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    • 22. 发明申请
    • SCREENING METHOD USING NEW SUBSTRATE EPHA4 OF GAMMA-SECRETASE
    • 使用GAMMA-SECRETASE的新基片EPHA4的筛选方法
    • US20090142788A1
    • 2009-06-04
    • US12135307
    • 2008-06-09
    • Eiji Inoue
    • Eiji Inoue
    • C12Q1/37
    • C12Q1/37G01N2500/02Y10S435/975
    • The present invention provides a method of screening for compounds which affect the processing of EphA4 by γ-secretase, comprising the following steps: (i) contacting a first biological composition containing γ-secretase or a biologically active fragment thereof with a second biological composition containing EphA4 in the presence and absence of a candidate compound; (ii) measuring the cleavage of the EphA4 in the presence and absence of the candidate compound; (iii) selecting those candidate compounds which affect the cleavage of the EphA4 by γ-secretase; and (iv) identifying the candidate compounds selected in step (iii) as compounds which affect the processing of EphA4 by γ-secretase.
    • 本发明提供一种筛选影响通过γ-分泌酶处理EphA4的化合物的方法,包括以下步骤:(i)使含有γ-分泌酶或其生物活性片段的第一生物组合物与含有 EphA4在候选化合物的存在和不存在下; (ii)在存在和不存在候选化合物的情况下测量EphA4的切割; (iii)通过γ-分泌酶选择影响EphA4切割的候选化合物; 和(iv)将步骤(iii)中选择的候选化合物鉴定为影响通过γ-分泌酶处理EphA4的化合物。
    • 23. 发明授权
    • Toroidal type continuously variable transmission
    • 环形无级变速器
    • US07465249B2
    • 2008-12-16
    • US11258516
    • 2005-10-26
    • Hiroki NishiiEiji Inoue
    • Hiroki NishiiEiji Inoue
    • F16H55/32
    • F16H15/38
    • A toroidal type continuously variable transmission has an input shaft to which a rotation torque is input, an input side disk and an output side disk that are concentrically and rotatably supported by the input shaft in a state that an inner peripheral surface of the input side disk opposes to an inner peripheral surface of the output side disk, a power roller held between the input side disk and the output side disk and a hydraulic loading device applying predetermined pressing force so that the power roller is pressed between the input and output side disks. Fine grooves are formed on at least a radially inner part of the inner peripheral surface of the input side disk and at least radially outer part of the inner peripheral surface of the output side disk, respectively.
    • 环形无级变速器具有输入轴,输入侧盘和输出侧盘,输入侧盘和输出侧盘在输入侧盘的内周面同时被可转动地支承在输入轴上 与输出侧盘的内周表面相对,保持在输入侧盘和输出侧盘之间的动力辊和施加预定按压力的液压装载装置,使得动力辊在输入侧和输出侧盘之间被按压。 分别在输入侧盘的内周面的至少内径部分和输出侧盘的内周面的至少径向外侧部分上分别形成微细的槽。
    • 24. 发明授权
    • Continuously variable transmission apparatus
    • 连续可变传动装置
    • US06958029B2
    • 2005-10-25
    • US10721274
    • 2003-11-26
    • Eiji Inoue
    • Eiji Inoue
    • F16H37/02F16H37/08
    • F16H37/086F16H2037/0886
    • A continuously variable transmission apparatus, has: an input shaft; a toroidal-type continuously variable transmission; a first rotation transmission shaft; a first planetary-gear-type transmission; a second planetary-gear-type transmission; a second rotation transmission shaft; an output shaft; a first power transmission mechanism; a second power transmission mechanism; and a switching mechanism, wherein, in a state where the power transmission through the first power transmission mechanism is allowed and the power transmission through the second power transmission mechanism is cut off, in accordance with the control of the transmission ratio of the toroidal-type continuously variable transmission, the output shaft be stopped while leaving the input shaft rotating.
    • 一种无级变速传动装置,具有:输入轴; 环形无级变速器; 第一旋转传动轴; 第一行星齿轮式变速器; 第二行星齿轮式变速器; 第二旋转传动轴; 输出轴; 第一动力传动机构; 第二动力传动机构; 以及切换机构,其中,在通过所述第一动力传递机构的动力传递被允许并且通过所述第二动力传递机构的动力传递被切断的状态下,根据所述环形轮胎的传动比的控制 无级变速器,输出轴在输入轴旋转时停止。
    • 27. 发明申请
    • Toroidal-type continuously variable transmission
    • 环形无级变速器
    • US20050014598A1
    • 2005-01-20
    • US10820787
    • 2004-04-09
    • Kouji IshikawaHiroshi KatoEiji InoueHiroki Nishii
    • Kouji IshikawaHiroshi KatoEiji InoueHiroki Nishii
    • F16C33/78F16H15/38F16H57/04
    • F16H57/043F16H15/38F16H57/049
    • A toroidal-type continuously variable transmission according to the present invention includes an input shaft, an input disk and an output disk, plural power rollers, a power roller bearing, an oil passage, and a mesh filter. The input and output disks are supported mutually concentrically with said input shaft and mutually independently rotatably. The plural power rollers are sandwiched between said input disk and said output disks. The power roller bearing rotatably supports said power rollers. The oil passage for leading lubricating oil to said power roller bearing. The mesh filter is provided in said oil passage. Accordingly, the toroidal-type continuously variable transmission can prevent an occurrence of biting-in of foreign substances at a power roller bearing, to thereby increase the life of the power roller bearing.
    • 根据本发明的环形无级变速器包括输入轴,输入盘和输出盘,多个动力辊,动力滚子轴承,油通道和网状过滤器。 输入和输出盘与所述输入轴相互同心地支撑并相互独立地可旋转。 多个动力辊夹在所述输入盘和所述输出盘之间。 动力滚子轴承可旋转地支撑所述动力辊。 用于将润滑油引导到所述动力滚子轴承的油路。 所述油路中设有网状过滤器。 因此,环形无级变速器能够防止在动力滚子轴承上产生异物侵入,从而延长动力滚子轴承的使用寿命。
    • 28. 发明授权
    • Power driving device
    • 动力驱动装置
    • US06460669B2
    • 2002-10-08
    • US09778918
    • 2001-02-08
    • Eiji InoueHidetaka KogaAtsushi YanazakiTakefumi Okamoto
    • Eiji InoueHidetaka KogaAtsushi YanazakiTakefumi Okamoto
    • F16H4122
    • F02B65/00F02B61/00
    • A power driving device comprises a fluid coupling operated by an engine, a wet-type friction clutch disposed between said fluid coupling and a transmission, and a fluid operation means for circulating the operation fluid through said fluid coupling and for feeding the operation fluid to the wet-type friction clutch. In the pump housing of the fluid operation means, there is disposed a hydraulic pump that works as a source of hydraulic pressure, there are formed passages for communicating said hydraulic pump with said fluid coupling and with said wet-type friction clutch, and there are disposed a relief valve for adjusting the pressure of the operation fluid blown out from the hydraulic pump, a control valve for changing over the passage communicated with the fluid coupling and a control valve for changing over the passage communicated with the wet-type friction clutch.
    • 动力驱动装置包括由发动机操作的流体联接器,设置在所述流体联接器和变速器之间的湿式摩擦离合器,以及流体操作装置,用于使操作流体循环通过所述流体联接器,并将操作流体供给到 湿式摩擦离合器。 在流体操作装置的泵壳体中,设置有用作液压源的液压泵,形成有用于使所述液压泵与所述流体联轴器和所述湿式摩擦离合器连通的通道,并且存在 设置有用于调节从液压泵吹出的操作流体的压力的安全阀,用于切换与流体联轴器连通的通道的控制阀和用于切换与湿式摩擦离合器连通的通道的控制阀。