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    • 28. 发明授权
    • Bicyclic amines and their use as insecticides
    • 双环胺及其用作杀虫剂
    • US06294545B1
    • 2001-09-25
    • US09554423
    • 2000-05-12
    • Christopher John UrchRoger Salmon
    • Christopher John UrchRoger Salmon
    • A61K31439
    • C07D451/02A01N43/90
    • A compound of formula (I) wherein A is a bidentate group of the formula: XC═CY or XCH—CHY (wherein X and Y are independently hydrogen, hydroxy, acyloxy, alkoxy, cyano or halogen); and Ar is optionally substituted phenyl or optionally substituted heteroaryl; or an acid addition salt, quaternary ammonium salt or N-oxide derived therefrom; provided that when A is CH2—H2 then Ar is neither 5-chloropyrid-3-yl nor 5-trifluoromethylpyrid-3-yl; an insecticidal, acaricidal or nematicidal composition comprising an insecticidally, acaricidally or nematicidally effective amount of a compound of formula (I); a method of using a compound of formula (I) to combat or control insect, acarine or nematode pests; and processes for preparing a compound of said formula.
    • 式(I)的化合物,其中A是下式的二齿基团:XC = CY或XCH-CHY(其中X和Y独立地是氢,羟基,酰氧基,烷氧基,氰基或卤素); 并且Ar是任选取代的苯基或任选取代的杂芳基; 或由其衍生的酸加成盐,季铵盐或N-氧化物; 条件是当A是CH 2 -H 2时,Ar不是5-氯吡啶-3-基也不是5-三氟甲基吡啶-3-基; 杀虫,杀螨或杀线虫组合物,其包含杀虫,杀螨或杀线虫有效量的式(I)化合物; 使用式(I)化合物对抗或控制昆虫,蜱虫或线虫的方法; 以及制备所述式的化合物的方法。
    • 29. 发明授权
    • Bicyclic amine derivatives
    • 双环胺衍生物
    • US06291474B1
    • 2001-09-18
    • US09635879
    • 2000-08-10
    • Christopher Ian BrightwellChristopher Richard Ayles GodfreyChristopher John UrchMatthew Brian HotsonRaymond Leo SunleyRoger SalmonTerence Lewis
    • Christopher Ian BrightwellChristopher Richard Ayles GodfreyChristopher John UrchMatthew Brian HotsonRaymond Leo SunleyRoger SalmonTerence Lewis
    • A61K31435
    • C07D451/02A01N43/90A01N47/16A01N47/18C07D451/04C07D451/06C07D451/14
    • The invention provides a compound of formula (I): wherein A is CH═CH; Ar is an optionally substituted 5-membered heterocyclic ring system containing from 1 to 3 heteroatoms individually selected from nitrogen, oxygen and sulfur atoms, and at least one unsaturation (double bond) between adjacent atoms in the ring, said heterocyclic ring being optionally fused to a benzene ring, and R′ is hydrogen, cyano, hydroxy, alkyl, alkoxy, amino, nitro, isocyanato, acylamino, hydroxyalkyl, optionally substituted heteroaryl, alkoxyalkyl, haloalkyl, halohydroxyalkyl, aralkyloxyalkyl, acyloxyalkyl, amidoximido, sulfonyloxyalkyl, aminoalkyl, alkoxycarbonylamino, acylaminoalkyl, cyanoalkyl, imino, formyl, acyl or carboxylic acid or an ester or amide thereof, or alkenyl or alkynyl either of which is optionally substituted by halogen, alkoxy, cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl or cyano; or an acid addition salt, quaternary ammonium salt or N-oxide derived therefrom; an insecticidal, acaricidal or nematicidal composition comprising a compound of formula (I) and a suitable carrier or diluent therefor; a method of combating and controlling insect, acarine or nematode pests at a locus which comprises treating the pests or the locus of the pests with an effective amount of a compound of formula (I) or a composition as hereinbefore described.
    • 本发明提供式(I)化合物:其中A为CH = CH; Ar是任选取代的5元杂环系统,其含有1-3个分别选自氮,氧和硫原子的杂原子,以及环中相邻原子之间的至少一个不饱和键(双键),所述杂环任选地与 苯环,R'是氢,氰基,羟基,烷基,烷氧基,氨基,硝基,异氰酸根合,酰氨基,羟基烷基,任选取代的杂芳基,烷氧基烷基,卤代烷基,卤代羟烷基,芳烷氧基烷基,酰氧基烷基,酰氨基亚氨基,磺酰氧基烷基,氨基烷基,烷氧基羰基氨基, 酰基氨基烷基,氰基烷基,亚氨基,甲酰基,酰基或羧酸或其酯或酰胺,或任选被卤素,烷氧基,环烷基,任选取代的芳基,任选取代的杂芳基或氰基取代的链烯基或炔基; 或由其衍生的酸加成盐,季铵盐或N-氧化物; 杀虫杀螨或杀线虫组合物,其包含式(I)化合物及其合适的载体或稀释剂; 一种防治昆虫,螨虫或线虫害虫的方法,包括用有效量的式(I)化合物或上述组合物处理害虫或害虫的场所。
    • 30. 发明授权
    • Bicyclic amines
    • 双环胺
    • US5922732A
    • 1999-07-13
    • US651182
    • 1996-05-24
    • Christopher John UrchRoger SalmonTerence LewisChristopher Richard Ayles GodfreyMartin Stephen Clough
    • Christopher John UrchRoger SalmonTerence LewisChristopher Richard Ayles GodfreyMartin Stephen Clough
    • A01N43/42A01N43/90A01N47/16A01N47/22A01N47/38C07D401/04C07D451/02A61K31/44
    • C07D451/02A01N43/90A01N47/16A01N47/22A01N47/38C07D401/04
    • A compound of formula (I): ##STR1## wherein R.sup.1 represents a group of formula (A) where each of W, X, Y and Z and Z represents either a group CR or the nitrogen atom, provided that not more than two of W, X, Y and Z represent the nitrogen atom and where each R present is independently selected from hydrogen and halogen atoms and cyano, amino, hydrazino, acylamino, hydroxy, alkyl, hydroxyalkyl, alkoxy, haloalkyl, haloalkoxy, alkenyl, alkenyloxy, alkoxyalkenyl, alkynyl, carboxylic acyl, alkoxycarbonyl, aryl and heterocyclyl groups, said groups comprising up to 6 carbon atoms, and wherein R.sup.2 represents hydrogen or cyano or a group selected from alkyl, aryl, heteroaryl, aralkyl, heteroarylalkyl, alkenyl, aralkenyl, alkynyl, alkoxycarbonyl, alkanesulfonyl, arenesulfonyl, alkanyloxycarbonyl, aralkyloxycarbonyl, aryloxycarbonyl, heterocyclylalkyl, carbamyl or dithiocarboxyl groups, said groups comprising from 1 to 15 carbon atoms, said groups being optionally substituted with one or more substituents selected from, halogen, cyano, carboxyl, carboxylic acyl, carbamyl, alkoxycarbonyl, alkoxy, alkylenedioxy, hydroxy, nitro, haloalkyl, alkyl, amino, acylamino, imidate and phosphonato groups; and acid addition salts and quaternary ammonium salts and N-oxides derived therefrom. The compounds are useful as insecticides.
    • 式(I)的化合物:其中R 1表示式(A)的基团,其中W,X,Y和Z和Z各自表示基团CR或氮原子,条件是不大于2个W,X ,Y和Z代表氮原子,其中每个R独立地选自氢和卤素原子和氰基,氨基,肼基,酰氨基,羟基,烷基,羟基烷基,烷氧基,卤代烷基,卤代烷氧基,烯基,烯氧基,烷氧基烯基,炔基, 羧基酰基,烷氧基羰基,芳基和杂环基,所述基团包含至多6个碳原子,并且其中R 2表示氢或氰基或选自烷基,芳基,杂芳基,芳烷基,杂芳基烷基,烯基,芳烯基,炔基,烷氧基羰基,链烷磺酰基 ,芳基磺酰基,烷氧基羰基,芳烷氧基羰基,芳氧基羰基,杂环基烷基,氨基甲酰基或二硫代羧基,​​所述基团包含1至15个碳原子,所述基团任选被一个或多个取代基 选自卤素,氰基,羧基,羧基酰基,氨基甲酰基,烷氧基羰基,烷氧基,亚烷基二氧基,羟基,硝基,卤代烷基,烷基,氨基,酰氨基,亚胺基和膦酸酯基。 和酸加成盐和季铵盐和由其衍生的N-氧化物。 这些化合物可用作杀虫剂。