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21. 发明授权

US08895579B2 Heterotricyclic AMPA receptor antagonists for treatment of epilepsy, pain, and other neurological disorders and diseases 有权
标题翻译：异环AMPA受体拮抗剂用于治疗癫痫，疼痛和其他神经系统疾病和疾病
公开(公告)号：US08895579B2
公开(公告)日：2014-11-25
申请号：US13052742
申请日：2011-03-21
申请人： Geoffrey T. Swanson , Martin B. Gill , Ryuichi Sakai , Masato Oikawa
发明人： Geoffrey T. Swanson , Martin B. Gill , Ryuichi Sakai , Masato Oikawa
IPC分类号： A61K31/437 , A61K31/407 , A61K31/4355
CPC分类号： A61K31/437 , A61K31/407
摘要： Disclosed are heterotricyclic compounds, pharmaceutical compositions, methods of treatment, and methods for selectively antagonizing a glutamate receptor. The pharmaceutical compositions may include and the methods may utilize heterotricyclic compounds that are glutamate analogues which have specificity for AMPA receptors. The pharmaceutical compositions may be utilized to treat or prevent neurological diseases or disorders.
摘要翻译：公开了异三环化合物，药物组合物，治疗方法和选择性拮抗谷氨酸受体的方法。药物组合物可以包括并且该方法可以利用具有对AMPA受体具有特异性的谷氨酸类似物的异三环化合物。药物组合物可用于治疗或预防神经疾病或病症。

22. 发明申请

US20060212913A1 Remote control system, controllable device, and remote control method 审中-公开
标题翻译：遥控系统，可控设备和遥控方式
公开(公告)号：US20060212913A1
公开(公告)日：2006-09-21
申请号：US10550630
申请日：2004-03-26
申请人： Koji Hirose , Ryuichi Sakai , Takashi Maniwa
发明人： Koji Hirose , Ryuichi Sakai , Takashi Maniwa
IPC分类号： H04N5/445 , H04N7/173
CPC分类号： H04N5/4403 , H04N5/44582 , H04N5/50 , H04N21/2362 , H04N21/4227 , H04N21/4334 , H04N21/4345 , H04N21/43615 , H04N21/47214 , H04N21/4782 , H04N21/6125 , H04N21/6175 , H04N2005/4414 , H04N2005/4425
摘要： In a remote control system to control remotely a controlled device through a network from a terminal at a remote place, the controlled device stores a channel table associating broadcast station numbers recognized by a remote control device and allocated to each broadcast station with channel numbers recognized by the controlled device and allocated to each broadcast station. This allows channel numbers to be designated remotely according to an area, even though a relation between broadcast station numbers and channel numbers is different depending on an area. The remote controller can read the channel table of the controlled device and correct the channel table according to user's operation on the terminal.
摘要翻译：在遥控系统中，通过远程控制设备通过网络远程控制受控设备，受控设备存储与远程控制设备识别并分配给每个广播电台的广播电台号码相关联的频道表，通道号由受控设备并分配给每个广播电台。这允许根据区域远程地指定频道号码，即使广播电台号码和频道号码之间的关系根据区域而不同。遥控器可以读取受控设备的通道表，并根据用户在终端上的操作对通道表进行校正。

23. 发明申请

US20060044106A1 Remote control device, remote control method, and remotely controlled device 有权
标题翻译：遥控装置，遥控方式和遥控装置
公开(公告)号：US20060044106A1
公开(公告)日：2006-03-02
申请号：US10530478
申请日：2004-03-05
申请人： Koji Hirose , Ryuichi Sakai
发明人： Koji Hirose , Ryuichi Sakai
IPC分类号： G05B23/02
CPC分类号： H04L12/2825 , H04L12/2805 , H04L29/12113 , H04L61/1541 , H04L67/02 , H04L67/025 , H04L67/125 , H04L67/325 , H04L69/329 , H04M1/72533 , H04M11/007
摘要： A remote control system capable of detecting an operating status of devices through the Internet at real time is provided. A remote controller (20) which enables a terminal device to control an operation of the device (30a, . . . ) through a network (100), acquires a latest address of the device for the network by communicating with the device at predetermined time intervals through the network, stores the address, transmits a status notification request to the device through the network while referring to the stored address, receives status information from the device, stores the status information received from the device, and transmits the stored status information on the device to the terminal device (10) through the network.
摘要翻译：提供能够通过因特网实时检测设备的操作状态的遥控系统。使终端设备能够通过网络（100）控制设备（30a ...）的操作的遥控器（20）通过与预定的设备通信而获取用于网络的设备的最新地址通过网络的时间间隔，存储地址，参考存储的地址通过网络向设备发送状态通知请求，从设备接收状态信息，存储从设备接收的状态信息，并发送存储的状态信息在设备上通过网络连接到终端设备（10）。

24. 发明申请

US20060030571A1 Ecteinascidins 审中-公开
公开(公告)号：US20060030571A1
公开(公告)日：2006-02-09
申请号：US11132466
申请日：2005-05-18
申请人： Kenneth Rinehart , Ryuichi Sakai
发明人： Kenneth Rinehart , Ryuichi Sakai
IPC分类号： A61K31/519 , C07D491/14
CPC分类号： C07D515/22
摘要： The present invention is directed to several newly discovered ecteinascidin (Et) species, designated herein as Et 731, Et 745B, Et 815, Et 808, Et 596, Et 597, Et 583, Et 594 and a synthetic derivative of Et 594, N-Acetyl Et 597. The physical properties of these compounds, their preparation and bioactivities are also reported.
摘要翻译：本发明涉及几种新发现的被称为Et 731，Et 745B，Et 815，Et 808，Et 596，Et 597，Et 583，Et 594和Et 594的合成衍生物，N， - 乙酰基Et 597.还报道了这些化合物的物理性质，它们的制备和生物活性。

25. 发明授权

US06532587B1 Electronic equipment 失效
标题翻译：一种用于在rom中修改程序的方法和系统
公开(公告)号：US06532587B1
公开(公告)日：2003-03-11
申请号：US09260422
申请日：1999-03-01
申请人： Ryuichi Sakai , Koji Hirose
发明人： Ryuichi Sakai , Koji Hirose
IPC分类号： G06F944
CPC分类号： G06F8/66
摘要： A data transfer unit is connected with an external nonvolatile memory storing a correction program and the like data, and it transfers the correction program, etc. of the external nonvolatile memory to an internal nonvolatile memory upon detecting it having been connected with the external nonvolatile memory. The external nonvolatile memory is disconnected from the data transfer unit after completion of the data transfer. When a CPU unit is reset thereafter, it transfers the correction program, etc. to a RAM unit, executes a program in a ROM unit, and also executes the correction program in the RAM unit upon reaching a correcting point stored in the RAM unit.
摘要翻译：数据传送单元与存储校正程序等的数据的外部非易失性存储器连接，并且在检测到外部非易失性存储器已经与外部非易失性存储器连接的情况下，将外部非易失性存储器的校正程序等传送到内部非易失性存储器。完成数据传输后，外部非易失性存储器与数据传输单元断开连接。当CPU单元此后被复位时，它将校正程序等传送到RAM单元，执行ROM单元中的程序，并且在到达存储在RAM单元中的校正点时也在RAM单元中执行校正程序。

26. 发明授权

US6147230A Amino acid dysiherbaine 失效
标题翻译：氨基酸dysiherbaine
公开(公告)号：US6147230A
公开(公告)日：2000-11-14
申请号：US77371
申请日：1999-05-26
申请人： Keiko Shimamoto , Ryuichi Sakai , Hisao Kamiya , Michio Murata
发明人： Keiko Shimamoto , Ryuichi Sakai , Hisao Kamiya , Michio Murata
IPC分类号： A61K31/35 , A61K35/56 , A61P25/00 , A61P43/00 , C07D493/04 , C07D311/00
CPC分类号： C07D493/04
摘要： The present invention provides a novel amino acid dysiherbaine which is a non-NMDA type glutamate receptor agonist as well as salts and biological precursors thereof, which are useful as experimental materials for elucidating neuronal death or the functions of signal transduction of the central nervous system associated with glutamate receptors and which provide a possibility for the development of a glutamate receptor blocker.A novel amino acid dysiherbaine represented by the formula (1): ##STR1## is obtained by purifying an aqueous extract of a sponge such as D. herbacea on the basis of toxicity to mice by liquid chromatography using Sephadex LH20 or the like and HPLC using a C18 column, and optionally converting it into a biological precursor thereof.
摘要翻译： PCT No.PCT / JP97 / 03047 Sec。 371日期：1998年5月26日 102（e）日期1998年5月26日PCT 1997年9月1日提交PCT本发明提供了一种新型氨基酸异丁啡碱，其是非NMDA型谷氨酸受体激动剂及其盐和生物前体，其可用作实验材料阐明神经元死亡或与谷氨酸受体相关的中枢神经系统的信号转导的功能，并且其提供谷氨酸受体阻断剂发展的可能性。通过使用Sephadex LH20等进行液相色谱纯化基于对小鼠的毒性的海绵的含水提取物的纯化得到的式（1）所示的新型氨基酸异冰贴肉碱，使用C18柱，并且任选地将其转化为其生物前体。

27. 发明授权

US5149804A Ecteinascidins 736 and 722 失效
标题翻译： ECTEINASCIDINS 736 AND 722
公开(公告)号：US5149804A
公开(公告)日：1992-09-22
申请号：US620427
申请日：1990-11-30
申请人： Kenneth Rinehart , Ryuichi Sakai
发明人： Kenneth Rinehart , Ryuichi Sakai
IPC分类号： A61K31/435 , A61P35/00 , C07D515/22
CPC分类号： C07D515/22
摘要： Ecteinascidins 722 and 736 (Et's 722 and 736) have been isolated from the Caribbean tunicate Ecteinascidia turbinata and their structures have been assigned as tetrahydro-.beta.-carboline-substituted bis(tetrahydro- isoquinolines) related to the previously reported Et's 729 and 743. Et's 722 and 736 protect mice in vivo at very low concentrations against P388 lymphoma, B16 melanoma, and Lewis lung carcinoma.
摘要翻译： Ecteinascidins 722和736（Et的722和736）已经从加勒比海带的Ecteinascidia turbinata中分离出来，其结构被分配为与先前报道的Et的729和743相关的四氢-β-咔啉取代的双（四氢 - 异喹啉）。Et 722和736保护小鼠在非常低的浓度对P388淋巴瘤，B16黑素瘤和Lewis肺癌。

28. 发明授权

US4895854A Antitumor alkaloids 失效
标题翻译：抗肿瘤生物碱
公开(公告)号：US4895854A
公开(公告)日：1990-01-23
申请号：US228868
申请日：1988-08-05
申请人： Tatsuo Higa , Ryuichi Sakai
发明人： Tatsuo Higa , Ryuichi Sakai
IPC分类号： C07D519/00
CPC分类号： C07D519/00
摘要： This invention relates to antitumor alkaloid compositions, a process of producing the compositions and a method for inhibiting tumors utilizing the compositions. More particularly, the compositions are antitumor alkaloids which are derived from marine organisms, i.e., the marine sponge genus Haliclona.
摘要翻译：本发明涉及抗肿瘤生物碱组合物，制备组合物的方法和利用该组合物抑制肿瘤的方法。更具体地，组合物是衍生自海洋生物体的海洋海绵属Haliclona的抗肿瘤生物碱。

29. 发明授权

US4895852A Antitumor alkaloids 失效
标题翻译：抗肿瘤生物碱
公开(公告)号：US4895852A
公开(公告)日：1990-01-23
申请号：US124672
申请日：1987-11-24
申请人： Tatsuo Higa , Ryuichi Sakai , Toshio Ichiba
发明人： Tatsuo Higa , Ryuichi Sakai , Toshio Ichiba
IPC分类号： C07D519/00
CPC分类号： C07D519/00
摘要： This invention relates to antitumor alkaloid compositions, a process of producing the compositions and a method for inhibiting tumors utilizing the compositions. More particularly, the compositions are antitumor alkaloids which are derived from marine organisms, i.e., the marine sponge Xestospongia, sp.
摘要翻译：本发明涉及抗肿瘤生物碱组合物，制备组合物的方法和利用该组合物抑制肿瘤的方法。更具体地，组合物是衍生自海洋生物的抗肿瘤生物碱，即海洋海绵Xestospongia，sp。

30. 发明授权

US4772609A Antiviral guanidine derivatives and compositions therefor 失效
标题翻译：抗病毒胍衍生物及其组合物
公开(公告)号：US4772609A
公开(公告)日：1988-09-20
申请号：US879079
申请日：1986-06-26
申请人： Tatsuo Higa , Ryuichi Sakai
发明人： Tatsuo Higa , Ryuichi Sakai
IPC分类号： A61K31/155 , A61K31/505 , A61P31/12 , C07C67/00 , C07C239/00 , C07C279/08 , C07C301/00 , C07C313/00 , C07D239/42 , C07D239/30 , C07D239/32
CPC分类号： C07D239/42 , C07C279/08
摘要： This invention relates to antiviral organic guanidine derivatives compositions; a process of producing the antiviral compositions; and a method for inhibiting viruses utilizing the compositions. More particularly, the compositions are tubastrines derived from marine coral tubastrea aurea.
摘要翻译：本发明涉及抗病毒有机胍衍生物组合物; 制备抗病毒组合物的方法; 以及利用该组合物抑制病毒的方法。更具体地，组合物是衍生自海洋珊瑚tubastrea aurea的大麻素。

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