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21. 发明授权

US07308306B1 System and method for dynamic ventricular overdrive pacing 有权
标题翻译：动态心室超速起搏的系统和方法
公开(公告)号：US07308306B1
公开(公告)日：2007-12-11
申请号：US10456060
申请日：2003-06-06
申请人： Euljoon Park , Peter Boileau , Joseph J. Florio , Gene A. Bornzin , Eric Falkenberg
发明人： Euljoon Park , Peter Boileau , Joseph J. Florio , Gene A. Bornzin , Eric Falkenberg
IPC分类号： A61N1/368
CPC分类号： A61N1/3621 , A61N1/365
摘要： Techniques are provided for overdrive pacing the ventricles using a pacemaker wherein an increase in an overdrive pacing rate is performed primarily to achieve a high degree of rate smoothing. The ventricles are paced at an overdrive pacing rate selected to permit the detection of the least some intrinsic ventricular pulses and then the overdrive pacing rate is dynamically adjusted based on the detected intrinsic ventricular pulses. In one example, an increase in the ventricular overdrive rate is performed only in response to detection of at least two intrinsic ventricular beats within a predetermined search period. If at least two intrinsic ventricular beats are not detected within the search period, the overdrive pacing rate is decreased. Various techniques are also provided for determining when to activate ventricular overdrive pacing depending, in part, on the capabilities of the particular pacemaker, the current mode of operation, the density of premature ventricular contractions, the degree of heart rate stability, and the presence of atrial fibrillation. Adaptive techniques for automatically adjusting ventricular overdrive pacing control parameters are also described.
摘要翻译：提供技术用于使用起搏器超速起搏心室，其中主要执行超速起搏速率的增加以实现高程度的速率平滑。心室以选择的超速起搏速度进行起搏，以允许检测至少一些内在的心室脉冲，然后基于检测到的内在心室脉冲来动态地调整超速起搏速率。在一个示例中，仅在响应于在预定搜索周期内检测到至少两个本征心室搏动来执行心室超速率的增加。如果在搜索期内未检测到至少两个内在心室搏动，则超速起搏速率降低。还提供了各种技术来确定何时激活心室过度起搏起搏，其部分取决于特定起搏器的能力，当前的手术方式，早期心室收缩的密度，心率稳定程度以及是否存在心房颤动。还描述了用于自动调节心室超速起搏控制参数的自适应技术。

22. 发明授权

US06904320B2 Sleep apnea therapy device using dynamic overdrive pacing 有权
标题翻译：使用动态超速起搏的睡眠呼吸暂停治疗装置
公开(公告)号：US06904320B2
公开(公告)日：2005-06-07
申请号：US10077053
申请日：2002-02-14
申请人： Euljoon Park , Gene A. Bornzin , Paul A. Levine , Eric Falkenberg
发明人： Euljoon Park , Gene A. Bornzin , Paul A. Levine , Eric Falkenberg
IPC分类号： A61N1/365 , A61N1/18
CPC分类号： A61N1/365 , A61N1/36557
摘要： A cardiac stimulation device uses dynamic overdrive pacing to prevent sleep apnea. In another aspect, the device can use dynamic overdrive pacing to terminate sleep apnea after detection. An implantable cardiac stimulation device comprises a sensor and one or more pulse generators. The sensor senses intrinsic cardiac electrical phenomena. The pulse generators can generate cardiac pacing pulses with timing based on the sensed intrinsic cardiac electrical phenomena to dynamically overdrive the intrinsic cardiac electrical phenomena. The timed cardiac pacing pulses can prevent a sleep apnea condition.
摘要翻译：心脏刺激装置使用动态超速起搏来预防睡眠呼吸暂停。另一方面，该设备可以使用动态超速起搏来终止检测后的睡眠呼吸暂停。可植入心脏刺激装置包括传感器和一个或多个脉冲发生器。传感器感测内在的心脏电学现象。脉冲发生器可以基于感测到的固有心脏电现象产生心脏起搏脉冲，以动态地过度驱动固有的心脏电学现象。定时的心脏起搏脉冲可以防止睡眠呼吸暂停状态。

23. 发明授权

US08702616B2 Determination of diastolic heart failure 有权
标题翻译：舒张性心力衰竭的测定
公开(公告)号：US08702616B2
公开(公告)日：2014-04-22
申请号：US12943653
申请日：2010-11-10
申请人： Jong Gill , Xiaoyi Min , Gene A. Bornzin , Eric Falkenberg
发明人： Jong Gill , Xiaoyi Min , Gene A. Bornzin , Eric Falkenberg
IPC分类号： A61B5/0205
CPC分类号： A61B5/0215 , A61B5/042 , A61B5/0464 , A61B5/053 , A61B7/00 , A61N1/36578
摘要： An exemplary method includes detecting a change in state of a cardiac valve, detecting elongation of the left ventricle substantially along its major axis, determining a time difference between the change in state of the cardiac valve and the elongation of the left ventricle and, based at least in part on the time difference, deciding whether a diastolic abnormality exists. Other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：示例性方法包括检测心脏瓣膜的状态变化，检测左心室基本上沿其长轴的伸长，确定心脏瓣膜状态变化与左心室伸长之间的时间差，并基于至少部分地基于时间差，决定是否存在舒张异常。还公开了其它示例性方法，装置，系统等。

24. 发明申请

US20110060230A1 DETERMINATION OF DIASTOLIC HEART FAILURE 有权
标题翻译：糖尿病心绞痛的确定
公开(公告)号：US20110060230A1
公开(公告)日：2011-03-10
申请号：US12943653
申请日：2010-11-10
申请人： Jong Gill , Xiaoyi Min , Gene A. Bornzin , Eric Falkenberg
发明人： Jong Gill , Xiaoyi Min , Gene A. Bornzin , Eric Falkenberg
IPC分类号： A61B5/0215 , A61B5/02
CPC分类号： A61B5/0215 , A61B5/042 , A61B5/0464 , A61B5/053 , A61B7/00 , A61N1/36578
摘要： An exemplary method includes detecting a change in state of a cardiac valve, detecting elongation of the left ventricle substantially along its major axis, determining a time difference between the change in state of the cardiac valve and the elongation of the left ventricle and, based at least in part on the time difference, deciding whether a diastolic abnormality exists. Other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：示例性方法包括检测心脏瓣膜的状态变化，检测左心室基本上沿其长轴的伸长，确定心脏瓣膜状态变化与左心室伸长之间的时间差，并基于至少部分地基于时间差，决定是否存在舒张异常。还公开了其它示例性方法，装置，系统等。

25. 发明申请

US20080234769A1 SUBCUTANEOUS CARDIAC STIMULATION DEVICE PROVIDING ANTI-TACHYCARDIA PACING THERAPY AND METHOD 有权
标题翻译：提供抗惊厥药治疗和方法的免疫性心脏刺激装置
公开(公告)号：US20080234769A1
公开(公告)日：2008-09-25
申请号：US12113895
申请日：2008-05-01
申请人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
发明人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
IPC分类号： A61N1/39 , A61N1/362
CPC分类号： A61N1/0504 , A61N1/3622 , A61N1/37252
摘要： An implantable subcutaneous cardiac device includes at least two subcutaneous electrodes adapted for placement external to a heart beneath the skin of a patient. The device further includes an arrhythmia detector that detects a sustained tachyarrhythmia of the heart and a pulse generator that delivers anti-tachycardia pacing pulses to the subcutaneous electrodes in response to detection of a sustained tachyarrhythmia. The pacing pulses preferably have waveforms devoid of any exponential voltage decay and include rounded or substantially constant portions to minimize pain.
摘要翻译：植入式皮下心脏装置包括至少两个皮下电极，其适于放置在患者皮肤下方的心脏外部。该装置还包括检测心脏持续快速性心律失常的心律失常检测器和响应于持续快速性心律失常的检测而向皮下电极递送抗心动过速起搏脉冲的脉冲发生器。起搏脉冲优选具有没有任何指数电压衰减的波形，并且包括圆形或基本恒定的部分以最小化疼痛。

26. 发明授权

US07006868B2 Method and apparatus for using a rest mode indicator to automatically adjust control parameters of an implantable cardiac stimulation device 失效
公开(公告)号：US07006868B2
公开(公告)日：2006-02-28
申请号：US10092695
申请日：2002-03-06
申请人： Joseph J. Florio , Gene A. Bornzin , Peter Boileau , Eric Falkenberg , Janice Barstad
发明人： Joseph J. Florio , Gene A. Bornzin , Peter Boileau , Eric Falkenberg , Janice Barstad
IPC分类号： A61N1/365
CPC分类号： A61N1/3622 , A61N1/37211
摘要： An implantable cardiac stimulation device is described wherein a controller of the cardiac stimulation device controls selected functions of the device based on whether the patient is at rest and further based on whether the patient is prone to vagally-mediated arrhythmias. Functions of the device that may be controlled include, for example, a pacing base rate, an AV/PV delay, and a refractory period as well as overdrive pacing parameters and diagnostic data gathering parameters. In one example, if the patient is not prone to vagally-mediated arrhythmias, the base rate is lowered while the patient is at rest. Also, overdrive pacing parameters are set to be less aggressive. As such, the operation of the cardiac stimulation device is controlled to make it easier for the patient to rest while also reducing power consumption. However, if the patient is prone to vagally-mediated arrhythmias, the base rate is not lowered while the patient is at rest. Overdrive pacing parameters are instead set to be more aggressive, rather than less aggressive. In this manner, the cardiac stimulation device attempts to compensate for any increased risk of arrhythmia that may occur while the patient, who is prone to vagally-mediated arrhythmias, is at rest. Numerous other parameters may be adjusted dependent upon whether the patient is at rest or dependent upon whether the patient is prone to vagally-mediated arrhythmias.

27. 发明授权

US06760622B2 Implantable multi-chamber cardiac stimulation device with sensing vectors 有权
标题翻译：植入式多室心脏刺激装置与传感向量
公开(公告)号：US06760622B2
公开(公告)日：2004-07-06
申请号：US09897300
申请日：2001-07-03
申请人： John R. Helland , Eric Falkenberg
发明人： John R. Helland , Eric Falkenberg
IPC分类号： A61N118
CPC分类号： A61N1/368 , A61N1/3684
摘要： An implantable multi-chamber cardiac stimulation device and method are provided for accurately sensing cardiac activity from three or four heart chambers using passive sensing electrodes placed in each heart chamber. Multiple intra-chamber or inter-chamber sensing vectors are established between passive sensing electrodes. Sampled sensing vector signals are processed such that a cardiac depolarization may be accurately detected, as well as its origin and direction of propagation. Time intervals between detected depolarization signals may be used to determine conduction time or heart rate. Diagnostic indicators of heart failure condition normally obtained from a 12-lead surface ECG study, such as P-wave or R-wave duration, may also be determined from the sensing vectors. Based on precise and detailed evaluation of sensing vector signals, stimulation therapy may be provided immediately upon a detected change in heart rhythm or heart failure condition.
摘要翻译：提供可植入的多室心脏刺激装置和方法，用于使用放置在每个心室中的无源感测电极来精确地感测来自三个或四个心室的心脏活动。在无源感测电极之间建立多个室内或室间感应向量。对采样的感测向量信号进行处理，使得可以精确地检测心脏去极化，以及其起始点和传播方向。可以使用检测到的去极化信号之间的时间间隔来确定传导时间或心率。通常从12导联表面ECG研究获得的心力衰竭病例的诊断指标，例如P波或R波持续时间，也可以从感测向量确定。基于感测矢量信号的精确和详细的评估，可以在检测到的心律或心力衰竭状况的变化时立即提供刺激治疗。

28. 发明申请

US20050149138A1 System and method for determining optimal pacing sites based on myocardial activation times 审中-公开
标题翻译：基于心肌激活时间确定最佳起搏部位的系统和方法
公开(公告)号：US20050149138A1
公开(公告)日：2005-07-07
申请号：US10745841
申请日：2003-12-24
申请人： Xiaoyi Min , Michael Yang , Kevin Morgan , Eric Falkenberg
发明人： Xiaoyi Min , Michael Yang , Kevin Morgan , Eric Falkenberg
IPC分类号： A61B5/04 , A61N1/05 , A61N1/08 , A61N1/362 , A61N1/365 , A61N1/368 , A61N1/37
CPC分类号： A61N1/36514 , A61B5/04012 , A61N1/056 , A61N1/0587 , A61N1/08 , A61N1/3627
摘要： The optimal location for delivering pacing pulses to a given cardiac chamber (such as the left ventricle) is determined by identifying the last electrically or mechanically activated site within the chamber. For example, the last site within the left ventricular myocardium to depolarize during an intrinsic ventricular contraction triggered by an initial atrial depolarization is identified as being the optimal pacing location for the left ventricle. A pacing electrode is then implanted as close as possible to that location. The technique is particularly effective for use in identifying optimal epicardial pacing locations for mounting satellite pacing devices for use in delivering cardiac resynchronization therapy. However, the techniques may also be applied to identify locations for mounting endocardial electrodes as well. Capture thresholds may also be taken into account in determining the optimal location. Examples are described for both master/satellite pacing systems as well as biventricular single device systems.
摘要翻译：通过识别腔室内最后一个电或机械激活的位置来确定向给定心室（如左心室）输送起搏脉冲的最佳位置。例如，在由初始心房去极化触发的内在心室收缩期间左心室心肌内去极化的最后位置被确定为左心室的最佳起搏位置。然后将起搏电极植入尽可能靠近该位置。该技术特别有效地用于鉴定用于安装用于递送心脏再同步治疗的卫星起搏装置的最佳心外膜起搏位置。然而，这些技术也可以应用于识别用于安装心内膜电极的位置。在确定最佳位置时也可以考虑采集阈值。描述了主/卫星起搏系统以及双心室单一设备系统的示例。

29. 发明授权

US08630692B2 Method and implantable system for blood-glucose concentration monitoring using parallel methodologies 有权
标题翻译：使用并行方法进行血糖浓度监测的方法和植入式系统
公开(公告)号：US08630692B2
公开(公告)日：2014-01-14
申请号：US12433414
申请日：2009-04-30
申请人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi , Euljoon Park , Eric Falkenberg , Michael E. Benser
发明人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi , Euljoon Park , Eric Falkenberg , Michael E. Benser
IPC分类号： A61B5/0205 , A61B5/0402 , A61B5/042 , A61B5/0452 , A61B5/145
CPC分类号： A61B5/0006 , A61B5/0205 , A61B5/04012 , A61B5/0428 , A61B5/0452 , A61B5/14532 , A61B5/14542 , A61B5/14551 , A61B5/1459 , A61B5/4836 , A61B5/4866 , A61B5/6846 , A61B5/686 , A61B5/7285 , A61B5/746
摘要： In an implantable medical device for monitoring glucose concentration in the blood, a blood-glucose concentration analysis is performed using correlations of blood-glucose concentration with measures of metabolic oxygen consumption including oxymetric, and/or temperature. Analysis of electrocardiographic data is used in a parallel method to detect and/or confirm the onset and/or existence and/or extent of hypoglycemia and/or hyperglycemia. Blood-glucose concentration calculation is enhanced by using the combination of the oxygen metabolism analysis and electrocardiographic analysis.
摘要翻译：在用于监测血液中葡萄糖浓度的可植入医疗装置中，使用血糖浓度与包括氧测量和/或温度在内的代谢氧消耗量的相关性进行血糖浓度分析。使用并行方法来分析心电图数据以检测和/或确认低血糖和/或高血糖症的发作和/或存在和/或程度。通过使用氧代谢分析和心电图分析的组合，提高血糖浓度计算。

30. 发明授权

US07519425B2 Tiered therapy for respiratory oscillations characteristic of Cheyne-Stokes respiration 有权
标题翻译： Cheyne-Stokes呼吸特征的分层治疗呼吸振荡
公开(公告)号：US07519425B2
公开(公告)日：2009-04-14
申请号：US10968730
申请日：2004-10-18
申请人： Michael Benser , Eric Falkenberg
发明人： Michael Benser , Eric Falkenberg
IPC分类号： A61N1/00
CPC分类号： A61N1/36514 , A61N1/3601
摘要： An exemplary method includes delivering a maintenance therapy that aims to prevent occurrence of apnea, sensing information, based at least in part on the information, determining if apnea exists and, if apnea exists, delivering a termination therapy that aims to terminate the apnea. An exemplary implantable device includes an input for information pertaining to respiration and control logic to call for overdrive pacing at a first rate that aims to minimize occurrence of a respiratory condition, to analyze the information for occurrence of the respiratory condition and, upon occurrence of the respiratory condition, to call for overdrive pacing at a higher rate. Other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：一种示例性方法包括：至少部分地基于信息来确定是否存在呼吸暂停，并且如果存在呼吸暂停，则提供旨在防止呼吸暂停发生的感测信息，感测信息，传递旨在终止呼吸暂停的终止疗法。示例性可植入装置包括用于与呼吸和控制逻辑相关的信息的输入，以以旨在最小化呼吸状况发生的第一速率来呼叫超速起搏，分析呼吸状况发生的信息，并且在出现呼吸状况，以更高的速度呼叫超速起搏。还公开了其它示例性方法，装置，系统等。

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