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21. 发明授权

US07776597B2 Method of inducing embryonic stem cells into pancreatic cells 有权
标题翻译：将胚胎干细胞诱导进入胰腺细胞的方法
公开(公告)号：US07776597B2
公开(公告)日：2010-08-17
申请号：US11911378
申请日：2006-04-14
申请人： Hongkui Deng , Mingxiao Ding , Yan Shi , Wei Jiang , Lingling Hou , Fuchou Tang
发明人： Hongkui Deng , Mingxiao Ding , Yan Shi , Wei Jiang , Lingling Hou , Fuchou Tang
IPC分类号： C12N5/00 , C12N5/02 , C12N5/071
CPC分类号： C12N5/0676 , A61K35/12 , C12N2500/25 , C12N2500/38 , C12N2500/44 , C12N2501/115 , C12N2501/16 , C12N2501/385 , C12N2506/02 , C12N2533/52 , C12N2533/90
摘要： The present invention provided a simple three-step approach based on the combinational induction with activin A, all-trans retinoic acid and, optionally, other maturation factors which are able to induce embryonic stem cells to differentiate into insulin-producing cells. A kit used to induce embryonic stem cells to differentiate into insulin-producing cells was also provided.
摘要翻译：本发明提供了基于与激活素A，全反式视黄酸和任选地能够诱导胚胎干细胞分化成胰岛素生成细胞的其它成熟因子的组合诱导的简单的三步法。还提供了用于诱导胚胎干细胞分化成胰岛素生成细胞的试剂盒。

22. 发明申请

US20090030046A1 NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME 有权
标题翻译：新型GLUCOKINASE激活剂及其使用方法
公开(公告)号：US20090030046A1
公开(公告)日：2009-01-29
申请号：US12179648
申请日：2008-07-25
申请人： Yan Shi , Peter T.W. Cheng , Ying Wang , Denis E. Ryono
发明人： Yan Shi , Peter T.W. Cheng , Ying Wang , Denis E. Ryono
IPC分类号： A61K31/4439 , C07D277/56 , A61K31/426 , C07D277/68 , C07D417/12 , A61P3/04 , A61P3/10 , A61K31/428 , C07D233/28 , A61K31/4164
CPC分类号： C07D277/56 , C07C317/22 , C07D213/81 , C07D231/14 , C07D233/90 , C07D241/24 , C07D249/10 , C07D277/68 , C07D471/04 , C07D513/04
摘要： Compounds are provided which are activators of the enzyme glucokinase and thus are useful in treating diabetes and related diseases, which compounds have the structure where Q is and R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein or a pharmaceutically acceptable salt thereof.A method for treating diabetes and related diseases employing the above compounds is also provided.
摘要翻译：提供了作为葡糖激酶酶的激活剂的化合物，因此可用于治疗糖尿病和相关疾病，该化合物具有Q为结构，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8如本文所定义或其药学上可接受的盐。还提供了使用上述化合物治疗糖尿病和相关疾病的方法。

23. 发明申请

US20080009533A1 SUBSTITUTED ACID DERIVATIVES USEFUL AS ANTI-ATHEROSCLEROTIC, ANTI-DYSLIPIDEMIC, ANTI-DIABETIC AND ANTI-OBESITY AGENTS AND METHOD 有权
标题翻译：取代的酸衍生物有助于抗甲状腺激素，抗血糖，抗糖尿病和抗胆碱药物和方法
公开(公告)号：US20080009533A1
公开(公告)日：2008-01-10
申请号：US11773545
申请日：2007-07-05
申请人： Joseph Tino , Peter Cheng , Yan Shi , Jun Li , Ranjan Mukherjee
发明人： Joseph Tino , Peter Cheng , Yan Shi , Jun Li , Ranjan Mukherjee
IPC分类号： A61K31/421 , A61P3/08 , C07D263/30
CPC分类号： C07D263/32
摘要： Compounds are provided which have the structure of Formula (I): wherein R1 is halogen; and X is hydrogen or halogen, and salts thereof, which compounds are useful as anti-atherosclerotic, anti-dyslipidemic, anti-diabetic, and anti-obesity agents.
摘要翻译：提供具有式（I）结构的化合物：其中R 1是卤素; 并且X是氢或卤素，及其盐，该化合物可用作抗动脉粥样硬化，抗血脂异常，抗糖尿病和抗肥胖剂。

24. 发明申请

US20080009465A1 NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME 有权
标题翻译：新型GLUCOKINASE激活剂及其使用方法
公开(公告)号：US20080009465A1
公开(公告)日：2008-01-10
申请号：US11769964
申请日：2007-06-28
申请人： Denis E. Ryono , Peter T.W. Cheng , Scott A. Bolton , Sean Chen , Yan Shi , Wei Meng , Joseph A. Tino , Hao Zhang , Richard B. Sulsky
发明人： Denis E. Ryono , Peter T.W. Cheng , Scott A. Bolton , Sean Chen , Yan Shi , Wei Meng , Joseph A. Tino , Hao Zhang , Richard B. Sulsky
IPC分类号： A61K31/675 , A61P19/00 , A61P25/00 , A61P3/04 , A61P3/10 , A61P9/00 , C07F9/28
CPC分类号： C07F9/6539 , C07F9/58 , C07F9/65031 , C07F9/650952 , C07F9/6518
摘要： Compounds are provided which are phosphonate and phosphinate activators and thus are useful in treating diabetes and related diseases and have the structure wherein is a heteroaryl ring; R4 is —(CH2)n-Z-(CH2)m—PO(OR7)(OR8), —(CH2)nZ-(CH2)m—PO(OR7)Rg, —(CH2)n-Z-(CH2)m—OPO(OR7)Rg, —(CH2)nZ—(CH2)m—OPO(R9)(R10), or —(CH2)nZ—(CH2)m—PO(R9)(R10); R5 and R6 are independently selected from H, alkyl and halogen; Y is R7(CH2)s or is absent; and X, n, Z, m, R4, R5, R6, R7, and s are as defined herein; or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.
摘要翻译：提供了膦酸酯和次膦酸酯活化剂的化合物，因此可用于治疗糖尿病和相关疾病，并且其结构是杂芳基环; R 4是 - （CH 2 CH 2）n - （Z）（CH 2）n - （OR 7）（OR 8）， - （CH 2 CH 2）n - Z - （ CH 2 - ）（OR 7）R g， - （CH 2 CH 2）（CH 3）n -Z-（CH 2）2 - （O）7 - （CH 3）（CH 2）n - Z - （CH 2）m - （O） - （CH 2）n - （R 10），或 - （CH 2）n - Z - （CH 2）（R 9） - （R 9））（R 10）。 R 5和R 6独立地选自H，烷基和卤素; Y是R 7（CH 2）2，或不存在; 和X，n，Z，m，R 4，R 5，R 6，R 7，和 s如本文所定义; 或其药学上可接受的盐。还提供了使用上述化合物治疗糖尿病和相关疾病的方法。

25. 发明申请

US20050025790A1 Endogenous adjuvant molecules and uses thereof 有权
标题翻译：内源性佐剂分子及其用途
公开(公告)号：US20050025790A1
公开(公告)日：2005-02-03
申请号：US10846381
申请日：2004-05-13
申请人： Kenneth Rock , Yan Shi
发明人： Kenneth Rock , Yan Shi
IPC分类号： A61K9/00 , A61K39/39 , G01N33/53 , A61K39/00 , A61K39/002 , A61K39/02 , A61K39/12 , A61K45/00 , A61K47/00
CPC分类号： A61K39/39 , A61K2039/55505 , A61K2039/55511
摘要： Methods of modulating the immune response using pharmaceutical compositions containing crystalline adjuvants are described. In various embodiments the crystalline adjuvants are selected from the group consisting of monosodium urate (MSU), xanthine, basic calcium phosphate (BCP), calcium pyrophosphate dihydrate (CPPD), hydroxyapatite, calcium oxalate, cholesterol, lipid liquid, other crystalline lipids, lithium heparin, talc, and starch.
摘要翻译：描述了使用含有结晶佐剂的药物组合物来调节免疫应答的方法。在各种实施方案中，结晶佐剂选自由尿酸单钠（MSU），黄嘌呤，碱式磷酸钙（BCP），焦磷酸钙二水合物（CPPD），羟基磷灰石，草酸钙，胆固醇，脂质液体，其它结晶脂质，锂肝素，滑石粉和淀粉。

26. 发明申请

US20050002669A1 Method, apparatus and system for the automatic provisioning of a network element 失效
标题翻译：用于自动配置网元的方法，装置和系统
公开(公告)号：US20050002669A1
公开(公告)日：2005-01-06
申请号：US10447015
申请日：2003-05-28
申请人： Richard Adleman , Peter Bartman , Heribert Blach , Ellen Eng , Narasimhan Raghavan , Yan Shi , Mary Socratous , William Thompson
发明人： Richard Adleman , Peter Bartman , Heribert Blach , Ellen Eng , Narasimhan Raghavan , Yan Shi , Mary Socratous , William Thompson
IPC分类号： H04B10/02 , H04B10/08
CPC分类号： H04B10/079
摘要： A method for the automatic provisioning of a network element (NE) includes receiving a client signal at a tunable optical translator (OT) in the NE, determining the set of channels supported by the OT that are able to correspond to the client signal, eliminating the channels that have connections, that may be present on a line side of the NE in a laser off scan process, or that have not been equipped or otherwise provisioned for transmission, tuning the OT to each of the remaining channels and determining the optical power level of each channel on a line side of the NE in a laser on scan process. Subsequently, the channel with the highest power level is selected to transmit the client signal and associations for a point to point connection for that channel are added for that OT to a database of associations for the NE.
摘要翻译：一种用于自动提供网元（NE）的方法包括：在NE中的可调光转换器（OT）处接收客户端信号，确定由OT支持的能够对应于客户信号的信道集，消除具有连接的通道，其可以存在于激光关闭扫描处理中的NE的线路侧，或者尚未配备或以其他方式设置用于传输，将OT调谐到每个剩余通道并确定光功率在激光扫描过程中NE的线路侧的每个通道的电平。随后，选择具有最高功率电平的信道来发送客户端信号，并且将该频道的点对点连接的关联被添加到该OT到与NE的关联的数据库。

27. 发明授权

US06555542B1 Sulfonamide lactam inhibitors of FXa and method 有权
标题翻译： FXa的磺酰胺内酰胺抑制剂及方法
公开(公告)号：US06555542B1
公开(公告)日：2003-04-29
申请号：US10059621
申请日：2002-01-29
申请人： Stephen P. O'Connor , Michael Lawrence , Yan Shi , Philip D. Stein
发明人： Stephen P. O'Connor , Michael Lawrence , Yan Shi , Philip D. Stein
IPC分类号： A61K314412
CPC分类号： C07D211/56 , C07D401/06 , C07D401/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/08 , C07D491/08
摘要： Sulfonamide lactams of the following formula wherein X, R1, R2, R3, R4, R4a, R5, R5a, R6, R6a, R7 and R8 are as described herein, are provided which inhibitors of Factor Xa and are useful as anticoagulants in the treatment of cardiovascular diseases associated with thromboses.
摘要翻译：本文所述的X，R 1，R 2，R 3，R 4，R 4a，R 5，R 5a，R 7a，R 8，R 8，R 7和R 8如下所述的下列化学式的磺酰胺内酰胺被提供为因子Xa的哪种抑制剂并且可用作抗凝剂与血栓相关的心血管疾病。

28. 发明授权

US08614332B2 Substituted pyrazolylamides useful as glucokinase activators 有权
标题翻译：用作葡糖激酶活化剂的取代的吡唑基酰胺
公开(公告)号：US08614332B2
公开(公告)日：2013-12-24
申请号：US13397123
申请日：2012-02-15
申请人： Denis E. Ryono , Peter T. W. Cheng , Scott A. Bolton , Sean Chen , Yan Shi , Wei Meng , Joseph A. Tino , Richard B. Sulsky
发明人： Denis E. Ryono , Peter T. W. Cheng , Scott A. Bolton , Sean Chen , Yan Shi , Wei Meng , Joseph A. Tino , Richard B. Sulsky
IPC分类号： C07D231/00
CPC分类号： C07F9/6539 , C07F9/58 , C07F9/65031 , C07F9/650952 , C07F9/6518
摘要： Compounds are provided which are phosphonate and phosphinate activators and thus are useful in treating diabetes and related diseases and have the structure is a heteroaryl ring; R4 is —(CH2)n—Z—(CH2)m—PO(OR7)(OR8), —(CH2)nZ—(CH2)m—PO(OR7)R9, —(CH2)n—Z—(CH2)m—OPO(OR7)R9, —(CH2)nZ—(CH2)m—OPO(R9)(R10), or —(CH2)nZ—(CH2)m—PO(R9)(R10); R5 and R6 are independently selected from H, alkyl and halogen; Y is R7(CH2)s or is absent; and X, n, Z, m, R4, R5, R6, R7, and s are as defined herein; or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.
摘要翻译：提供了膦酸酯和次膦酸酯活化剂的化合物，因此可用于治疗糖尿病和相关疾病，并且其结构是杂芳基环; R4是 - （CH2）nZ-（CH2）m-PO（OR7）（OR8）， - （CH2）nZ-（CH2）m-PO（OR7）R9， - （CH2）nZ-（CH2）（OR7）R9， - （CH2）nZ-（CH2）m-OPO（R9）（R10）或 - （CH2）nZ-（CH2）m-PO（R9）（R10） R5和R6独立地选自H，烷基和卤素; Y为R 7（CH 2）s或不存在; 并且X，n，Z，m，R 4，R 5，R 6，R 7和s如本文所定义; 或其药学上可接受的盐。还提供了使用上述化合物治疗糖尿病和相关疾病的方法。

29. 发明授权

US08597664B2 Endogenous adjuvant molecules and uses thereof 有权
标题翻译：内源性佐剂分子及其用途
公开(公告)号：US08597664B2
公开(公告)日：2013-12-03
申请号：US12879471
申请日：2010-09-10
申请人： Kenneth L. Rock , Yan Shi
发明人： Kenneth L. Rock , Yan Shi
IPC分类号： A61K39/00
CPC分类号： A61K39/39 , A61K2039/55505 , A61K2039/55511
摘要： Methods of modulating the immune response using pharmaceutical compositions containing crystalline adjuvants are described. In various embodiments the crystalline adjuvants are selected from the group consisting of monosodium urate (MSU), xanthine, basic calcium phosphate (BCP), calcium pyrophosphate dihydrate (CPPD), hydroxyapatite, calcium oxalate, cholesterol, lipid liquid, other crystalline lipids, lithium heparin, talc, and starch.
摘要翻译：描述了使用含有结晶佐剂的药物组合物调节免疫应答的方法。在各种实施方案中，结晶佐剂选自由尿酸单钠（MSU），黄嘌呤，碱式磷酸钙（BCP），焦磷酸钙二水合物（CPPD），羟基磷灰石，草酸钙，胆固醇，脂质液体，其它结晶脂质，锂肝素，滑石粉和淀粉。

30. 发明授权

US08410782B2 Switch testing circuit 失效
标题翻译：开关测试电路
公开(公告)号：US08410782B2
公开(公告)日：2013-04-02
申请号：US12820081
申请日：2010-06-21
申请人： Yan Shi
发明人： Yan Shi
IPC分类号： G01R31/02
CPC分类号： G01R31/3277 , G01R31/025
摘要： A switch testing circuit is configured for testing a switch. The switch testing circuit includes a switch element, a first light emitting diode, and a control chip. The first light emitting diode, the switch element, and the switch are connected in series. The first light emitting diode is configured for indicating connection condition between the switch and the switch testing circuit. The control chip is configured for acquiring a voltage from one terminal of the switch element and comparing the acquired voltage with a comparison voltage to judge whether the switch is qualified or disqualified according to the comparison result.
摘要翻译：开关测试电路被配置用于测试开关。开关测试电路包括开关元件，第一发光二极管和控制芯片。第一发光二极管，开关元件和开关串联连接。第一发光二极管被配置用于指示开关和开关测试电路之间的连接状态。控制芯片被配置为从开关元件的一个端子获取电压，并将所获取的电压与比较电压进行比较，以根据比较结果判断开关是合格的还是不合格的。

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