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21. 发明授权

US07598250B2 Cyclic amine BACE-1 inhibitors having a heterocyclic substituent 有权
标题翻译：具有杂环取代基的环胺BACE-1抑制剂
公开(公告)号：US07598250B2
公开(公告)日：2009-10-06
申请号：US10911030
申请日：2004-08-04
申请人： Jared N. Cumming , Ying Huang , Guoqing Li , Ulrich Iserloh , Andrew Stamford , Corey Strickland , Johannes H. Voigt , Yusheng Wu , Jianping Pan , Tao Guo , Douglas W. Hobbs , Thuy X. H. Le , Jeffrey F. Lowrie
发明人： Jared N. Cumming , Ying Huang , Guoqing Li , Ulrich Iserloh , Andrew Stamford , Corey Strickland , Johannes H. Voigt , Yusheng Wu , Jianping Pan , Tao Guo , Douglas W. Hobbs , Thuy X. H. Le , Jeffrey F. Lowrie
IPC分类号： A61K31/506 , A61K31/496 , C07D403/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
CPC分类号： C04B35/632 , C07D207/277 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14
摘要： Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1 is X is —O—, —C(R14)2— or —N(R)—; Z is —C(R14)2— or —N(R)—; t is 0, 1, 2 or 3; each R and R2 is independently H, alkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, alkenyl or alkynyl; each R14 is H, alkyl, alkenyl, alkynyl, halo, —CN, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, —OR35, —N(R24)(R25) or —SR35; R41 is alkyl, cycloalkyl, —SO2(alkyl), —C(O)-alkyl, —C(O)-cycloalkyl or -alkyl-NH—C(O)CH3; and the remaining variables are as defined in the specification. Also disclosed are pharmaceutical compositions comprising the compounds of formula I and methods of treating cognitive or neurodegenerative diseases with compounds of formula I.Also disclosed are pharmaceutical compositions and methods of treatment comprising compounds of formula I in combination with other agents useful in treating cognitive or neurodegenerative diseases.
摘要翻译：公开了下式的新化合物或其药学上可接受的盐或溶剂合物，其中R 1是X是-O - ， - C（R 14）2 - 或-N（R） - ; Z是-C（R 14）2 - 或-N（R） - ; t为0,1,2或3; 每个R和R 2独立地为H，烷基，环烷基，环烷基烷基，芳基，杂芳基，杂环烷基，芳基烷基，杂芳基烷基，杂环烷基烷基，烯基或炔基; 每个R 14是H，烷基，烯基，炔基，卤素，-CN，卤代烷基，环烷基，环烷基烷基，芳基，杂芳基，杂环烷基，芳基烷基，杂芳基烷基，杂环烷基烷基，-OR 35，-N（R 24）（R 25）或-SR 35; R41是烷基，环烷基，-SO2（烷基），-C（O） - 烷基，-C（O） - 环烷基或 - 烷基-NH-C（O）CH3; 其余变量如本说明书中所定义。还公开了包含式I化合物的药物组合物和用式I化合物治疗认知障碍或神经变性疾病的方法。还公开了药物组合物和治疗方法，其包含式I化合物与用于治疗认知或神经变性的其它药剂疾病

22. 发明授权

US07511062B2 Substituted 2-quinolyl-oxazoles useful as PDE4 inhibitors 失效
标题翻译：用作PDE4抑制剂的取代的2-喹啉基 - 恶唑
公开(公告)号：US07511062B2
公开(公告)日：2009-03-31
申请号：US11130359
申请日：2005-05-16
申请人： Rongze Kuang , David Blythin , Neng-Yang Shih , Ho-Jane Shue , Xiao Chen , Jianhua Cao , Danlin Gu , Ying Huang , John H. Schwerdt , Pauline C. Ting , Shing-Chun Wong , Li Xiao
发明人： Rongze Kuang , David Blythin , Neng-Yang Shih , Ho-Jane Shue , Xiao Chen , Jianhua Cao , Danlin Gu , Ying Huang , John H. Schwerdt , Pauline C. Ting , Shing-Chun Wong , Li Xiao
IPC分类号： C07D215/38 , A61K31/44
CPC分类号： C07D405/14 , C07D401/04 , C07D405/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The invention claims compounds of the formula wherein is a 5-membered heteroaryl; X is S or O; R1 is H, alkyl, cycloalkyl, cylcoalkylalkyl-, —CH2F, —CHF2, —CF3, —C(O)alkyl or —C(O)NR18R19; R3 and R4 H, alkyl, hydroxyalkyl or —C(O)Oalkyl; R5 and R6 are H, alkyl, hydroxyalkyl, alkoxyalkyl, mercaptoalkyl, —CH2F, —CHF2, —CF3, —C(O)OH or —C(O)Oalkyl; R7 is H, alkyl, alkenyl, hydroxyalkyl, cycloalkyl, alkoxyalkyl, aminoalkyl, (R17-phenyl)alkyl or —CH2—C(O)—O-alkyl; and R8 comprises alkyl, heteroaryl, phenyl or cycloalkyl, or heterocycloalkyl, all optionally substituted, or a cycloalkyl- or heterocycloalkyl-substituted amide; or R7 and R8 and the nitrogen to which they are attached together form an optionally substituted ring; and the remaining variables are as defined in the specification. Also claimed are pharmaceutical compositions, the use of the compounds as PDE4 inhibitors, and combinations with other actives.
摘要翻译：本发明要求具有下式的化合物其中是5元杂芳基; X是S或O; R 1是H，烷基，环烷基，环烷基烷基 - ， - CH 2 F，-CHF 2，-CF 3，-C（O）烷基或-C（O）NR 18 R 19; R 3和R 4 H，烷基，羟基烷基或-C（O）O烷基; R5和R6是H，烷基，羟基烷基，烷氧基烷基，巯基烷基，-CH2F，-CHF2，-CF3，-C（O）OH或-C（O） R 7是H，烷基，烯基，羟基烷基，环烷基，烷氧基烷基，氨基烷基，（R 17 - 苯基）烷基或-CH 2 -C（O）-O-烷基; 和R8包括烷基，杂芳基，苯基或环烷基，或杂环烷基，全部任意取代，或环烷基 - 或杂环烷基取代的酰胺; 或R 7和R 8，并且与它们相连的氮一起形成任选取代的环; 其余变量如本说明书中所定义。还要求保护的是药物组合物，化合物作为PDE4抑制剂的用途，以及与其它活性物质的组合。

23. 发明授权

US07433490B2 System and method for real time lip synchronization 有权
标题翻译：用于实时唇形同步的系统和方法
公开(公告)号：US07433490B2
公开(公告)日：2008-10-07
申请号：US11435122
申请日：2006-05-16
申请人： Ying Huang , Stephen Ssu-te Lin , Baining Guo , Heung-Yeung Shum
发明人： Ying Huang , Stephen Ssu-te Lin , Baining Guo , Heung-Yeung Shum
IPC分类号： G06K9/00 , G10L15/00
CPC分类号： G06K9/00335 , G10L2021/105
摘要： A novel method for synchronizing the lips of a sketched face to an input voice. The lip synchronization system and method approach is to use training video as much as possible when the input voice is similar to the training voice sequences. Initially, face sequences are clustered from video segments, then by making use of sub-sequence Hidden Markov Models, a correlation between speech signals and face shape sequences is built. From this re-use of video, the discontinuity between two consecutive output faces is decreased and accurate and realistic synthesized animations are obtained. The lip synchronization system and method can synthesize faces from input audio in real-time without noticeable delay. Since acoustic feature data calculated from audio is directly used to drive the system without considering its phonemic representation, the method can adapt to any kind of voice, language or sound.
摘要翻译：一种用于将草绘脸部的嘴唇同步到输入声音的新颖方法。唇部同步系统和方法方法是当输入的声音类似于训练声音序列时尽可能多地使用训练视频。最初，面部序列从视频片段聚类，然后通过利用子序列隐马尔可夫模型，构建了语音信号和面部形状序列之间的相关性。从这种视频的再次使用，两个连续的输出面之间的不连续性被降低，并且获得准确而逼真的合成动画。唇同步系统和方法可以实时地从输入音频合成面部，而没有明显的延迟。由于从音频计算的声学特征数据直接用于驱动系统而不考虑其音位表示，该方法可以适应任何种类的语音，语言或声音。

24. 发明申请

US20080215397A1 SYSTEM AND MECHANISM TO CREATE AUTONOMIC BUSINESS SOLUTIONS 审中-公开
标题翻译：创造自动化业务解决方案的制度与机制
公开(公告)号：US20080215397A1
公开(公告)日：2008-09-04
申请号：US12051396
申请日：2008-03-19
申请人： Kamal Bhattacharya , Ying Huang , Jun-Jang Jeng , Shubir Kapoor , Santhosh Kumaran , Yingjie Li , Anil Nigam , Frederick Y. Wu , Liangzhao Zeng
发明人： Kamal Bhattacharya , Ying Huang , Jun-Jang Jeng , Shubir Kapoor , Santhosh Kumaran , Yingjie Li , Anil Nigam , Frederick Y. Wu , Liangzhao Zeng
IPC分类号： G06Q10/00 , G06F17/00
CPC分类号： G06Q10/06 , G06Q10/06375
摘要： Automomic business processes management solutions have capabilities to adapt themselves to changes in the business environment. These autonomic business solutions are built by wiring together autonomic solution components called BPbots (Business Process robots). BPbots are granular solution components representing an aspect of a business process. In general, BPbots consist of two parts, an execution module and a managerial module. The execution module represents the standard, non-autonomic solution component, such as a standard process flow model describing the long-running flow or business adapter describing the communication of the solution with service providers (such as applications). The managerial module is responsible for the autonomic behavior of the BPbot. The managerial component has the ability to monitor the execution module, analyze the performance, plan new, more appropriate execution patterns and change the behavior of the execution module according to the new plan.
摘要翻译：自动化业务流程管理解决方案具有适应业务环境变化的能力。这些自主业务解决方案是通过将称为BPbots（业务流程机器人）的自主解决方案组件连接在一起构建的。 BPbots是代表业务流程方面的细粒度的解决方案组件。一般来说，BPbots由两部分组成，一个执行模块和一个管理模块。执行模块表示标准的非自主性解决方案组件，例如描述长时间运行的流程或描述与服务提供商（例如应用程序）的解决方案通信的业务适配器的标准流程模型。管理模块负责BPbot的自主行为。管理组件能够监视执行模块，分析性能，计划新的更合适的执行模式，并根据新计划改变执行模块的行为。

25. 发明申请

US20080183530A1 Method and Apparatus for Model-Driven Managed Business Services 审中-公开
标题翻译：用于模型驱动的管理业务服务的方法和装置
公开(公告)号：US20080183530A1
公开(公告)日：2008-07-31
申请号：US12060982
申请日：2008-04-02
申请人： Sugato Bagchi , Kumar Bhaskaran , Shiwa S. Fu , Ying Huang , Hai Tao Hu , Anca-Andreea Ivan , Shubir Kapoor , Santhosh Kumaran , Lun Quoc Nguyen , Thejaswini Ramachandra
发明人： Sugato Bagchi , Kumar Bhaskaran , Shiwa S. Fu , Ying Huang , Hai Tao Hu , Anca-Andreea Ivan , Shubir Kapoor , Santhosh Kumaran , Lun Quoc Nguyen , Thejaswini Ramachandra
IPC分类号： G06Q10/00
CPC分类号： G06Q10/06 , G06Q10/06315 , G06Q10/0637 , G06Q10/06375 , G06Q30/0201 , G06Q30/0203 , G06Q30/0283
摘要： A mechanism provides a model-driven solution template-based approach for managed business services. Key assets of the business services are templatized and made configurable. The mechanism implements a metamodel describing standard service offerings that can be configured to meet specific business and operational requirements at a level of business process and system components. A cost and pricing model of service offerings helps assess the service costs and resource requirements based on a client's selection of standard and customized processes and system components. A supporting system solution is developed based upon underlying solution templates and solution artifacts as well as client-specific requirements.
摘要翻译：一种机制为托管业务服务提供了基于模型驱动的基于解决方案模板的方法。业务服务的主要资产被模板化，可配置。该机制实现了描述标准服务产品的元模型，可以将其配置为在业务流程和系统组件级别满足特定的业务和操作需求。服务产品的成本和定价模式有助于根据客户对标准和定制流程和系统组件的选择来评估服务成本和资源需求。基于底层解决方案模板和解决方案工件以及客户特定的需求开发了支持系统解决方案。

26. 发明申请

US20080176868A1 Preparation and use of compounds as protease inhibitors 有权
标题翻译：化合物作为蛋白酶抑制剂的制备和使用
公开(公告)号：US20080176868A1
公开(公告)日：2008-07-24
申请号：US11451065
申请日：2006-06-12
申请人： Andrew Stamford , Guoqing Li , William Greenlee , Zhaoning Zhu , Brian McKittrick , Robert Mazzola , Ying Huang , Tao Guo , Thuy X.H. Le , Gang Qian , Yuefei Shao
发明人： Andrew Stamford , Guoqing Li , William Greenlee , Zhaoning Zhu , Brian McKittrick , Robert Mazzola , Ying Huang , Tao Guo , Thuy X.H. Le , Gang Qian , Yuefei Shao
IPC分类号： A61K31/519 , C07D209/44 , A61K31/4035 , A61P25/00 , A61P25/28 , A61P31/18 , A61P9/00 , C07D487/04
CPC分类号： C07D471/04 , C07D209/44 , C07D487/04
摘要： Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein Q is a bond or —N(R5)—; T is a bond, —O—, —C(O)—; S, —N(R5)—, or —C(R6′R7′); U is a bond or —C(R6)(R7)— Y is C or N; Z is C or N; ring A, including variables Y and Z, is a three to nine membered cycloalkyl, cycloalkenyl, heterocylcyl, heterocyclenyl, aryl, and heteroaryl ring having 0 to 4, preferably 0 to 2, heteroatoms independently selected from the group consisting of O, S, N and —N(R)—, wherein ring A is unsubstituted or substituted with 1 to 5 independently selected R1 moieties and/or oxo when ring A is cycloalkyl, cycloalkenyl, heterocyclyl or heterocyclenyl;and R, R1, R2, R3, R4, R5, R6, R6, R7 and R7′ are as defined in the specification; pharmaceutical compositions comprising the compounds of formula I and the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases.
摘要翻译：公开了式I化合物或其立体异构体，互变异构体或其药学上可接受的盐或溶剂化物，其中Q是一个键或-N（R 5） - ; T是键，-O - ， - C（O） - ; S，-N（R 5） - 或-C（R 6'，R 7'）; U是键或-C（R 6）（R 7） - Y是C或N; Z是C或N; 环A包括变量Y和Z是具有0至4个，优选0至2个杂原子的3至9元环烷基，环烯基，杂环基，杂环烯基，芳基和杂芳基环，其独立地选自O，S， N和-N（R） - ，其中当环A是环烷基，环烯基，杂环基或杂环烯基时，环A是未取代的或被1至5个独立选择的R 1 O 1部分和/或氧代取代。 R 1，R 2，R 2，R 3，R 4，R 5， R 4，R 6，R 6，R 7和R 7'如说明书中所定义; 包含式I化合物的药物组合物和抑制天冬氨酰蛋白酶的方法，特别是治疗心血管疾病，认知和神经变性疾病的方法。

27. 发明申请

US20080140795A1 METHOD AND APPARATUS FOR ALERTING NODES OF A MALICIOUS NODE IN A MOBILE AD-HOC COMMUNICATION SYSTEM 有权
标题翻译：用于在移动通信系统中警告恶意节点的方法和装置
公开(公告)号：US20080140795A1
公开(公告)日：2008-06-12
申请号：US11608452
申请日：2006-12-08
申请人： Wenbo He , Ying Huang , Klara Nahrstedt , Whay Chiou Lee
发明人： Wenbo He , Ying Huang , Klara Nahrstedt , Whay Chiou Lee
IPC分类号： G06F15/16
CPC分类号： H04L63/1416 , H04W12/12 , H04W84/18
摘要： A method and apparatus for alerting nodes of a malicious node in a mobile ad-hoc communication system is provided herein. Particularly, a method and apparatus for distributing an alert message to nodes surrounding a recently discovered malicious node is provided. This alert technique further leverages mobility to distribute the alert message to a large majority of nodes in the ad hoc wireless network within a reasonable amount of time.
摘要翻译：本文提供了用于在移动自组织通信系统中警告恶意节点的节点的方法和装置。特别地，提供了用于向最近发现的恶意节点周围的节点分发警报消息的方法和装置。该警报技术进一步利用移动性在合理的时间内将警报消息分发到自组织无线网络中的大多数节点。

28. 发明授权

US07139406B2 Remote baggage screening system, software and method 有权
公开(公告)号：US07139406B2
公开(公告)日：2006-11-21
申请号：US10116693
申请日：2002-04-03
申请人： Keith M. McClelland , Craig Dawson , Ying Huang , Andrea L. Whitson
发明人： Keith M. McClelland , Craig Dawson , Ying Huang , Andrea L. Whitson
IPC分类号： G06K17/00 , G01N9/00 , G01T1/38
CPC分类号： G01V5/0083 , B64F1/368 , G06Q10/02 , H04L29/06 , H04L67/02 , H04L67/12 , H04L69/329
摘要： A method of advance baggage screening includes steps of transmitting a threat file corresponding to an item under inspection to a processing center, analyzing the threat file according to a detection algorithm at the processing center to determine a screening result for the item under inspection, and transmitting the screening result to a remotely located operator interface for access by an operator.

29. 发明申请

US20060074725A1 Method and apparatus for simulating implementation models of business solutions 审中-公开
标题翻译：用于模拟业务解决方案实现模型的方法和装置
公开(公告)号：US20060074725A1
公开(公告)日：2006-04-06
申请号：US10952935
申请日：2004-09-30
申请人： Ying Huang , Makoto Kano , Akio Koide , Bala Ramachandran , Frederick Wu
发明人： Ying Huang , Makoto Kano , Akio Koide , Bala Ramachandran , Frederick Wu
IPC分类号： G06F9/44
CPC分类号： G06Q10/04
摘要： A method (and system) for simulating an implementation model of a business solution includes simulating business artifacts that invoke the implementation model of the business solution, at least one of simulating and executing a component of the business solution during at least one intermediate stage of a development and integration lifecycle of the implementation model, and analyzing results from the simulation of the implementation model during said at least one intermediate stage of the development and integration lifecycle of the implementation model, thereby allowing a user to simulate an implementation model using both real solution components and simulated solution components.
摘要翻译：用于模拟业务解决方案的实现模型的方法（和系统）包括模拟业务工件，其调用业务解决方案的实现模型，至少一个在业务解决方案的至少一个中间阶段中模拟和执行业务解决方案的组件实现模型的开发和集成生命周期，以及在实施模型的开发和集成生命周期的至少一个中间阶段分析实施模型的模拟结果，从而允许用户使用实际解决方案来模拟实现模型组件和模拟解决方案组件。

30. 发明申请

US20060040994A1 Substituted amide beta secretase inhibitors 有权
标题翻译：取代的酰胺β分泌酶抑制剂
公开(公告)号：US20060040994A1
公开(公告)日：2006-02-23
申请号：US11185419
申请日：2005-07-20
申请人： Ying Huang , Guoqing Li , Andrew Stamford
发明人： Ying Huang , Guoqing Li , Andrew Stamford
IPC分类号： A61K31/4439 , A61K31/4178 , A61K31/4166 , C07D405/02 , C07D403/02
CPC分类号： C07D401/12 , C07D241/04 , C07D241/08 , C07D401/10 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, R3, R4 and X are as defined in the specification. Also disclosed are pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of treating cognitive or neurodegenerative diseases such as Alzheimer's disease. Also disclosed are methods of treating a cognitive or neurodegenerative disease comprising administering to a patient I need of such treatment a combination of at least one compound of formula I and at least one compound selected from the group consisting of β-secretase inhibitors other than those of formula I, HMG-CoA reductase inhibitors, gamma-secretase inhibitors, non-steroidal anti-inflammatory agents, N-methyl-D-aspartate receptor antagonists, cholinesterase inhibitors and anti-amyloid antibodies.
摘要翻译：公开了下式的新化合物或其药学上可接受的盐或溶剂化物，其中R 1，R 2，R 3，R SUP > 4和X如说明书中所定义。还公开了包含式I化合物的药物组合物。还公开了治疗认知或神经变性疾病如阿尔茨海默病的方法。还公开了治疗认知或神经变性疾病的方法，其包括向需要这种治疗的患者施用至少一种式I化合物和至少一种选自β-分泌酶抑制剂的化合物的组合，所述β-分泌酶抑制剂除式I，HMG-CoA还原酶抑制剂，γ-分泌酶抑制剂，非甾体抗炎剂，N-甲基-D-天冬氨酸受体拮抗剂，胆碱酯酶抑制剂和抗淀粉样蛋白抗体。

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