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21. 发明授权

US08150526B2 Retinal prosthesis 有权
标题翻译：视网膜假体
公开(公告)号：US08150526B2
公开(公告)日：2012-04-03
申请号：US12368150
申请日：2009-02-09
申请人： Yossi Gross , Shai Vaingast
发明人： Yossi Gross , Shai Vaingast
IPC分类号： A61N1/36
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/37217 , A61N1/3787 , H01L27/14621 , H01L27/14627 , H01L31/145
摘要： Apparatus is provided, including an external device, including a mount, which is placed in front of an eye of a subject. A laser is coupled to the mount and configured to emit toward the eye radiation that is outside of 380-750 nm. A partially-transparent mirror is coupled to the mount. An intraocular device is implanted entirely in the subject's eye, and includes a plurality of stimulating electrodes, and an energy receiver, which receives the radiation from the laser and generates a voltage drop in response thereto. A plurality of photosensors detect photons and generate a signal in response thereto. Driving circuitry is coupled to the energy receiver and to the photosensors, and receives the signals from the photosensors and utilizes the voltage drop to drive the electrodes to apply currents to the retina in response to the signals from the photosensors. Other embodiments are also described.
摘要翻译：提供了一种装置，包括外部装置，其包括安装件，该安装件放置在被检体的眼睛前方。激光器耦合到安装座并且被配置为朝向在380-750nm之外的眼睛辐射发射。部分透明的镜子连接到安装座。眼内装置完全植入受试者的眼睛，并且包括多个刺激电极和能量接收器，其接收来自激光器的辐射并响应于此产生电压降。多个光电传感器检测光子并响应于此产生信号。驱动电路耦合到能量接收器和光电传感器，并且接收来自光电传感器的信号，并且利用电压降来驱动电极，以响应于来自光电传感器的信号而向视网膜施加电流。还描述了其它实施例。

22. 发明授权

US08135478B2 Peltier unidirectional and selective nerve stimulation 有权
标题翻译：帕尔帖单向和选择性神经刺激
公开(公告)号：US08135478B2
公开(公告)日：2012-03-13
申请号：US12352644
申请日：2009-01-13
申请人： Yossi Gross
发明人： Yossi Gross
IPC分类号： A61N1/18
CPC分类号： A61F7/12 , A61F2007/0075 , A61F2007/126 , A61N1/0432 , A61N1/0551 , A61N1/36017 , A61N1/3605 , F25B21/02
摘要： Apparatus is provided including an assembly (22) and a control unit (36). The assembly (22) includes a housing (34) configured to be applied to a nerve (20) of a subject, and at least one cathode (30) and at least one Peltier cooler (32), which are fixed to the housing (34). The control unit (36) is configured to drive the cathode (30) to apply an activating current to the nerve (20) that generates action potentials traveling in first and second directions (38 and 40) in the nerve (20), and the Peltier cooler (32) to cool the nerve (20) sufficiently to block propagation of at least a portion of the cathode-generated action potentials traveling in the second direction (40). Other embodiments are also described.
摘要翻译：提供了包括组件（22）和控制单元（36）的设备。组件（22）包括构造成施加到受试者的神经（20）的壳体（34）和至少一个阴极（30）和至少一个珀尔帖冷却器（32），固定到壳体 34）。控制单元（36）被配置为驱动阴极（30）向神经（20）施加激活电流，所述神经（20）产生在神经（20）中的第一和第二方向（38和40）上行进的动作电位，并且珀尔帖冷却器（32）以充分地冷却神经（20）以阻止至少一部分在第二方向（40）上行进的阴极产生动作电位的传播。还描述了其它实施例。

23. 发明授权

US08088161B2 Compressed haptics 有权
标题翻译：压缩的触觉
公开(公告)号：US08088161B2
公开(公告)日：2012-01-03
申请号：US11193781
申请日：2005-07-28
申请人： Eli Aharoni , Yossi Gross , Gideon Dotan , Iden Avihar
发明人： Eli Aharoni , Yossi Gross , Gideon Dotan , Iden Avihar
IPC分类号： A61F2/16
CPC分类号： A61F2/1613 , A61F2/1662 , A61F2/1678 , A61F2220/0025 , A61F2250/0071
摘要： An injectable intraocular implant including an optics portion and a resilient, flexible haptics portion mounted coaxially with the optics portion and a method for inserting the implant into the eye.
摘要翻译：一种可注射的眼内植入物，其包括与所述光学部件同轴安装的光学部分和弹性的柔性触觉部分，以及用于将所述植入物插入所述眼睛中的方法。

24. 发明申请

US20110301670A1 TIBIAL NERVE STIMULATION 有权
标题翻译： TIBIAL神经刺激
公开(公告)号：US20110301670A1
公开(公告)日：2011-12-08
申请号：US12796102
申请日：2010-06-08
申请人： Yossi Gross , Noam Kinrot
发明人： Yossi Gross , Noam Kinrot
IPC分类号： A61N1/08 , A61N1/36
CPC分类号： A61N1/372 , A61N1/0556 , A61N1/0558 , A61N1/36071 , A61N1/36157 , A61N1/36171 , A61N1/37205 , A61N1/3756
摘要： Apparatus and methods are described, including identifying a subject as suffering from polyneuropathy. In response to the identifying, electrodes are placed within 1 mm of a tibial nerve of the subject, the electrodes being disposed on a housing that is at least partially flexible. The electrodes are driven to treat the polyneuropathy by driving a current into the tibial nerve. Other embodiments are also described.
摘要翻译：描述了装置和方法，包括识别受试者患有多发性神经病。响应于识别，将电极放置在受试者的胫骨神经的1mm内，电极设置在至少部分柔性的壳体上。通过驱动电流进入胫神经来驱动电极以治疗多发性神经病。还描述了其它实施例。

25. 发明申请

US20110282203A1 REFLECTANCE-FACILITATED ULTRASOUND TREATMENT AND MONITORING 有权
标题翻译：反射辅助超声治疗和监测
公开(公告)号：US20110282203A1
公开(公告)日：2011-11-17
申请号：US13015951
申请日：2011-01-28
申请人： Liat TSOREF , Yossi Gross
发明人： Liat TSOREF , Yossi Gross
IPC分类号： A61B8/14
CPC分类号： A61B34/20 , A61B8/0841 , A61B8/0883 , A61B8/12 , A61B8/445 , A61B8/481 , A61B8/5223 , A61B17/320016 , A61B17/320092 , A61B2017/00026 , A61B2017/00084 , A61B2017/00106 , A61B2017/00243 , A61B2017/320052 , A61B2018/00285 , A61B2034/2063 , A61B2090/3784 , A61N7/022 , A61N2007/0052 , A61N2007/0056 , A61N2007/0069 , A61N2007/0091
摘要： A method comprising providing a reflective region at a far side of tissue of a subject is provided. The method includes assessing whether the reflective region is in a desired location, by means of acoustic sensing; and in response to assessing that the reflective region is in the desired location, activating an ultrasound transducer to ablate the tissue by applying ultrasound energy to a near side of the tissue, such that at least a portion of the transmitted energy is reflected by the reflective region onto the tissue of the subject. Other embodiments are also described.
摘要翻译：提供了一种方法，包括在受试者的组织的远侧提供反射区域。该方法包括通过声学感测来评估反射区域是否在期望的位置; 并且响应于评估反射区域处于所需位置，激活超声换能器以通过向组织的近侧施加超声能量来消融组织，使得至少一部分透射能量被反射区域到受试者的组织上。还描述了其它实施例。

26. 发明申请

US20110178416A1 DEVICES AND METHODS FOR CONTROL OF BLOOD PRESSURE 有权
标题翻译：用于控制血压的装置和方法
公开(公告)号：US20110178416A1
公开(公告)日：2011-07-21
申请号：US13030384
申请日：2011-02-18
申请人： Yossi Gross , Itzik Avneri , Ori Weisberg , Moshe Eshkol
发明人： Yossi Gross , Itzik Avneri , Ori Weisberg , Moshe Eshkol
IPC分类号： A61B5/02
CPC分类号： A61M29/02 , A61F2/06 , A61F2/82 , A61F2/86 , A61F2002/825 , A61F2230/0019
摘要： Apparatus and methods are described including an implantable device shaped to define (a) at least two artery-contact regions, the artery-contact regions comprising struts that are configured to stretch an arterial wall by applying pressure to the arterial wall, and (b) at least two crimping regions that comprise locking mechanisms configured to prevent the crimping regions from becoming crimped due to pressure from the wall of the artery on the artery-contact regions. The crimping regions are configured to be crimped during insertion of the device, via a catheter, by the locking mechanisms being unlocked during insertion of the device. Other embodiments are also described.
摘要翻译：描述了一种装置和方法，其包括成形为限定（a）至少两个动脉接触区域的植入式装置，所述动脉接触区域包括支柱，所述支柱构造成通过向所述动脉壁施加压力来拉伸动脉壁，以及（b）包括锁定机构的至少两个压接区域，其构造成防止卷曲区域由于在动脉接触区域上的动脉壁的压力而变得卷曲。压接区域被构造成在插入设备期间通过导管被压接，所述锁定机构在插入设备期间被解锁。还描述了其它实施例。

27. 发明授权

US07951357B2 Implantable power sources and sensors 有权
标题翻译：可植入电源和传感器
公开(公告)号：US07951357B2
公开(公告)日：2011-05-31
申请号：US11632587
申请日：2005-07-13
申请人： Yossi Gross , Ben-Tsion Williger , Tehila Hyman , Tova Neufeld
发明人： Yossi Gross , Ben-Tsion Williger , Tehila Hyman , Tova Neufeld
IPC分类号： A61B5/00 , C07H21/04 , C07K14/00 , C12N15/85
CPC分类号： C07K14/43595 , A61B5/14532 , A61K49/0045 , A61K49/0047 , A61K49/0056 , C07K2319/60 , G01N33/54373
摘要： A protein is provided, including a glucose binding site, cyan fluorescent protein (CFP), and yellow fluorescent protein (YFP). The protein is configured such that binding of glucose to the glucose binding site causes a reduction in a distance between the CFP and the YFP. Substance monitoring apparatus (210) is also provided, including a semi-permeable barrier (212), adapted to be implanted in a body of a subject and to allow passage therethrough of a substance, while inhibiting passage therethrough of immune cells; and microorganisms (214), disposed within the semi-permeable barrier (212) so as to produce a measurable response to a level of the substance. A sensor (220) is adapted to measure the measurable response and not to measure a response of any mammalian cells that may be disposed within the semi-permeable barrier (212).
摘要翻译：提供蛋白质，包括葡萄糖结合位点，青色荧光蛋白（CFP）和黄色荧光蛋白（YFP）。配置蛋白质使得葡萄糖与葡萄糖结合位点的结合导致CFP和YFP之间的距离减小。还提供了物质监测设备（210），其包括半渗透屏障（212），其适于植入受试者体内并允许物质通过，同时抑制免疫细胞通过; 和微生物（214），其设置在半渗透屏障（212）内，以便产生对物质水平的可测量响应。传感器（220）适于测量可测量的响应并且不测量可以设置在半渗透屏障（212）内的任何哺乳动物细胞的响应。

28. 发明申请

US20110118773A1 ELLIPTICAL DEVICE FOR TREATING AFTERLOAD 审中-公开
标题翻译：用于处理卸载的ELLIPTICAL装置
公开(公告)号：US20110118773A1
公开(公告)日：2011-05-19
申请号：US12959126
申请日：2010-12-02
申请人： Yossi Gross , Amir Dagan , Nitai Hanani
发明人： Yossi Gross , Amir Dagan , Nitai Hanani
IPC分类号： A61M29/00
CPC分类号： A61F2/82 , A61F2230/0008 , A61M2025/0681 , A61M2025/09183
摘要： Apparatus and methods are provided, including an elongate element that is inserted into a subject's artery via a catheter, the catheter being configured to be withdrawn from the artery subsequent to the insertion. Expandable elements are disposed on the elongate element, the expandable elements comprising respective distal tips that are substantially aligned with the elongate element. During insertion of the elongate element via the catheter, the expandable elements are in contracted states thereof. In response to the withdrawal of the catheter from the artery, the expandable elements cause the artery to change a shape thereof, by the expandable elements expanding such that the distal tips of the expandable elements contact respective contact points on the wall of the artery. Subsequently, the distal tips of the expandable elements are freed from the contact points upon pulling of the elongate element. Other embodiments are also described.
摘要翻译：提供了装置和方法，包括通过导管插入受试者的动脉的细长元件，该导管构造成在插入之后从动脉中取出。可膨胀元件设置在细长元件上，可膨胀元件包括与细长元件基本上对准的相应的远侧末端。在通过导管插入细长元件时，可膨胀元件处于收缩状态。响应于导管从动脉撤回，可膨胀元件使得动脉改变其形状，由可膨胀元件膨胀使得可膨胀元件的远侧末端接触动脉壁上的相应接触点。随后，在拉伸细长元件时，可膨胀元件的远端头部从接触点脱离。还描述了其它实施例。

29. 发明授权

US07918886B2 Double insertion intraocular implant 有权
标题翻译：双插入眼内植入物
公开(公告)号：US07918886B2
公开(公告)日：2011-04-05
申请号：US11420327
申请日：2006-05-25
申请人： Eli Aharoni , Yossi Gross
发明人： Eli Aharoni , Yossi Gross
IPC分类号： A61F2/16
CPC分类号： A61F2/1648 , A61F2/1651 , A61F2002/1699 , A61F2250/0053
摘要： An intraocular telescopic lens assembly including a negative lens having a negative lens optical axis, a positive lens having a positive lens optical axis and a spacer disposed intermediate the negative lens and the positive lens, the spacer being operative to maintain mutual orientation of the negative lens and the positive lens such that the negative lens optical axis is coaxial with the positive lens optical axis.
摘要翻译：一种眼内望远镜透镜组件，包括具有负透镜光轴的负透镜，具有正透镜光轴的正透镜和设置在负透镜和正透镜之间的间隔件，间隔件可操作以保持负透镜的相互取向和正透镜，使得负透镜光轴与正透镜光轴同轴。

30. 发明申请

US20100286767A1 ANNULOPLASTY RING WITH INTRA-RING ANCHORING 有权
标题翻译：环形锚固环与内环锚固
公开(公告)号：US20100286767A1
公开(公告)日：2010-11-11
申请号：US12437103
申请日：2009-05-07
申请人： Yuval Zipory , Oz Cabiri , Yossi Gross
发明人： Yuval Zipory , Oz Cabiri , Yossi Gross
IPC分类号： A61F2/24
CPC分类号： A61F2/2466 , A61B17/00234 , A61B17/064 , A61B17/068 , A61B2017/00243 , A61B2017/0647 , A61B2017/0649 , A61F2/2442 , A61F2/2445 , A61F2220/0016
摘要： Apparatus is provided that includes an annuloplasty system for use on a subject. The system includes an annuloplasty ring, which includes a sleeve having a lumen, and at least one anchor, shaped so as to define a coupling head and a tissue coupling element, which tissue coupling element is shaped so as to define a longitudinal axis, and is configured to penetrate cardiac tissue of the subject in a direction parallel to the longitudinal axis. The system further includes an anchor deployment manipulator, configured to be removably positioned within the lumen of the sleeve, and, while so positioned, to deploy the tissue coupling element from a distal end of the deployment manipulator through a wall of the sleeve into the cardiac tissue in the direction parallel to the longitudinal axis of the tissue coupling element and parallel to a central longitudinal axis through the distal end of the deployment manipulator.
摘要翻译：提供了包括用于受试者的瓣膜成形术系统的装置。该系统包括瓣环成形术环，其包括具有内腔的套筒和至少一个锚固件，该锚定件成形为限定联接头部和组织连接元件，该组织连接元件成形为限定纵向轴线，以及构造成在平行于纵向轴线的方向上穿透受试者的心脏组织。所述系统还包括锚定部署操纵器，其构造成可移除地定位在所述套管的内腔内，并且在如此定位的同时将所述组织连接元件从所述展开操纵器的远端部分穿过所述套筒的壁部分进入心脏组织在平行于组织联接元件的纵向轴线的方向上并且平行于通过展开机械手的远端的中心纵向轴线。

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