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21. 发明授权

US4751083A Production of neutralizing antibodies by polypeptide VP1 of enteroviruses and by oligopeptide fragments of polypeptide VP1 失效
标题翻译：通过肠道病毒的多肽VP1和多肽VP1的寡肽片段产生中和抗体
公开(公告)号：US4751083A
公开(公告)日：1988-06-14
申请号：US75595
申请日：1987-07-20
申请人： David Baltimore , Marie B. Chow
发明人： David Baltimore , Marie B. Chow
IPC分类号： A61K39/42 , G01N33/569
CPC分类号： G01N33/569 , A61K39/42 , Y10S530/806 , Y10S530/809
摘要： The production of neutralizing antibodies for poliovirus, or other enteroviruses, are disclosed herein employing the capsid polypeptide VP1. Vaccines can be produced employing this polypeptide in place of killed or live attenuated virus, and the VP1 polypeptide can be employed in assays in place of whole virions. VP1 polypeptide can be produced by isolating it from live virion or can be produced by cloning cDNA sequences coding for this protein in recombinant cDNA vectors.
摘要翻译：本文公开了使用衣壳多肽VP1产生脊髓灰质炎病毒或其他肠道病毒的中和抗体。可以使用该多肽代替杀死的或活的减毒病毒产生疫苗，并且VP1多肽可以用于测定而不是整个病毒体。 VP1多肽可以通过从活病毒体分离而产生，或者可以通过在重组cDNA载体中克隆编码该蛋白的cDNA序列来产生。

22. 发明授权

US4719177A Production of complementary DNA representing RNA viral sequences by recombinant DNA methods and uses therefor 失效
标题翻译：通过重组DNA方法生产代表RNA病毒序列的互补DNA，并用于此
公开(公告)号：US4719177A
公开(公告)日：1988-01-12
申请号：US320525
申请日：1981-11-12
申请人： David Baltimore , Vincent R. Racaniello
发明人： David Baltimore , Vincent R. Racaniello
IPC分类号： C12P19/34 , A61K39/12 , A61K39/13 , C07H21/04 , C07K14/105 , C12N1/00 , C12N1/21 , C12N7/00 , C12N15/00 , C12N15/09 , C12P21/00 , C12Q1/68 , C12Q1/70 , C12R1/19 , C12R1/91 , C12R1/92 , C12N1/20
CPC分类号： C07K14/005 , C12Q1/701 , C12N2770/32622 , Y10S435/849
摘要： Methods for producing RNA viral cDNA, such as poliovirus ds cDNA, products thereof, and uses thereof, are described. Poliovirus cDNA is produced, for example, by reverse transcribing poliovirus RNA and subsequently inserting the poliovirus cDNA into bacterial plasmids by genetic-engineering techniques. Transformed bacteria are then cloned and cultured to produce replicated chimeric plasmids containing the cDNA poliovirus. Such poliovirus cDNA is useful in assaying for the presence of poliovirus and in the production of antibodies against poliovirus. It has also been found that full-length poliovirus cDNA is infectious, which means it can be employed in producing altered virus particles for vaccines.
摘要翻译：描述了产生RNA病毒cDNA的方法，例如脊髓灰质炎病毒ds cDNA，其产物及其用途。脊髓灰质炎病毒cDNA例如通过逆转录脊髓灰质炎病毒RNA并随后通过基因工程技术将脊髓灰质炎病毒cDNA插入细菌质粒来产生。然后克隆和培养转化的细菌以产生含有脊髓灰质炎病毒的复制嵌合质粒。这样的脊髓灰质炎病毒cDNA可用于测定脊髓灰质炎病毒的存在和产生针对脊髓灰质炎病毒的抗体。还发现全长脊髓灰质炎病毒cDNA是感染性的，这意味着它可以用于生产用于疫苗的改变的病毒颗粒。

23. 发明申请

US20200309765A1 TROGOCYTOSIS MEDIATED EPITOPE DISCOVERY 审中-公开
公开(公告)号：US20200309765A1
公开(公告)日：2020-10-01
申请号：US16633451
申请日：2018-07-24
申请人： Michael T. BETHUNE , David BALTIMORE , California Institute of Technology , PACT PHARMA, INC.
发明人： Michael T. Bethune , Jocelyn T. Kim , David Baltimore , Guideng Li , Stephanie Wong
IPC分类号： G01N33/50 , G01N33/566 , G06F16/27
摘要： Disclosed herein are trogocytosis based TCR ligand discovery platforms and methods of using the same, trogocytosis based TCR discovery platforms and methods of using the same, and trogocytosis based ligand discovery platforms and methods of using the same. Also disclosed herein are isolated cells, nucleotides, sequences, and sequence databases produced using trogocytosis based discovery platforms.

24. 发明授权

US09145560B2 Method for producing transgenic rats 有权
标题翻译：生产转基因大鼠的方法
公开(公告)号：US09145560B2
公开(公告)日：2015-09-29
申请号：US12011762
申请日：2008-01-28
申请人： David Baltimore , Elizabeth J. Hong , Carlos Lois-Caballe , Shirley Pease
发明人： David Baltimore , Elizabeth J. Hong , Carlos Lois-Caballe , Shirley Pease
IPC分类号： C12N15/00 , C12N15/113 , C12N15/85 , C12N15/86 , A61K48/00
CPC分类号： C12N15/86 , A01K2217/05 , A01K2227/30 , A01K2227/40 , A61K38/00 , A61K48/00 , C12N15/1132 , C12N15/1138 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2330/30 , C12N2740/16043 , C12N2800/60 , C12N2830/003 , C12N2830/006 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12N2840/20 , C12N2840/203 , C12N2840/44 , Y02A50/463 , Y02A50/465
摘要： The present invention relates to methods for producing transgenic animals, particularly transgenic rats, using retroviral constructs engineered to carry the transgene(s) of interest.
摘要翻译：本发明涉及使用工程改造来携带感兴趣的转基因的逆转录病毒构建体来生产转基因动物，特别是转基因大鼠的方法。

25. 发明授权

US08685727B2 Regulation of macrophage activation using miR-125b 有权
标题翻译：使用miR-125b调节巨噬细胞活化
公开(公告)号：US08685727B2
公开(公告)日：2014-04-01
申请号：US13526347
申请日：2012-06-18
申请人： Aadel Chaudhuri , Alex Steven So , David Baltimore , Ryan M. O'Connell
发明人： Aadel Chaudhuri , Alex Steven So , David Baltimore , Ryan M. O'Connell
IPC分类号： C12N15/85 , C07H21/02 , C07H21/04
CPC分类号： A61K31/7088
摘要： The present disclosure relates to regulation of macrophage activation by delivering of miRNAs, for example miR-125b or anti-miR-125b, to macrophages. For example, in some embodiments, macrophage activation can be elevated or reduced by administering miR-125b or anti-miR-125b oligonucleotides. Also disclosed are methods for promoting T cell activation and method for treating various disorders such as tumor and autoimmune diseases.
摘要翻译：本公开涉及通过向巨噬细胞递送miRNA（例如miR-125b或抗miR-125b）来调节巨噬细胞活化。例如，在一些实施方案中，可通过施用miR-125b或抗miR-125b寡核苷酸来升高或降低巨噬细胞活化。还公开了促进T细胞活化的方法和用于治疗各种疾病如肿瘤和自身免疫性疾病的方法。

26. 发明授权

US08598137B2 Use of SAM68 for modulating signaling through the TNF receptor 有权
标题翻译：使用SAM68通过TNF受体调节信号
公开(公告)号：US08598137B2
公开(公告)日：2013-12-03
申请号：US13284792
申请日：2011-10-28
申请人： Parameswaran Ramakrishnan , David Baltimore
发明人： Parameswaran Ramakrishnan , David Baltimore
IPC分类号： C12N15/113 , A61K39/395 , C07H21/04
CPC分类号： A61K31/7105 , C12N15/1135 , C12N2310/14
摘要： Sam68 plays a role in TNF-dependent signaling, including NF-kB signaling and extrinsic activation of apoptosis. In some embodiments, inhibitors of Sam68 are administered to inhibit TNF-dependent signaling, for example to inhibit NF-kB signaling or apoptosis in a patient in need. In some embodiments, functional Sam68 is administered to increase TNF-dependent signaling, for example to induce apoptosis in a patient in need. In some embodiments, methods are provided determining whether the TNF-dependent or TNF-independent branch of a signaling pathway is active in a cell or cells, or for drug screening applications.
摘要翻译： Sam68在TNF依赖性信号传导中起重要作用，包括NF-kB信号传导和凋亡的外在激活。在一些实施方案中，施用Sam68的抑制剂以抑制TNF依赖性信号传导，例如抑制需要的患者中的NF-kB信号传导或凋亡。在一些实施方案中，施用功能性Sam68以增加TNF依赖性信号传导，例如在需要的患者中诱导细胞凋亡。在一些实施方案中，提供了确定信号传导途径的TNF依赖性或不依赖于TNF的分支在细胞或细胞中活性或用于药物筛选应用的方法。

27. 发明授权

US08497071B2 Isolation of unknown rearranged T-cell receptors from single cells 有权
标题翻译：从单细胞中分离未知重排的T细胞受体
公开(公告)号：US08497071B2
公开(公告)日：2013-07-30
申请号：US12824744
申请日：2010-06-28
申请人： Alejandro Benjamin Balazs , Jonathan Michael Tsai , David Baltimore
发明人： Alejandro Benjamin Balazs , Jonathan Michael Tsai , David Baltimore
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C07K14/705 , C07K14/3156
摘要： Disclosed herein are methods and materials for isolating and identifying T cell receptors from single cells. In some embodiments, genomic DNA from a single T cell is isolated using whole genome amplification (WGA). A series of PCR reactions is carried out to enrich the genomic template for sequences encoding the TCR alpha and beta chains, and then to isolate the sequences encoding the TCR alpha and beta chains.
摘要翻译：本文公开了用于从单细胞分离和鉴定T细胞受体的方法和材料。在一些实施方案中，使用全基因组扩增（WGA）分离来自单个T细胞的基因组DNA。进行一系列PCR反应以丰富编码TCRα和β链的序列的基因组模板，然后分离编码TCRα和β链的序列。

28. 发明授权

US08119772B2 MART-1 T cell receptors 有权
标题翻译： MART-1 T细胞受体
公开(公告)号：US08119772B2
公开(公告)日：2012-02-21
申请号：US11864841
申请日：2007-09-28
申请人： Lili Yang , David Baltimore , Pin Wang , James Economou , Antoni Ribas
发明人： Lili Yang , David Baltimore , Pin Wang , James Economou , Antoni Ribas
IPC分类号： A61K35/14
CPC分类号： C07K14/4748
摘要： T-cell receptors that recognize MART-1 antigen are provided. The TCRs can be used, for example, to treat patients suffering from melanoma.
摘要翻译：提供了识别MART-1抗原的T细胞受体。 TCR可用于例如治疗患有黑素瘤的患者。

29. 发明申请

US20110258716A1 MODULATING IMMUNE SYSTEM DEVELOPMENT AND FUNCTION THROUGH MICRORNA MIR-146 审中-公开
标题翻译：通过MICRORNA MIR-146调节免疫系统发育和功能
公开(公告)号：US20110258716A1
公开(公告)日：2011-10-20
申请号：US13151053
申请日：2011-06-01
申请人： David Baltimore , Mark Boldin , Konstantin Taganov
发明人： David Baltimore , Mark Boldin , Konstantin Taganov
IPC分类号： A01K67/027 , C12N5/10
CPC分类号： C12N15/113 , C12N2310/111 , C12N2310/113 , C12N2310/141 , C12N2330/10
摘要： The present disclosure relates to the finding that microRNA-146 plays a role in modulating the development and function of the immune system. Immune cell development and function can be modulated by delivery of microRNA-146 (miR-146) or antisense miR-146 to target immune cells or precursor cells. For example, in some embodiments, activity and/or proliferation of certain immune cells is regulated by administering miR-146 oligonucleotides or anti-miR-146 oligonucleotides. In other embodiments, pro-inflammatory cytokine expression in immune cells is regulated by administering a miR-146 oligonucleotide or anti-miR-146. In further embodiments, methods of regulating macrophage activity using antisense miR-146 are provided. Additional methods and compositions for regulating immune system function and development using miR-146 are disclosed.
摘要翻译：本公开涉及微RNA-146在调节免疫系统的发育和功能中起作用的发现。免疫细胞发育和功能可以通过将microRNA-146（miR-146）或反义miR-146递送到靶向免疫细胞或前体细胞来调节。例如，在一些实施方案中，通过施用miR-146寡核苷酸或抗miR-146寡核苷酸调节某些免疫细胞的活性和/或增殖。在其它实施方案中，通过施用miR-146寡核苷酸或抗miR-146调节免疫细胞中的促炎细胞因子表达。在另外的实施方案中，提供了使用反义miR-146调节巨噬细胞活性的方法。公开了使用miR-146调节免疫系统功能和发育的其它方法和组合物。

30. 发明申请

US20110212530A1 METHOD OF TARGETED GENE DELIVERY USING VIRAL VECTORS 有权
标题翻译：使用病毒载体的目标基因传递方法
公开(公告)号：US20110212530A1
公开(公告)日：2011-09-01
申请号：US13041115
申请日：2011-03-04
申请人： David Baltimore , Pin Wang , Lili Yang
发明人： David Baltimore , Pin Wang , Lili Yang
IPC分类号： C12N15/63
CPC分类号： C12N15/86 , A61K2039/505 , C07K16/2887 , C07K2317/53 , C07K2317/622 , C07K2319/00 , C07K2319/03 , C12N2740/15043 , C12N2740/16043 , C12N2740/16045 , C12N2799/027 , C12N2810/80 , C12N2810/851 , C12N2810/859 , Y02A50/386 , Y02A50/396
摘要： Methods and compositions are provided for delivering a polynucleotide encoding a gene of interest to a target cell using a virus. The virus envelope comprises a cell-specific binding determinant that recognizes and binds to a component on the target cell surface, leading to endocytosis of the virus. A separate fusogenic molecule is also present on the envelope and facilitates delivery of the polynucleotide across the membrane and into the cytosol of the target cell. The methods and related compositions can be used for treating patients having suffering from a wide range of conditions, including infection, such as HIV; cancers, such as non-Hodgkin's lymphoma and breast cancer; and hematological disorders, such as severe combined immunodeficiency.
摘要翻译：提供了使用病毒将编码目标基因的多核苷酸递送至靶细胞的方法和组合物。病毒包膜包含识别和结合靶细胞表面上的组分的细胞特异性结合决定簇，导致病毒的内吞。单独的融合分子也存在于包膜上并促进多核苷酸穿过膜并进入靶细胞的胞质溶胶。方法和相关组合物可用于治疗患有广泛病症（包括HIV感染）的患者; 癌症，如非霍奇金淋巴瘤和乳腺癌; 和血液学疾病，如严重的联合免疫缺陷。

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