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    • 28. 发明申请
    • METHODS AND COMPOSITIONS FOR ORGAN PROTECTION
    • 用于组织保护的方法和组合
    • US20100266501A1
    • 2010-10-21
    • US12312093
    • 2007-11-06
    • Markus MeyerMartin M. LeWinterHarold L. DauermanStephen P. Bell
    • Markus MeyerMartin M. LeWinterHarold L. DauermanStephen P. Bell
    • A61K49/00A61P9/10A61P9/14A61P13/12A61P39/06
    • A61K49/0447A61K31/195A61K45/06A61K2300/00
    • The invention relates in some aspects to compositions that include a contrast agent and an antioxidant compound and the use of such compositions to prevent (e.g., reduce) organ damage in a subject. In some aspects, the invention relates to compositions that include N— acetylcysteine (NAC) and a contrast agent and the use of such compositions for preventing organ damage in a subject. Methods of preventing organ damage may include the simultaneous administration of a composition of the invention, such that a contrast agent and an antioxidant compound or a contrast agent and NAC are administered intravascularly to a subject. Examples of organ damage that may be treated with compositions and methods of the invention include contrast-induced and non-contrast induced organ damage associated with myocardial ischemia, myocardial infarction, reperfusion damage, nephropathy, etc. The invention, in some aspects, also includes kits that may include a contrast agent and NAC and/or an antioxidant compound.
    • 本发明在一些方面涉及包括造影剂和抗氧化剂化合物的组合物,以及这些组合物用于预防(例如减少)受试者器官损害的用途。 在一些方面,本发明涉及包含N-乙酰半胱氨酸(NAC)和造影剂的组合物,以及这些组合物用于预防受试者器官损伤的用途。 预防器官损害的方法可以包括同时施用本发明的组合物,使得造影剂和抗氧化剂化合物或造影剂和NAC被血管内施用于受试者。 可以用本发明的组合物和方法治疗的器官损伤的实例包括与心肌缺血,心肌梗塞,再灌注损伤,肾病等相关的造影诱导和非造影诱导的器官损伤。在一些方面,本发明还包括 可以包括造影剂和NAC和/或抗氧化剂化合物的试剂盒。
    • 30. 发明授权
    • Variable valve gear for internal combustion engine
    • 内燃机用可变气门齿轮
    • US07367298B2
    • 2008-05-06
    • US11494202
    • 2006-07-27
    • Markus MeyerAndreas WerlerJörg Wutzler
    • Markus MeyerAndreas WerlerJörg Wutzler
    • F01L1/34
    • F01L13/0063F01L13/0026F01L2013/0068F01L2105/00
    • A variable valve gear for internal combustion engines, having at least one camshaft and pivot lever disposed in the cylinder head, which lever contacts a valve that closes by means of spring force. An intermediate element of a transfer element is mounted in a supporting and displaceable manner, twice on the supporting body and on the pivot lever. The intermediate element engages a supporting surface disposed on the supporting body, first by way of a supporting cam segment disposed on the intermediate element, and second with the controlling cam segment of the supporting body, and third with the pivot lever, by way of an outer contour surface disposed on the intermediate element. The intermediate element indirectly contacts the cam of the camshaft, by way of a roller disposed on an oscillating crank, which is connected with the intermediate element in articulated manner.
    • 一种用于内燃机的可变气门齿轮,具有设置在气缸盖中的至少一个凸轮轴和枢转杆,该杆接触通过弹簧力闭合的阀。 传递元件的中间元件以支撑和可移动的方式安装在支撑体上和枢转杆上两次。 中间元件接合设置在支撑体上的支撑表面,首先通过设置在中间元件上的支撑凸轮段,和第二支撑体与支撑体的控制凸轮段接合,并且第三与枢轴杠杆接合 外轮廓表面设置在中间元件上。 中间元件通过布置在摆动曲柄上的辊间接地接触凸轮轴的凸轮,其以铰接方式与中间元件连接。