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21. 发明授权

US09069079B2 Obstacle detection system with ultrasonic sensors located at either side of a bumper, having own beam axes at an angle deflected in a horizontal direction from a surface-normal direction of the bumper 有权
标题翻译：具有位于保险杠两侧的超声波传感器的障碍物检测系统，其具有沿着保险杠的表面法线方向在水平方向上偏转的角度的自身梁轴
公开(公告)号：US09069079B2
公开(公告)日：2015-06-30
申请号：US13641312
申请日：2010-04-15
申请人： Takashi Tsuji , Naoya Azuma , Yasushi Nagano
发明人： Takashi Tsuji , Naoya Azuma , Yasushi Nagano
IPC分类号： G08B21/00 , G01S15/93 , G01S7/521 , B60R19/48
CPC分类号： G01S15/931 , B60R19/483 , G01S7/521 , G01S2015/938
摘要： An obstacle detection system includes ultrasonic sensors and a controller. The ultrasonic sensors include first and second ultrasonic sensors. Each of them is located at either side of a vehicle bumper so that its own beam axis has an angle deflected in a horizontal direction from a surface-normal direction of the bumper and is directed towards an intermediate portion of the bumper.
摘要翻译：障碍物检测系统包括超声波传感器和控制器。超声波传感器包括第一和第二超声波传感器。它们中的每一个位于车辆保险杠的任一侧，使得其自身的梁轴具有从保险杠的表面法线方向在水平方向上偏转的角度并且朝向保险杠的中间部分。

22. 发明授权

US08785462B2 5-hydroxypyrimidine-4-carboxamide derivative 有权
标题翻译： 5-羟基嘧啶-4-甲酰胺衍生物
公开(公告)号：US08785462B2
公开(公告)日：2014-07-22
申请号：US13503340
申请日：2010-10-20
申请人： Takeshi Kuribayashi , Hideki Kubota , Naoki Tanaka , Takeshi Fukuda , Takashi Tsuji , Riki Goto
发明人： Takeshi Kuribayashi , Hideki Kubota , Naoki Tanaka , Takeshi Fukuda , Takashi Tsuji , Riki Goto
IPC分类号： A61K31/505 , A61K31/40 , C07D239/02
CPC分类号： C07D401/06 , C07D401/14
摘要： The present invention provides a compound which enhances the production of erythropoietin. The present invention provides a compound represented by formula (1): [wherein, R1: formula (1A): [wherein, R4 and R5: H, halogen, or alkyl; R6: H, halogen, alkyl, or the like; R7: substitutable hydroxyalkyl, substitutable hydroxyhalo alkyl, substitutable alkoxyalkyl, or the like; substituent group α: oxo, hydroxy, amino, or the like; ring Q1: a monocyclic heterocyclic group; ring Q2: a monocyclic hydrocarbon ring group, or a monocyclic heterocyclic group; ring Q3: a monocyclic hydrocarbon ring group, or a monocyclic heterocyclic group; X: a single bond, methylene, ethylene, or the like]; R2: alkyl, or methylsulfanyl; and R3: H, or methyl], or the like.
摘要翻译：本发明提供了促进促红细胞生成素生成的化合物。本发明提供由式（1）表示的化合物：[其中，R1：式（1A）：[其中，R4和R5：H，卤素或烷基; R6：H，卤素，烷基等; R7：可取代的羟烷基，可取代的羟基卤代烷基，可取代的烷氧基烷基等; 取代基组α：氧代，羟基，氨基等; 环Q1：单环杂环基; 环Q2：单环烃环基或单环杂环基; 环Q3：单环烃环基或单环杂环基; X：单键，亚甲基，亚乙基等）; R2：烷基或甲硫基; 和R 3：H或甲基]等。

23. 发明授权

US08765669B2 Glycosylated GLP-1 peptide 有权
标题翻译：糖基化GLP-1肽
公开(公告)号：US08765669B2
公开(公告)日：2014-07-01
申请号：US12999654
申请日：2009-06-15
申请人： Yasuhiro Kajihara , Takashi Tsuji , Izumi Sakamoto , Yuri Nambu , Naohiro Hayashi , Kazuyuki Ishii , Kazuhiro Fukae , Katsunari Tezuka , Hiroaki Asai
发明人： Yasuhiro Kajihara , Takashi Tsuji , Izumi Sakamoto , Yuri Nambu , Naohiro Hayashi , Kazuyuki Ishii , Kazuhiro Fukae , Katsunari Tezuka , Hiroaki Asai
IPC分类号： A61K38/26 , A61P3/10 , A61P7/12 , C07K14/605 , C07K1/00 , C07K14/00 , C07K17/00
CPC分类号： C07K14/605 , A61K38/00
摘要： Oligosaccharide chain added GLP-1 peptides are more stable in blood and more active in controlling blood-sugar levels than GLP-1 peptides without added oligosaccharides. Oligosaccharide chain added GLP-1 peptides having GLP-1 activity include at least one or at least two amino acids each substituted with an oligosaccharide chain added amino acid in GLP-1; a peptide having the amino acid sequence of GLP-1 with deletion, substitution or addition of one or several amino acids; or a GLP-1 analog. Oligosaccharide chain added GLP-1 peptides with at least one amino acid substituted with an oligosaccharide chain added amino acid include an oligosaccharide chain with oligo hyaluronic acid. Oligosaccharide chain added amino acids include oligosaccharide chains attached to amino acids via linkers.
摘要翻译：添加糖链的GLP-1肽在血液中更稳定，并且在没有添加低聚糖的情况下比GLP-1肽更有效地控制血糖水平。具有GLP-1活性的添加糖链的GLP-1肽包括GLP-1中由糖链连接的氨基酸取代的至少一个或至少两个氨基酸; 具有GLP-1的氨基酸序列的肽，其具有缺失，取代或添加一个或几个氨基酸; 或GLP-1类似物。具有至少一个被寡糖链添加的氨基酸取代的氨基酸的添加糖链的GLP-1肽包括具有寡聚透明质酸的寡糖链。寡糖链添加的氨基酸包括通过接头连接到氨基酸的寡糖链。

24. 发明申请

US20140052167A1 METHOD OF PREPARING REGENERATED HAIR FOLLICLE GERM FOR TRANSPLANTATION IN WHICH HAIR COLOR IS CONTROLLED, COMPOSITION INCLUDING REGENERATED HAIR FOLLICLE GERM FOR TRANSPLANTATION, AND METHOD OF TRANSPLANTING REGENERATED HAIR FOLLICLE GERM 有权
标题翻译：制备再生头发毛发的方法，用于移植头发颜色的移植，包括再生头发毛发的组合物，用于移植，以及移植再生毛发微生物的方法
公开(公告)号：US20140052167A1
公开(公告)日：2014-02-20
申请号：US14000939
申请日：2012-02-21
申请人： Koh-ei Toyoshima , Takashi Tsuji
发明人： Koh-ei Toyoshima , Takashi Tsuji
IPC分类号： C12N5/071 , A61L27/38
CPC分类号： C12N5/0697 , A61L27/3813 , A61L27/3834 , A61L27/3886 , A61L27/3891 , A61L2430/18 , C12N2506/092 , C12N2506/1376
摘要： A method for producing a regenerative hair follicle germ for transplantation, in which a color of hair that grows after transplantation is controlled, includes preparing a first cell mass containing mesenchymal cells; preparing a second cell mass containing epithelial cells; preparing a cell mass containing pigment stem cells; binding the cell mass containing the pigment stem cells to at least one among the first cell mass and the second cell mass, and closely contacting the first cell mass and the second cell mass, at least one of which has been bound to the cell mass containing the pigment stem cells, and culturing them within a support.
摘要翻译：一种生产用于移植的再生毛囊胚芽的方法，其中控制移植后生长的毛发的颜色，包括制备含有间充质细胞的第一细胞块; 制备含有上皮细胞的第二细胞团; 制备含有色素干细胞的细胞团; 将含有色素干细胞的细胞团结合到第一细胞团和第二细胞团中的至少一个，并且紧密接触第一细胞团和第二细胞团，其中至少一个细胞团与第二细胞团结合，色素干细胞，并在支持体内培养它们。

25. 发明申请

US20130250732A1 ULTRASONIC-TRANSDUCER MOUNTING STRUCTURE 有权
标题翻译：超声波传感器安装结构
公开(公告)号：US20130250732A1
公开(公告)日：2013-09-26
申请号：US13992671
申请日：2011-12-09
申请人： Takashi Tsuji , Naoya Azuma , Yasushi Nagano
发明人： Takashi Tsuji , Naoya Azuma , Yasushi Nagano
IPC分类号： G10K11/00 , B60R19/48
CPC分类号： G10K11/004 , B60R19/483 , G01S7/521 , G01S2015/937 , G01S2015/938
摘要： The ultrasonic-transducer mounting structure includes: a housing including: a body part which is formed into a hollow cylindrical shape and is provided at its front surface with a transmission surface allowing an ultrasonic wave to pass therethrough and is designed to accommodate an ultrasonic transducer therein; and plural connection pieces provided to a side surface of the body part; and a holder fixed to a rear surface of a bumper and designed to hold the housing such that the transmission surface of the housing is exposed via an opening of the bumper. The holder includes plural reception pieces to which the plural connection pieces are detachably coupled respectively. The plural reception pieces are fixed to the rear surface of the bumper to surround the opening.
摘要翻译：超声换能器安装结构包括：壳体，包括：主体部分，其形成为中空圆柱形，并在其前表面设置有允许超声波通过的传输表面，并被设计成在其中容纳超声换能器 ; 以及设置在所述主体部的侧面的多个连接片; 以及保持器，其固定到保险杠的后表面并且被设计成保持壳体，使得壳体的传动表面经由保险杠的开口暴露。保持器包括多个接合件，多个连接件分别可拆卸地连接到该接收件。多个接收件被固定到保险杠的后表面以包围开口。

26. 发明申请

US20130028053A1 OBSTACLE DETECTION SYSTEM 有权
标题翻译： OBSTACLE检测系统
公开(公告)号：US20130028053A1
公开(公告)日：2013-01-31
申请号：US13641312
申请日：2010-04-15
申请人： Takashi Tsuji , Naoya Azuma , Yasushi Nagano
发明人： Takashi Tsuji , Naoya Azuma , Yasushi Nagano
IPC分类号： G01S15/93
CPC分类号： G01S15/931 , B60R19/483 , G01S7/521 , G01S2015/938
摘要： An obstacle detection system includes ultrasonic sensors and a controller. The ultrasonic sensors include first and second ultrasonic sensors. Each of them is located at either side of a vehicle bumper so that its own beam axis has an angle deflected in a horizontal direction from a surface-normal direction of the bumper and is directed towards an intermediate portion of the bumper.
摘要翻译：障碍物检测系统包括超声波传感器和控制器。超声波传感器包括第一和第二超声波传感器。它们中的每一个位于车辆保险杠的任一侧，使得其自身的梁轴具有从保险杠的表面法线方向在水平方向上偏转的角度并且朝向保险杠的中间部分。

27. 发明申请

US20110207159A1 SCREENING METHOD FOR EFFICIENTLY OBTAINING USEFUL MICROBIAL STRAINS FROM MICROBIAL SAMPLE OBTAINED FROM NATURAL ENVIRONMENT AND REAGENT AND SCREENING KIT TO BE USED THEREFOR 审中-公开
标题翻译：从自然环境和试剂获得的微生物样品中有效获取有用的微生物菌株的筛选方法及其使用的筛选试剂盒
公开(公告)号：US20110207159A1
公开(公告)日：2011-08-25
申请号：US12922696
申请日：2008-03-17
申请人： Takashi Tsuji
发明人： Takashi Tsuji
IPC分类号： C12Q1/04 , C12Q1/44
CPC分类号： C12Q1/44 , C12N1/20 , C12Q1/02
摘要： A screening method for efficiently obtaining useful microbial strains from a sample comprises a first step of inoculating a culture medium with the sample potentially containing multiple microbial cells to culture the sample in the presence of a cell enlarger; a second step of introducing an esterase substrate fluorescent stain into the culture medium; a third step of isolating enlarged microbial cells stained in the second step according to a micromanipulation method to produce multiple culture media for establishment each inoculated with a single microbial cell; a fourth step of culturing the microbial cell in each of the culture media for establishment; and a fifth step of selecting culture media for establishment, in which cell proliferation has been confirmed, among the multiple culture media for establishment cultured in the fourth step.
摘要翻译：用于从样品有效获得有用的微生物菌株的筛选方法包括用可能含有多种微生物细胞的样品接种培养基的第一步骤，以在细胞扩增器存在下培养样品; 将酯酶底物荧光染料引入培养基的第二步骤; 第三步，根据显微操作方法分离在第二步中染色的扩大的微生物细胞以产生用于建立的多个培养基，每个接种单个微生物细胞; 在每个培养基中培养微生物细胞用于建立的第四步骤; 在第四步培养的多种培养培养基中选择细胞增殖的培养基的第五步，确定细胞增殖。

28. 发明申请

US20110129917A1 CELL ISOLATION METHOD 审中-公开
标题翻译：细胞分离方法
公开(公告)号：US20110129917A1
公开(公告)日：2011-06-02
申请号：US12599161
申请日：2007-05-08
申请人： Takashi Tsuji , Hidenori Wada
发明人： Takashi Tsuji , Hidenori Wada
IPC分类号： C12N5/07 , C12N5/04 , C12N1/00 , C12N1/02
CPC分类号： C12N1/20 , C12Q1/24
摘要： The present invention is a method for isolating a desired cell, which comprises selectively applying culture conditions including a culture medium to a sample potentially containing various cells, with addition of a cell enlarger simultaneously with, before or after the application. Thereby, it is possible to conveniently and efficiently obtain unknown but useful microorganisms occurring in a natural environment that are less competitive.
摘要翻译：本发明是一种分离所需细胞的方法，其包括向包含各种细胞的样品选择性地施加包括培养基的培养条件，同时加入细胞扩增器，施用前或施用后。因此，可以方便有效地获得在竞争较弱的自然环境中发生的未知但有用的微生物。

29. 发明授权

US07759388B2 Phenylalanine derivatives 失效
标题翻译：苯丙氨酸衍生物
公开(公告)号：US07759388B2
公开(公告)日：2010-07-20
申请号：US12253060
申请日：2008-10-16
申请人： Nobuyasu Suzuki , Toshihiko Yoshimura , Hiroyuki Izawa , Kazuyuki Sagi , Shingo Makino , Eiji Nakanishi , Masahiro Murata , Takashi Tsuji
发明人： Nobuyasu Suzuki , Toshihiko Yoshimura , Hiroyuki Izawa , Kazuyuki Sagi , Shingo Makino , Eiji Nakanishi , Masahiro Murata , Takashi Tsuji
IPC分类号： A61K31/4035 , C07D209/48
CPC分类号： C07D207/452 , A61K31/395 , A61K31/4015 , A61K31/403 , A61K31/4035 , A61K31/435 , A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/438 , A61K31/4412 , A61K31/45 , A61K31/472 , A61K31/48 , A61K31/4985 , A61K31/55 , C07D207/38 , C07D209/46 , C07D209/48 , C07D209/52 , C07D209/66 , C07D209/76 , C07D211/88 , C07D217/24 , C07D217/26 , C07D221/14 , C07D221/20 , C07D223/10 , C07D223/18 , C07D403/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要： Specific phenylalanine derivatives or pharmaceutically acceptable salts thereof have an antagonistic effect on the α 4 integrins and, therefore, are usable as therapeutic agents or preventive agents for diseases in which α 4 integrin-depending adhesion process participates in the pathology, such as inflammatory diseases, rheumatoid arthritis, inflammatory bowel diseases, systemic lupus erythematosus, multiple sclerosis, Sjögren's syndrome, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation, tumor metastasis and transplantation rejection.
摘要翻译：特定的苯丙氨酸衍生物或其药学上可接受的盐对α4整联蛋白具有拮抗作用，因此可用作治疗剂或其中α4整联蛋白依赖性粘附过程参与疾病如疾病的疾病的治疗剂或预防剂，类风湿关节炎，炎性肠病，系统性红斑狼疮，多发性硬化症，Sjögren综合征，哮喘，牛皮癣，过敏，糖尿病，心血管疾病，动脉硬化，再狭窄，肿瘤增生，肿瘤转移和移植排斥。

30. 发明授权

US07105520B2 Phenylalanine derivatives 失效
标题翻译：苯丙氨酸衍生物
公开(公告)号：US07105520B2
公开(公告)日：2006-09-12
申请号：US10252003
申请日：2002-09-23
申请人： Nobuyasu Suzuki , Toshihiko Yoshimura , Hiroyuki Izawa , Shingo Makino , Eiji Nakanishi , Masahiro Murata , Takashi Tsuji
发明人： Nobuyasu Suzuki , Toshihiko Yoshimura , Hiroyuki Izawa , Shingo Makino , Eiji Nakanishi , Masahiro Murata , Takashi Tsuji
IPC分类号： C07D239/30 , A61K31/505 , A61P9/00 , A61P11/06 , A61P35/00
CPC分类号： C07D295/155 , C07B2200/11 , C07C237/36 , C07C237/40 , C07D211/22 , C07D211/42 , C07D211/46 , C07D211/74 , C07D239/38 , C07D285/06
摘要： Phenylalanine derivatives of the following formulae and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin
摘要翻译：下式的苯丙氨酸衍生物及其类似物对α4整联蛋白具有拮抗作用。它们被用作关于α4整联蛋白的各种疾病的治疗剂

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