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21. 发明授权

US08501175B2 TMPRSS4-specific human antibody 有权
标题翻译： TMPRSS4特异性人抗体
公开(公告)号：US08501175B2
公开(公告)日：2013-08-06
申请号：US13124603
申请日：2008-11-10
申请人： Young Woo Park , So-Young Choi , Young-Soon Jang , Ji Hyun Park , Eun-Jung Song , Jung Yu , Myung-Ho Sohn , Jae Won Jeon , Joon-Goo Jung , Sungsub Kim , Myeoung Hee Jang
发明人： Young Woo Park , So-Young Choi , Young-Soon Jang , Ji Hyun Park , Eun-Jung Song , Jung Yu , Myung-Ho Sohn , Jae Won Jeon , Joon-Goo Jung , Sungsub Kim , Myeoung Hee Jang
IPC分类号： C07K16/00
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/21 , C07K2317/52 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C12N9/6424
摘要： The present invention relates to a transmembrane protease, serine (TMPRSS4)-specific human antibody, and more particularly to a human antibody including a complementarity determining region (CDR) and a framework region (FR) derived from a human antibody specifically bound to TMPRSS4. The TMPRSS4-specific human antibody expressed in the various kinds of cancer cells of the present invention may be used in diagnosis of the cancer, classification of the disease, visualization, treatment, and prognostic evaluation.
摘要翻译：本发明涉及跨膜蛋白酶，丝氨酸（TMPRSS4） - 特异性人抗体，更具体地涉及包含衍生自特异性结合TMPRSS4的人抗体的互补决定区（CDR）和构架区（FR）的人抗体。在本发明的各种癌细胞中表达的TMPRSS4特异性人抗体可用于诊断癌症，分类疾病，可视化，治疗和预后评价。

22. 发明授权

US08197809B2 CD9-specific human antibodies 有权
标题翻译： CD9特异性人抗体
公开(公告)号：US08197809B2
公开(公告)日：2012-06-12
申请号：US12523516
申请日：2008-11-24
申请人： Young Woo Park , So-Young Choi , Ji Hyun Park , Jung Yu , Eun-Jung Song , Sungsub Kim , Myeoung Hee Jang , Mi-Ju Park , Je-Ho Lee , Jae Ryoung Hwang
发明人： Young Woo Park , So-Young Choi , Ji Hyun Park , Jung Yu , Eun-Jung Song , Sungsub Kim , Myeoung Hee Jang , Mi-Ju Park , Je-Ho Lee , Jae Ryoung Hwang
IPC分类号： C07K16/00 , G01N33/53 , A61K39/395
CPC分类号： C07K16/2896 , C07K2317/21 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要： The present invention relates to a CD9-specific human antibody, more precisely a CD9-specific human antibody composed of human derived CD9-specific complementarity determining region (CDR) and framework region (FR). The human antibody of the present invention recognizes CD9 extracellular loop 2 domain (CD9-ECL2) as an epitope and thereby strongly binding thereto. The human antibody of the present invention also has CD9 antigen neutralizing effect and at the same time inhibiting effect on tumor cell lines. Therefore, it can be effectively used for the prevention and treatment of cancer overexpressing CD9.
摘要翻译：本发明涉及CD9特异性人抗体，更确切地说，涉及由人衍生的CD9特异性互补决定区（CDR）和框架区（FR）组成的CD9特异性人抗体。本发明的人抗体识别CD9细胞外环2结构域（CD9-ECL2）作为表位，从而与其强结合。本发明的人抗体也具有CD9抗原中和作用，同时对肿瘤细胞株具有抑制作用。因此，它可以有效地用于预防和治疗过度表达CD9的癌细胞。

23. 发明授权

US06482696B2 Method of forming storage nodes in a DRAM 有权
标题翻译：在DRAM中形成存储节点的方法
公开(公告)号：US06482696B2
公开(公告)日：2002-11-19
申请号：US09901048
申请日：2001-07-10
申请人： Young Woo Park
发明人： Young Woo Park
IPC分类号： H01L218242
CPC分类号： H01L28/91 , H01L21/31625 , H01L27/10852
摘要： A method of forming capacitor over bit line storage nodes in dynamic random access memory cell includes forming a multi-layered structure having at least two silicon oxide layers as a thick molding layer, e.g., to a thickness of more than 8000 Å. The at least two silicon oxide layers are disposed to have an etch speed of relatively lower-positioned silicon oxide layer to be relatively faster than that of relatively upper-positioned silicon oxide layer. Holes are then etched in the multi-layered structure, thereby reducing a width differential between the upper and lower layers.
摘要翻译：在动态随机存取存储器单元中的位线存储节点上形成电容器的方法包括形成具有至少两个氧化硅层的多层结构作为厚的成型层，例如厚度超过8000埃。至少两个氧化硅层被设置为具有相对较低位置的氧化硅层的蚀刻速度将比相对较高位置的氧化硅层的蚀刻速度相对更快。然后在多层结构中蚀刻孔，从而减小上层和下层之间的宽度差。

24. 发明授权

US09887208B2 Vertical memory device 有权
公开(公告)号：US09887208B2
公开(公告)日：2018-02-06
申请号：US15218421
申请日：2016-07-25
申请人： Young Hwan Son , Young Woo Park , Jae Duk Lee
发明人： Young Hwan Son , Young Woo Park , Jae Duk Lee
IPC分类号： H01L27/115 , H01L27/11582 , H01L27/11573 , G11C16/04 , G11C16/26 , G11C16/10 , H01L27/11565 , H01L27/1157 , H01L27/11575
CPC分类号： H01L27/11582 , G11C16/0466 , G11C16/10 , G11C16/26 , H01L27/11565 , H01L27/1157 , H01L27/11573 , H01L27/11575
摘要： A memory device may include a peripheral region and a cell region. The peripheral region may include a first substrate, a plurality of circuit elements disposed on the first substrate, a first insulating layer disposed on the plurality of circuit elements, and a first protective layer disposed in the first insulating layer. The cell region may include a second substrate disposed on the first insulating layer, wherein the cell region includes a first impurity region, a channel region extending in a direction substantially perpendicular to an upper surface of the second substrate, a plurality of gate electrode layers stacked on the second substrate and adjacent to the channel region, and a first contact electrically connected to the first impurity region, wherein the first protective layer is disposed below the first impurity region, and has a shape corresponding to a shape of the first impurity region.

25. 发明申请

US20170125540A1 NON-VOLATILE MEMORY DEVICES AND MANUFACTURING METHODS THEREOF 审中-公开
公开(公告)号：US20170125540A1
公开(公告)日：2017-05-04
申请号：US15408017
申请日：2017-01-17
申请人： Jin Taek Park , Young Woo Park , Jae Duk Lee
发明人： Jin Taek Park , Young Woo Park , Jae Duk Lee
IPC分类号： H01L29/51 , H01L21/28 , H01L29/49 , H01L29/423 , H01L27/11556 , H01L27/11582
CPC分类号： H01L29/513 , G11C16/0483 , H01L21/28273 , H01L27/11556 , H01L27/11582 , H01L29/42324 , H01L29/4234 , H01L29/42364 , H01L29/4916 , H01L29/66825 , H01L29/66833 , H01L29/7789 , H01L29/7926
摘要： There is provided a method of manufacturing a non-volatile memory device including: alternatively stacking a plurality of insulating layers and a plurality of conductive layers on a top surface of a substrate; forming an opening that exposes the top surface of the substrate and lateral surfaces of the insulating layers and the conductive layers; forming an anti-oxidation layer on at least the exposed lateral surfaces of the conductive layers; forming a gate dielectric layer on the anti-oxidation layer, the gate dielectric layer including a blocking layer, an electric charge storage layer, and a tunneling layer that are sequentially formed on the anti-oxidation layer; and forming a channel region on the tunneling layer.

26. 发明授权

US09490228B2 Anisotropic conductive film including conductive adhesive layer and semiconductor device connected by the same 有权
标题翻译：各向异性导电膜包括导电粘合剂层和与其相连的半导体器件
公开(公告)号：US09490228B2
公开(公告)日：2016-11-08
申请号：US14229003
申请日：2014-03-28
申请人： Kyoung Soo Park , Soon Young Kwon , Ji Yeon Kim , Young Woo Park , Jae Sun Han , Ja Young Hwang
发明人： Kyoung Soo Park , Soon Young Kwon , Ji Yeon Kim , Young Woo Park , Jae Sun Han , Ja Young Hwang
IPC分类号： H01L23/00 , C09J9/02 , C09J7/00 , C09J11/00 , H05K3/32 , C08K7/16 , C08K9/02
CPC分类号： H01L24/29 , C08K7/16 , C08K9/02 , C09J7/00 , C09J7/10 , C09J9/02 , C09J11/00 , C09J2201/36 , C09J2201/602 , C09J2203/326 , C09J2205/102 , H01L24/13 , H01L24/16 , H01L24/27 , H01L24/32 , H01L24/81 , H01L24/83 , H01L2224/13013 , H01L2224/16225 , H01L2224/27003 , H01L2224/271 , H01L2224/29082 , H01L2224/29083 , H01L2224/2919 , H01L2224/2929 , H01L2224/29311 , H01L2224/29316 , H01L2224/29324 , H01L2224/29339 , H01L2224/29344 , H01L2224/29347 , H01L2224/29355 , H01L2224/29364 , H01L2224/29366 , H01L2224/29371 , H01L2224/29387 , H01L2224/2939 , H01L2224/29411 , H01L2224/29416 , H01L2224/29424 , H01L2224/29439 , H01L2224/29444 , H01L2224/29447 , H01L2224/29455 , H01L2224/29464 , H01L2224/29466 , H01L2224/29471 , H01L2224/29499 , H01L2224/32225 , H01L2224/81191 , H01L2224/81903 , H01L2224/83192 , H01L2224/83203 , H01L2224/83851 , H01L2924/07802 , H01L2924/15788 , H05K3/323 , Y10T428/24959 , Y10T428/25 , Y10T428/28 , Y10T428/2848 , H01L2924/00 , H01L2924/00014 , H01L2924/00012
摘要： An anisotropic conductive film includes a conductive adhesive layer including conductive particles and insulating particles, and an insulating adhesive layer not including conductive particles. In the anisotropic conductive film, the conductive particles and the insulating particles of the conductive adhesive layer have a total particle density of 7.0×105/d2 to 10.0×105/d2 (particles) per square millimeter (mm2) (where d is a diameter of the conductive particles in μm).
摘要翻译：各向异性导电膜包括导电性粘合剂层，其包含导电性粒子和绝缘性粒子，以及不含导电性粒子的绝缘性粘合剂层。在各向异性导电膜中，导电性粘接剂层的导电性粒子和绝缘性粒子的总粒子密度为7.0×10 5 / d 2〜10 10×10 6（粒子）/平方毫米（mm 2）（d为直径的导电粒子）。

27. 发明授权

US09200058B2 Dual antagonist for TNF-α and IL-21 for preventing and treating autoimmune diseases 有权
标题翻译：用于预防和治疗自身免疫性疾病的TNF-α和IL-21的双重拮抗剂
公开(公告)号：US09200058B2
公开(公告)日：2015-12-01
申请号：US13635874
申请日：2011-03-18
申请人： Young Woo Park , Ki Won Jo , Srok Ho Yoo , Jung Yu , Sun-Ha Yoon , Ji Hyun Park , Eun Jung Song , Jong-Ho Lee , Min Ji Seo , Sun Jung Cho , Mi La Cho , Ho Youn Kim , Mi Kyung Park , Hye Jwa Oh , Jin Sil Park , Yun Ju Woo , Jae Kyeong Byun , Jun Geol Ryu
发明人： Young Woo Park , Ki Won Jo , Srok Ho Yoo , Jung Yu , Sun-Ha Yoon , Ji Hyun Park , Eun Jung Song , Jong-Ho Lee , Min Ji Seo , Sun Jung Cho , Mi La Cho , Ho Youn Kim , Mi Kyung Park , Hye Jwa Oh , Jin Sil Park , Yun Ju Woo , Jae Kyeong Byun , Jun Geol Ryu
IPC分类号： C07K14/715
CPC分类号： C07K14/7151 , C07K14/7155 , C07K2319/00
摘要： The present invention relates to TNFR2-IL21R fusion protein acting as a double-antagonist to TNF-alpha (α) and IL-21. The composition containing the double antagonist to TNF-α and Il-21 (TNFR2-IL21R fusion protein), known as major causes of autoimmune rheumatoid arthritis, one of autoimmune diseases, can reduce the secretion of inflammatory cytokine, increase the secretion of anti-inflammatory cytokine, and suppress the differentiation of osteoclasts better than single proteins such as TNFR2-Fc and IL21R-Fc. The TNFR2-IL21R fusion protein of the present invention has not only excellent treatment effect on arthritis in CIA mouse model not also excellent treatment effect on autoimmune rheumatoid arthritis by increasing the expression of Treg, the immune suppressive cells. Therefore, the TNFR2-IL21R fusion protein of the present invention can be effectively used as an active ingredient for the composition for the prevention and treatment of autoimmune disease.
摘要翻译：本发明涉及作为TNF-α（α）和IL-21的双重拮抗剂的TNFR2-IL21R融合蛋白。含有TNF-α和II-21（TNFR2-IL21R融合蛋白）的双重拮抗剂的组合物，被称为自身免疫性类风湿性关节炎的主要原因（自身免疫性疾病之一）可以减少炎性细胞因子的分泌，炎性细胞因子，并且比单一蛋白如TNFR2-Fc和IL21R-Fc更好地抑制破骨细胞的分化。本发明的TNFR2-IL21R融合蛋白不仅对CIA小鼠模型的关节炎具有优异的治疗作用，而且通过增加免疫抑制细胞Treg的表达，对自身免疫性类风湿性关节炎也不是很好的治疗效果。因此，本发明的TNFR2-IL21R融合蛋白可以有效地用作预防和治疗自身免疫性疾病的组合物的活性成分。

28. 发明授权

US09048240B2 Anisotropic conductive film and electronic device including the same 有权
标题翻译：各向异性导电膜和包括其的电子器件
公开(公告)号：US09048240B2
公开(公告)日：2015-06-02
申请号：US13728215
申请日：2012-12-27
申请人： Young Woo Park , Nam Ju Kim , Kyoung Soo Park , Joon Mo Seo , Kyung Il Sul , Dong Seon Uh , Arum Yu , Hyun Min Choi
发明人： Young Woo Park , Nam Ju Kim , Kyoung Soo Park , Joon Mo Seo , Kyung Il Sul , Dong Seon Uh , Arum Yu , Hyun Min Choi
IPC分类号： H01B1/00 , H01L23/48 , H01L23/538 , C09J9/02 , C08G59/22 , C08G59/24 , H01L23/00 , C08L63/00
CPC分类号： H01L23/538 , C08G59/226 , C08G59/245 , C08K2201/001 , C08K2201/011 , C09J9/02 , H01L24/16 , H01L24/29 , H01L24/32 , H01L24/73 , H01L2224/16225 , H01L2224/2929 , H01L2224/29324 , H01L2224/29339 , H01L2224/29344 , H01L2224/29347 , H01L2224/29355 , H01L2224/29364 , H01L2224/29366 , H01L2224/29371 , H01L2224/29386 , H01L2224/2939 , H01L2224/29393 , H01L2224/29439 , H01L2224/29444 , H01L2224/29447 , H01L2224/29455 , H01L2224/32225 , H01L2224/73204 , H01L2924/07802 , H01L2924/07811 , H01L2924/15788 , H01L2924/00 , C08L63/00 , C08K3/36 , C08K3/10
摘要： An electronic device includes an anisotropic conductive film as a connection material, the anisotropic conductive film being formed from an anisotropic conductive film-forming composition. The anisotropic conductive film-forming composition includes a polycyclic aromatic ring-containing epoxy resin, a fluorene epoxy resin, nano silica and conductive particles.
摘要翻译：电子器件包括各向异性导电膜作为连接材料，各向异性导电膜由各向异性导电膜形成组合物形成。各向异性导电膜形成组合物包括多环芳族环的环氧树脂，芴环氧树脂，纳米二氧化硅和导电颗粒。

29. 发明授权

US09035192B2 Anisotropic conductive adhesive composite and film, and circuit connecting structure including the same 有权
标题翻译：各向异性导电胶复合膜及电路连接结构包括相同
公开(公告)号：US09035192B2
公开(公告)日：2015-05-19
申请号：US12974476
申请日：2010-12-21
申请人： Gyu Ho Lee , Young Woo Park , Il Rae Cho , Young Hun Kim , Kyoung Soo Park , Jin Seong Park , Dong Seon Uh , Kyung Jin Lee , Kwang Jin Jung
发明人： Gyu Ho Lee , Young Woo Park , Il Rae Cho , Young Hun Kim , Kyoung Soo Park , Jin Seong Park , Dong Seon Uh , Kyung Jin Lee , Kwang Jin Jung
IPC分类号： H05K1/09 , C09J11/04 , C09J9/02 , H05K3/32 , C08K3/00 , C08K9/02
CPC分类号： C09J11/04 , C08K3/017 , C08K9/02 , C09J9/02 , H05K3/323 , H05K2201/0218
摘要： An anisotropic conductive adhesive composite and film include a binder and conductive particles dispersed in the binder. The conductive particles include a copper core particle and a metal coating layer coated on a surface of the corresponding copper core particle.
摘要翻译：各向异性导电粘合剂复合物和膜包括粘合剂和分散在粘合剂中的导电颗粒。导电颗粒包括铜芯颗粒和涂覆在相应的铜芯颗粒的表面上的金属涂层。

30. 发明授权

US08916525B2 TNF-A and TWEAK dual antagonist for the prophylaxis and treatment of autoimmune diseases 有权
标题翻译： TNF-A和TWEAK双重拮抗剂用于预防和治疗自身免疫性疾病
公开(公告)号：US08916525B2
公开(公告)日：2014-12-23
申请号：US13635868
申请日：2011-03-18
申请人： Young Woo Park , Ki Won Jo , Srok Ho Yoo , Jung Yu , Dong Jin Kim , Sun-Ha Yoon , Eun Jung Song , Eun Kyung Lee , Jin Mi Oh , Kyu Won Cho , Mi La Cho , Ho Youn Kim , Mi Kyung Park , Hye Jwa Oh , Jin Sil Park , Yun Ju Woo , Jae Kyeong Byun , Jun Geol Ryu
发明人： Young Woo Park , Ki Won Jo , Srok Ho Yoo , Jung Yu , Dong Jin Kim , Sun-Ha Yoon , Eun Jung Song , Eun Kyung Lee , Jin Mi Oh , Kyu Won Cho , Mi La Cho , Ho Youn Kim , Mi Kyung Park , Hye Jwa Oh , Jin Sil Park , Yun Ju Woo , Jae Kyeong Byun , Jun Geol Ryu
IPC分类号： A61K38/17 , A61P17/00 , A61P19/02 , A61P19/04 , A61P21/00 , A61P25/00 , A61P3/10 , A61P7/06 , C07K14/525 , C07K14/705
CPC分类号： C07K14/525 , C07K14/70575 , C07K2319/32 , Y10S514/814 , Y10S514/885 , Y10S514/886 , Y10S514/903
摘要： The present invention relates to TNFR2-TWEAKR fusion protein, more precisely to TNFR2-TWEAKR fusion protein acting as a double-antagonist to TNF-α and TWEAK, known as major causes of autoimmune arthritis which is one of autoimmune diseases. When the composition comprising TNFR2-TWEAKR fusion protein was treated to Th17 cells, the secretion of the inflammatory cytokine IL-17 was reduced but the secretion of the anti-inflammatory cytokine IL-10 generated in Treg cells was increased. Such effect of TNFR2-TWEAKR fusion protein was far greater than that of a single protein such as TNFR2-Fc or TWEAK-Fc. The TNFR2-TWEAKR fusion protein of the present invention has not only excellent treatment effect on arthritis in CIA mouse model not also excellent treatment effect on autoimmune rheumatoid arthritis by increasing the expression of Treg, the immune suppressive cells. Therefore, the TNFR2-TWEAKR fusion protein of the present invention can be effectively used as an active ingredient for the composition for the prevention and treatment of autoimmune disease.
摘要翻译：本发明涉及TNFR2-TWEAKR融合蛋白，更确切地说，作为TNF-α和TWEAK的双拮抗剂的TNFR2-TWEAKR融合蛋白，被称为自身免疫性疾病之一的自身免疫性关节炎的主要原因。当将包含TNFR2-TWEAKR融合蛋白的组合物治疗至Th17细胞时，炎性细胞因子IL-17的分泌减少，但在Treg细胞中产生的抗炎细胞因子IL-10的分泌增加。 TNFR2-TWEAKR融合蛋白的这种作用远远大于单一蛋白如TNFR2-Fc或TWEAK-Fc的这种作用。本发明的TNFR2-TWEAKR融合蛋白不仅对CIA小鼠模型的关节炎具有优异的治疗作用，而且通过增加免疫抑制细胞Treg的表达，对自身免疫性类风湿性关节炎也不是很好的治疗效果。因此，本发明的TNFR2-TWEAKR融合蛋白可以有效地用作预防和治疗自身免疫性疾病的组合物的活性成分。

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