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21. 发明申请

US20060041256A1 GERD treatment apparatus and method 有权
标题翻译： GERD治疗仪和方法
公开(公告)号：US20060041256A1
公开(公告)日：2006-02-23
申请号：US11254951
申请日：2005-10-20
申请人： Stuart Edwards , David Utley
发明人： Stuart Edwards , David Utley
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00553
摘要： A method of forming a composite lesion pattern in a tissue region at or near a sphincter comprising providing a catheter having a plurality of energy delivery devices coupled to the catheter. The catheter is introduced at least partially into the sphincter. Energy is delivered from the energy delivery devices to produce the composite lesion pattern. The composite lesion pattern comprises a radial distribution of lesions about the tissue region and a longitudinal distribution of lesions along the tissue region.
摘要翻译：在括约肌处或附近在组织区域中形成复合损伤图案的方法，包括提供具有耦合到导管的多个能量输送装置的导管。将导管至少部分地引入括约肌。能量从能量输送装置输送以产生复合损伤模式。复合损伤图案包括围绕组织区域的损伤的径向分布和沿着组织区域的损伤的纵向分布。

22. 发明申请

US20050245926A1 Sphincter treatment apparatus 失效
标题翻译：括约肌治疗仪
公开(公告)号：US20050245926A1
公开(公告)日：2005-11-03
申请号：US11175471
申请日：2005-07-06
申请人： Stuart Edwards , David Utley , Ronald Lax , Theodore Kucklick , Peter Muller
发明人： Stuart Edwards , David Utley , Ronald Lax , Theodore Kucklick , Peter Muller
IPC分类号： A61B18/00 , A61B18/14
CPC分类号： A61B18/14 , A61B17/32 , A61B18/1477 , A61B18/1492 , A61B18/1815 , A61B2018/00011 , A61B2018/00029 , A61B2018/00148 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00494 , A61B2018/00553 , A61B2018/00577 , A61B2018/00702 , A61B2018/00726 , A61B2018/00744 , A61B2018/00791 , A61B2018/00875 , A61B2018/00916 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1472 , A61B2018/183 , A61B2090/3614 , A61B2090/3782
摘要： A sphincter treatment apparatus includes an energy delivery device introduction member including a proximal end with a first radius of curvature and a distal end with a second radius of curvature. The introduction member is configured to be introduced into the sphincter in a non-deployed state and to be expanded to a deployed state to at least partially expand the sphincter or an adjoining structure. An energy delivery device is coupled to the introduction member. A retainer member is coupled to the energy delivery device introduction member and configured to controllably position the introduction member in an orifice of the sphincter.
摘要翻译：括约肌治疗装置包括能量输送装置导入构件，其包括具有第一曲率半径的近端和具有第二曲率半径的远端。引入构件被配置为以非展开状态引入括约肌并且被扩展到展开状态以至少部分地扩展括约肌或相邻结构。能量输送装置联接到引入构件。保持器构件联接到能量输送装置引入构件并构造成将引导构件可控地定位在括约肌的孔中。

23. 发明申请

US20050203503A1 Infusion array ablation apparatus 审中-公开
标题翻译：输液阵列消融装置
公开(公告)号：US20050203503A1
公开(公告)日：2005-09-15
申请号：US11034503
申请日：2005-01-12
申请人： Stuart Edwards , James Baker , Hugh Sharkey , Ronald Lax
发明人： Stuart Edwards , James Baker , Hugh Sharkey , Ronald Lax
IPC分类号： A61B17/00 , A61B18/00 , A61B18/12 , A61B18/14 , A61B18/18 , A61B18/22 , A61M3/02 , A61M25/00 , A61N1/40 , A61N5/04 , C22C1/04 , C22C14/00 , C22F1/18
摘要： An infusion array ablation apparatus includes an elongated delivery device having a lumen and an infusion array positionable in the lumen. The infusion array includes an RF electrode and at least a first and a second infusion member. Each infusion member has a tissue piercing distal portion and an infusion lumen. At least one of the first or second infusion members is positionable in the elongated delivery device in a compacted state and deployable from the elongated delivery device with curvature in a deployed state. Also, at least one of the first or second infusion members exhibits a changing direction of travel when advanced from the elongated delivery device to a selected tissue site. At least one infusion port is coupled to one of the elongated delivery device, the infusion array, the first infusion member or the second infusion member.
摘要翻译：输液阵列消融装置包括细长递送装置，其具有可定位在内腔中的内腔和输液排列。输注阵列包括RF电极和至少第一和第二输注构件。每个输注构件具有组织穿刺远端部分和输注腔。第一或第二输注构件中的至少一个可以处于压实状态的细长输送装置中定位并且可以从伸长的输送装置以部署状态的曲率展开。此外，第一或第二输注构件中的至少一个表现出当从细长递送装置前进到选定的组织部位时改变的行进方向。至少一个输注端口连接到细长递送装置，输注阵列，第一输注构件或第二输注构件中的一个。

24. 发明申请

US20050183732A1 Surgical weight control device 失效
标题翻译：手术重量控制装置
公开(公告)号：US20050183732A1
公开(公告)日：2005-08-25
申请号：US11043902
申请日：2005-01-26
申请人： Stuart Edwards
发明人： Stuart Edwards
IPC分类号： A61B18/00 , A61B18/14 , A61F2/958 , A61F5/00 , A61N1/06 , A61N1/36 , A61B19/00 , A61B18/18
CPC分类号： A61F5/0026 , A61B18/1485 , A61B18/1492 , A61B2018/00029 , A61B2018/00065 , A61B2018/00214 , A61B2018/00232 , A61B2018/00238 , A61B2018/00261 , A61B2018/00482 , A61B2018/00654 , A61B2018/00797 , A61B2018/1467 , A61B2218/002 , A61B2218/007 , A61M25/1011 , A61M2025/105 , A61M2210/1053 , A61N1/0509 , A61N1/06 , A61N1/36007 , A61N1/36014
摘要： This invention provides a method and system for the curative treatment of obesity. A first aspect of this invention is that it enables identification of the nerves responsible for the relaxation of the stomach muscles that occurs prior to and during eating. A second aspect of the invention is that it allows the physician to identify focal nerve sites in the stomach and upper duodenum that are associated with producing sensations of hunger and satiety. Nervous transmission from these sites can be modulated or blocked all together so as to minimize the sensation of hunger. A third aspect of this invention is that allows a physician to shrink selected portions of the innermost oblique muscle and middle circular muscle layers of the stomach. This can be performed in a physician's office using local anesthesia. Shrinkage of these muscles produces a feeling of satiety that enhances the patient's efforts to restrict his caloric intake.
摘要翻译：本发明提供了治疗肥胖症的方法和系统。本发明的第一方面是能够识别在进食之前和期间发生的负责放松胃肌肉的神经。本发明的第二方面是其允许医师识别与产生饥饿感和饱腹感相关的胃和上十二指肠中的局灶性神经部位。这些地点的神经传播可以一起被调制或阻挡，以便最大限度地减少饥饿感。本发明的第三方面是允许医师收缩胃的最内倾斜肌肉和中间圆形肌肉层的选定部分。这可以在医生办公室使用局部麻醉进行。这些肌肉的收缩会产生饱腹感，从而增强患者的限制热量摄取的努力。

25. 发明授权

US06464697B1 Stomach and adjoining tissue regions in the esophagus 失效
标题翻译：用于治疗胃贲门和邻近食管组织区域的系统和方法。
公开(公告)号：US06464697B1
公开(公告)日：2002-10-15
申请号：US09304737
申请日：1999-05-04
申请人： Stuart Edwards , John Gaiser , David S Utley , Scott West , Jay Chin
发明人： Stuart Edwards , John Gaiser , David S Utley , Scott West , Jay Chin
IPC分类号： A61B1818
CPC分类号： A61B18/1492 , A61B18/12 , A61B18/1206 , A61B18/1477 , A61B18/1485 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/1475 , A61B2090/3782 , A61B2218/002 , A61B2218/007
摘要： Systems and methods treat a tissue region. In one arrangement, the systems and methods deploy an electrode on a support structure in a tissue region at or near the cardia of the stomach. The support structure has a proximal region and a distal region. The proximal region is enlarged in comparison to the distal region, and the electrode is carried by the enlarged proximal surface. The systems and methods advance the electrode in a path to penetrate the tissue region and couple the electrode to a source of radio frequency energy to ohmically heat tissue and create a lesion in the tissue region. In another arrangement, the systems and methods treat abnormal epithelium tissue at or near the lower esophageal sphincter by bringing an array of surface electrodes into contact with abnormal epithelium tissue. The systems and methods couple the surface electrodes to a source of radio frequency energy to ohmically heat tissue and cause necrosis of the abnormal epithelium tissue.
摘要翻译：系统和方法处理组织区域。在一种布置中，系统和方法将电极部署在胃贲门处或附近的组织区域中的支撑结构上。支撑结构具有近端区域和远侧区域。近端区域与远侧区域相比放大，并且电极由扩大的近侧表面承载。系统和方法使电极在路径中前进以穿透组织区域并将电极耦合到射频能量源以欧姆加热组织并在组织区域中产生损伤。在另一种布置中，系统和方法通过使表面电极阵列与异常上皮组织接触来治疗食管下括约肌或其附近的异常上皮组织。系统和方法将表面电极耦合到射频能量源以欧姆加热组织并引起异常上皮组织的坏死。

26. 发明授权

US06355031B1 Control systems for multiple electrode arrays to create lesions in tissue regions at or near a sphincter 有权
标题翻译：用于多个电极阵列的控制系统以在括约肌处或附近的组织区域中产生损伤
公开(公告)号：US06355031B1
公开(公告)日：2002-03-12
申请号：US09304733
申请日：1999-05-04
申请人： Stuart Edwards , John Gaiser , David S Utley , Scott West , Jay Qin
发明人： Stuart Edwards , John Gaiser , David S Utley , Scott West , Jay Qin
IPC分类号： A61B1818
CPC分类号： A61B18/1206 , A61B18/12 , A61B18/1477 , A61B18/1485 , A61B18/1492 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00494 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1253 , A61B2018/126 , A61B2018/1425 , A61B2018/1475 , A61B2090/3782 , A61B2218/002 , A61B2218/007
摘要： Multiple electrodes are coupled together in monopolar or bipolar arrays to form lesion patterns in tissue regions at or near a sphincter. A controller couples the electrodes to a generator so that a single power channel serves more than a single electrode.
摘要翻译：多个电极以单极或双极阵列耦合在一起，以在括约肌处或附近的组织区域中形成病变图案。控制器将电极耦合到发生器，使得单个功率通道服务于单个电极。

27. 发明授权

US06325798B1 Vacuum-assisted systems and methods for treating sphincters and adjoining tissue regions 有权
标题翻译：真空辅助系统和治疗括约肌和邻近组织区域的方法
公开(公告)号：US06325798B1
公开(公告)日：2001-12-04
申请号：US09304743
申请日：1999-05-04
申请人： Stuart Edwards , John Gaiser , David Utley , Scott West , Jay Chin , Ronald Lax
发明人： Stuart Edwards , John Gaiser , David Utley , Scott West , Jay Chin , Ronald Lax
IPC分类号： A61B1818
CPC分类号： A61B18/1206 , A61B18/12 , A61B18/1477 , A61B18/1485 , A61B18/1492 , A61B2017/22067 , A61B2017/308 , A61B2017/3488 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/1475 , A61B2090/036 , A61B2090/3782 , A61B2218/002 , A61B2218/007
摘要： Systems and methods treat a tissue region at or near a sphincter by deploying a carrier, which carries an electrode that can be advanced to penetrate tissue. Negative pressure is applied through a suction port on the carrier near the electrode, to draw tissue in the tissue region inward against the carrier. The systems and methods advance the electrode to penetrate tissue drawn against the carrier. The vacuum anchors the surrounding tissue and mediates against the “tenting” of tissue during electrode penetration. Without tenting, the electrode penetrates mucosal tissue fully, to obtain a desired depth of penetration.
摘要翻译：系统和方法通过展开携带可以被推进穿透组织的电极的载体来处理括约肌处或附近的组织区域。通过电极附近的载体上的吸入口施加负压，将组织区域中的组织向内抵靠载体。这些系统和方法使电极移动以穿透抵靠载体的组织。真空锚定周围的组织，并在电极穿透期间抵抗组织的“隆起”进行介导。没有隆起，电极完全渗透粘膜组织，以获得所需的穿透深度。

28. 发明申请

US20080097422A1 Graphical user interface for association with an electrode structure deployed in contact with a tissue region 有权
标题翻译：图形用户界面，用于与部署为与组织区域接触的电极结构相关联
公开(公告)号：US20080097422A1
公开(公告)日：2008-04-24
申请号：US12001091
申请日：2007-12-10
申请人： Stuart Edwards , John Gaiser , David Utley , Scott West , Jay Qin , Peter Muller
发明人： Stuart Edwards , John Gaiser , David Utley , Scott West , Jay Qin , Peter Muller
IPC分类号： A61B18/12
CPC分类号： A61B18/12 , A61B18/1206 , A61B18/1477 , A61B18/1485 , A61B18/1492 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/1475 , A61B2090/3782 , A61B2218/002 , A61B2218/007
摘要： Systems and methods deploy an electrode structure in contact with the tissue region. The electrode structure carries a sensor at a known location on the electrode structure to monitor an operating condition. The systems and methods provide an interface, which generate an idealized image of the electrode structure and an indicator image to represent the monitored operating condition in a spatial position on the idealized image corresponding to the location of the sensor on the electrode structure. The interface displays a view image comprising the idealized image and indicator image. The systems and methods cause the electrode structure to apply energy to heat the tissue region while the view image is displayed on the display screen.
摘要翻译：系统和方法部署与组织区域接触的电极结构。电极结构在电极结构上的已知位置处携带传感器以监测操作状态。系统和方法提供了一种接口，其产生电极结构的理想化图像和指示图像，以在对应于电极结构上的传感器的位置的理想化图像上的空间位置中表示监视的操作条件。界面显示包含理想图像和指示图像的视图。当视觉图像显示在显示屏上时，系统和方法使电极结构施加能量来加热组织区域。

29. 发明申请

US20070239134A1 Catheter system for delivery of therapeutic compounds to cardiac tissue 失效
标题翻译：用于将治疗性化合物递送至心脏组织的导管系统
公开(公告)号：US20070239134A1
公开(公告)日：2007-10-11
申请号：US11809022
申请日：2007-05-30
申请人： Michael Lesh , Thomas Kordis , Stuart Edwards
发明人： Michael Lesh , Thomas Kordis , Stuart Edwards
IPC分类号： A61M25/00
CPC分类号： A61M25/0136 , A61B17/22 , A61B2017/00243 , A61B2017/22082 , A61B2017/3488 , A61B2018/00273 , A61B2018/00815 , A61B2018/1425 , A61B2018/1435 , A61B2090/3784 , A61M25/0084 , A61M25/0133 , A61M25/0147 , A61N7/02
摘要： This is a method and an apparatus for the treatment or introduction of contrast fluids into tissue, particularly cardiac tissue. The apparatus includes a catheter having an elongated flexible body and a tissue infusion apparatus including a hollow infusion needle configured to secure the needle into the tissue when the needle is at least partially inserted into the tissue to help prevent inadvertent removal of the needle from the tissue. This permits the selected treatment or contrast fluid to be confined to a specific site. The catheter may also include a visualization assembly including a transducer at the distal end of the body.
摘要翻译：这是用于将对比流体治疗或引入组织，特别是心脏组织的方法和装置。所述装置包括具有细长柔性体的导管和包括中空输液针的组织浸液装置，所述中空灌注针构造成当针至少部分插入组织中时将针固定到组织中，以帮助防止针头从组织中无意中移除。这允许所选择的治疗或造影剂被限制在特定部位。导管还可以包括可视化组件，其包括在身体的远端处的换能器。

30. 发明申请

US20070093809A1 Apparatus to treat esophageal sphincters 审中-公开
标题翻译：食管括约肌治疗仪
公开(公告)号：US20070093809A1
公开(公告)日：2007-04-26
申请号：US11638952
申请日：2006-12-14
申请人： Stuart Edwards , David Utley
发明人： Stuart Edwards , David Utley
IPC分类号： A61B18/14
CPC分类号： A61B18/1477 , A61B5/4233 , A61B18/0218 , A61B18/1492 , A61B2017/3445 , A61B2017/345 , A61B2018/00267 , A61B2018/00488 , A61B2018/00553 , A61B2018/00589 , A61B2018/00648 , A61B2018/00702 , A61B2018/00821 , A61B2018/00827 , A61B2018/00875 , A61B2018/00892 , A61B2018/00994 , A61B2018/0262 , A61B2018/0293 , A61B2018/046 , A61B2018/1861 , A61B2018/1869
摘要： A sphincter treatment apparatus has an introducer means including a distal portion means. An expandable device means includes a plurality of arm means. Each arm means of the plurality has a distal section means and a proximal section means. Each of distal sections means of the arm means are coupled and each of the proximal sections means of the arm means are coupled to the introducer means distal portion means. The expandable device means is configured to at least partially dilate a sphincter in a deployed state. An energy delivery device means is introduceable from the introducer means into a selected site of the sphincter. The energy delivery device means is configured to deliver sufficient energy to reduce a frequency of relaxation of the sphincter.
摘要翻译：括约肌治疗装置具有包括远端部分装置的导引装置。可扩张装置包括多个臂装置。多个臂的每个臂装置具有远端部分装置和近端部分装置。臂装置的每个远端部分装置联接，并且臂装置的每个近端部分装置联接到导引装置远端部分装置。可扩张装置装置构造成在展开状态下至少部分地扩张括约肌。能量输送装置装置可从导引器装置引入括约肌的选定部位。能量递送装置装置被配置为递送足够的能量以减少括约肌的松弛频率。

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