature gauge for the ambient temperature is provided in addition to an existing first temperature gauge and a temperature regulating unit. In the method according to the invention, a temperature regulating unit is controlled in such a way by a controlling and evaluating unit in the evaluation of the measurement values determined by two temperature gauges that the temperature of the detector remains constant. With the arrangement according to the invention, the cross-influence of the environment on the detector can be compensated so that the stabilization of the detector temperature is improved. Improved stabilization of the detector temperature is ensured by the additional component of ambient temperature.
    • 本发明涉及一种用于补偿光谱仪中检测器的温度依赖性的布置和相关方法。 在根据本发明的解决方案中,用于补偿光谱仪中检测器的温度依赖性的装置包括照明单元,入口狭缝,成像光栅,检测器和控制和评估单元。 除了现有的第一温度计和温度调节单元之外,还提供了用于环境温度的第二温度计。 在根据本发明的方法中,温度调节单元通过控制和评估单元在由两个温度计确定的测量值的评估中被控制,使得检测器的温度保持恒定。 利用根据本发明的布置,可以补偿环境对检测器的交叉影响,从而提高检测器温度的稳定性。 通过环境温度的附加组件确保提高检测器温度的稳定性。
    • 26. 发明授权
    • Microscope tube
    • 显微镜管
    • US07522336B2
    • 2009-04-21
    • US11241895
    • 2005-09-30
    • Andreas HermannJoerg SprengerHubert Wahl
    • Andreas HermannJoerg SprengerHubert Wahl
    • G02B21/22
    • G02B21/20G02B21/24
    • An adjustable microscope tube for a microscope includes, in this order, along its beam path coming from an entrance to the microscope tube: an optical system, which images a first intermediate image to infinity; at least one deflecting element, which folds the parallel beam path following the optical system, and collecting optics, arranged following the deflecting element in the beam path, for imaging the first intermediate image, which has been imaged to infinity, onto a second intermediate image, wherein the length of at least one portion of the folded, parallel beam path can be changed by displacement of the deflecting element relative to the optical system.
    • 用于显微镜的可调节显微镜管依次包括从入口到显微镜管的光束路径:将第一中间图像成像为无穷远的光学系统; 至少一个折射元件,其折叠在光学系统之后的平行光束路径,以及收集光学元件,其布置在光束路径中的偏转元件之后,用于将已被成像为无限远的第一中间图像成像到第二中间图像 其中折叠的平行光束路径的至少一部分的长度可以通过偏转元件相对于光学系统的位移而改变。
    • 28. 发明授权
    • Method for determining the focal position during imaging of a sample using an inclined position receiving device
    • 用于在样品成像期间确定焦点位置的方法和阵列
    • US07488924B2
    • 2009-02-10
    • US10554899
    • 2004-04-27
    • Daniel BublitzDieter GraefePeter Westphal
    • Daniel BublitzDieter GraefePeter Westphal
    • G02B7/04G02B27/40G02B27/64
    • G02B21/244G02B7/32G02B21/245
    • The invention refers to a process for determining the focus position when imaging a specimen (4) with a field stop imaged onto the specimen detecting this image using a position-sensitive receiving-device inclined relative to the field stop defining the focus position by means of intensity distribution in the receiving device. The invention also refers to set-ups as regards implementation of the process according to the invention.According to the invention, in a process of the above-mentioned type, imaging of the field stop onto the specimen (4) is at least partially superposed by an optical lattice; the position-sensitive receiving device is used to determine intensity values for the light reflected by the specimen; these intensity values are assigned to positions in the receiving device; position-related contrast values are determined from the position-related intensity values; the position of the contrast focus in the receiving device as equivalent of the current focus position is determined using these contrast values.
    • 一种用于通过利用接收装置中的强度分布相对于通过强度分布定义聚焦位置的场停止而倾斜的位置敏感的接收装置对具有使用场停止成像的样本成像到检测该图像的样本上的确定焦点位置的处理。 本发明还包括用于实施根据本发明的方法的装置。 根据本发明,在上述类型的过程中,场停止物到样本上的成像至少部分地被光栅重叠; 位置敏感接收装置用于确定由样本反射的光的强度值; 这些强度值被分配给接收装置中的位置; 与位置相关的强度值确定位置相关的对比度值; 使用这些对比度值确定接收装置中的对比度聚焦的位置等同于当前焦点位置。
    • 29. 发明申请
    • MICROSCOPE OBJECTIVE
    • MICROSCOPE目标
    • US20080247050A1
    • 2008-10-09
    • US12053368
    • 2008-03-21
    • Renhu ShiAnke VogelgsangThomas BocherWerner Kleinschmidt
    • Renhu ShiAnke VogelgsangThomas BocherWerner Kleinschmidt
    • G02B21/02
    • G02B21/02G02B27/52
    • The invention relates to a microscope objective which consists of at least four lenses or groups of lenses and can preferably be used to improve image contrast.According to the invention, a phase plate, aligned concentrically to the optical axis, can be integrated into and taken out of the air space between the first lens and the second lens, as viewed from the object side.The defined arrangement of the phase plate and the associated shift of the real pupil into the air space between the first two lenses or groups of lenses, respectively, of the microscope objective allows a microscope objective, initially designed as a bright-field variant, to be redesigned as a phase contrast variant with relative ease.
    • 本发明涉及由至少四个透镜或透镜组组成的显微镜物镜,并且可以优选地用于改善图像对比度。 根据本发明,从对象侧观察,与光轴同心对准的相位板可以集成到第一透镜和第二透镜之间的空间中并从其中取出。 相位板的限定布置以及分别在显微镜物镜的前两个透镜或透镜组之间的真实光瞳相关位移到空间中允许将最初被设计为亮场变体的显微镜物镜 相对容易地重新设计为相位差变体。