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21. 发明授权

US08796318B2 Modulators of sphingosine phosphate receptors 有权
标题翻译：新型磷酸腺苷受体调节剂
公开(公告)号：US08796318B2
公开(公告)日：2014-08-05
申请号：US12465767
申请日：2009-05-14
申请人： Edward Roberts , Hugh Rosen , Steven Brown , Miguel A. Guerrero , Xuemei Peng , Ramulu Poddutoori
发明人： Edward Roberts , Hugh Rosen , Steven Brown , Miguel A. Guerrero , Xuemei Peng , Ramulu Poddutoori
IPC分类号： A61K31/4245 , C07D271/06
CPC分类号： C07D271/06 , A61K31/4245 , C07D263/32 , C07D401/04 , C07D413/04 , C07D413/14 , C07D471/04
摘要： Compounds that activate a sphingosine-1-phosphate receptor of the subtype 1 are provided. Certain compounds selectively activate the receptor subtype 1 in relation to the sphinogosine-1-phosphate receptor subtype 3. Uses and methods of inventive compounds for treatment of malconditions wherein activation, agonism, inhibition or antagonism of the S1P1 is medically indicated are provided.
摘要翻译：提供激活亚型1的鞘氨醇-1-磷酸受体的化合物。某些化合物选择性地激活了关于鞘氨醇 - 1-磷酸受体亚型3的受体亚型1。本发明化合物的用途和方法用于治疗病症，其中在医学上指示S1P1的活化，激动，抑制或拮抗作用。

22. 发明授权

US08629255B2 Nucleic acid molecules conferring enhanced ethanol tolerance and microorganisms having enhanced tolerance to ethanol 有权
标题翻译：赋予提高乙醇耐受性的核酸分子和对乙醇具有增强耐受性的微生物
公开(公告)号：US08629255B2
公开(公告)日：2014-01-14
申请号：US13112641
申请日：2011-05-20
申请人： Steven Brown , Adam Guss , Shihui Yang , Tatiana Karpinets , Lee Lynd , Xiongjun Shao
发明人： Steven Brown , Adam Guss , Shihui Yang , Tatiana Karpinets , Lee Lynd , Xiongjun Shao
IPC分类号： C07H21/00 , C12P7/02 , C12N1/00 , C12N15/75 , C12N1/15
CPC分类号： C12N9/0006 , C12P7/10 , Y02E50/16
摘要： The present invention provides isolated nucleic acid molecules which encode a mutant acetaldehyde-CoA/alcohol dehydrogenase or mutant alcohol dehydrogenase and confer enhanced tolerance to ethanol. The invention also provides related expression vectors, genetically engineered microorganisms having enhanced tolerance to ethanol, as well as methods of making and using such genetically modified microorganisms for production of biofuels based on fermentation of biomass materials.
摘要翻译：本发明提供了分离的核酸分子，其编码突变乙醛-CoA /醇脱氢酶或突变型醇脱氢酶并赋予对乙醇增强的耐受性。本发明还提供相关表达载体，具有增强的对乙醇的耐受性的遗传工程微生物，以及基于生物质材料的发酵制备和使用这些基因修饰的微生物生产生物燃料的方法。

23. 发明申请

US20120329840A1 NOVEL MODULATORS OF SPHINGOSINE PHOSPHATE RECEPTORS 有权
公开(公告)号：US20120329840A1
公开(公告)日：2012-12-27
申请号：US13605561
申请日：2012-09-06
申请人： Edward Roberts , Hugh Rose , Steven Brown , Miguel A. Guerrero , Xuemei Peng , Ramulu Poddutoori
发明人： Edward Roberts , Hugh Rose , Steven Brown , Miguel A. Guerrero , Xuemei Peng , Ramulu Poddutoori
IPC分类号： A61K31/4245 , A61P11/00 , A61P37/06 , C07D271/06 , A61P25/00
CPC分类号： C07D271/06 , A61K31/4245 , C07D263/32 , C07D401/04 , C07D413/04 , C07D413/14 , C07D471/04
摘要： Compounds that activate a sphingosine-1-phosphate receptor of the subtype 1 are provided. Certain compounds selectively activate the receptor subtype 1 in relation to the sphinogosine-1-phosphate receptor subtype 3. Uses and methods of inventive compounds for treatment of malconditions wherein activation, agonism, inhibition or antagonism of the S1P1 is medically indicated are provided.

24. 发明授权

US08147518B2 Dynamic connector for spinal device 失效
标题翻译：脊柱装置的动态连接器
公开(公告)号：US08147518B2
公开(公告)日：2012-04-03
申请号：US12124374
申请日：2008-05-21
申请人： Steven Brown , Manoj Krishna , Tai Friesem
发明人： Steven Brown , Manoj Krishna , Tai Friesem
IPC分类号： A61B17/70
CPC分类号： A61B17/7023 , A61B17/7001 , A61B17/7004 , A61B17/7014 , A61B17/7025 , A61B17/7032 , A61B17/7041 , A61B17/7049 , A61F2/442
摘要： The present invention provides a dynamic stabilization device positionable about a portion of a spinal column. The stabilization device may generally include a first component and a second component, where the first and second components are movably coupled to one another to define an arcuate path of motion. The stabilization device may also include one or more adjustment elements positionable within first and second adjustment openings to affect the path of motion between the first and second components and/or the behavior and characteristics of the movement. In addition, one or more resistive elements may be adjustably positionable within either and/or both of the first and second adjustment openings to provide resistance and/or dampening of the forces experienced as the first and second components move relative to one another. The stabilization device may further define a joint having three degrees of freedom to adapt to movement of a spinal column.
摘要翻译：本发明提供了可围绕脊柱的一部分定位的动态稳定装置。稳定装置通常可以包括第一部件和第二部件，其中第一和第二部件彼此可移动地联接以限定弓形运动路径。稳定装置还可以包括可定位在第一和第二调节开口内的一个或多个调节元件，以影响第一和第二部件之间的运动路径和/或运动的行为和特征。此外，一个或多个电阻元件可以可调节地定位在第一和第二调节开口内和/或两者中，以提供当第一和第二部件相对于彼此移动时所经受的力的电阻和/或阻尼。稳定装置还可以限定具有三个自由度以适应脊柱的运动的关节。

25. 发明申请

US20110287499A1 Nucleic Acid Molecules Conferring Enhanced Ethanol Tolerance And Microorganisms Having Enhanced Tolerance To Ethanol 有权
标题翻译：赋予增强乙醇耐受性和增强乙醇耐受性的微生物的核酸分子
公开(公告)号：US20110287499A1
公开(公告)日：2011-11-24
申请号：US13112641
申请日：2011-05-20
申请人： Steven Brown , Adam Guss , Shihui Yang , Tatiana Karpinets , Lee Lynd , Xiongjun Shao
发明人： Steven Brown , Adam Guss , Shihui Yang , Tatiana Karpinets , Lee Lynd , Xiongjun Shao
IPC分类号： C12P7/02 , C12N15/75 , C12N1/00 , C12N1/15 , C12N15/80 , C12N1/21 , C12N15/81 , C07H21/00 , C12N15/74
CPC分类号： C12N9/0006 , C12P7/10 , Y02E50/16
摘要： The present invention provides isolated nucleic acid molecules which encode a mutant acetaldehyde-CoA/alcohol dehydrogenase or mutant alcohol dehydrogenase and confer enhanced tolerance to ethanol. The invention also provides related expression vectors, genetically engineered microorganisms having enhanced tolerance to ethanol, as well as methods of making and using such genetically modified microorganisms for production of biofuels based on fermentation of biomass materials.
摘要翻译：本发明提供了分离的核酸分子，其编码突变乙醛-CoA /醇脱氢酶或突变型醇脱氢酶并赋予对乙醇的增强的耐受性。本发明还提供相关表达载体，具有增强的对乙醇的耐受性的遗传工程微生物，以及基于生物质材料的发酵制备和使用这些基因修饰的微生物生产生物燃料的方法。

26. 外观设计

USD618348S1 Spinal stabilization device 有权
标题翻译：脊柱稳定装置
公开(公告)号：USD618348S1
公开(公告)日：2010-06-22
申请号：US29326534
申请日：2008-10-20
申请人： Manoj Krishna , Tai Friesem , Steven Brown
设计人： Manoj Krishna , Tai Friesem , Steven Brown

27. 发明申请

US20100152638A1 Heel Ulcer Prevention and Cushioning Boot 有权
标题翻译：足跟溃疡预防和缓解靴
公开(公告)号：US20100152638A1
公开(公告)日：2010-06-17
申请号：US12709633
申请日：2010-02-22
申请人： Lawrence G. Ponsi , Barbara T. Skiba , Steven Brown
发明人： Lawrence G. Ponsi , Barbara T. Skiba , Steven Brown
IPC分类号： A61F5/00
CPC分类号： A61F5/0111 , A61F5/012
摘要： A cushioning boot for bed-ridden patients. The boot includes a thickly-padded leg engaging portion and foot engaging portion with a front opening for easy insertion of a patient foot and leg. A series of stretchable, adjustable closure panels are removably secured to the boot for positioning and inserted leg in the proper orientation and retaining it in place.
摘要翻译：卧床的患者的缓冲靴。靴子包括厚填充的腿部接合部分和具有前开口的脚部接合部分，用于容易地插入患者脚和腿部。一系列可拉伸，可调节的封闭面板可拆卸地固定在靴子上，用于定位和插入腿部，并将其保持在适当位置。

28. 发明授权

US07706967B2 Vehicle information system 有权
标题翻译：车辆信息系统
公开(公告)号：US07706967B2
公开(公告)日：2010-04-27
申请号：US12057837
申请日：2008-03-28
申请人： Ronald P. Knockeart , Bob Drury , Melvin A. Rode , Steven Brown , Harry Asher , Paul A. Jozefowicz
发明人： Ronald P. Knockeart , Bob Drury , Melvin A. Rode , Steven Brown , Harry Asher , Paul A. Jozefowicz
IPC分类号： G08G1/127
CPC分类号： G08G1/096811 , G01C21/3415 , G01C21/3492 , G08G1/096838 , G08G1/096844 , G08G1/096861 , G08G1/096872 , G08G1/096883
摘要： A vehicle information system which includes an in-vehicle system 105 and a centralized server system 120. The in-vehicle system communicates with the server system using a wireless communication link 110, such as over a cellular telephone system. A position system, such as a set of GPS satellites 140, provides positioning signals that are used by the in-vehicle systems, and optionally by the centralized server system to increase the accuracy of position estimates. In one version of the system, an operator specifies a destination to an in-vehicle system which validates the destination. The in-vehicle system transmits specification of the destination to a server system 125 at the centralized server. The server system computes a route to the destination and transmits the computed route to the in-vehicle system. The in-vehicle system guides the operator along the route. If the in-vehicle system detects that the vehicle as deviated from the planned route, it re-plans a new route to the destination using an in-vehicle map database.
摘要翻译：一种包括车载系统105和集中式服务器系统120的车辆信息系统。车载系统使用诸如蜂窝电话系统之类的无线通信链路110与服务器系统进行通信。诸如一组GPS卫星140的位置系统提供由车载系统使用的定位信号，并且可选地由中央服务器系统提供定位信号，以增加位置估计的准确性。在系统的一个版本中，操作员将目的地指定给车辆系统，以验证目的地。车载系统将目的地的规范发送到集中式服务器处的服务器系统125。服务器系统计算到目的地的路由，并将计算的路由发送到车载系统。车内系统沿着路线引导操作员。如果车内系统检测到车辆偏离计划路线，则使用车载地图数据库重新计划到达目的地的新路线。

29. 发明申请

US20100010001A1 NOVEL MODULATORS OF SPHINGOSINE PHOSPHATE RECEPTORS 有权
标题翻译：磷酸肌磷酸受体的新型调节剂
公开(公告)号：US20100010001A1
公开(公告)日：2010-01-14
申请号：US12465767
申请日：2009-05-14
申请人： Edward Roberts , Hugh Rosen , Steven Brown , Miguel A. Guerrero , Xuemei Peng , Ramulu Poddutoori
发明人： Edward Roberts , Hugh Rosen , Steven Brown , Miguel A. Guerrero , Xuemei Peng , Ramulu Poddutoori
IPC分类号： A61K31/506 , A61K31/497 , A61K31/4439 , A61K31/4245 , C07D413/00 , C07D271/06
CPC分类号： C07D271/06 , A61K31/4245 , C07D263/32 , C07D401/04 , C07D413/04 , C07D413/14 , C07D471/04
摘要： Compounds that activate a sphingosine-1-phosphate receptor of the subtype 1 are provided. Certain compounds selectively activate the receptor subtype 1 in relation to the sphinogosine-4-phosphate receptor subtype 3. Uses and methods of inventive compounds for treatment of malconditions wherein activation, agonism, inhibition or antagonism of the S1P1 is medically indicated are provided.
摘要翻译：提供激活亚型1的鞘氨醇-1-磷酸受体的化合物。某些化合物选择性地激活相关于鞘氨醇-4-磷酸受体亚型3的受体亚型1。本发明化合物的用途和方法用于治疗其中药学上指示S1P1的活化，激动，抑制或拮抗作用的病症。

30. 发明申请

US20090088847A1 SURGICAL INSTRUMENT SYSTEM 审中-公开
标题翻译：手术仪器系统
公开(公告)号：US20090088847A1
公开(公告)日：2009-04-02
申请号：US11865172
申请日：2007-10-01
申请人： Manoj Krishna , Tai Friesem , Steven Brown
发明人： Manoj Krishna , Tai Friesem , Steven Brown
IPC分类号： A61F2/44
CPC分类号： A61B17/025 , A61B17/1757 , A61B17/320016 , A61B2017/00261 , A61B2017/0256 , A61B2017/3447
摘要： The present invention provides a surgical instrument system including a first instrument defining a track extending along a length thereof, a second instrument releasably engageable with a prosthesis and having an engagement structure slidably engageable with the track of the first instrument, a third instrument having a cutting element and an engagement structure slidably engageable with the track of the first instrument, and a fourth instrument having a prosthesis trial element sized and shaped substantially similar to the prosthesis, and including an engagement structure slidably engageable with the track of the first instrument.
摘要翻译：本发明提供了一种外科器械系统，其包括限定沿其长度延伸的轨道的第一器械，可释放地与假体接合并具有可滑动地与第一器械的轨道接合的接合结构的第二器械，具有切割元件和可与第一器具的轨道可滑动接合的接合结构，以及第四器械，具有尺寸和形状基本上类似于假体的假体试验元件，并且包括可滑动地与第一器械的轨道接合的接合结构。

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