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21. 发明申请

US20110081657A1 CONTROLLED PLATELET ACTIVATION TO MONITOR THERAPY OF ADP ANTAGONISTS 有权
公开(公告)号：US20110081657A1
公开(公告)日：2011-04-07
申请号：US12943413
申请日：2010-11-10
申请人： Barry S. COLLER , Dennis Durbin
发明人： Barry S. COLLER , Dennis Durbin
IPC分类号： G01N33/53
CPC分类号： G01N33/86
摘要： A method is provided of determining whether an individual has reduced ability to form platelet thrombi due to inhibition of platelet activation initiation, signal transduction and/or GPIIb/IIIa blockade. A blood sample is obtained from the individual being assessed. The blood sample is mixed in combination with 1) an anticoagulant; 2) sufficient buffer to maintain the pH and salt concentration of the anticoagulated blood within a range suitable for platelet aggregation; 3) a platelet GPIIb/IIIa receptor ligand immobilized on a solid surface; 4) one or more agents to enhance a signal transduction pathway and 5) a receptor activator. The combination is incubated under conditions for agglutinating particles. Platelet-mediated agglutination is assessed in the agitated mixture. The absence of agglutination indicates that the individual has a reduced ability to form platelet thrombi.

22. 发明授权

US07790362B2 Controlled platelet activation to monitor therapy of ADP antagonists 有权
标题翻译：控制血小板活化以监测ADP拮抗剂的治疗
公开(公告)号：US07790362B2
公开(公告)日：2010-09-07
申请号：US10886155
申请日：2004-07-06
申请人： Barry S. Coller , Dennis Durbin
发明人： Barry S. Coller , Dennis Durbin
IPC分类号： C12Q1/00
CPC分类号： G01N33/86
摘要： A method is provided of determining whether an individual has reduced ability to form platelet thrombi. An ADP platelet activator and one or platelet inhibitors are provided. At least one of the platelet inhibitors is Prostaglandin E1 (PGE1). An alternate signal transduction pathway is produced. A final concentration of ADP is 2 to 35 μM and a final concentration of PGE1 is 2 to 30 nM, preferably 20 to 25 nM.
摘要翻译：提供一种确定个体是否具有降低形成血小板血栓形成能力的方法。提供ADP血小板激活剂和一种或血小板抑制剂。至少有一种血小板抑制剂是前列腺素E1（PGE1）。产生替代的信号转导途径。 ADP的终浓度为2〜35μM，PGE1的终浓度为2〜30nM，优选为20〜25nM。

23. 发明授权

US07595169B2 Method for determining percent platelet aggregation 有权
标题翻译：确定血小板聚集百分比的方法
公开(公告)号：US07595169B2
公开(公告)日：2009-09-29
申请号：US11411239
申请日：2006-04-24
申请人： Lisa Swaim , Dennis Durbin
发明人： Lisa Swaim , Dennis Durbin
IPC分类号： C12Q1/56
CPC分类号： C12Q1/56 , G01N33/86
摘要： A method for obtaining a percent aggregation or inhibition of platelets resulting from anti-platelet using a single blood sample is achieved. An assay device is provided. The assay device has multiple channels, each coupled to a common introduction port. A first platelet activator is sensitive to activation pathway targeted by the anti-platelet drug. A second platelet activator is insensitive to the activation pathway targeted by the anti-platelet drug. An anti-coagulated sample is introduced simultaneously to the first and second channels. A level of platelet aggregation is simultaneously made in both channels.
摘要翻译：实现了使用单一血液样品获得由抗血小板产生的血小板聚集或抑制百分比的方法。提供测定装置。测定装置具有多个通道，每个通道耦合到公共引入端口。第一种血小板活化剂对抗血小板药物靶向的活化途径敏感。第二种血小板激活剂对抗血小板药物靶向的激活途径不敏感。将抗凝凝样品同时引入第一和第二通道。在两个通道中同时进行血小板聚集的水平。

24. 发明申请

US20070154092A1 Code Reader Performing Coded Image Decoding Using Non-Dedicated Decode Processor 审中-公开
标题翻译：代码读取器使用非专用解码处理器执行编码图像解码
公开(公告)号：US20070154092A1
公开(公告)日：2007-07-05
申请号：US11681783
申请日：2007-03-04
申请人： Dennis Durbin , Jon Rasmussen
发明人： Dennis Durbin , Jon Rasmussen
IPC分类号： G06K9/18
CPC分类号： G06K7/1491 , G06K7/14
摘要： A coded image capture and decoding system includes an image capture unit and a host unit which operate to capture image data, generate a plurality of coded images, and, thereafter, to decode the plurality of coded images with a non-dedicated host processing circuitry. The system comprises an image capture unit and a host unit which may be installed together or separately in one or more physical devices. The image capture unit includes an image processor, an image buffer, an optical unit, an image buffer and an interface module. The host unit includes a host processor, conventional hardware and software functions, and an interface module. During a capture cycle, the image capture unit repeatedly captures images from a coded target. When the capture cycle is complete, the image capture unit attempts to interrupt the host unit. The host unit responds to the interrupt when it is available, receives the plurality of coded images over a communication link, and performs decode processing of the coded images. A proximity detector and proximity screening rules may be employed within the image capture unit in an attempt to prevent non-code images from being delivered to the host processor. The host processor may also operate on a composite image and/or parallel process the plurality of coded images to achieve a valid decode.
摘要翻译：编码图像捕获和解码系统包括图像捕获单元和主机单元，其操作以捕获图像数据，生成多个编码图像，然后用非专用主机处理电路对多个编码图像进行解码。该系统包括图像捕获单元和可以一起安装在一个或多个物理设备中的主机单元。图像捕获单元包括图像处理器，图像缓冲器，光学单元，图像缓冲器和接口模块。主机单元包括主处理器，常规硬件和软件功能以及接口模块。在捕获周期期间，图像捕获单元重复地从编码目标捕获图像。捕获周期完成后，图像捕获单元会尝试中断主机。主机单元在可用时响应中断，通过通信链路接收多个编码图像，并对编码图像进行解码处理。可以在图像捕获单元内采用接近检测器和接近度筛选规则，以试图防止非码图像被传送到主机处理器。主机处理器还可以对合成图像进行操作和/或并行处理多个编码图像以实现有效的解码。

25. 发明申请

US20050153257A1 Method and system for dental model occlusal determination using a replicate bite registration impression 有权
标题翻译：牙科模型咬合确定的方法和系统使用复制咬注册印象
公开(公告)号：US20050153257A1
公开(公告)日：2005-07-14
申请号：US10753226
申请日：2004-01-08
申请人： Duane Durbin , Dennis Durbin
发明人： Duane Durbin , Dennis Durbin
IPC分类号： A61C9/00 , A61C19/05 , A61C19/04 , A61C11/00
CPC分类号： A61C19/05 , A61C9/006 , A61C13/0013 , B33Y50/00 , B33Y80/00
摘要： Systems and methods for imaging a dental occlusal registration impression; developing a digital 3D surface contour model of the occlusal registration impression from the image data; electronically transferring the data representing the digital 3D surface contour model of the occlusal registration impression; fabricating a physical replicate of the occlusal registration impression; correlating features on upper and lower jaw dental models with features on the replicate occlusal registration impression model; and determining occlusal alignment of the upper and lower jaw dental models using the replicate occlusal registration impression model.
摘要翻译：用于成像牙科咬合注册印象的系统和方法; 从图像数据开发咬合注册印象的数字3D表面轮廓模型; 电子传递代表咬合注册印象的数字3D表面轮廓模型的数据; 制作咬合注册印象的实体复制品; 上下爪牙模型的关联特征与重复咬合注册印模模型的特征相关; 以及使用重复咬合注册印模模型确定上下牙牙模型的咬合对准。

26. 发明申请

US20050040239A1 Reader for decoding two-dimensional optically readable information 失效
标题翻译：用于解码二维光学可读信息的读取器
公开(公告)号：US20050040239A1
公开(公告)日：2005-02-24
申请号：US10807519
申请日：2004-03-23
申请人： Dennis Durbin
发明人： Dennis Durbin
IPC分类号： G06K7/10 , G06K17/00 , H04N1/00 , H04N1/107 , G06K9/22
CPC分类号： G06K7/10881 , G06K7/10722 , G06K7/1417 , G06K17/0022 , G06K2007/10524 , G06K2207/1011 , H04N1/00127 , H04N1/00307 , H04N1/00326 , H04N1/00334 , H04N1/107 , H04N2101/00 , H04N2201/0084
摘要： An apparatus and method for reading optical information including a photosensitive system oriented to capture optical information. Also included is an optical system focusing optical information onto the photosensitive system, and a display oriented to display optical information captured by the photosensitive system. The apparatus also includes a portable, hand-held housing.
摘要翻译：一种用于读取光学信息的装置和方法，包括面向捕获光学信息的光敏系统。还包括将光学信息聚焦到感光系统上的光学系统，以及用于显示由感光系统捕获的光学信息的显示器。该装置还包括便携式手持式外壳。

27. 发明申请

US20050031616A1 Controlled platelet activation to monitor therapy of ADP antagonists 有权
标题翻译：控制血小板活化以监测ADP拮抗剂的治疗
公开(公告)号：US20050031616A1
公开(公告)日：2005-02-10
申请号：US10886155
申请日：2004-07-06
申请人： Barry Coller , Dennis Durbin
发明人： Barry Coller , Dennis Durbin
IPC分类号： A61K31/557 , A61K39/395 , A61K49/00 , C12Q20060101 , C12Q1/00 , G01N33/53 , G01N33/567 , G01N33/86
CPC分类号： G01N33/86
摘要： A method is provided of determining whether an individual has reduced ability to form platelet thrombi due to inhibition of platelet activation initiation, signal transduction and/or GPIIb/IIIa blockade. A blood sample is obtained from the individual being assessed. The blood sample is mixed in combination with 1) an anticoagulant; 2) sufficient buffer to maintain the pH and salt concentration of the anticoagulated blood within a range suitable for platelet aggregation; 3) a platelet GPIIb/IIIa receptor ligand immobilized on a solid surface; 4) one or more agents to enhance a signal transduction pathway and 5) a receptor activator. The combination is incubated under conditions for agglutinating particles. Platelet-mediated agglutination is assessed in the agitated mixture. The absence of agglutination indicates that the individual has a reduced ability to form platelet thrombi.
摘要翻译：提供一种确定个体是否由于抑制血小板活化起始，信号转导和/或GPIIb / IIIa阻断而形成血小板血栓形成能力降低的方法。从被评估的个体获得血液样本。血液样品与1）抗凝剂混合; 2）足够的缓冲液将抗凝血液的pH和盐浓度保持在适合血小板聚集的范围内; 3）固定在固体表面上的血小板GPIIb / IIIa受体配体; 4）增强信号转导途径的一种或多种药物和5）受体激活剂。将该组合在凝集颗粒的条件下孵育。在搅拌的混合物中评估血小板介导的凝集。没有凝集表明个体具有降低形成血小板血栓的能力。

28. 发明授权

US06592371B2 Method and system for imaging and modeling a three dimensional structure 有权
公开(公告)号：US06592371B2
公开(公告)日：2003-07-15
申请号：US09993110
申请日：2001-11-06
申请人： Duane Durbin , Dennis Durbin
发明人： Duane Durbin , Dennis Durbin
IPC分类号： G01B1124
CPC分类号： G06T17/00 , A61C9/00 , A61C9/0053
摘要： Systems and methods for generating a three-dimensional (3D) model of a structure include coating the structure with a luminescent substance to enhance the image quality, the luminescent substance having an excitation range; and capturing one or more images of the structure through at least one image aperture each having a frequency sensitivity, wherein the frequency sensitivity of each image aperture is maximized for the luminescent material emission range.

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