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    • 23. 发明授权
    • Process for producing drug-containing microspheres by oil-in-water
evaporation process
    • 通过水包油蒸发法生产含药微球的方法
    • US5980947A
    • 1999-11-09
    • US352188
    • 1994-12-01
    • Ichiro YamakawaRyoichi MachidaSumio Watanabe
    • Ichiro YamakawaRyoichi MachidaSumio Watanabe
    • A61K9/16A61K9/50B01J13/12A61K9/14
    • A61K9/1694A61K9/1617A61K9/1647
    • Formation of a drug into microspheres by an oil-on-water solvent evaporation process in which a mixed solvent of at least one water-insoluble solvent and at least one water-miscible solvent is used as a solvent of an oil phase. A fatty acid or a salt thereof or at least one glycerin fatty acid ester and/or at least one propylene glycol fatty acid ester are added to the mixed solvent. The oil phase may also comprise the mixed solvent; a fatty acid or a salt thereof; and at least one glycerin fatty acid ester and/or at least one propylene glycol fatty acid ester. This oil phase is mixed and emulsified with an aqueous phase to form an oil-in-water emulsion. The emulsion with a drug contained therein is then subjected to an oil-in water solvent evaporation to produce the microspheres. The resulting drug-containing microspheres contain the drug at a high concentration and slowly release from the initial stage after administration.
    • 通过油包水溶剂蒸发方法将药物形成为微球,其中使用至少一种水不溶性溶剂和至少一种与水相混溶的溶剂的混合溶剂作为油相的溶剂。 向混合溶剂中加入脂肪酸或其盐或至少一种甘油脂肪酸酯和/或至少一种丙二醇脂肪酸酯。 油相也可以包含混合溶剂; 脂肪酸或其盐; 和至少一种甘油脂肪酸酯和/或至少一种丙二醇脂肪酸酯。 将该油相与水相混合并乳化以形成水包油乳液。 然后将其中含有药物的乳液进行油包水溶剂蒸发以产生微球体。 所得含药微球含有高浓度的药物,并在给药后从初始阶段缓慢释放。
    • 24. 发明授权
    • Thermal printer having an elastic print head support
    • 具有弹性打印头支架的热敏打印机
    • US5846003A
    • 1998-12-08
    • US851534
    • 1997-05-05
    • Yukihiro MoriSumio Watanabe
    • Yukihiro MoriSumio Watanabe
    • B41J2/32B41J25/312B41J25/316B41J2/315
    • B41J25/312
    • A thermal head, rotatably supported by a supporting shaft parallel to the shaft of a platen, is resiliently pressed by an elastic member, such as a sheet spring, and comes into contact with the platen. A pair of arm members are provided on either side of the platen, the arms having through holes which allow for rotatably fitting and supporting therein the platen shaft. A bar member for receiving a resilient force of the elastic member is linked to other ends of the arm members, passing across the space between the arm members. The bar member is relieved from contact with the elastic member by rotating at least one of the arm members around the platen shaft or by moving at least one end of the bar member in a direction away from the platen. In the latter case, a crank mechanism is used for changing the effective length of one of the arm members. The thermal printer is compact and light, has high printing reliability, and facilitates ease in maintenance and replacement of the thermal head.
    • 由与平台的轴平行的支撑轴可旋转地支撑的热敏头由诸如片簧的弹性构件弹性地按压,并与压板接触。 一对臂构件设置在压板的任一侧上,臂具有允许可旋转地装配并在其中支撑压板轴的通孔。 用于接收弹性构件的弹力的杆构件连接到臂构件的另一端,穿过臂构件之间的空间。 通过使至少一个臂构件绕压板轴旋转,或者通过沿远离压板的方向移动杆构件的至少一个端部,杆构件被释放以与弹性构件接触。 在后一种情况下,曲柄机构用于改变一个臂构件的有效长度。 热敏打印机紧凑轻巧,印刷可靠性高,便于维护和更换热敏头。