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21. 发明授权

US07041951B2 Method and apparatus for investigating layers of tissues in living animals using a microscope 有权
标题翻译：使用显微镜研究活体组织层的方法和装置
公开(公告)号：US07041951B2
公开(公告)日：2006-05-09
申请号：US10700929
申请日：2003-11-04
申请人： Martin Hoppe , Werner Knebel , Kyra Moellmann , Rafael Storz
发明人： Martin Hoppe , Werner Knebel , Kyra Moellmann , Rafael Storz
IPC分类号： G02B27/64 , A61B6/00
CPC分类号： G02B21/241
摘要： The invention concerns a method and an apparatus for investigating layers (1) of tissues in living animals using a microscope (2). The microscope (2) is focused onto a layer (1), and images of the layer (1) are acquired or optical measurements are performed on it. Positional changes of the layer (1) are brought about by movements of the animal or of its organs. The positional changes are sensed, and corresponding signals are generated. The signals are stored, together with the corresponding images or measurement results, for later evaluation; or they are processed in such a way that the positional changes are compensated for in order to investigate the layer (1). As a result, the layer (1) can be qualitatively or quantitatively investigated microscopically, irrespective of the movement of the animal or its organs.
摘要翻译：本发明涉及一种使用显微镜（2）研究活体组织的层（1）的方法和装置。显微镜（2）被聚焦到层（1）上，并且获取层（1）的图像或对其进行光学测量。层（1）的位置变化是由动物或其器官的运动引起的。检测到位置变化，并产生相应的信号。将信号与相应的图像或测量结果一起存储以供稍后评估; 或者它们以这样的方式进行处理，以便补偿位置变化以便研究层（1）。结果，无论动物或其器官的移动如何，层（1）可以在显微镜下进行定性或定量研究。

22. 发明申请

US20060077383A1 Device for selecting and detecting at least two spectral regions of a light beam 有权
公开(公告)号：US20060077383A1
公开(公告)日：2006-04-13
申请号：US11247750
申请日：2005-10-11
申请人： Werner Knebel , Gabriele Burger
发明人： Werner Knebel , Gabriele Burger
IPC分类号： G01J3/44
CPC分类号： G01J3/26 , G01J3/14 , G01J3/36 , G02B21/0064
摘要： An apparatus for selecting and detecting at least two spectral regions of a light beam includes a selection device, a detection device, and a light suppression device. The light suppression device suppresses reflected and/or scattered light of an illuminating light of a microscope. The light suppression device is located in an optical path between the selection device and the detection device, and includes a graded filter.

23. 发明授权

US06977724B2 Method for spectral analysis, and scanning microscope 有权
标题翻译：光谱分析方法和扫描显微镜
公开(公告)号：US06977724B2
公开(公告)日：2005-12-20
申请号：US10393607
申请日：2003-03-21
申请人： Werner Knebel
发明人： Werner Knebel
IPC分类号： G01J3/32 , G01J3/36 , G01N21/64 , G02B21/00 , G02B21/16 , G02B21/36 , G01J3/06
CPC分类号： G01N21/6458 , G01J3/1256 , G01J3/32 , G01J3/36 , G01N2021/6421 , G02B21/0064 , G02B21/0076 , G02B21/008 , G02B21/16 , G02B21/365
摘要： A method for spectral analysis of the light proceeding from a specimen using a multi-band detector comprises the steps of defining an overall spectral region; from the overall spectral region, defining a first spectral subregion and defining at least a second spectral subregion; simultaneously detecting the light proceeding from the specimen in the first and the second spectral subregion, and generating detection values; displacing the first spectral subregion and displacing the second spectral subregion within the overall spectral region; and repeating steps c) and d) until the light has been detected over the entire overall spectral region.
摘要翻译：用于使用多频带检测器从样本进行光的光谱分析的方法包括以下步骤：定义整个光谱区域; 从整个光谱区域，定义第一光谱子区域并限定至少第二光谱子区域; 同时检测从第一和第二频谱子区域中的样本进行的光，并产生检测值; 移位所述第一频谱子区域并且移位所述整个频谱区域内的所述第二频谱子区域; 并重复步骤c）和d），直到在整个光谱区域上检测到光。

24. 发明授权

US06852967B2 Scanning microscope and methods for wavelength-dependent detection 有权
标题翻译：扫描显微镜和波长相关检测方法
公开(公告)号：US06852967B2
公开(公告)日：2005-02-08
申请号：US10188622
申请日：2002-07-03
申请人： Johann Engelhardt , Werner Knebel
发明人： Johann Engelhardt , Werner Knebel
IPC分类号： G02B21/00 , G01G3/50
CPC分类号： G02B21/0064
摘要： A scanning microscope for examination of a sample (31), having at least one optical component (89) that exhibits a wavelength-dependent characteristic and having an apparatus for wavelength-dependent detection that acquires measured values in at least two wavelength regions each characterized by a spectral width and a spectral position, is disclosed. The scanning microscope is characterized in that the wavelength-dependent characteristic of the at least one optical component (89) can be ascertained, can be at least temporarily stored in the form of a data set in a memory (49, 81), and can be considered upon acquisition and/or upon utilization of the measured values.
摘要翻译：一种用于检查样品（31）的扫描显微镜，其具有至少一个具有波长相关特性的光学部件（89），并具有用于波长相关检测的装置，其获取至少两个波长区域中的测量值，每个特征在于光谱宽度和光谱位置。扫描显微镜的特征在于，可以确定至少一个光学部件（89）的波长相关特性，至少可以以数据集的形式临时存储在存储器（49,81）中，并且可以在获得和/或利用测量值时考虑。

25. 发明申请

US20050024721A1 Scanning microscope 有权
标题翻译：扫描显微镜
公开(公告)号：US20050024721A1
公开(公告)日：2005-02-03
申请号：US10903139
申请日：2004-07-30
申请人： Rafael Storz , Werner Knebel
发明人： Rafael Storz , Werner Knebel
IPC分类号： G02B21/06 , G02B21/00
CPC分类号： G02B21/0076 , G02B21/002 , G02B21/0032 , G02B21/008
摘要： A detector, arranged in the detection beam path of a scanning microscope, for the detection of detected light proceeding from a sample can be used to detect other than the detected light for example of external optical experiments. The scanning microscope comprises an incoupling apparatus with which light other than the detected light can be coupled into the detection beam path and conveyed to the detector.
摘要翻译：布置在扫描显微镜的检测光束路径中的用于检测从样品进行的检测光的检测器可以用于检测除了例如外部光学实验的检测到的光。扫描显微镜包括一个去耦装置，除了检测到的光之外，其中的光可以被耦合到检测光束路径中并传送到检测器。

26. 发明授权

US06836359B2 Microscope and segmenting device for a microscope 有权
标题翻译：显微镜和显微镜分割装置
公开(公告)号：US06836359B2
公开(公告)日：2004-12-28
申请号：US10266005
申请日：2002-10-07
申请人： Werner Knebel
发明人： Werner Knebel
IPC分类号： G02B2106
CPC分类号： G02B21/0032 , G02B21/0052 , G02B21/0076 , G02B21/082 , G02B21/18
摘要： A microscope, in particular for confocal scanning microscopy, having a light source (1) for illuminating an object (6) to be investigated. An optical device (9, 12) is provided for splitting transmitted light (15) passing through the object (6) and fluorescent light (10, 13) produced in the object (6). A segmenting device (17) acting on the transmitted light (15) is configured with regard to a detection-light path which is as short as possible in such a way that the segmenting device (17) is arranged between the object (6) and the light-splitting device (9, 12).
摘要翻译：显微镜，特别是用于共聚焦扫描显微镜的显微镜，具有用于照亮被研究物体（6）的光源（1）。提供了一种用于分离穿过物体（6）的透射光（15）和在物体（6）中产生的荧光（10,13）的光学装置（9,12）。作用在透射光（15）上的分割装置（17）相对于尽可能短的检测光路被配置，使得分割装置（17）布置在物体（6）和分光装置（9,12）。

27. 发明授权

US06788456B2 Illumination device and illumination method for a scanning microscope 有权
标题翻译：扫描显微镜的照明装置和照明方法
公开(公告)号：US06788456B2
公开(公告)日：2004-09-07
申请号：US10064653
申请日：2002-08-02
申请人： Werner Knebel
发明人： Werner Knebel
IPC分类号： G02B2106
CPC分类号： G02B21/002 , G02B21/06
摘要： When specimens are illuminated in a scanning microscope, it is often necessary to use radiations of different wavelengths in order to examine the sample. A device and a method for illumination of specimens in a scanning microscope is proposed, a laser being used to generate a laser beam, and an optical system being used to image the laser beam onto the specimen. The optical system comprises a switchable beam deflection device that can direct the laser beam onto the specimen either along a first beam path or along an alternative beam path. In addition, a device for frequency conversion is arranged in the beam path of the alternative beam path.
摘要翻译：当在扫描显微镜下照射样本时，为了检查样品，通常需要使用不同波长的辐射。提出了一种用于在扫描显微镜中照射样品的装置和方法，用于产生激光束的激光器和用于将激光束成像到样品上的光学系统。光学系统包括可切换的光束偏转装置，其可以沿着第一光束路径或沿着替代光束路径将激光束引导到样本上。此外，用于频率转换的装置被布置在替代光束路径的光束路径中。

28. 发明授权

US4694512A Plumbing mixing circuit control apparatus for a combination set 失效
标题翻译：管道混合电路控制装置组合
公开(公告)号：US4694512A
公开(公告)日：1987-09-22
申请号：US870818
申请日：1986-06-05
申请人： Werner Knebel , Gunter Sieberhagen
发明人： Werner Knebel , Gunter Sieberhagen
IPC分类号： G05D23/13 , E03C1/04
CPC分类号： G05D23/1393 , Y10S4/03
摘要： In order to achieve a fully automatic, electronic adjustment by means of a process for controlling a plumbing combination set with a multi-disc mixing valve for hot and cold water, whereby temperature is adjusted by making a comparison between the actual temperature of the mixing water and the target temperature of the mixing water, it is proposed that the actual mixing value be constantly measured and that a factor for the regulator of the appropriate mixing valve adjustment disc be derived from the target/actual divergence, and that at the same time the preselected flow of the mixture can be maintained at a constant level without measurement of the flow quantities, a correction factor being derived from the factor of the aforementioned adjustment disc for the factor of the flow adjustment disc regulator.
摘要翻译：为了通过用于控制用于冷热水的多盘混合阀来控制管道组合的方法来实现全自动的电子调节，由此通过比较混合水的实际温度来调节温度和混合水的目标温度，建议不断测量实际混合值，并从目标/实际发散度得出适当混合阀调节盘调节器的因子，同时将可以将混合物的预选流量保持在恒定水平而不测量流量，校正因子是根据上述调节盘的因子导出流量调节盘调节器的因子。

29. 发明授权

US4407444A Thermostatically controlled mixer battery 失效
标题翻译：恒温搅拌电池
公开(公告)号：US4407444A
公开(公告)日：1983-10-04
申请号：US318310
申请日：1981-11-04
申请人： Werner Knebel , Norbert Ronzon , Eugen Weidner
发明人： Werner Knebel , Norbert Ronzon , Eugen Weidner
IPC分类号： F24H9/00 , F16K11/074 , F16K11/20 , G05D23/13
CPC分类号： F16K11/0746 , F16K11/205 , G05D23/1353 , Y10T137/86823
摘要： A thermostatically controlled mixer battery. The appropriate mixer battery having plate control means 2 comprising at least one rotatable control plate 24 for controlling the quantity of water delivered and manually actuable from externally by a user, the plate 24 having bores 243, 244 selectively alignable with hot and cold water inlet bores 233, 234 and a temperature control plate 25, which is thermostatically actuated and is sealingly displaceable relative to the quantity control plate 24, the plate 25 having bores 253, 254 formed therein which permit the hot and cold water to pass therethrough in a desired ratio to a mixing chamber 15.
摘要翻译：恒温控制混合电池。适当的混合器电池具有板控制装置2，其包括至少一个可旋转的控制板24，用于控制用户从外部输送的水量并可手动地致动，板24具有可选择性地与热水和冷水入口孔对准的孔243,244 233,234和温度控制板25，其被恒温驱动并且相对于量控制板24可密封地移位，板25具有形成在其中的孔253,254，其允许热水和冷水以期望的比例通过到混合室15。

30. 发明授权

US08339703B2 Scanning microscope and method for manipulating samples by means of a manipulating light beam in a scanning microscope 有权
标题翻译：扫描显微镜和在扫描显微镜中通过操纵光束操作样品的方法
公开(公告)号：US08339703B2
公开(公告)日：2012-12-25
申请号：US12088416
申请日：2006-09-27
申请人： Werner Knebel
发明人： Werner Knebel
IPC分类号： G02B21/06
CPC分类号： G02B21/0032 , G02B21/32
摘要： A scanning microscope for manipulating a sample, the microscope, having a first light source, a second light source, a beam deflector, and an optical device. The first light source is configured to emit an illuminating light beam that follows an illuminating beam. A second light source is configured to produce a manipulating light beam which has a manipulating beam focus and follows a manipulating beam path. The beam deflection device is configured to guide the illuminating light beam and the manipulating beam focus over or through the sample. The optical device is disposed downstream of the second light in the manipulating beam and is configured to modify the size of the manipulating beam focus.
摘要翻译：一种用于操纵样品的扫描显微镜，该显微镜具有第一光源，第二光源，光束偏转器和光学装置。第一光源被配置为发射跟随照明光束的照明光束。第二光源被配置为产生操纵光束，其具有操纵束聚焦并跟随操纵光束路径。光束偏转装置被配置为引导照明光束和操纵光束聚焦在样本上或穿过样本。光学装置设置在操纵光束中的第二光的下游，并且被配置为修改操纵光束焦点的尺寸。

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