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21. 发明授权

US5992845A Sheet-guiding device with a cooled sheet-guiding plate 失效
标题翻译：具有冷却片导板的片导向装置
公开(公告)号：US5992845A
公开(公告)日：1999-11-30
申请号：US789487
申请日：1997-01-27
申请人： Wolfram Fendler , Matthias Schuster , Burkhard Mack , Bernhard Waltenberger
发明人： Wolfram Fendler , Matthias Schuster , Burkhard Mack , Bernhard Waltenberger
IPC分类号： B41F21/00 , B41F23/04 , B65H5/00 , B65H29/52 , B65H29/24
CPC分类号： B41F23/04 , B65H29/52 , B65H2406/00
摘要： A sheet-guiding device with a cooled sheet-guiding plate formed with air outlet openings, the sheet-guiding plate having a sheet-guiding surface on one side thereof and being connected, at the other side thereof opposite to the one side, to coolant ducts permitting the air outlet openings to remain freely open, and a cooling-duct plate having deformations forming the coolant ducts, the cooling-duct plate being connected by welding to the sheet-guiding plate and being sealed with respect thereto, includes a sealing element disposed between the other side of the sheet-guiding plate and the cooling-duct plate, the sealing element being in a groove-shaped indentation formed in the cooling-duct plate and surrounding a respective air outlet opening, and welding zones located in the vicinity of the sealing element for forming a connection between the sheet-guiding plate and the cooling-duct plate by weldments.
摘要翻译：一种片材引导装置，其具有形成有排气口的冷却片材引导板，片材引导板在其一侧具有片材引导表面，并且在与其一侧相对的另一侧连接到冷却剂允许空气出口开口保持自由打开的管道和具有形成冷却剂管道的变形的冷却管道板，冷却管道板通过焊接连接到片材引导板并相对于其密封，包括密封元件所述密封元件设置在所述导板的另一侧与所述冷却管板之间，所述密封元件位于形成在所述冷却管道板中的槽形凹部中，并且包围相应的出气口，并且位于所述附近的焊接区域用于通过焊件形成片材引导板和冷却管板之间的连接的密封元件。

22. 发明授权

US5350682A Process for preparing peptides 失效
标题翻译：制备肽的方法
公开(公告)号：US5350682A
公开(公告)日：1994-09-27
申请号：US956025
申请日：1993-02-12
申请人： Hans-Dieter Jakubke , Matthias Schuster , Aavo Aaviksaar
发明人： Hans-Dieter Jakubke , Matthias Schuster , Aavo Aaviksaar
IPC分类号： C07K1/02 , C07K1/06 , C12P21/02 , C12P21/00 , C12N9/50 , C12N9/76
CPC分类号： C12P21/02 , C07K1/023 , Y02P20/55
摘要： The invention relates to a process for preparing chirally uniform peptides. The aim of the invention is the preparation of chirally uniform peptides with the aid of proteolytic enzymes. The object comprises reacting alkyl esters of N-acylamino acids with proteases with amino acids, amino acid derivatives or peptides. The object is achieved by reacting an ester of an N-acylamino acid with a suitable amino acid derivative or peptide derivative with an unprotected N-terminal alphaamino group in frozen aqueous solution during catalysis with a serine protease or cysteine protease.
摘要翻译： PCT No.PCT / EP91 / 00877 Sec。 371日期：1993年2月12日 102（e）日期1993年2月12日PCT提交1991年5月10日PCT公布。第WO91 / 19811号公报日期1991年12月26日。本发明涉及一种制备手性均匀肽的方法。本发明的目的是借助蛋白水解酶制备手性均匀的肽。该目的包括使N-酰基氨基酸的烷基酯与蛋白酶与氨基酸，氨基酸衍生物或肽反应。该目的是通过在用丝氨酸蛋白酶或半胱氨酸蛋白酶催化的过程中，将N-酰基氨基酸的酯与合适的氨基酸衍生物或肽衍生物与未保护的N-末端α-氨基在冷冻水溶液中反应来实现的。

23. 发明申请

US20090155857A1 Facilitator and method for amplification 审中-公开
标题翻译：辅导员和扩增方法
公开(公告)号：US20090155857A1
公开(公告)日：2009-06-18
申请号：US12316623
申请日：2008-12-15
申请人： Matthias Schuster
发明人： Matthias Schuster
IPC分类号： C12P19/34 , C07H21/00 , C12N9/10
CPC分类号： C12Q1/6853 , C12Q2600/156 , C12Q2537/162 , C12Q2525/161 , C12Q2523/125
摘要： Subject matter of the invention is a method for amplification of nucleic acids, wherein a successful binding of a primer and a facilitator onto the template is required for amplification. The invention further comprises the inventive facilitator, inventive kits comprising a facilitator and the use of said inventive method, facilitator or kit.
摘要翻译：本发明的主题是用于扩增核酸的方法，其中扩增需要引物和促进子的成功结合到模板上。本发明还包括本发明的促进者，本发明的试剂盒，其包括促进剂和所述发明方法，促进剂或试剂盒的用途。

24. 发明申请

US20080124735A1 Method for detection of one or more CpG positions 审中-公开
标题翻译：用于检测一个或多个CpG位置的方法
公开(公告)号：US20080124735A1
公开(公告)日：2008-05-29
申请号：US11974919
申请日：2007-10-16
申请人： Matthias Schuster , Philipp Schatz , Esmeralda Heiden
发明人： Matthias Schuster , Philipp Schatz , Esmeralda Heiden
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6818 , C12Q2537/164
摘要： The invention relates generally to novel and substantially improved methods for detecting CpG positions. Particular aspects relate to a method for detection of one or more CpG positions. Said method comprises: providing a sample, binding a protein or peptide onto the DNA of said sample, hybridizing a probe onto the DNA of said sample, detecting a signal determined by said bound proteins or peptides and by said hybridized probes. Thereby one or more CpG positions are detected in a methylation specific and sequence specific manner.
摘要翻译：本发明一般涉及用于检测CpG位置的新颖且显着改进的方法。特定方面涉及用于检测一个或多个CpG位置的方法。所述方法包括：提供样品，将蛋白质或肽结合到所述样品的DNA上，将探针与所述样品的DNA杂交，检测由所述结合的蛋白质或肽和所述杂交探针确定的信号。从而以甲基化特异性和序列特异性方式检测一个或多个CpG位置。

25. 发明申请

US20090208941A1 Method for investigating cytosine methylations in dna 审中-公开
标题翻译：在dna中调查胞嘧啶甲基化的方法
公开(公告)号：US20090208941A1
公开(公告)日：2009-08-20
申请号：US11989081
申请日：2006-07-19
申请人： Kurt Berlin , Matthias Schuster , Philipp Schatz
发明人： Kurt Berlin , Matthias Schuster , Philipp Schatz
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827
摘要： A method for sensitive and specific detection of cytosine methylation is described wherein the DNA to be analyzed is subjected to initial enrichment. More specifically, said enrichment can be effected in a methylation-specific, sequence-specific or origin-specific fashion. Thereafter, the enriched DNA is converted in a methylation-specific fashion. The converted DNA can be analyzed using various methods, particularly real-time PCR methods.
摘要翻译：描述了用于敏感和特异性检测胞嘧啶甲基化的方法，其中待分析的DNA经受初始富集。更具体地，所述富集可以以甲基化特异性，序列特异性或起始特异性方式实现。此后，富集的DNA以甲基化特异性方式转化。可以使用各种方法，特别是实时PCR方法分析转化的DNA。

26. 发明申请

US20090004646A1 Method for Quantifying Methylated Dna 审中-公开
标题翻译：甲基化Dna的定量方法
公开(公告)号：US20090004646A1
公开(公告)日：2009-01-01
申请号：US11629743
申请日：2005-06-15
申请人： Matthias Schuster , Philipp Schatz
发明人： Matthias Schuster , Philipp Schatz
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q2537/164 , C12Q2521/331
摘要： The inventive method makes it possible to quantify methylated DNA by combining the restricted digestion and real-time PCR. For this purpose, the inventive method consists in isolating the examined DNA from a biological sample, in reacting the isolated AND with a methylation specific restriction enzyme, in amplifying by means of a real-time PCR, wherein the amplified products are formed only when the DNA is precut-off and, afterwards, in calculated the methylated and unmethylated DNA proportion in the initial sample with the aid of a reference measurement. Said method is particularly suitable for diagnosis and prognosis cancer and other diseases associated with a methylation state modification and for predicting the drug effects.
摘要翻译：本发明的方法使得可以通过组合限制性消化和实时PCR来定量甲基化DNA。为此目的，本发明的方法在于通过实时PCR扩增从分离出的生物样品中的DNA，使分离的AND与甲基化特异性限制酶反应，其中扩增产物仅在 DNA被去除，然后借助于参考测量计算初始样品中的甲基化和非甲基化DNA比例。所述方法特别适用于与甲基化状态修饰相关的癌症和其他疾病的诊断和预后，并用于预测药物作用。

27. 发明申请

US20080220418A1 Method For Providing Dna Fragments Derived From An Archived Sample 有权
标题翻译：提供从存档样本派生的Dna片段的方法
公开(公告)号：US20080220418A1
公开(公告)日：2008-09-11
申请号：US11664367
申请日：2005-09-30
申请人： Matthias Ballhause , Kurt Berlin , Dimo Dietrich , Antje Lukas , Matthias Schuster , Ute Wagner , Reinhold Wasserkort , Heike Ziebarth
发明人： Matthias Ballhause , Kurt Berlin , Dimo Dietrich , Antje Lukas , Matthias Schuster , Ute Wagner , Reinhold Wasserkort , Heike Ziebarth
IPC分类号： C12Q1/68 , C07H1/00 , C12P19/34
CPC分类号： C12Q1/6806 , C12N15/1003 , C12Q1/6858 , C12Q1/686 , C12Q2523/125 , C12Q2527/137 , C12Q2527/149 , C12Q2531/107
摘要： Aspects of the present invention relate to compositions and methods for providing DNA fragments from an archived sample (e.g., paraffin-embedded and/or fixed-tissue biopsies, etc). Particular aspects provide methods whereby high yields of DNA are isolated as well as a substantial portion of the DNA consists of long DNA fragments, and where the isolated genomic DNA is free of associated or cross-linked contaminants like proteins, peptides, amino acids or RNA. The methods are facile, cost-effective, an are characterized by high reproducibility and reliability. Particular aspects provide methods for providing DNA fragments derived from an archived sample, wherein the yield of DNA before, for example, an amplification step is at least 20%, and amplicons up to a length of about 1,000 base pairs are amplifiable.
摘要翻译：本发明的方面涉及从归档样品（例如石蜡包埋和/或固定组织活组织检查等）提供DNA片段的组合物和方法。具体方面提供了分离DNA的高产率以及大部分DNA由长DNA片段组成并且分离的基因组DNA不含相关或交联的污染物如蛋白质，肽，氨基酸或RNA的方法。这些方法是容易的，具有成本效益的，其特征在于重现性和可靠性高。特定方面提供用于提供衍生自归档样品的DNA片段的方法，其中在例如扩增步骤之前的DNA的产量为至少20％，并且可扩增至约1000个碱基对的扩增子。

28. 发明申请

US20060053615A1 Method for the production of an air restrictor and machine incorporating the air restrictor 审中-公开
标题翻译：用于生产包含空气限制器的空气限制器和机器的方法
公开(公告)号：US20060053615A1
公开(公告)日：2006-03-16
申请号：US11225801
申请日：2005-09-13
申请人： Andre Kreller , Andreas Muller , Matthias Schuster , Monika Blumm , Andreas Detloff , Michael Pasuch , Ludwig Reinhard , Frank Schaum
发明人： Andre Kreller , Andreas Muller , Matthias Schuster , Monika Blumm , Andreas Detloff , Michael Pasuch , Ludwig Reinhard , Frank Schaum
IPC分类号： B32B37/00 , B23K31/02 , B29C65/00 , B23P25/00 , B31B1/60
CPC分类号： B65H5/222 , B65H29/686 , B65H2401/10 , B65H2801/21 , Y10T29/49885 , Y10T29/49982 , Y10T156/10 , Y10T156/1056
摘要： In a method for producing an air restrictor, use is made of at least one liquid or tacky substance to join perforated plates to one another and to seal the air restrictor. The substance can be, for example, an adhesive contained in capsules. The adhesive is liberated by bursting the capsules inserted between the perforated plates.
摘要翻译：在制造空气限制器的方法中，使用至少一种液体或粘性物质将多孔板彼此连接并密封空气限制器。该物质可以是例如胶囊中所含的粘合剂。通过将插入多孔板之间的胶囊破裂来释放粘合剂。

29. 发明授权

US06752392B2 Device for picking up a sheet trailing edge from an upstream cylinder and for transferring the sheet trailing edge to a gripper system 失效
标题翻译：用于从上游圆筒拾取片材后缘并将片材后缘传送到夹具系统的装置
公开(公告)号：US06752392B2
公开(公告)日：2004-06-22
申请号：US10254728
申请日：2002-09-25
申请人： Andreas Fricke , Michael Puckl , Ludwig Reinhard , Matthias Schuster , Gunter Siebdrath
发明人： Andreas Fricke , Michael Puckl , Ludwig Reinhard , Matthias Schuster , Gunter Siebdrath
IPC分类号： B65H2900
CPC分类号： B41F21/106 , B65H5/12 , B65H5/14 , B65H2404/656 , B65H2701/1313
摘要： A device for picking up a sheet trailing edge from an upstream cylinder and transferring the sheet trailing edge to a gripper system of a downstream drum, as viewed in sheet travel direction, includes a sucker guide mechanism having a movably mounted sucker carrier whereon sucker heads subjectible to an application of vacuum or suction air are disposed. The sucker carrier is constructed as a tubular part having a longitudinal axis and being movable perpendicularly to the longitudinal axis thereof. The tubular part is formed with a vacuum or suction air duct extending in the interior thereof and is formed of carbon fiber-reinforced plastic-material laminate.
摘要翻译：一种用于从上游圆筒拾取片材后缘并将片材后缘转移到下游鼓的夹持系统的装置，如从片材行进方向看，包括一个吸盘引导机构，其具有可移动地安装的吸盘载体，吸盘可吸入设置真空或抽吸空气的应用。吸盘载体构造为具有纵向轴线并且可垂直于其纵向轴线移动的管状部件。管状部分形成有在其内部延伸的真空或吸入空气管道，并由碳纤维增强的塑料材料层压体形成。

30. 发明授权

US5369017A Process for solid phase glycopeptide synthesis 失效
标题翻译：固相糖肽合成方法
公开(公告)号：US5369017A
公开(公告)日：1994-11-29
申请号：US191777
申请日：1994-02-04
申请人： Chi-Huey Wong , Matthias Schuster
发明人： Chi-Huey Wong , Matthias Schuster
IPC分类号： C07K1/04 , C12P21/00
CPC分类号： C07K1/042
摘要： A process for the synthesis of a glycopeptide using a solid phase matrix is disclosed. The matrix is compatible with aqueous and organic solvents and is comprised of a silica-based solid support to which is linked a two-part spacer group having a chain length of about 12 to about 40 methylene groups. The first part of the spacer is covalently bonded to the silica-based support and has a length of about 3 to about 10 methylene groups. The second spacer part is covalently bonded to the first part of the spacer and comprises the distal end of the two part spacer. The second part is soluble as a free molecule in each of water, dimethylformamide and dichloromethane and has a terminal amine or hydroxyl group to which the C-terminal residue of the peptide portion of the glycopeptide chain is bonded. The chain of atoms connecting the desired glycopeptide to the solid phase matrix also includes a moiety having a selectively severable bond which on cleavage of that bond separates the matrix from whatever else is bonded to that moiety.
摘要翻译：公开了使用固相基质合成糖肽的方法。该基质与水性和有机溶剂相容，并且由二氧化硅基固体载体组成，其连接有链长约12至约40个亚甲基的两部分间隔基团。间隔基的第一部分共价结合到二氧化硅基载体上，其长度为约3至约10个亚甲基。第二间隔部分共价结合到间隔物的第一部分并且包括两部分间隔物的远端。第二部分作为水，二甲基甲酰胺和二氯甲烷中的每一个中的游离分子是可溶的，并且具有结合糖肽链的肽部分的C末端残基的末端胺或羟基。将所需糖肽连接到固相基质上的原子链还包括具有选择性可分离键的部分，其在该键的切割时将基质与与该部分键合的任何其它基团分开。

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