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21. 发明授权

US08937093B2 Heterocyclic aspartyl protease inhibitors 有权
标题翻译：杂环天门冬氨酰蛋白酶抑制剂
公开(公告)号：US08937093B2
公开(公告)日：2015-01-20
申请号：US13402521
申请日：2012-02-22
申请人： Kurt W. Saionz , Tao Guo , Andrew W. Stamford , Zhaoning Zhu
发明人： Kurt W. Saionz , Tao Guo , Andrew W. Stamford , Zhaoning Zhu
IPC分类号： A61K31/4245 , C07D271/07 , A61K31/5377 , C07D233/46 , C07D233/70 , C07D233/88 , C07D239/22 , C07D239/70 , C07D273/00 , C07D401/04 , C07D401/08 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/10 , C07D403/12 , C07D405/10 , C07D409/04 , C07D409/10 , C07D409/14 , C07D413/10 , C07D413/12 , C07D417/06 , A61K31/4168 , A61K31/4178 , A61K31/4184 , A61K31/4439 , A61K31/454 , A61K45/06 , C07D295/15 , C07D401/06 , C07D405/06 , C07D409/06
CPC分类号： C07D233/88 , A61K31/4168 , A61K31/4178 , A61K31/4184 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/4725 , A61K31/5377 , A61K31/655 , A61K45/06 , C07D233/46 , C07D233/70 , C07D235/02 , C07D239/22 , C07D239/70 , C07D271/07 , C07D273/00 , C07D295/15 , C07D401/04 , C07D401/06 , C07D401/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/04 , C07D409/06 , C07D409/10 , C07D409/14 , C07D413/10 , C07D413/12 , C07D417/06 , Y02A50/411
摘要： Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein W, X, U, R1, R2, R3, and R4, are as defined herein, and pharmaceutical compositions comprising the compounds of formula I. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic antagonist.
摘要翻译：公开了式I化合物或其立体异构体，互变异构体或其药学上可接受的盐或溶剂合物，其中W，X，U，R 1，R 2，R 3和R 4如本文所定义，以及包含式 I.还公开了抑制天冬氨酰蛋白酶的方法，特别是治疗心血管疾病，认知和神经变性疾病的方法，以及抑制人类免疫缺陷病毒，plasmepins，组织蛋白酶D和原生动物酶的方法。还公开了使用式I化合物与胆碱酯酶抑制剂或毒蕈碱拮抗剂组合来治疗认知或神经变性疾病的方法。

22. 发明授权

US08434766B2 Turbine engine seals 有权
标题翻译：涡轮发动机密封
公开(公告)号：US08434766B2
公开(公告)日：2013-05-07
申请号：US12858701
申请日：2010-08-18
申请人： Xiaoqiang Zeng , Jonathon Edward Slepski , Tao Guo , Joshy John , Sudhakar Neeli
发明人： Xiaoqiang Zeng , Jonathon Edward Slepski , Tao Guo , Joshy John , Sudhakar Neeli
IPC分类号： F16J15/447
CPC分类号： F01D11/001 , F01D11/02 , F05D2250/232 , F16J15/441 , F16J15/4472
摘要： A seal is provided for preventing axial leakage through a radial gap between a stationary structure and a rotating structure. The radial gap is defined by an inner radial surface opposing an outer radial surface across the radial gap. The seal includes at least one land disposed on one of the inner radial surface and outer radial surface. At least one first tooth and at least one second tooth project from the other of the radial surfaces. The second tooth is shorter than the first tooth. At least one of the first tooth and second tooth, is configured to extend at an angle upstream. This angle is defined between a radial surface from which the first or second tooth projects and an upstream surface of the same tooth. The angle is less than or equal to about 80 degrees.
摘要翻译：提供密封件以防止通过固定结构和旋转结构之间的径向间隙的轴向泄漏。径向间隙由跨越径向间隙的与外径向表面相对的内径向表面限定。密封件包括设置在内径向表面和外径向表面中的一个上的至少一个区域。至少一个第一齿和至少一个第二齿从另一个径向表面突出。第二个齿比第一个牙齿短。第一齿和第二齿中的至少一个构造成在上游以一定角度延伸。该角度限定在第一或第二齿突出的径向表面与同一牙齿的上游表面之间。该角度小于或等于约80度。

23. 发明授权

US08106191B2 Synthetic multimerizing agents 失效
标题翻译：合成多聚化剂
公开(公告)号：US08106191B2
公开(公告)日：2012-01-31
申请号：US10461705
申请日：2003-06-13
申请人： Dennis A. Holt , Terence P. Keenan , Tao Guo , Edgardo Laborde , Wu Yang
发明人： Dennis A. Holt , Terence P. Keenan , Tao Guo , Edgardo Laborde , Wu Yang
IPC分类号： C07D413/00 , C07D211/00 , C07D409/00 , C07D207/00 , C07D205/00 , C07F7/02
CPC分类号： C07D401/14 , C07D207/16 , C07D211/60 , C07D401/12 , C07D405/12
摘要： New compounds are disclosed for multimerizing immunophilins and proteins containing immunophilin or immunophilin-related domains. The compounds are of the formula M-L-Q where M is a synthetic ligand for an FKBP protein.
摘要翻译：公开了用于多聚化免疫亲和素和含有免疫亲和素相关结构域的蛋白质的新化合物。该化合物具有式M-L-Q，其中M是FKBP蛋白质的合成配体。

24. 发明申请

US20110135447A1 SYSTEM FOR REDUCING THE LEVEL OF EROSION AFFECTING A COMPONENT 有权
标题翻译：用于降低影响组件的腐蚀水平的系统
公开(公告)号：US20110135447A1
公开(公告)日：2011-06-09
申请号：US12632152
申请日：2009-12-07
申请人： Tao Guo , Jonathon E. Slepski , Kenneth M. Koza
发明人： Tao Guo , Jonathon E. Slepski , Kenneth M. Koza
IPC分类号： F01D25/32
CPC分类号： F01D9/041 , F01D5/147 , F01D5/18 , F01D25/32 , F05D2220/31 , F05D2260/602
摘要： A system for removing moisture from a steam/water mixture engaging a stationary component of a steam turbine. The system includes an airfoil located within a flow path of a steam turbine. The airfoil is configured for removing moisture from a steam/water mixture traveling in the flow path. To this end, the airfoil includes a cavity in flow communication with the steam path through at least one inlet and outlet opening, near the leading and trailing edge of the airfoil, respectively. Moisture and steam are extracted from the surface through the inlet openings, the steam and water are separated in the cavity, the separated water flows towards the bottom end, and the dry steam flows through the outlet opening and returns to the steam path. The dry steam blowing out of the trailing edge reduces the size of secondary droplets, and thereby prevents erosion.
摘要翻译：用于从与蒸汽轮机的固定部件接合的蒸汽/水混合物中除去水分的系统。该系统包括位于蒸汽轮机的流动路径内的翼型件。翼型件构造成用于从在流动路径中行进的蒸汽/水混合物中除去水分。为此，翼型件分别包括通过至少一个入口和出口开口与翼型件的前缘和后缘接近的与蒸汽通道流体连通的空腔。水分和蒸汽通过入口从表面抽出，蒸汽和水在空腔中分离，分离的水流向底端，干蒸汽流过出口，返回到蒸汽通道。从后缘吹出的干燥蒸汽减小二次液滴的尺寸，从而防止侵蚀。

25. 发明授权

US07759353B2 Substituted spiro iminopyrimidinones as aspartyl protease inhibitors, compositions, and methods of treatment 有权
标题翻译：取代的螺亚氨基嘧啶酮作为天冬氨酰蛋白酶抑制剂，组合物和治疗方法
公开(公告)号：US07759353B2
公开(公告)日：2010-07-20
申请号：US11451195
申请日：2006-06-12
申请人： Zhaoning Zhu , Brian McKittrick , Andrew Stamford , Tao Guo , Thuy X. H. Le
发明人： Zhaoning Zhu , Brian McKittrick , Andrew Stamford , Tao Guo , Thuy X. H. Le
IPC分类号： C07D239/22 , A61K31/527 , A61P9/00 , A61P25/00 , A61P25/28
CPC分类号： C07D471/10 , C07D239/70 , C07D487/10 , C07D491/10 , C07D495/10
摘要： Disclosed are certain substituted spiro iminopyrimidinones and other compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein U, W, A, R, R1, R2, R6a and R7, are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of using such compounds and compositions to inhibit aspartyl protease, and to treat a variety of disease and indications including (but not limited) to cardiovascular disease and cognitive and neurodegenerative disease. The compounds of the present invention are disclosed for use alone or in combination with one or more additional active ingredients such as cholinesterase inhibitors and a muscarinic m1 agonist and/or m2 antagonists.
摘要翻译：公开了某些取代的螺亚氨基嘧啶酮和其它式I化合物或其立体异构体，互变异构体或其药学上可接受的盐或溶剂化物，其中U，W，A，R，R 1，R 2，R 6a和R 7如本说明书中所定义 ; 以及包含式I化合物的药物组合物。还公开了使用这些化合物和组合物来抑制天冬氨酰蛋白酶的方法，以及治疗多种疾病和适应证，包括（但不限于）心血管疾病和认知和神经变性疾病。公开本发明的化合物单独使用或与一种或多种另外的活性成分如胆碱酯酶抑制剂和毒蕈碱m1激动剂和/或m2拮抗剂组合使用。

26. 发明申请

US20100152138A1 CYCLIC AMINE BACE-1 INHIBITORS HAVING A BENZAMIDE SUBSTITUENT 有权
标题翻译：具有苯甲酸替代物的循环胺BACE-1抑制剂
公开(公告)号：US20100152138A1
公开(公告)日：2010-06-17
申请号：US12641952
申请日：2009-12-18
申请人： Jared N. Cumming , Ulrich Iserloh , Andrew Stamford , Corey Strickland , Johannes H. Voigt , Yusheng Wu , Ying Huang , Yan Xia , Samuel Chackalamannil , Tao Guo , Douglas W. Hobbs , Thuy X.H. Le , Jeffrey F. Lowrie , Kurt W. Saionz , Suresh D. Babu
发明人： Jared N. Cumming , Ulrich Iserloh , Andrew Stamford , Corey Strickland , Johannes H. Voigt , Yusheng Wu , Ying Huang , Yan Xia , Samuel Chackalamannil , Tao Guo , Douglas W. Hobbs , Thuy X.H. Le , Jeffrey F. Lowrie , Kurt W. Saionz , Suresh D. Babu
IPC分类号： A61K31/4015 , C07D207/12 , C07D217/24 , C07D413/12 , C07D243/08 , A61K31/47 , A61K31/675 , A61K31/397 , A61K31/5377 , A61K31/551 , A61P25/28
CPC分类号： C07D243/08 , C07D205/04 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/26 , C07D209/52 , C07D211/26 , C07D211/46 , C07D217/18 , C07D233/32 , C07D241/04 , C07D241/08 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/12 , C07D403/14 , C07D409/06 , C07D409/12 , C07D413/06
摘要： Disclosed are compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1 is R is —C(O)—N(R27)(R28) or and the remaining variables are as defined in the specification.Also disclosed are pharmaceutical compositions comprising the compounds of formula I.Also disclosed are methods of treating cognitive or neurodegenerative diseases such as Alzheimer's disease.Also disclosed are pharmaceutical compositions and methods of treating cognitive or neurodegenerative diseases comprising the compounds of formula I in combination with a β-secretase inhibitor other than those of formula I, an HMG-CoA reductase inhibitor, a gamma-secretase inhibitor, a non-steroidal anti-inflammatory agent, an N-methyl-D-aspartate receptor antagonist, a cholinesterase inhibitor or an anti-amyloid antibody.
摘要翻译：公开了下式的化合物或其药学上可接受的盐或溶剂化物，其中R1是R是-C（O）-N（R27）（R28），或其余的变量如说明书中所定义。还公开了包含式I化合物的药物组合物。还公开了治疗认知或神经变性疾病如阿尔茨海默病的方法。还公开了治疗认知或神经变性疾病的药物组合物和方法，其包含式I化合物与除式I以外的分泌抑制剂抑制剂，HMG-CoA还原酶抑制剂，γ-分泌酶抑制剂，非 - 甾族抗炎药，N-甲基-D-天冬氨酸受体拮抗剂，胆碱酯酶抑制剂或抗淀粉样蛋白抗体。

27. 发明申请

US20090312341A1 CYCLIC AMINE BACE-1 INHIBITORS HAVING A HETEROCYCLIC SUBSTITUENT 有权
标题翻译：具有杂环取代基的循环胺BACE-1抑制剂
公开(公告)号：US20090312341A1
公开(公告)日：2009-12-17
申请号：US12490884
申请日：2009-06-24
申请人： Jared N. Cumming , Ying Huang , Guoqing Li , Ulrich Iserloh , Andrew Stamford , Corey Strickland , Johannes H. Voigt , Yusheng Wu , Jianping Pan , Tao Guo , Douglas W. Hobbs , Thuy X. H. Le , Jeffrey F. Lowrie
发明人： Jared N. Cumming , Ying Huang , Guoqing Li , Ulrich Iserloh , Andrew Stamford , Corey Strickland , Johannes H. Voigt , Yusheng Wu , Jianping Pan , Tao Guo , Douglas W. Hobbs , Thuy X. H. Le , Jeffrey F. Lowrie
IPC分类号： A61K31/496 , C12N9/99 , A61P25/28
CPC分类号： C04B35/632 , C07D207/277 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14
摘要： Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1 is X is —O—, —C(R14)2— or —N(R)—; Z is —C(R14)2— or —N(R)—; t is 0, 1, 2 or 3; each R and R2 is independently H, alkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, alkenyl or alkynyl; each R14 is H, alkyl, alkenyl, alkynyl, halo, —CN, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, —OR35, —N(R24) (R25) or —SR35; R41 is alkyl, cycloalkyl, —SO2(alkyl), —C(O)-alkyl, —C(O)-cycloalkyl or -alkyl-NH—C(O)CH3; and the remaining variables are as defined in the specification. Also disclosed are pharmaceutical compositions comprising the compounds of formula I and methods of treating cognitive or neurodegenerative diseases with compounds of formula I.Also disclosed are pharmaceutical compositions and methods of treatment comprising compounds of formula I in combination with other agents useful in treating cognitive or neurodegenerative diseases.
摘要翻译：公开了下式的新化合物或其药学上可接受的盐或溶剂合物，其中R 1是X是-O - ， - C（R 14）2 - 或-N（R） - ; Z是-C（R 14）2 - 或-N（R） - ; t为0,1,2或3; 每个R和R 2独立地为H，烷基，环烷基，环烷基烷基，芳基，杂芳基，杂环烷基，芳基烷基，杂芳基烷基，杂环烷基烷基，烯基或炔基; 每个R 14是H，烷基，烯基，炔基，卤素，-CN，卤代烷基，环烷基，环烷基烷基，芳基，杂芳基，杂环烷基，芳基烷基，杂芳基烷基，杂环烷基烷基，-OR 35，-N（R 24）（R 25）或-SR 35; R41是烷基，环烷基，-SO2（烷基），-C（O） - 烷基，-C（O） - 环烷基或 - 烷基-NH-C（O）CH3; 其余变量如本说明书中所定义。还公开了包含式I化合物的药物组合物和用式I化合物治疗认知障碍或神经变性疾病的方法。还公开了药物组合物和治疗方法，其包含式I化合物与用于治疗认知或神经变性的其它药剂疾病

28. 发明授权

US07603801B2 Device for de-wrinkling garments 失效
标题翻译：脱衣服装置
公开(公告)号：US07603801B2
公开(公告)日：2009-10-20
申请号：US10579023
申请日：2004-11-04
申请人： Yong Jiang , Mohankumar Valiyambath Krishnan , Boon Khian Ching , Tao Guo , Vidya Sagar Gannamani
发明人： Yong Jiang , Mohankumar Valiyambath Krishnan , Boon Khian Ching , Tao Guo , Vidya Sagar Gannamani
IPC分类号： D06F58/10 , D06F71/34
CPC分类号： D06F81/08 , D06F73/02 , D06F81/00 , D06F87/00
摘要： A garment de-wrinkling device (1) comprises an enclosure (10) for moistening garments (20). An ironing board (40) and an adjacent standby area (41), which are both permeable to steam, are arranged on top of the enclosure (10). During operation of the device (1), the ironing board (40) and a steam iron (30) are used to iron garments (20) which have first been moistened inside the enclosure (10). In the process, steam released by the iron (30) penetrates the garments (20) and enters the enclosure (10) through the ironing board (40). In this way, both the garments (20) on the ironing board (40) and those inside the enclosure (10) are treated by means of steam that is released by the iron (30), and steam is used in an efficient manner. A pressed look is obtained in that the garments (20) are subjected to a moistening process and a subsequent steam ironing process.
摘要翻译：衣服消除皱纹装置（1）包括用于润湿衣服（20）的外壳（10）。在外壳（10）的顶部设置有可渗透蒸汽的熨衣板（40）和相邻的备用区域（41）。在设备（1）的操作期间，熨衣板（40）和蒸汽熨斗（30）用于熨烫首先在外壳（10）内被润湿的衣服（20）。在此过程中，由熨斗（30）释放的蒸汽穿过衣服（20）并穿过熨衣板（40）进入外壳（10）。以这种方式，熨衣板（40）上的衣服（20）和外壳（10）内的衣服都被熨斗（30）释放的蒸汽处理，并且以有效的方式使用蒸汽。得到压制外观，其中衣服（20）经受湿润处理和随后的蒸汽熨烫过程。

29. 发明申请

US20090143245A1 MICROARRAYS FOR GENOTYPING AND METHODS OF USE 审中-公开
标题翻译：用于基因组的微阵列和使用方法
公开(公告)号：US20090143245A1
公开(公告)日：2009-06-04
申请号：US12093504
申请日：2006-02-20
申请人： Huafang Gao , Ze Li , Dong Wang , Yanhua Liu , Xiang Liu , Yangzhou Jiang , Chuanzan Zhao , Li Li , Gengxin Lan , Tao Guo , Bin Cai , Wanli Xing , Yuxiang Zhou , Jing Cheng
发明人： Huafang Gao , Ze Li , Dong Wang , Yanhua Liu , Xiang Liu , Yangzhou Jiang , Chuanzan Zhao , Li Li , Gengxin Lan , Tao Guo , Bin Cai , Wanli Xing , Yuxiang Zhou , Jing Cheng
IPC分类号： C40B30/10 , C40B40/08 , C40B50/06
CPC分类号： C12Q1/6881 , C12Q1/6837 , C12Q2600/156
摘要： The present invention provides a microarray for detecting a genotype at a polymorphic site in a plurality of nucleic acid samples, comprising a first set of nucleic acid fragments derived from the samples and a second set of nucleic acid fragments derived from a plurality of references immobilized thereon. The invention also provides a microarray comprising a set of nucleic acid fragments immobilized on the surface of the microarray, wherein the nucleic acid fragments are derived from the samples by amplifying a region in the sample containing the polymorphism through asymmetric PCR amplification. Methods of using and making the microarrays are also provided.
摘要翻译：本发明提供了用于检测多个核酸样品中多态性位点处的基因型的微阵列，其包含衍生自样品的第一组核酸片段和衍生自多个固定在其上的参考文献的第二组核酸片段。本发明还提供了一种微阵列，其包含固定在微阵列表面上的一组核酸片段，其中通过不对称PCR扩增扩增含有多态性的样品中的区域，来从样品衍生出核酸片段。还提供了使用和制造微阵列的方法。

30. 发明申请

US20070072852A1 Heterocyclic aspartyl protease inhibitors 有权
公开(公告)号：US20070072852A1
公开(公告)日：2007-03-29
申请号：US11010772
申请日：2004-12-13
申请人： Zhaoning Zhu , Brian McKittrick , Zhong-Yue Sun , Yuanzan Ye , Johannes Voigt , Corey Strickland , Elizabeth Smith , Andrew Stamford , William Greenlee , Robert Mazzola , John Caldwell , Jared Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Tao Guo , Thuy Le , Kurt Saionz , Suresh Babu , Rachael Hunter
发明人： Zhaoning Zhu , Brian McKittrick , Zhong-Yue Sun , Yuanzan Ye , Johannes Voigt , Corey Strickland , Elizabeth Smith , Andrew Stamford , William Greenlee , Robert Mazzola , John Caldwell , Jared Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Tao Guo , Thuy Le , Kurt Saionz , Suresh Babu , Rachael Hunter
IPC分类号： A61K31/549 , A61K31/5395 , A61K31/513
CPC分类号： C07D233/88 , A61K31/4168 , A61K31/4178 , A61K31/4184 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/4725 , A61K31/5377 , A61K31/655 , A61K45/06 , C07D233/46 , C07D233/70 , C07D235/02 , C07D239/22 , C07D239/70 , C07D271/07 , C07D273/00 , C07D295/15 , C07D401/04 , C07D401/06 , C07D401/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/04 , C07D409/06 , C07D409/10 , C07D409/14 , C07D413/10 , C07D413/12 , C07D417/06 , Y02A50/411
摘要： Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein W is a bond, —C(═S)—, —S(O)—, —S(O)2—, —C(═O)—, —O—, —C(R6)(R7)—, —N(R5)— or —C(═N(R5))—; X is —O—, —N(R5)— or —C(R6)(R7)—; provided that when X is —O—, U is not —O—, —S(O)—, —S(O)2—, —C(═O)— or —C(═NR5)—; U is a bond, —S(O)—, —S(O)2—, —C(O)—, —O—, —P(O)(OR15)—, —C(═NR5)—, —(C(R6)(R7))b— or —N(R5)—; wherein b is 1 or 2; provided that when W is —S(O)—, —S(O)2—, —O—, or —N(R5)—, U is not —S(O)—, —S(O)2—, —O—, or —N(R5)—; provided that when X is —N(R5)— and W is —S(O)—, —S(O)2—, —O—, or —N(R5)—, then U is not a bond; and R1, R2, R3, R4, R5, R6, and R7 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic antagonist.

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