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21. 发明申请

US20130085728A1 Method And System For Phasing Individual Genomes In The Context Of Clinical Interpretation 有权
标题翻译：临床解释背景下个体基因组分型方法与系统
公开(公告)号：US20130085728A1
公开(公告)日：2013-04-04
申请号：US13487064
申请日：2012-06-01
申请人： Hua Tang , Michael Snyder , Jennifer Li-Pook-Than , Konrad J. Karczewski , Nicholas Johnson , Wing H. Wong
发明人： Hua Tang , Michael Snyder , Jennifer Li-Pook-Than , Konrad J. Karczewski , Nicholas Johnson , Wing H. Wong
IPC分类号： G06F19/00
CPC分类号： G06F19/22 , G06F19/18 , G06F19/24 , G06F19/34 , G16H20/10
摘要： The present disclosure presents a unified system to phase a personal genome for downstream clinical interpretation. In an embodiment, an initial phasing is generated using public datasets, such as haplotypes from the 1000 Genomes Project, and a phasing toolkit. A local perturbation algorithm is applied to improve long range phasing. If available, a Mendelian inheritance pipeline is applied to identify phasing of novel and rare variants. These datasets are merged, followed by correction by any experimental data. This allows for full clinical interpretation of the role of a group of variants in a gene, whether inherited or de novo variants.
摘要翻译：本公开提供了一个统一的系统，用于将个体基因组分阶段用于下游临床解释。在一个实施例中，使用公共数据集（例如来自1000基因组计划的单倍型）和定相工具包来生成初始定相。应用局部扰动算法来改善长距离定相。如果可用，应用孟德尔遗传管道来识别新颖和罕见的变种的定相。合并这些数据集，然后通过任何实验数据进行校正。这允许对基因中的一组变体的作用的全面临床解释，无论是遗传的还是从头的变体。

22. 发明申请

US20070280026A1 Low voltage memory device and method thereof 有权
标题翻译：低电压存储器件及其方法
公开(公告)号：US20070280026A1
公开(公告)日：2007-12-06
申请号：US11435942
申请日：2006-05-17
申请人： Bradford Hunter , David Burnett , Troy Cooper , Prashant Kenkare , Ravindraj Ramaraju , Andrew Russel , Shayan Zhang , Michael Snyder
发明人： Bradford Hunter , David Burnett , Troy Cooper , Prashant Kenkare , Ravindraj Ramaraju , Andrew Russel , Shayan Zhang , Michael Snyder
IPC分类号： G11C5/14
CPC分类号： G11C5/143 , G11C5/147
摘要： A device is disclosed having a low-voltage memory device. The device includes a first memory having a first memory topology and a second memory having a second memory topology, with both memories located in an integrated circuit. The first memory is a relatively high-density memory device, capable of storing large amounts of data relative to the second memory. The second memory is a low-voltage memory device capable of being accessed at low-voltages relative to the voltage at which the first memory can be accessed. Accordingly, the second memory is accessible when the integrated circuit is placed in a low-voltage mode of operation, which may represent a data retention state (sleep state) for the first memory or other portions of the integrated circuit. Thus, the device is able to store large amounts of data in the high density memory in a normal or active mode of operation, and also have access to the low-voltage memory during the low-voltage mode of operation.
摘要翻译：公开了一种具有低电压存储器件的器件。该设备包括具有第一存储器拓扑的第一存储器和具有第二存储器拓扑的第二存储器，其中两个存储器位于集成电路中。第一存储器是相对高密度存储器件，能够存储相对于第二存储器的大量数据。第二存储器是能够相对于可以访问第一存储器的电压的低电压访问的低电压存储器件。因此，当集成电路处于低电压工作模式时，第二存储器可访问，这可以表示第一存储器或集成电路的其它部分的数据保持状态（睡眠状态）。因此，该设备能够在正常或主动操作模式下将大量数据存储在高密度存储器中，并且还可以在低电压操作模式期间访问低电压存储器。

23. 发明申请

US20070131209A1 Electronic paintball marker 审中-公开
公开(公告)号：US20070131209A1
公开(公告)日：2007-06-14
申请号：US11603261
申请日：2006-11-21
申请人： John Campo , Michael Snyder , Robert Ballarini
发明人： John Campo , Michael Snyder , Robert Ballarini
IPC分类号： F41B11/00
CPC分类号： F41B11/71 , F41B11/57 , F41B11/62 , F41B11/723 , F41B11/73
摘要： An electronic paintball marker has a breech having an opening that receives a paintball to be fired, the paintball having substantially two positions within the breech, a loaded position and a firing position, and a bolt with two corresponding rearward and forward positions that moves the paintball between the loaded and firing positions. The marker also has a sensor in communication with an electronic controller and positioned to detect a paintball in the loaded position within the breech, wherein, when the sensor detects the paintball in the loaded position, the sensor sends a detection signal to the electronic controller which in turn allows the bolt to move from the rearward to the forward position. Finally, the marker has a trigger that sends a firing signal to the electronic controller, the firing signal initiating a firing sequence comprising the sensor detecting a paintball within the breech, the electronic controller moving the valve from the closed state to the open state, and firing the paintball.

24. 发明申请

US20060246112A1 SUSTAINED RELEASE OPHTHALMOLOGICAL DEVICE AND METHOD OF MAKING AND USING THE SAME 审中-公开
标题翻译：可持续发布的眼科装置及其制造和使用方法
公开(公告)号：US20060246112A1
公开(公告)日：2006-11-02
申请号：US11457628
申请日：2006-07-14
申请人： Michael Snyder , Eric Dobrusin
发明人： Michael Snyder , Eric Dobrusin
IPC分类号： A61F2/00
CPC分类号： A61F9/0017 , A61F2/147 , A61F2/1694 , A61F2002/1683 , A61F2210/0004 , A61F2250/0067 , A61F2250/0068 , Y10S623/901
摘要： An ophthalmological implant including a layer of pharmaceutical agent and an overlying layer of a bioerodible material, a biodegradable material a bioavailable material or a mixture thereof.
摘要翻译：一种眼科植入物，包括药剂层和生物可腐蚀材料的上层，可生物降解材料，生物可利用材料或其混合物。

25. 发明申请

US20060235068A1 OPHTHALMOLOGICAL SURGERY COLORANT AND DELIVERY SYSTEM 审中-公开
公开(公告)号：US20060235068A1
公开(公告)日：2006-10-19
申请号：US11426145
申请日：2006-06-23
申请人： Michael Snyder , Robert Cionni , Scott Burk
发明人： Michael Snyder , Robert Cionni , Scott Burk
IPC分类号： A61K31/404 , A61F9/00
CPC分类号： A61F9/0008 , Y10S623/905
摘要： Improved ophthalmological surgical methods, systems and devices, employing a colorant.
摘要翻译：改进的眼科手术方法，系统和装置，使用着色剂。

26. 发明申请

US20050021573A1 Primary-backup group with backup resources failover handler 有权
标题翻译：主备份组与备份资源故障转移处理程序
公开(公告)号：US20050021573A1
公开(公告)日：2005-01-27
申请号：US10626087
申请日：2003-07-24
申请人： Michael McDermott , Robert Miller , Michael Snyder , Kiswanto Thayib
发明人： Michael McDermott , Robert Miller , Michael Snyder , Kiswanto Thayib
IPC分类号： G06F12/00
CPC分类号： G06F11/2033 , G06F11/2025 , G06F11/2028 , G06F11/2069
摘要： Failover processing that accommodates failures of backup computing nodes and resources, such as data storage units and printers. Failure of a computing node that controls resources causes another computing node to assume control of the resources controlled by the failed node. Failure of the primary computing node causes another computing node, at either the same or at a different site, to be selected as the new primary node. Failure of a resource at the primary site causes the site with the next highest priority backup resource to become the new primary site. Failure of a backup computing node causes a new backup node at the same site as the failed backup node to replace the failed backup node as host for the site's resources. Backup mirroring data flows are then adjusted to reflect the new functions of the affected nodes.
摘要翻译：适应备份计算节点和资源（如数据存储单元和打印机）故障的故障转移处理。控制资源的计算节点的失败导致另一个计算节点承担由故障节点控制的资源的控制。主计算节点的故障导致在相同或不同站点处的另一个计算节点被选为新的主节点。主站点资源的故障导致具有次高优先级备份资源的站点成为新的主站点。备份计算节点的故障导致与故障备份节点位于同一站点的新备份节点将故障备份节点替换为站点资源的主机。然后调整备份镜像数据流以反映受影响节点的新功能。

27. 发明申请

US20230054347A1 OPHTHALMIC PROSTHETIC TO TREAT NEGATIVE AND POSITIVE DYSPHOTOPSIA 有权
公开(公告)号：US20230054347A1
公开(公告)日：2023-02-23
申请号：US17405741
申请日：2021-08-18
申请人： Michael Snyder
发明人： Michael Snyder
IPC分类号： A61F2/16
摘要： An ophthalmic prosthetic and method for correcting negative and positive dysphotopsia. The ophthalmic prosthetic comprises a peripheral light blocking implant member adapted to locate in a gap between an iris and an intraocular implant lens. The gap is between the anterior surface of the lens and the posterior portion of the iris. An opacity of the peripheral light blocking implant member is selectively positioned to block passage of light.

28. 发明授权

US08399383B2 Protein chips for high throughput screening of protein activity 有权
公开(公告)号：US08399383B2
公开(公告)日：2013-03-19
申请号：US09849781
申请日：2001-05-04
申请人： Michael Snyder , Mark Reed , Heng Zhu , James Frank Klemic
发明人： Michael Snyder , Mark Reed , Heng Zhu , James Frank Klemic
IPC分类号： C40B40/02 , C40B40/10
CPC分类号： C12Q1/485 , B01J19/0046 , B01J2219/00274 , B01J2219/00313 , B01J2219/00317 , B01J2219/00382 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00702 , B01J2219/00722 , B01J2219/00725 , B01L3/5085 , B82Y15/00 , B82Y30/00 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/5008 , G01N33/5041 , G01N33/543 , G01N33/54313 , G01N2500/00
摘要： The present invention relates to protein chips useful for the large-scale study of protein function where the chip contains densely packed reaction wells. The invention also relates to methods of using protein chips to assay simultaneously the presence, amount, and/or function of proteins present in a protein sample or on one protein chip, or to assay the presence, relative specificity, and binding affinity of each probe in a mixture of probes for each of the proteins on the chip. The invention also relates to methods of using the protein chips for high density and small volume chemical reactions. Also, the invention relates to polymers useful as protein chip substrates and methods of making protein chips. The invention further relates to compounds useful for the derivatization of protein chip substrates.

29. 发明授权

US08276035B1 High performance digital communications resiliency in a roamable virtual private network 有权
标题翻译：可漫游虚拟专用网络中的高性能数字通信弹性
公开(公告)号：US08276035B1
公开(公告)日：2012-09-25
申请号：US12435018
申请日：2009-05-04
申请人： Joseph T. Savarese , Erik Olson , Michael Snyder , David Thompson , Emil Sturniolo
发明人： Joseph T. Savarese , Erik Olson , Michael Snyder , David Thompson , Emil Sturniolo
IPC分类号： G06F11/00
CPC分类号： H04L1/0007 , H04L1/0057 , H04L1/188
摘要： There is a class of applications that favor expediency of the communications over reliability. Counter-intuitively, the reliability aspect of a protocol may cause sub-optimal performance when considering this special class of applications in some environments. To resolve this performance issue, the exemplary illustrative non-limiting protocol implementation favors timeliness over reliability by allowing for loss of data, thus providing a non-guaranteed, order sensitive level of service. Such features can be combined in the same system and data stream/channel with a guaranteed-reliable protocol to provide a roamable VPN simultaneously providing both guaranteed-reliable and real-time, dynamically adaptable performance.
摘要翻译：有一类应用程序可以通过可靠性来优化通信。反直觉地，在某些环境中考虑这种特殊类别的应用时，协议的可靠性方面可能会导致次优性能。为了解决这个性能问题，示例性的说明性非限制性协议实现通过允许数据丢失而有利于可靠性的及时性，从而提供非保证的订单敏感级别的服务。这些特征可以在相同的系统和数据流/信道中结合使用保证可靠的协议，以提供可漫游的VPN，同时提供可靠和实时的动态适应性能。

30. 发明申请

US20090266722A1 REUSABLE SHIPPING CONTAINER AND SYSTEMS THEREOF 审中-公开
标题翻译：可重复运输集装箱及其系统
公开(公告)号：US20090266722A1
公开(公告)日：2009-10-29
申请号：US12115057
申请日：2008-05-05
申请人： Jason Rogers , Danny Clark , Richard Speakman , Michael Snyder , Nissim Ozer , Gary Argabrite , Kent Dickinson
发明人： Jason Rogers , Danny Clark , Richard Speakman , Michael Snyder , Nissim Ozer , Gary Argabrite , Kent Dickinson
IPC分类号： B65D81/02
CPC分类号： B65D25/205 , B62B1/008 , B62B1/14 , B65D5/643 , B65D19/0016 , B65D21/0223 , B65D33/25 , B65D71/0096 , B65D71/04 , B65D81/03 , B65D81/051 , B65D81/052 , B65D81/127 , B65D81/1275 , B65D2101/00 , B65D2519/00268 , B65D2519/00288 , B65D2519/00318 , B65D2519/00333 , B65D2519/00945 , B65D2519/00965 , Y02W30/807
摘要： A container system includes a container for shipping a parcel and a labeling system for providing information about the shipping of the container, such as to/from information. The container system further includes a closure mechanism for closing the lid of the container, a protection system for protecting the item housed in the container, and a rail system for supporting the container and maintaining its structure.
摘要翻译：容器系统包括用于运送包裹的容器和用于提供关于容器的运输的信息的标签系统，诸如从/从信息。容器系统还包括用于封闭容器盖的封闭机构，用于保护容纳在容器中的物品的保护系统和用于支撑容器并维持其结构的轨道系统。

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