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    • 21. 发明申请
    • WORMHOLE DEVICES FOR USABLE SECURE ACCESS TO REMOTE RESOURCE
    • 用于可靠安全访问远程资源的WORMHOLE设备
    • US20080229402A1
    • 2008-09-18
    • US11744451
    • 2007-05-04
    • Diana K. SmettersTrevor F. SmithKyung-Hee Lee
    • Diana K. SmettersTrevor F. SmithKyung-Hee Lee
    • H04L9/32
    • H04L63/0853
    • A token has a memory, an interface allow connection to a host, and a processor. The processor, in response to user input for configuring a remote access connection, executes a first set of processing instructions to establish a trusted connection with the server host, exchanges credentials over the trusted connection to establish a secure connection with the server host over an untrusted connection, and defines configuration information for accessing user selected data or services. The processor, in response to user input received in a legacy environment, executes a second set of processing instructions that includes establishing, over an untrusted connection, a secure connection with the server host using the security credentials, configuring the secure connection for access to the data or services, making the data or services available in the legacy environment, and defends against attempted access to data or services available at the token other than the data or services made available in the legacy environment.
    • 令牌具有内存,接口允许连接到主机和处理器。 响应于用于配置远程访问连接的用户输入,处理器执行第一组处理指令以建立与服务器主机的可信连接,通过可信连接交换凭证,以通过不可信的方式与服务器主机建立安全连接 连接,并定义用于访问用户选择的数据或服务的配置信息。 响应于在传统环境中接收的用户输入,处理器执行第二组处理指令,其包括通过不可信连接在使用安全凭证的情况下建立与服务器主机的安全连接,配置安全连接以访问 数据或服务,使数据或服务在遗留环境中可用,并防止尝试访问在令牌上可用的数据或服务,而不是在传统环境中提供的数据或服务。
    • 23. 发明申请
    • Benzothiophen-2-carbonylguanidine derivatives, preparation thereof, and pharmaceutical composition containing the same
    • 苯并噻吩-2-羰基胍衍生物及其制备方法和含有它们的药物组合物
    • US20100004466A1
    • 2010-01-07
    • US11794238
    • 2005-12-27
    • Kyu Yang YiSunKyung LeeJee Hee SuhNak Jeong KimHyunsuk LeeByung-Ho LeeSung-eun YooKyung-Hee LeeYong Oh Lee
    • Kyu Yang YiSunKyung LeeJee Hee SuhNak Jeong KimHyunsuk LeeByung-Ho LeeSung-eun YooKyung-Hee LeeYong Oh Lee
    • C07D333/54
    • C07D333/70
    • The present invention is related to benzothiophen-2-carbonylguanidine derivatives, a preparation method thereof, and pharmaceutical compositions containing the same. The derivatives have potent inhibitory effect on the sodium/hydrogen exchanger NHE-I, improve the functional recovery of ischemia/reperfusion-induced heart injury in isolated ischemic heart models, and significantly reduce the myocardiac infarct size in in vivo ischemic animal models, thereby showing excellent cardioprotective effects. Also, the derivatives are protective of both neuronal cells and the brain as proven by their protective effects on neuronal cells from necrosis and apoptosis and by their ability to significantly reduce cerebral infarct sizes in in vivo ischemic brain models. The derivatives can be effectively used for the prevention and treatment of ischemic heart diseases such as myocardiac infarction, arrhythmia, angina pectoris and the like, and cerebrovascular diseases such as cerebral stroke and be used as cardioprotective agents to the patients undergoing reperfusion therapy including chemicals such as thrombolytic agents, or surgery such as coronary artery bypass and percutaneous transluminal coronary angioplasty.
    • 本发明涉及苯并噻吩-2-羰基胍衍生物,其制备方法和含有它们的药物组合物。 该衍生物对钠/氢交换器NHE-1具有有效的抑制作用,改善了分离缺血心脏模型缺血/再灌注诱导的心脏损伤的功能恢复,并显着降低了体内缺血动物模型中的心肌梗死面积,从而显示 良好的心脏保护作用。 此外,衍生物保护神经元细胞和脑,如通过其对来自坏死和凋亡的神经元细胞的保护作用以及通过其在体内缺血性脑模型中显着降低脑梗塞大小的能力所证明的。 该衍生物可以有效地用于预防和治疗心肌梗塞,心律失常,心绞痛等缺血性心脏病,脑血管疾病如脑卒中,并用作心脏保护剂,用于接受再灌注治疗的患者,包括化学药剂 作为溶栓剂,或手术如冠状动脉旁路和经皮腔内冠状动脉成形术。
    • 25. 发明授权
    • Benzothiophen-2-carbonylguanidine derivatives, preparation thereof, and pharmaceutical composition containing the same
    • 苯并噻吩-2-羰基胍衍生物及其制备方法和含有它们的药物组合物
    • US08143307B2
    • 2012-03-27
    • US11794238
    • 2005-12-27
    • Kyu Yang YiSunKyung LeeJee Hee SuhNak Jeong KimHyunsuk LeeByung-Ho LeeSung-eun YooKyung-Hee LeeYong Oh Lee
    • Kyu Yang YiSunKyung LeeJee Hee SuhNak Jeong KimHyunsuk LeeByung-Ho LeeSung-eun YooKyung-Hee LeeYong Oh Lee
    • A61K31/381C07D333/56
    • C07D333/70
    • The present invention is related to benzothiophen-2-carbonylguanidine derivatives, a preparation method thereof, and pharmaceutical compositions containing the same. The derivatives have potent inhibitory effect on the sodium/hydrogen exchanger NHE-I, improve the functional recovery of ischemia/reperfusion-induced heart injury in isolated ischemic heart models, and significantly reduce the myocardiac infarct size in in vivo ischemic animal models, thereby showing excellent cardioprotective effects. Also, the derivatives are protective of both neuronal cells and the brain as proven by their protective effects on neuronal cells from necrosis and apoptosis and by their ability to significantly reduce cerebral infarct sizes in in vivo ischemic brain models. The derivatives can be effectively used for the prevention and treatment of ischemic heart diseases such as myocardiac infarction, arrhythmia, angina pectoris and the like, and cerebrovascular diseases such as cerebral stroke and be used as cardioprotective agents to the patients undergoing reperfusion therapy including chemicals such as thrombolytic agents, or surgery such as coronary artery bypass and percutaneous transluminal coronary angioplasty.
    • 本发明涉及苯并噻吩-2-羰基胍衍生物,其制备方法和含有它们的药物组合物。 该衍生物对钠/氢交换器NHE-1具有有效的抑制作用,改善了分离缺血心脏模型缺血/再灌注诱导的心脏损伤的功能恢复,并显着降低了体内缺血动物模型中的心肌梗死面积,从而显示 良好的心脏保护作用。 此外,衍生物保护神经元细胞和脑,如通过其对来自坏死和凋亡的神经元细胞的保护作用以及通过其在体内缺血性脑模型中显着降低脑梗塞大小的能力所证明的。 该衍生物可以有效地用于预防和治疗心肌梗塞,心律失常,心绞痛等缺血性心脏病,脑血管疾病如脑卒中,并用作心脏保护剂,用于接受再灌注治疗的患者,包括化学药剂 作为溶栓剂,或手术如冠状动脉旁路和经皮腔内冠状动脉成形术。