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21. 发明申请

US20100092796A1 Microforming method and apparatus 有权
标题翻译：微成型方法和装置
公开(公告)号：US20100092796A1
公开(公告)日：2010-04-15
申请号：US12587408
申请日：2009-10-06
申请人： Jian Cao , Anthony Swanson , Tiffany Davis
发明人： Jian Cao , Anthony Swanson , Tiffany Davis
IPC分类号： B32B3/30 , B21D31/00 , B21D5/02 , B29C59/02 , B32B15/01
CPC分类号： B29C59/022 , B29C2059/023 , Y10T428/12389 , Y10T428/24479
摘要： Method of forming depressions (e.g. dimples) in a sheet material to form a textured surface thereon involves pressing one or more tool tips into a metallic or non-metallic sheet material while the sheet material is supported by a support layer that is relatively softer (e.g. having a lower Young's modulus) than the sheet material so as to allow plastic deformation and reduce pile-up of raised displaced material of the sheet material at the edges of the depressions.
摘要翻译：在片材中形成凹凸（例如凹坑）以形成其上的纹理化表面的方法包括将一个或多个工具尖端压入金属或非金属片材中，同时片材由相对较软的支撑层（例如，具有较低的杨氏模量），从而允许塑性变形并减少在凹陷的边缘处的片材的凸起的位移材料的堆积。

22. 发明申请

US20090226272A1 DEFORMATION MACHINING SYSTEMS AND METHODS 有权
标题翻译：变形加工系统和方法
公开(公告)号：US20090226272A1
公开(公告)日：2009-09-10
申请号：US12399703
申请日：2009-03-06
申请人： Kevin Scott SMITH , Bethany A. Woody , John C. Ziegert , Jian Cao
发明人： Kevin Scott SMITH , Bethany A. Woody , John C. Ziegert , Jian Cao
IPC分类号： B23C9/00 , B23C1/16 , B21D22/02 , B21D31/00
CPC分类号： B21D22/18 , B21D31/005 , B23C2215/04 , B23C2270/06 , B23P23/04 , Y10T409/300896
摘要： The present invention relates generally to deformation machining systems and methods that combine, in a single machine tool setup, the machining of thin structures and single point incremental forming (SPIF), such that novel part geometries and enhanced material properties may be obtained that are not achievable using conventional machining or forming systems and methods, individually or collectively. Important to many applications, lighter weight parts may be produced at lower cost using a conventional 3-axis computer numerically controlled (CNC) machine tool or the like, instead of the conventional 5-axis CNC machine tool or the like that is typically required.
摘要翻译：本发明一般涉及在单个机床设备中组合薄结构和单点增量成形（SPIF）的加工的变形加工系统和方法，使得可以获得不是的新颖零件几何形状和增强的材料性质可以使用常规加工或成型系统和方法单独地或集体地实现。对许多应用来说重要的是，使用常规的三轴计算机数控（CNC）机床等，可以以较低的成本生产较轻的部件，而不是通常需要的常规的5轴CNC机床等。

23. 发明申请

US20080082014A1 METHOD FOR DETERMINING OVERSENSING IN AN IMPLANTABLE DEVICE 有权
标题翻译：用于确定可植入装置中的过盈量的方法
公开(公告)号：US20080082014A1
公开(公告)日：2008-04-03
申请号：US11537171
申请日：2006-09-29
申请人： Jian Cao , Jeffrey M. Gillberg , Maneesh Shrivastav , Scott R. Stanskaski
发明人： Jian Cao , Jeffrey M. Gillberg , Maneesh Shrivastav , Scott R. Stanskaski
IPC分类号： A61B5/04
CPC分类号： A61B5/0452 , A61B5/7225 , A61B5/7264 , A61N1/3704
摘要： An implantable medical device system and method detect oversensing of cardiac signals. A cardiac signal including first events and second events is acquired. Cardiac events are sensed in response to the cardiac signal crossing a first threshold. A filtered cardiac signal is determined from the sensed cardiac signal, and a second threshold is determined from the filtered cardiac signal. A sensed cardiac event is classified either as a first event when the sensed cardiac event corresponds to a filtered cardiac signal peak crossing the second threshold or a second event when the sensed cardiac event corresponds to a filtered cardiac signal peak being less than the second threshold. Classification of sensed cardiac events as second events is used in determining oversensing.
摘要翻译：可植入医疗装置系统和方法检测心脏信号的过度感知。获取包括第一事件和第二事件的心脏信号。响应于穿过第一阈值的心脏信号感测心脏事件。从感测到的心脏信号确定滤波的心脏信号，并且从滤波的心脏信号确定第二阈值。感测的心脏事件被分类为当感测的心脏事件对应于穿过第二阈值的经滤波的心脏信号峰值时的第一事件或当感测到的心脏事件对应于小于第二阈值的经过滤的心脏信号峰值时的第二事件。感测心脏事件作为第二次事件的分类用于确定过敏。

24. 发明申请

US20070276276A1 METHOD AND APPARATUS FOR GENERATING A TEMPLATE FOR ARRHYTHMIA DETECTION AND ELECTROGRAM MORPHOLOGY CLASSIFICATION 有权
标题翻译：用于产生ARRHYTHMIA检测和电子形态学分类的模板的方法和装置
公开(公告)号：US20070276276A1
公开(公告)日：2007-11-29
申请号：US11757495
申请日：2007-06-04
申请人： Jian Cao , Jeffrey Gillberg , Chris Gennaro
发明人： Jian Cao , Jeffrey Gillberg , Chris Gennaro
IPC分类号： A61B5/0452
CPC分类号： A61B5/7264 , A61B5/04525 , A61B5/0464 , A61B5/726 , A61N1/3622 , A61N1/3956
摘要： An implantable medical device and associated method for automatically generating morphology templates during fast cardiac rhythms, confirming a provisional template as a confirmed template, and using the confirmed template to classify subsequent detected arrhythmias. A provisional SVT template may be created during a fast ventricular rate and activated as a confirmed SVT template upon verification that the fast rate was due to an SVT. The confirmed SVT template may be used to discriminate SVT from VT/VF.
摘要翻译：一种用于在快速心脏节律期间自动生成形态学模板的可植入医疗装置和相关联的方法，确认临时模板作为确认的模板，并使用确认的模板来分类随后检测的心律失常。可以在快速心室率期间创建临时SVT模板，并且在验证快速率是由于SVT引起的情况下被激活为确认的SVT模板。可以使用确认的SVT模板来区分SVT与VT / VF。

25. 发明申请

US20070077934A1 Dynamic reuse partitioning and subchannel allocation scheme in multicell OFDMA downlink systems 审中-公开
标题翻译：多码OFDMA下行链路系统中的动态重用分区和子信道分配方案
公开(公告)号：US20070077934A1
公开(公告)日：2007-04-05
申请号：US11541284
申请日：2006-09-28
申请人： Aik Chindapol , Jian Cao
发明人： Aik Chindapol , Jian Cao
IPC分类号： H04Q7/20
CPC分类号： H04W16/12 , H04W16/02
摘要： The reuse partitioning problem for a cellular orthogonal frequency division multiple access (OFDMA) system with dynamic subcarrier allocation is considered. One objective is to allocate the network resources in an efficient way in order to maximize the system's total throughput under individual user's quality-of-service (QoS) constraint. A suboptimal two-step approach is used where the radio network controller (RNC) solves the network planning problem and each base station (BS) solves the cell throughput maximization problem. Compared with the optimal resource allocation scheme, the approach described herein has much lower computational complexity in the RNC. Moreover, the communication overhead between each BS and the RNC is reduced substantially which renders our approach more practical for delay sensitive applications. Throughput increase is demonstrated
摘要翻译：考虑了具有动态子载波分配的蜂窝正交频分多址（OFDMA）系统的重用分区问题。一个目标是以有效的方式分配网络资源，以便在单个用户的服务质量（QoS）约束下最大化系统的总吞吐量。无线网络控制器（RNC）解决了网络规划问题，而每个基站（BS）解决了小区吞吐量最大化问题，使用了次优的两步法。与最优资源分配方案相比，本文描述的方法在RNC中具有低得多的计算复杂度。此外，每个BS和RNC之间的通信开销大大降低，这使得我们的方法对于延迟敏感的应用更为实用。显示吞吐量增加

26. 发明申请

US20060270937A1 Automated Template Generation Algorithm for Implantable Device 有权
标题翻译：可植入装置的自动模板生成算法
公开(公告)号：US20060270937A1
公开(公告)日：2006-11-30
申请号：US11420521
申请日：2006-05-26
申请人： Lev Koyrakh , Eugene Davydov , Jeffrey Gillberg , Jian Cao
发明人： Lev Koyrakh , Eugene Davydov , Jeffrey Gillberg , Jian Cao
IPC分类号： A61B5/04
CPC分类号： A61B5/04525
摘要： A method of generating a template in an implantable medical device for implantation within a patient, and a processor readable medium for performing the method, that includes generating a template from collected events corresponding to the patient, delaying the generation of the template for a first predetermined time period in response to the template not being generated within a predetermined number of collected events, determining whether the template is valid, and monitoring the template to determine whether the template is an accurate representation of the patient.
摘要翻译：一种在用于植入患者体内的可植入医疗装置中生成模板的方法，以及用于执行该方法的处理器可读介质，其包括从与患者相对应的收集的事件生成模板，延迟模板的生成，用于第一预定响应于在预定数量的收集事件中不生成模板的时间段，确定模板是否有效，以及监视模板以确定模板是否是患者的准确表示。

27. 发明授权

US07027858B2 Methods and apparatus for cardiac R-wave sensing in a subcutaneous ECG waveform 有权
标题翻译：皮下心电图波形中心脏R波检测的方法和装置
公开(公告)号：US07027858B2
公开(公告)日：2006-04-11
申请号：US10238140
申请日：2002-09-11
申请人： Jian Cao , Lee B. Brian , Michael R. Kane , Spencer R. Hurd
发明人： Jian Cao , Lee B. Brian , Michael R. Kane , Spencer R. Hurd
IPC分类号： A61B5/04
CPC分类号： A61B5/0468 , A61B5/04325 , A61B5/0456 , A61B5/7203 , A61B5/7221
摘要： The present invention uses a R-wave sensing algorithm that uniquely combines an automatic threshold adjustment method with a new noise rejection technique. This algorithm has significant advantages in avoiding the sensing of T-waves, P-waves, and noise/artifacts. Detecting the presence of noise bursts uses features that determine if an R-R interval adjacent to or within the noise signal is valid. Circuitry that discriminates noise signals from R-waves can use any one of several features including, but not limited to, the following: detection events occurring so close together that they are outside normal physiologic heart rates; frequency content that is wider than that of QRS complexes; amplitudes that are different than the adjacent or encompassing R-waves; and amplitudes that display greater than normal variability. The present invention employs multiple discrete thresholds optionally with different decay constants, alone or in combination with one or more substantially constant magnitude sensing threshold.
摘要翻译：本发明使用独特地组合自动阈值调整方法和新的噪声抑制技术的R波感测算法。该算法在避免T波，P波和噪声/伪影的检测方面具有显着的优势。检测噪声突发的存在使用确定与噪声信号相邻或内部的R-R间隔是否有效的特征。鉴别来自R波的噪声信号的电路可以使用几个特征中的任何一个，包括但不限于以下：检测事件如此紧密地发生，使得它们在正常生理心率之外; 频率含量比QRS复合物宽; 与相邻或包围的R波不同的振幅; 和显示大于正常变异性的振幅。本发明单独或与一个或多个基本上恒定的幅度感测阈值组合使用多个离散阈值，其可选地具有不同的衰减常数。

28. 发明授权

US09993397B2 Composite particles and compositions with composite particles 有权
公开(公告)号：US09993397B2
公开(公告)日：2018-06-12
申请号：US13885721
申请日：2011-11-02
申请人： Jian Cao , Zhaoting Liu , Xiaoyi Pang , Robert Paul Velthuizen , Xiuxia Wang
发明人： Jian Cao , Zhaoting Liu , Xiaoyi Pang , Robert Paul Velthuizen , Xiuxia Wang
IPC分类号： A61K8/02 , C08K3/00 , C08K3/22 , A61K8/27 , A61K8/28 , A61K8/29 , A61Q19/00 , A61K8/81 , A61K8/19 , C08K9/10
CPC分类号： A61K8/0245 , A61K8/0279 , A61K8/19 , A61K8/27 , A61K8/28 , A61K8/29 , A61K8/8152 , A61K2800/412 , A61Q19/00 , C08K3/013 , C08K3/22 , C08K9/10
摘要： Composite particles and compositions with the composite particles are described. The particles have a polymeric base with or without voids and subparticles whereby the subparticles have indexes of refraction above and below the index of refraction of the polymeric base. When typically applied, the compositions impart excellent soft focus results on the skin of consumers.

29. 发明申请

US20160158934A1 TRANSLATIONAL PARALLEL MANIPULATORS AND METHODS OF OPERATING THE SAME 审中-公开
标题翻译：翻译并行操纵器及其操作方法
公开(公告)号：US20160158934A1
公开(公告)日：2016-06-09
申请号：US15040156
申请日：2016-02-10
申请人： Jian Cao , Kornel F. Ehmann , Qiang Zeng
发明人： Jian Cao , Kornel F. Ehmann , Qiang Zeng
IPC分类号： B25J9/00 , B25J9/16 , B25J9/10
摘要： In one aspect, a translational parallel manipulator is provided and includes a fixed platform including three guide members. The three guide members include first ends and second ends, and the first ends of the three guide members are all coupled to each other and the second ends of the three guide members are all spaced-apart from each other. The manipulator also includes a movable platform spaced-apart from the fixed platform and three serial subchains coupled between the three guide members and the movable platform. In one aspect, a translational parallel manipulator is provided and includes a fixed platform, a movable platform spaced-apart from the fixed platform, and a plurality of subchains coupled between the fixed platform and the movable platform. At least one of the plurality of subchains includes no more than four one degree-of-freedom joints.
摘要翻译：在一个方面，提供了平移并行操纵器，并且包括具有三个引导构件的固定平台。三个引导构件包括第一端和第二端，并且三个引导构件的第一端都彼此联接，并且三个引导构件的第二端彼此间隔开。机械手还包括与固定平台间隔开的可移动平台和联接在三个引导构件和可移动平台之间的三个串联子链。一方面，提供了一种平移并行机械手，包括固定平台，与固定平台间隔开的可移动平台以及耦合在固定平台与可移动平台之间的多个子链。多个子链中的至少一个包括不超过四个自由度关节。

30. 发明授权

US08900851B2 Multi-well platform 有权
标题翻译：多井平台
公开(公告)号：US08900851B2
公开(公告)日：2014-12-02
申请号：US13055088
申请日：2009-07-20
申请人： Jian Cao
发明人： Jian Cao
IPC分类号： C12M1/34 , C12Q1/68 , G01N33/50 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/154 , C12Q2600/158 , G01N33/5029 , G01N33/57415 , G01N2500/00
摘要： The present invention relates to the diagnosis and treatment of cancer, and in particular breast cancer. Specifically, in some embodiments the invention relates to methods of diagnosing cancer, and in particular breast cancer, using an antibody specific for a gene product that localizes selectively to the endoplasmic reticulum of the cancer cell(s). In some embodiments, the invention relates to methods of treating cancer, and in particular breast cancer, by administering a composition comprising an RNA interference sequence (e.g., shRNA, RNAi and/or siRNA molecule) characterized by an ability to inhibit an mRNA molecule, which mRNA molecule is encoded by the C43 gene (SEQ ID NO: 1). The invention additionally relates to methods for detecting cancer cells by detecting reduced methylation of the C43 promoter, and methods for reducing cancer metastasis by using demethylation inhibitors that result in increased methylation of the C43 promoter. The invention additionally relates to an in vitro 3-dimensional assay for detecting migrating cells, identifying test agents and/or nucleotide sequences that alter cell migration.
摘要翻译：本发明涉及癌症的诊断和治疗，特别涉及乳腺癌。具体来说，在一些实施方案中，本发明涉及使用对选择性定位于癌细胞的内质网的基因产物特异的抗体来诊断癌症的方法，特别是乳腺癌。在一些实施方案中，本发明涉及通过施用包含特征在于抑制mRNA分子的能力的RNA干扰序列（例如shRNA，RNAi和/或siRNA分子）的组合物来治疗癌症，特别是乳腺癌的方法，该mRNA分子由C43基因（SEQ ID NO：1）编码。本发明还涉及通过检测C43启动子的甲基化降低来检测癌细胞的方法，以及通过使用导致C43启动子的甲基化增加的去甲基化抑制剂来减少癌症转移的方法。本发明还涉及用于检测迁移细胞的体外三维测定，鉴定测试试剂和/或改变细胞迁移的核苷酸序列。

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