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21. 发明授权

US08494604B2 Wavelength-division multiplexing in a multi-wavelength photon density wave system 失效
标题翻译：多波长光子密度波系统中的波分复用
公开(公告)号：US08494604B2
公开(公告)日：2013-07-23
申请号：US12563848
申请日：2009-09-21
申请人： Youzhi Li , Andy S. Lin , Edward M. McKenna
发明人： Youzhi Li , Andy S. Lin , Edward M. McKenna
IPC分类号： A61B5/1455 , A61B6/00
CPC分类号： A61B5/14551 , A61B5/0059 , A61B2562/223
摘要： Multi-wavelength photon density wave medical systems, methods, and devices are provided. In one embodiment, a multi-wavelength photon density wave patient monitor includes multiple light sources, a driving circuit, a fiber coupler, a sensor cable connector, a wavelength demultiplexer, detectors, and data processing circuitry. The driving circuit may modulate the light sources to produce several single-wavelength input photon density wave signals, which the fiber coupler may join into a multi-wavelength input signal. The sensor cable connector may provide this multi-wavelength input signal to a sensor attached to the patient and receive a multi-wavelength output signal. The wavelength demultiplexer may separate the multi-wavelength output signal into single-wavelength output signals for detection by the detectors. Based on a comparison of one of the single-wavelength output signals to a corresponding one of the single-wavelength input signals, the data processing circuitry may determine a physiological parameter of the patient.
摘要翻译：提供了多波长光子密度波医疗系统，方法和装置。在一个实施例中，多波长光子密度波病人监视器包括多个光源，驱动电路，光纤耦合器，传感器电缆连接器，波长解复用器，检测器和数据处理电路。驱动电路可以调制光源以产生几个单波长输入光子密度波信号，光纤耦合器可以连接到多波长输入信号中。传感器电缆连接器可以将这种多波长输入信号提供给附接到患者的传感器并且接收多波长输出信号。波长解复用器可以将多波长输出信号分离成单波长输出信号，以便由检测器检测。基于单波长输出信号之一与单波长输入信号中的相应一个的比较，数据处理电路可以确定患者的生理参数。

22. 发明申请

US20110245636A1 Multi-Wavelength Photon Density Wave System Using An Optical Switch 有权
标题翻译：使用光开关的多波长光子密度波系统
公开(公告)号：US20110245636A1
公开(公告)日：2011-10-06
申请号：US12751264
申请日：2010-03-31
申请人： Youzhi Li , Andy S. Lin , Edward M. McKenna
发明人： Youzhi Li , Andy S. Lin , Edward M. McKenna
IPC分类号： A61B5/1455
CPC分类号： A61B5/14551 , A61B5/02416 , A61B5/1455 , A61B2562/0242 , A61B2562/223 , G01N21/3151 , G01N21/49
摘要： Multi-wavelength photon density wave (PDW) medical systems, methods, and devices are provided. In one embodiment, a multi-wavelength system may include a sensor, a sensor cable, and a patient monitor. The sensor may have an emitter and a detector configured to pass a multi-wavelength PDW input signal into a patient and receive a resulting multi-wavelength PDW output signal. The sensor cable may couple to the sensor and include two optical cables for transmitting and receiving the multi-wavelength PDW signals. The patient monitor may couple to the sensor cable and generate several single-wavelength PDW input signals by modulating a plurality of light sources. The monitor may include an optical switch configured to time-division multiplex the several single-wavelength PDW wave input signals by selecting one of the single-wavelength PDW signals at one time to produce a multi-wavelength PDW signal which is output from the monitor to the sensor via the sensor cable.
摘要翻译：提供了多波长光子密度波（PDW）医疗系统，方法和设备。在一个实施例中，多波长系统可以包括传感器，传感器电缆和患者监护仪。传感器可以具有发射器和检测器，其被配置为将多波长PDW输入信号传递到患者体内并且接收所得到的多波长PDW输出信号。传感器电缆可以耦合到传感器并且包括用于发射和接收多波长PDW信号的两条光缆。患者监视器可以耦合到传感器电缆并且通过调制多个光源来生成多个单波长PDW输入信号。监视器可以包括配置成通过一次选择一个单波长PDW信号来对多个单波长PDW波输入信号进行时分复用以产生从监视器输出的多波长PDW信号的光开关传感器通过传感器电缆。

23. 发明授权

US08886290B2 Method and system for determining placement of a tracheal tube in a subject 有权
标题翻译：用于确定受试者气管插管位置的方法和系统
公开(公告)号：US08886290B2
公开(公告)日：2014-11-11
申请号：US13608585
申请日：2012-09-10
申请人： Youzhi Li , Edward M. McKenna , Andy S. Lin , Sarah Hayman
发明人： Youzhi Li , Edward M. McKenna , Andy S. Lin , Sarah Hayman
IPC分类号： A61B5/00 , G01B11/02 , A61B5/107 , A61M25/01 , A61M16/04 , A61M25/00
CPC分类号： A61M16/0488 , A61B5/0084 , A61B5/0086 , A61B5/1076 , A61B2562/223 , A61M16/04 , A61M16/0434 , A61M16/0443 , A61M25/0043 , A61M25/01 , A61M2025/0166 , A61M2205/3306 , G01B11/026
摘要： According to various embodiments, a tracheal tube may employ optical sensing techniques for determining a distance between the inserted tube and an anatomical structure, such as a carina. The distance information may provide an indication as to whether or not the tracheal tube is properly placed within the trachea. The optical techniques may include backscattered intensity measurements.
摘要翻译：根据各种实施例，气管插管可以采用光学感测技术来确定插入的管和解剖结构之间的距离，例如小孔。距离信息可以提供关于气管管是否适当地放置在气管内的指示。光学技术可以包括后向散射强度测量。

24. 发明授权

US08712492B2 Photon density wave based determination of physiological blood parameters 失效
标题翻译：光子密度波测定生理血液参数
公开(公告)号：US08712492B2
公开(公告)日：2014-04-29
申请号：US13149606
申请日：2011-05-31
申请人： Daniel Lisogurski , Doug P. Miller , Friso Schlottau , Youzhi Li , Andy S. Lin , Edward M. McKenna
发明人： Daniel Lisogurski , Doug P. Miller , Friso Schlottau , Youzhi Li , Andy S. Lin , Edward M. McKenna
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B5/02028 , A61B5/024
摘要： A system for measuring a physiological parameter of blood in a patient is presented. The system includes a transmission module configured to emit a plurality of photon density waves into tissue of the patient from a plurality of modulated light sources. The system also includes a receiver module configured to detect characteristics of the plurality of photon density waves. The system also includes a processing module configured to identify characteristics of a pulsatile perturbation of the tissue based on the characteristics of the plurality of photon density waves, and identify a value of the physiological parameter based on at least the characteristics of the pulsatile perturbation of the tissue and the characteristics of the plurality of photon density waves.
摘要翻译：提出了一种用于测量患者血液生理参数的系统。该系统包括被配置为从多个调制光源向患者的组织发射多个光子密度波的传输模块。该系统还包括被配置为检测多个光子密度波的特性的接收器模块。该系统还包括处理模块，该处理模块被配置为基于多个光子密度波的特性来识别组织的脉动扰动的特性，并且至少基于脉冲扰动的特征来识别生理参数的值组织和多个光子密度波的特性。

25. 发明授权

US08391943B2 Multi-wavelength photon density wave system using an optical switch 有权
标题翻译：使用光开关的多波长光子密度波系统
公开(公告)号：US08391943B2
公开(公告)日：2013-03-05
申请号：US12751264
申请日：2010-03-31
申请人： Youzhi Li , Andy S. Lin , Edward M. McKenna
发明人： Youzhi Li , Andy S. Lin , Edward M. McKenna
IPC分类号： A61B5/00 , A61B6/00
CPC分类号： A61B5/14551 , A61B5/02416 , A61B5/1455 , A61B2562/0242 , A61B2562/223 , G01N21/3151 , G01N21/49
摘要： Multi-wavelength photon density wave (PDW) medical systems, methods, and devices are provided. In one embodiment, a multi-wavelength system may include a sensor, a sensor cable, and a patient monitor. The sensor may have an emitter and a detector configured to pass a multi-wavelength PDW input signal into a patient and receive a resulting multi-wavelength PDW output signal. The sensor cable may couple to the sensor and include two optical cables for transmitting and receiving the multi-wavelength PDW signals. The patient monitor may couple to the sensor cable and generate several single-wavelength PDW input signals by modulating a plurality of light sources. The monitor may include an optical switch configured to time-division multiplex the several single-wavelength PDW wave input signals by selecting one of the single-wavelength PDW signals at one time to produce a multi-wavelength PDW signal which is output from the monitor to the sensor via the sensor cable.
摘要翻译：提供了多波长光子密度波（PDW）医疗系统，方法和设备。在一个实施例中，多波长系统可以包括传感器，传感器电缆和患者监护仪。传感器可以具有发射器和检测器，其被配置为将多波长PDW输入信号传递到患者体内并且接收所得到的多波长PDW输出信号。传感器电缆可以耦合到传感器并且包括用于发射和接收多波长PDW信号的两条光缆。患者监视器可以耦合到传感器电缆并且通过调制多个光源来生成多个单波长PDW输入信号。监视器可以包括配置成通过一次选择一个单波长PDW信号来对多个单波长PDW波输入信号进行时分复用以产生从监视器输出的多波长PDW信号的光开关传感器通过传感器电缆。

26. 发明申请

US20120310062A1 PHOTON DENSITY WAVE BASED DETERMINATION OF PHYSIOLOGICAL BLOOD PARAMETERS 审中-公开
标题翻译：基于光子密度波的生物学参数的确定
公开(公告)号：US20120310062A1
公开(公告)日：2012-12-06
申请号：US13149623
申请日：2011-05-31
申请人： Youzhi Li , Clark R. Baker, JR. , Edward M. McKenna
发明人： Youzhi Li , Clark R. Baker, JR. , Edward M. McKenna
IPC分类号： A61B5/1455
CPC分类号： A61B5/14551
摘要： A method for measuring a physiological parameter of blood in a patient is presented. The method includes emitting light from a modulated light source into tissue of the patient to generate a photon density wave in the tissue, detecting the photon density wave during pulsatile perturbation of the tissue, and processing an amplitude and phase of the photon density wave over the pulsatile perturbation to determine a value of the physiological parameter.
摘要翻译：提出了一种测量患者血液生理参数的方法。该方法包括将来自调制光源的光发射到患者的组织中以在组织中产生光子密度波，在组织的脉动扰动期间检测光子密度波，以及处理光子密度波的振幅和相位脉动扰动来确定生理参数的值。

27. 发明申请

US20120310058A1 PHOTON DENSITY WAVE BASED DETERMINATION OF PHYSIOLOGICAL BLOOD PARAMETERS 失效
标题翻译：基于光子密度波的生物学参数的确定
公开(公告)号：US20120310058A1
公开(公告)日：2012-12-06
申请号：US13149606
申请日：2011-05-31
申请人： Daniel Lisogurski , Doug P. Miller , Friso Schlottau , Youzhi Li , Andy S. Lin , Edward M. McKenna
发明人： Daniel Lisogurski , Doug P. Miller , Friso Schlottau , Youzhi Li , Andy S. Lin , Edward M. McKenna
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B5/02028 , A61B5/024
摘要： A system for measuring a physiological parameter of blood in a patient is presented. The system includes a transmission module configured to emit a plurality of photon density waves into tissue of the patient from a plurality of modulated light sources. The system also includes a receiver module configured to detect characteristics of the plurality of photon density waves. The system also includes a processing module configured to identify characteristics of a pulsatile perturbation of the tissue based on the characteristics of the plurality of photon density waves, and identify a value of the physiological parameter based on at least the characteristics of the pulsatile perturbation of the tissue and the characteristics of the plurality of photon density waves.
摘要翻译：提出了一种用于测量患者血液生理参数的系统。该系统包括被配置为从多个调制光源向患者的组织发射多个光子密度波的传输模块。该系统还包括被配置为检测多个光子密度波的特性的接收器模块。该系统还包括处理模块，该处理模块被配置为基于多个光子密度波的特性来识别组织的脉动扰动的特性，并且至少基于脉冲扰动的特征来识别生理参数的值组织和多个光子密度波的特性。

28. 发明申请

US20120197133A1 Advanced Ultrasound Modulated Optical Spectroscopy And Its Application To Patient Monitoring 审中-公开
标题翻译：高级超声调制光谱及其在患者监测中的应用
公开(公告)号：US20120197133A1
公开(公告)日：2012-08-02
申请号：US13016629
申请日：2011-01-28
申请人： Edward M. McKenna , Youzhi Li , Andy S. Lin
发明人： Edward M. McKenna , Youzhi Li , Andy S. Lin
IPC分类号： A61B6/00
CPC分类号： A61B5/0075 , A61B5/004 , A61B5/0062 , A61B5/0097 , A61B5/02007 , A61B5/0261 , A61B5/14552
摘要： The present disclosure describes systems and methods that use spatial modulation to focus light into a localized region of interest such as an individual blood vessel. In certain embodiments, acoustic modulation techniques, such as ultrasound pulse modulation, are used in conjunction with spatial modulation to achieve more precise measurements through otherwise scattering medium. The focused beam of light is capable of penetrating several centimeters of tissue to deliver measurements and images associated with individual blood vessels and other discrete vascular components.
摘要翻译：本公开描述了使用空间调制以将光聚焦到诸如个体血管的局部感兴趣区域中的系统和方法。在某些实施例中，诸如超声波脉冲调制之类的声调制技术结合空间调制使用，以通过另外的散射介质实现更精确的测量。聚焦的光束能够穿透几厘米的组织以提供与各个血管和其他离散的血管成分相关联的测量和图像。

29. 发明申请

US20120113411A1 OPTICAL FIBER SENSORS 审中-公开
标题翻译：光纤传感器
公开(公告)号：US20120113411A1
公开(公告)日：2012-05-10
申请号：US12942135
申请日：2010-11-09
申请人： Youzhi Li , Edward M. McKenna , Andy S. Lin
发明人： Youzhi Li , Edward M. McKenna , Andy S. Lin
IPC分类号： G01N33/48 , G01N21/00 , B23P11/00 , G01J3/42
CPC分类号： A61B5/14552 , A61B5/6826 , A61B5/6884 , A61B2562/0233 , G01N2201/088 , Y10T29/49826
摘要： The present disclosure describes the use and the manufacture of a fiber optic sensor having an angled terminal portion of a fiber optic element. In one embodiment, an optical fiber is cut at an angle and a portion of the fiber's jacket is removed near the angle so that the cladding is exposed. Light may then travel through the fiber, reflect off the angled portion, and emit through the exposed cladding into a patient. Light may also be collected from the patient using the same or a different fiber optic element having an angled terminal portion. In one embodiment, the emitted light can then be collected and analyzed to derive various physiological parameters. In certain embodiments, the fiber optic sensor may be used in environments where metallic and/or electronic sensors are not suitable.
摘要翻译：本公开描述了具有光纤元件的倾斜端部的光纤传感器的使用和制造。在一个实施例中，以一定角度切割光纤，并且在角度附近去除光纤护套的一部分，使得包层被暴露。然后，光可以穿过光纤，从角部分反射，并通过暴露的包层发射到患者体内。还可以使用具有成角度的端部部分的相同或不同的光纤元件从患者收集光。在一个实施例中，然后可以收集和分析发射的光以得到各种生理参数。在某些实施例中，光纤传感器可用于金属和/或电子传感器不合适的环境中。

30. 发明申请

US20120029829A1 Light Focusing Continuous Wave Photoacoustic Spectroscopy And Its Applications To Patient Monitoring 有权
标题翻译：光聚焦连续波光声光谱及其在患者监测中的应用
公开(公告)号：US20120029829A1
公开(公告)日：2012-02-02
申请号：US12845198
申请日：2010-07-28
申请人： Youzhi Li , Edward M. McKenna , Andy S. Lin
发明人： Youzhi Li , Edward M. McKenna , Andy S. Lin
IPC分类号： G06F19/00 , G01N29/44 , G01N21/00
CPC分类号： A61B5/0059 , A61B5/0095 , A61B5/1455 , G01N21/1702
摘要： The present disclosure describes systems and methods that use spatial modulation to focus continuous wave light into a localized region of interest such as an individual blood vessel. In certain embodiments, intensity modulation techniques, such as linear frequency modulation, are used in conjunction with spatial modulation to achieve more precise measurements through otherwise scattering medium. The focused beam of continuous wave light is capable of penetrating several centimeters of tissue to deliver measurements and images associated with individual blood vessels and other discrete vascular components.
摘要翻译：本公开描述了使用空间调制以将连续波光聚焦到诸如个体血管的局部感兴趣区域中的系统和方法。在某些实施例中，诸如线性频率调制的强度调制技术与空间调制结合使用，以通过另外的散射介质实现更精确的测量。聚焦的连续波光束能够穿透几厘米的组织以提供与各个血管和其它离散的血管成分相关联的测量和图像。

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