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21. 发明授权

US07935843B2 Functionalized diphenolics and absorbable polymers therefrom 有权
标题翻译：官能化二元酚和可吸收的聚合物
公开(公告)号：US07935843B2
公开(公告)日：2011-05-03
申请号：US11608259
申请日：2006-12-08
申请人： Rao S Bezwada
发明人： Rao S Bezwada
IPC分类号： C07C229/00
CPC分类号： A61L31/10 , A61L27/18 , A61L27/58 , A61L31/06 , A61L31/148 , C07K5/06078 , C08L67/04
摘要： The present invention relates to dephenolic compounds, an example of which is shown below, which are functionalized, and polymers formed from the same. Polymers formed from the functionalized diphenolics are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.
摘要翻译：本发明涉及脱模化合物，其实例如下所示，其被官能化，和由其形成的聚合物。由功能性二元酚形成的聚合物预期具有可控的降解特征，使得它们能够在期望的时间范围内释放活性组分。聚合物也预期在各种医疗应用中是有用的。

22. 发明申请

US20100152272A1 FUNCTIONALIZED DRUGS AND POLYMERS THEREFROM 有权
标题翻译：功能性药物和聚合物
公开(公告)号：US20100152272A1
公开(公告)日：2010-06-17
申请号：US12706735
申请日：2010-02-17
申请人： Rao S. Bezwada
发明人： Rao S. Bezwada
IPC分类号： A61K31/405 , A61K31/135 , A61K31/192 , A61K31/167 , A61K31/355 , A61K31/352 , C07D311/02 , A61K31/09 , C07C233/02 , C07C43/275 , C07C57/30 , C07D209/26 , C07C57/03 , C07C233/25 , C07D311/06
CPC分类号： A61K9/1647 , A61K9/0058 , A61K31/00 , A61K31/05 , A61K31/185 , A61K31/192 , A61K31/343 , A61K31/352 , A61K31/353 , A61K31/381 , A61K31/403 , A61K31/404 , A61K31/405 , A61K31/4164 , A61K31/428 , A61K31/439 , A61K31/445 , A61K31/47 , A61K31/485 , A61K31/535 , A61K31/7135 , A61K47/51 , A61L31/10 , C07C69/734 , C07C69/92 , C08G18/3206 , C08G18/711 , C08G18/771 , C08G18/797 , C08L67/04
摘要： Compounds selected from: where DRUG-OH, DRUG-COOH and DRUG-NH2 are biologically active compounds; each X is independently selected from —CH2COO— (glycolic acid moiety), —CH(CH3)COO— (lactic acid moiety), —CH2CH2OCH2COO— (dioxanone moiety), —CH2CH2CH2CH2CH2COO— (caprolactone moiety), —(CH2)yCOO—, where y is 2-4 or 6-24 and —(CH2CH2O)zCH2COO—, where z is 2-24; each Y is independently selected from —COCH2O— (glycolic ester moiety), —COCH(CH3)O— (lactic ester moiety), —COCH2OCH2CH2O— (dioxanone ester moiety), —COCH2CH2CH2CH2CH2O— (caprolactone ester moiety), —CO(CH2)mO—, where m is 2-4 or 6-24 and —COCH2O(CH2CH2O)n— where n is between 2-24; R′ is hydrogen, benzyl or an alkyl group, the alkyl group being either straight-chained or branched; and p is 1-6. Multi-functional compounds and drug dimers, oligomers and polymers are also disclosed.
摘要翻译：选自：其中DRUG-OH，DRUG-COOH和DRUG-NH 2是生物活性化合物的化合物; 每个X独立地选自-CH 2 COO-（乙醇酸部分），-CH（CH 3）COO-（乳酸部分），-CH 2 CH 2 OCH 2 COO-（二恶烷酮部分），-CH 2 CH 2 CH 2 CH 2 CH 2 COO-（己内酯部分）， - （CH 2）y COO- 其中y为2-4或6-24和 - （CH2CH2O）zCH2COO-，其中z为2-24; 每个Y独立地选自-COCH2O-（乙醇酸酯部分），-COCH（CH3）O-（乳酸酯部分），-COCH2OCH2CH2O-（二恶烷酮酯部分），-COCH2CH2CH2CH2CH2O-（己内酯酯部分），-CO ）mO-，其中m为2-4或6-24，-COCH 2 O（CH 2 CH 2 O）n - ，其中n为2-24; R'是氢，苄基或烷基，烷基是直链或支链的; p为1-6。还公开了多功能化合物和药物二聚体，低聚物和聚合物。

23. 发明授权

US09328192B2 Bio-based monomers and polymers 有权
标题翻译：生物基单体和聚合物
公开(公告)号：US09328192B2
公开(公告)日：2016-05-03
申请号：US14645522
申请日：2015-03-12
申请人： Bezwada Biomedical, LLC
发明人： Rao S Bezwada , Neeti Srivastava
IPC分类号： C08G18/76 , C08G71/02 , C08G69/00 , C08G73/02 , C08G18/60 , C08G18/77 , C08G18/81 , C07C265/14
CPC分类号： C08G18/7657 , C07C265/14 , C08G18/603 , C08G18/771 , C08G18/8125 , C08G69/00 , C08G71/02 , C08G73/02 , C08G2230/00 , Y10T428/1352 , Y10T428/1355 , Y10T428/1393 , Y10T428/24999 , Y10T428/249991 , Y10T428/2804 , Y10T428/2896 , Y10T428/31551 , Y10T428/31605 , Y10T442/20
摘要： Described are novel ricinoleic acid/12-hydroxy stearic acid-based diisocyanates, which are useful as monomers to form polymers, which have applications inter alia as medical devices.
摘要翻译：描述了新颖的蓖麻油酸/ 12-羟基硬脂酸基二异氰酸酯，其可用作形成聚合物的单体，其尤其可用作医疗装置。

24. 再颁专利

USRE45548E1 Functionalized drugs and polymers derived therefrom 有权
标题翻译：功能化药物和衍生自其的聚合物
公开(公告)号：USRE45548E1
公开(公告)日：2015-06-09
申请号：US14049262
申请日：2013-10-09
申请人： Rao S. Bezwada
发明人： Rao S. Bezwada
IPC分类号： A61K9/14 , A61K9/16 , A61K47/48
CPC分类号： A61K9/1647 , A61K9/0058 , A61K31/00 , A61K31/05 , A61K31/185 , A61K31/192 , A61K31/343 , A61K31/352 , A61K31/353 , A61K31/381 , A61K31/403 , A61K31/404 , A61K31/405 , A61K31/4164 , A61K31/428 , A61K31/439 , A61K31/445 , A61K31/47 , A61K31/485 , A61K31/535 , A61K31/7135 , A61K47/51 , A61L31/10 , C07C69/734 , C07C69/92 , C08G18/3206 , C08G18/711 , C08G18/771 , C08G18/797 , C08L67/04
摘要： Compounds selected from: where DRUG-OH, DRUG-COOH and DRUG-NH2 are biologically active compounds; each X is independently selected from —CH2COO— (glycolic acid moiety), —CH(CH3)COO— (lactic acid moiety), —CH2CH2OCH2COO— (dioxanone moiety), —CH2CH2CH2CH2CH2COO— (caprolactone moiety), —(CH2)yCOO—, where y is 2-4 or 6-24 and —(CH2CH2O)zCH2C—, where z is 2-24; each Y is independently selected from —COCH2O— (glycolic ester moiety), —COCH(CH3)O— (lactic ester moiety), —COCH2OCH2CH2O— (dioxanone ester moiety), —COCH2CH2CH2CH2CH2O— (caprolactone ester moiety), —CO(CH2)mO—, where m is 2-4 or 6-24 and —COCH2O(CH2CH2O)n— where n is between 2-24; R′ is hydrogen, benzyl or an alkyl group, the alkyl group being either straight-chained or branched; and p is 1-6. Multi-functional compounds and drug dimers, oligomers and polymers are also disclosed.
摘要翻译：选自：其中DRUG-OH，DRUG-COOH和DRUG-NH 2是生物活性化合物的化合物; 每个X独立地选自-CH 2 COO-（乙醇酸部分），-CH（CH 3）COO-（乳酸部分），-CH 2 CH 2 OCH 2 COO-（二恶烷酮部分），-CH 2 CH 2 CH 2 CH 2 CH 2 COO-（己内酯部分）， - （CH 2）y COO- 其中y为2-4或6-24和 - （CH2CH2O）zCH2C-，其中z为2-24; 每个Y独立地选自-COCH2O-（乙醇酸酯部分），-COCH（CH3）O-（乳酸酯部分），-COCH2OCH2CH2O-（二恶烷酮酯部分），-COCH2CH2CH2CH2CH2O-（己内酯酯部分），-CO ）mO-，其中m为2-4或6-24，-COCH 2 O（CH 2 CH 2 O）n - ，其中n为2-24; R'是氢，苄基或烷基，烷基是直链或支链的; p为1-6。还公开了多功能化合物和药物二聚体，低聚物和聚合物。

25. 发明授权

US09045396B2 Hydrolysable linkers and cross-linkers for absorbable polymers 有权
标题翻译：可水解接头和可吸收聚合物的交联剂
公开(公告)号：US09045396B2
公开(公告)日：2015-06-02
申请号：US14180561
申请日：2014-02-14
申请人： Bezwada Biomedical, LLC
发明人： Rao S Bezwada
IPC分类号： C07C69/74 , C07C265/12 , A47F5/00 , B65D25/22 , C07C229/60 , C07C217/84
CPC分类号： C07C265/12 , A47F5/0006 , A61L17/00 , A61L17/105 , A61L17/12 , A61L17/145 , A61L24/06 , A61L27/18 , A61L27/34 , A61L27/52 , A61L27/58 , A61L31/10 , A61L31/145 , A61L31/148 , B65D25/22 , C07C69/34 , C07C69/67 , C07C69/708 , C07C205/37 , C07C205/43 , C07C205/57 , C07C217/84 , C07C219/34 , C07C225/22 , C07C229/18 , C07C229/60 , C07C235/16 , C08G63/16 , C08G63/916 , Y02W90/13 , Y10T24/44291 , Y10T24/51 , Y10T428/139 , Y10T442/10 , C08L67/04
摘要： The present invention relates to the discovery of new class of linear and multiarmed hydrolysable linkers and cross linkers for use in the synthesis of biodegradable polymers such as, polyesters, polyurethanes, polyamides, polyureas and degradable epoxy amine resin. The linear and multiarmed hydrolysable linkers of the present invention include symmetrical and/or unsymmetrical ether carboxylic acids, amines, amide diols, amine polyols and isocyanates.
摘要翻译：本发明涉及用于合成可生物降解聚合物如聚酯，聚氨酯，聚酰胺，聚脲和可降解环氧胺树脂的新类型的线性和多臂可水解连接体和交联剂的发现。本发明的线性和多臂可水解接头包括对称和/或不对称的醚羧酸，胺，酰胺二醇，胺多元醇和异氰酸酯。

26. 发明授权

US09012677B2 Amino acid derivatives and absorbable polymers therefrom 有权
标题翻译：氨基酸衍生物和可吸收的聚合物
公开(公告)号：US09012677B2
公开(公告)日：2015-04-21
申请号：US14542254
申请日：2014-11-14
申请人： Bezwada Biomedical, LLC
发明人： Rao S Bezwada
IPC分类号： C07C229/40 , A61K47/34 , A61L31/06 , A61L24/04 , A61L27/18 , A61L17/10 , A61L15/26 , A61L26/00
CPC分类号： C07C235/12 , A61K47/34 , A61L15/26 , A61L17/10 , A61L24/046 , A61L26/0019 , A61L27/18 , A61L31/06 , A61L31/10 , A61L2420/00 , C07C229/36 , C07C229/42 , C07C235/10 , C07C237/36 , C07C265/12 , C07C265/14 , C08G18/38 , C08G18/48 , C08G18/4837 , C08G18/6607 , C08G18/771 , C08G18/7812 , C08G2101/00 , Y10T428/139 , Y10T428/249921 , Y10T442/10 , C08L77/04
摘要： The present invention relates to the discovery of new class of hydrolysable amino acid derivatives and absorbable polyester amides, polyamides, polyepoxides, polyureas and polyurethanes prepared therefrom. The resultant absorbable polymers are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention, bone wax formulations, medical device coatings, stents, stent coatings, highly porous foams, reticulated foams, wound care, cardiovascular applications, orthopedic devices, surface modifying agents and other implantable medical devices. In addition, these absorbable polymers should have a controlled degradation profile.
摘要翻译：本发明涉及从其制备的新类可水解氨基酸衍生物和可吸收聚酯酰胺，聚酰胺，聚环氧化物，聚脲和聚氨酯的发现。所得的可吸收聚合物可用于药物递送，组织工程，组织粘合剂，防粘连，骨蜡制剂，医疗器械涂层，支架，支架涂层，高度多孔泡沫，网状泡沫，伤口护理，心血管应用，矫形装置，表面修饰药剂和其他可植入医疗器械。此外，这些可吸收聚合物应具有受控的降解特征。

27. 发明授权

US08754135B2 Functionalized non-phenolic amino acids and absorbable polymers therefrom 有权
标题翻译：官能化的非酚类氨基酸和可吸收的聚合物
公开(公告)号：US08754135B2
公开(公告)日：2014-06-17
申请号：US13961309
申请日：2013-08-07
申请人： Bezwada Biomedical, LLC
发明人： Rao S Bezwada
IPC分类号： A61K47/30
CPC分类号： A61K47/34 , A61K9/0024 , A61L27/227 , A61L27/54 , A61L27/58 , A61L31/047 , A61L31/148 , A61L31/16 , A61L2300/00 , C07C235/12 , Y10T428/1362 , Y10T428/1397 , Y10T442/40 , Y10T442/50
摘要： The present invention relates to compound of formula I, which are functionalized, non-phenolic amino acids, and polymers formed from the same. Polymers formed from the functionalized amino acids are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.
摘要翻译：本发明涉及式I化合物，其是官能化的，非酚类氨基酸，和由其形成的聚合物。由官能化氨基酸形成的聚合物预期具有可控的降解特征，使得它们能够在期望的时间范围内释放活性组分。聚合物也预期在各种医疗应用中是有用的。

28. 发明授权

US08664429B2 Hydrolysable linkers and cross-linkers for absorbable polymers 有权
标题翻译：可水解接头和可吸收聚合物的交联剂
公开(公告)号：US08664429B2
公开(公告)日：2014-03-04
申请号：US13672297
申请日：2012-11-08
申请人： Bezwada Biomedical, LLC
发明人： Rao S Bezwada
IPC分类号： C07C69/74
CPC分类号： C07C265/12 , A47F5/0006 , A61L17/00 , A61L17/105 , A61L17/12 , A61L17/145 , A61L24/06 , A61L27/18 , A61L27/34 , A61L27/52 , A61L27/58 , A61L31/10 , A61L31/145 , A61L31/148 , B65D25/22 , C07C69/34 , C07C69/67 , C07C69/708 , C07C205/37 , C07C205/43 , C07C205/57 , C07C217/84 , C07C219/34 , C07C225/22 , C07C229/18 , C07C229/60 , C07C235/16 , C08G63/16 , C08G63/916 , Y02W90/13 , Y10T24/44291 , Y10T24/51 , Y10T428/139 , Y10T442/10 , C08L67/04
摘要： The present invention relates to the discovery of new class of linear and multiarmed hydrolysable linkers and cross linkers for use in the synthesis of biodegradable polymers such as, polyesters, polyurethanes, polyamides, polyureas and degradable epoxy amine resin. The linear and multiarmed hydrolysable linkers of the present invention include symmetrical and/or unsymmetrical ether carboxylic acids, amines, amide diols, amine polyols and isocyanates.
摘要翻译：本发明涉及用于合成可生物降解聚合物如聚酯，聚氨酯，聚酰胺，聚脲和可降解环氧胺树脂的新类型的线性和多臂可水解连接体和交联剂的发现。本发明的线性和多臂可水解接头包括对称和/或不对称的醚羧酸，胺，酰胺二醇，胺多元醇和异氰酸酯。

29. 发明申请

US20130317120A1 FUNCTIONALIZED NON-PHENOLIC AMINO ACIDS AND ABSORBABLE POLYMERS THEREFROM 有权
公开(公告)号：US20130317120A1
公开(公告)日：2013-11-28
申请号：US13961309
申请日：2013-08-07
申请人： Bezwada Biomedical, LLC
发明人： Rao S. Bezwada
IPC分类号： A61K47/34
CPC分类号： A61K47/34 , A61K9/0024 , A61L27/227 , A61L27/54 , A61L27/58 , A61L31/047 , A61L31/148 , A61L31/16 , A61L2300/00 , C07C235/12 , Y10T428/1362 , Y10T428/1397 , Y10T442/40 , Y10T442/50
摘要： The present invention relates to compound of formula I, which are functionalized, non-phenolic amino acids, and polymers formed from the same. Polymers formed from the functionalized amino acids are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.

30. 发明授权

US08372882B2 Functionalized phenolic esters and amides and polymers therefrom 有权
标题翻译：官能化酚酯和酰胺及其聚合物
公开(公告)号：US08372882B2
公开(公告)日：2013-02-12
申请号：US12962195
申请日：2010-12-07
申请人： Rao S. Bezwada
发明人： Rao S. Bezwada
IPC分类号： A01N37/00
CPC分类号： A61K31/192 , A61K31/353 , A61K31/405 , C07C69/734 , C07C69/92
摘要： The present invention relates to a compound of the formula: R-AR—O—Y—R′ Wherein R represents one or more members selected from H, alkoxy, benzyloxy, aldehyde, halogen, carboxylic acid, —NO2, —NH2, —NHCOCH3, and —NH—Y—R′, which is attached directly to AR or attached through an aliphatic chain. The carboxylic acid moiety in R includes but is not limited to the following carboxylic acids: benzoic acids, cinnamic acids, ferulic acid, caffeic acid, syringic acid, salicyclic acid, vanillic acid, phenylacetic acids, phenylpropionic acids, and sinapinic acid.-AR—O— is a biologically active phenolic moiety comprising 1 to 6 substituted or unsubstituted aryl rings that are directly bonded to each other, fused together, or joined through a linking group. Y represents a member selected from: —COCH2O— (glycolic ester moiety) —COCH(CH3)O— (lactic ester moiety) —COCH2OCH2CH2O— (dioxanone ester moiety) —COCH2CH2CH2CH2CH2O— (caprolactone ester moiety) —CO(CH2)mO— where m is an integer between 2-4 and 6-24 inclusive —CO CH2O (CH2CH2O)n— where n is an integer between 2 and 24, inclusive; and R′ is either hydrogen or a benzyl or an alkyl group, the alkyl group being either straight-chained or branched. The resultant functionalized phenolic compounds, used singly or in combinations, and their polymers have controllable degradation profiles, releasing the active component over a desired time range. The polymers are useful for biomaterials and biomedical devices, wherein said biologically active phenolic moiety is a residue of a phenolic compound.
摘要翻译：本发明涉及式R-AR-O-Y-R'的化合物，其中R代表一个或多个选自H，烷氧基，苄氧基，醛，卤素，羧酸，-NO 2，-NH 2， NHCOCH 3和-NH-Y-R'，其直接连接到AR或通过脂族链连接。 R中的羧酸部分包括但不限于以下羧酸：苯甲酸，肉桂酸，阿魏酸，咖啡酸，丁香酸，水杨酸，香草酸，苯乙酸，苯基丙酸和芥子酸。 -AR-O-是包含1至6个取代或未取代的芳环的生物活性酚部分，其直接键合，稠合在一起或通过连接基团连接。 Y表示选自-COCH 2 O-（乙醇酸酯部分）-COCH（CH 3）O-（乳酸酯部分）-COCH 2 OCH 2 CH 2 O-（二氧杂环己酮酯部分）-COCH 2 CH 2 CH 2 CH 2 CH 2 O-（己内酯部分）-CO（CH 2）m O- 其中m是2-4和6-24之间的整数，包括-COCH 2 O（CH 2 CH 2 O）n - ，其中n是2和24之间的整数，包括端值; 并且R'是氢或苄基或烷基，烷基是直链或支链的。所得到的单独或组合使用的官能化酚类化合物及其聚合物具有可控的降解特征，在期望的时间范围内释放活性组分。聚合物可用于生物材料和生物医学装置，其中所述生物活性酚部分是酚类化合物的残基。

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